ADCY2 (adenylate cyclase 2)

Gene

• Entrez ID: 108
• Gene name: Adenylate cyclase 2
• Gene symbol: ADCY2
• Synonyms (NCBI Gene): AC2, HBAC2
• Chromosome: 5
• Chromosome location: 5p15.31
• Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is sti

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT673408	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT572894	hsa-miR-4643	PAR-CLIP	20371350
MIRT572892	hsa-miR-4714-5p	PAR-CLIP	20371350
MIRT572893	hsa-miR-4318	PAR-CLIP	20371350
MIRT572891	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT572890	hsa-miR-4539	PAR-CLIP	20371350
MIRT572889	hsa-miR-7114-5p	PAR-CLIP	20371350
MIRT572888	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT572887	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT572886	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT647015	hsa-miR-3135b	qRT-PCR	31824817
MIRT647015	hsa-miR-3135b	qRT-PCR	31824817
MIRT736147	hsa-miR-345-3p	qRT-PCR	31824817
MIRT736147	hsa-miR-345-3p	qRT-PCR	31824817
MIRT673408	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT572894	hsa-miR-4643	PAR-CLIP	20371350
MIRT572892	hsa-miR-4714-5p	PAR-CLIP	20371350
MIRT572893	hsa-miR-4318	PAR-CLIP	20371350
MIRT572891	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT572890	hsa-miR-4539	PAR-CLIP	20371350
MIRT572889	hsa-miR-7114-5p	PAR-CLIP	20371350
MIRT572888	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT572887	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT572886	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT756043	hsa-miR-1224-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35831436
MIRT767957	hsa-miR-1260	CLIP-seq
MIRT767958	hsa-miR-1260b	CLIP-seq
MIRT767959	hsa-miR-1270	CLIP-seq
MIRT767960	hsa-miR-1273f	CLIP-seq
MIRT767961	hsa-miR-129-5p	CLIP-seq
MIRT767962	hsa-miR-1297	CLIP-seq
MIRT767963	hsa-miR-1321	CLIP-seq
MIRT767964	hsa-miR-141	CLIP-seq
MIRT767965	hsa-miR-188-3p	CLIP-seq
MIRT767966	hsa-miR-193a-5p	CLIP-seq
MIRT767967	hsa-miR-200a	CLIP-seq
MIRT767968	hsa-miR-218	CLIP-seq
MIRT767969	hsa-miR-2467-3p	CLIP-seq
MIRT767970	hsa-miR-26a	CLIP-seq
MIRT767971	hsa-miR-26b	CLIP-seq
MIRT767972	hsa-miR-3150a-3p	CLIP-seq
MIRT767973	hsa-miR-3156-3p	CLIP-seq
MIRT767974	hsa-miR-3175	CLIP-seq
MIRT767975	hsa-miR-3678-3p	CLIP-seq
MIRT767976	hsa-miR-3977	CLIP-seq
MIRT767977	hsa-miR-4252	CLIP-seq
MIRT767978	hsa-miR-432	CLIP-seq
MIRT767979	hsa-miR-4419a	CLIP-seq
MIRT767980	hsa-miR-4444	CLIP-seq
MIRT767981	hsa-miR-4465	CLIP-seq
MIRT767982	hsa-miR-450b-5p	CLIP-seq
MIRT767983	hsa-miR-4510	CLIP-seq
MIRT767984	hsa-miR-4531	CLIP-seq
MIRT767985	hsa-miR-4667-5p	CLIP-seq
MIRT767986	hsa-miR-4700-5p	CLIP-seq
MIRT767987	hsa-miR-4728-5p	CLIP-seq
MIRT767988	hsa-miR-4739	CLIP-seq
MIRT767989	hsa-miR-4756-3p	CLIP-seq
MIRT767990	hsa-miR-4756-5p	CLIP-seq
MIRT767991	hsa-miR-507	CLIP-seq
MIRT767992	hsa-miR-520d-5p	CLIP-seq
MIRT767993	hsa-miR-524-5p	CLIP-seq
MIRT767994	hsa-miR-543	CLIP-seq
MIRT767995	hsa-miR-548p	CLIP-seq
MIRT767996	hsa-miR-553	CLIP-seq
MIRT767997	hsa-miR-557	CLIP-seq
MIRT767998	hsa-miR-620	CLIP-seq
MIRT767999	hsa-miR-636	CLIP-seq
MIRT768000	hsa-miR-939	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq
MIRT1926471	hsa-miR-1227	CLIP-seq
MIRT1926472	hsa-miR-1271	CLIP-seq
MIRT1926473	hsa-miR-1299	CLIP-seq
MIRT1926474	hsa-miR-1324	CLIP-seq
MIRT1926475	hsa-miR-1343	CLIP-seq
MIRT1926476	hsa-miR-182	CLIP-seq
MIRT1926477	hsa-miR-28-5p	CLIP-seq
MIRT1926478	hsa-miR-3139	CLIP-seq
MIRT1926479	hsa-miR-3140-3p	CLIP-seq
MIRT1926480	hsa-miR-3199	CLIP-seq
MIRT1926481	hsa-miR-3614-3p	CLIP-seq
MIRT1926482	hsa-miR-3622a-5p	CLIP-seq
MIRT1926483	hsa-miR-378	CLIP-seq
MIRT1926484	hsa-miR-378b	CLIP-seq
MIRT1926485	hsa-miR-378c	CLIP-seq
MIRT1926486	hsa-miR-378d	CLIP-seq
MIRT1926487	hsa-miR-378e	CLIP-seq
MIRT1926488	hsa-miR-378f	CLIP-seq
MIRT1926489	hsa-miR-378g	CLIP-seq
MIRT1926490	hsa-miR-378h	CLIP-seq
MIRT1926491	hsa-miR-378i	CLIP-seq
MIRT1926492	hsa-miR-3973	CLIP-seq
MIRT1926493	hsa-miR-422a	CLIP-seq
MIRT1926494	hsa-miR-4269	CLIP-seq
MIRT1926495	hsa-miR-4330	CLIP-seq
MIRT1926496	hsa-miR-4437	CLIP-seq
MIRT1926497	hsa-miR-4438	CLIP-seq
MIRT1926498	hsa-miR-4470	CLIP-seq
MIRT1926499	hsa-miR-4638-3p	CLIP-seq
MIRT1926500	hsa-miR-4674	CLIP-seq
MIRT1926501	hsa-miR-4715-3p	CLIP-seq
MIRT1926502	hsa-miR-4782-5p	CLIP-seq
MIRT1926503	hsa-miR-5095	CLIP-seq
MIRT1926504	hsa-miR-5096	CLIP-seq
MIRT1926505	hsa-miR-516b	CLIP-seq
MIRT1926506	hsa-miR-532-3p	CLIP-seq
MIRT1926507	hsa-miR-548l	CLIP-seq
MIRT1926508	hsa-miR-617	CLIP-seq
MIRT1926509	hsa-miR-708	CLIP-seq
MIRT1926510	hsa-miR-96	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq
MIRT2167501	hsa-miR-1224-3p	CLIP-seq
MIRT1926471	hsa-miR-1227	CLIP-seq
MIRT2167502	hsa-miR-1245	CLIP-seq
MIRT767957	hsa-miR-1260	CLIP-seq
MIRT767958	hsa-miR-1260b	CLIP-seq
MIRT2167503	hsa-miR-128	CLIP-seq
MIRT2167504	hsa-miR-1280	CLIP-seq
MIRT2167505	hsa-miR-1323	CLIP-seq
MIRT1926475	hsa-miR-1343	CLIP-seq
MIRT767964	hsa-miR-141	CLIP-seq
MIRT2167506	hsa-miR-1910	CLIP-seq
MIRT767967	hsa-miR-200a	CLIP-seq
MIRT2167507	hsa-miR-224	CLIP-seq
MIRT2167508	hsa-miR-27a	CLIP-seq
MIRT2167509	hsa-miR-27b	CLIP-seq
MIRT2167510	hsa-miR-3122	CLIP-seq
MIRT2167511	hsa-miR-3168	CLIP-seq
MIRT2167512	hsa-miR-3170	CLIP-seq
MIRT1926480	hsa-miR-3199	CLIP-seq
MIRT1926482	hsa-miR-3622a-5p	CLIP-seq
MIRT1926483	hsa-miR-378	CLIP-seq
MIRT1926484	hsa-miR-378b	CLIP-seq
MIRT1926485	hsa-miR-378c	CLIP-seq
MIRT1926486	hsa-miR-378d	CLIP-seq
MIRT1926487	hsa-miR-378e	CLIP-seq
MIRT1926488	hsa-miR-378f	CLIP-seq
MIRT1926489	hsa-miR-378g	CLIP-seq
MIRT1926490	hsa-miR-378h	CLIP-seq
MIRT1926491	hsa-miR-378i	CLIP-seq
MIRT2167513	hsa-miR-3913-5p	CLIP-seq
MIRT1926492	hsa-miR-3973	CLIP-seq
MIRT1926493	hsa-miR-422a	CLIP-seq
MIRT1926494	hsa-miR-4269	CLIP-seq
MIRT2167514	hsa-miR-4279	CLIP-seq
MIRT1926496	hsa-miR-4437	CLIP-seq
MIRT1926497	hsa-miR-4438	CLIP-seq
MIRT1926499	hsa-miR-4638-3p	CLIP-seq
MIRT1926500	hsa-miR-4674	CLIP-seq
MIRT1926501	hsa-miR-4715-3p	CLIP-seq
MIRT1926503	hsa-miR-5095	CLIP-seq
MIRT1926504	hsa-miR-5096	CLIP-seq
MIRT1926506	hsa-miR-532-3p	CLIP-seq
MIRT2167515	hsa-miR-548o	CLIP-seq
MIRT1926508	hsa-miR-617	CLIP-seq
MIRT767966	hsa-miR-193a-5p	CLIP-seq
MIRT767972	hsa-miR-3150a-3p	CLIP-seq
MIRT767974	hsa-miR-3175	CLIP-seq
MIRT2383926	hsa-miR-4299	CLIP-seq
MIRT768000	hsa-miR-939	CLIP-seq
MIRT2426020	hsa-miR-3190	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	ISS
GO:0004016	Function	Adenylate cyclase activity	IBA
GO:0004016	Function	Adenylate cyclase activity	IEA
GO:0004016	Function	Adenylate cyclase activity	ISS
GO:0004016	Function	Adenylate cyclase activity	NAS	1427768
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	11549699
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	11549699
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006171	Process	CAMP biosynthetic process	IBA
GO:0006171	Process	CAMP biosynthetic process	IEA
GO:0006171	Process	CAMP biosynthetic process	ISS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0008179	Function	Adenylate cyclase binding	ISS
GO:0009190	Process	Cyclic nucleotide biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016829	Function	Lyase activity	IEA
GO:0016849	Function	Phosphorus-oxygen lyase activity	IEA
GO:0030145	Function	Manganese ion binding	ISS
GO:0030425	Component	Dendrite	ISS
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0045121	Component	Membrane raft	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:1904322	Process	Cellular response to forskolin	ISS

Other IDs

• MIM: 103071
• HGNC: 233
• e!Ensembl: ENSG00000078295

Protein

• UniProt ID: Q08462
• Protein name: Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2)
• Protein function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16214	AC_N	28 → 266	Adenylyl cyclase N-terminal extracellular and transmembrane region	Family
  PF00211	Guanylate_cyc	281 → 465	Adenylate and Guanylate cyclase catalytic domain	Domain
  PF06327	DUF1053	495 → 600	Domain of Unknown Function (DUF1053)	Family
  PF00211	Guanylate_cyc	878 → 1078	Adenylate and Guanylate cyclase catalytic domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus. {ECO:0000269|PubMed:11549699, ECO:0000269|PubMe
• Sequence:

  MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLA
  LLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAM
  GYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT
  PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ
  ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT
  RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK
  MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG
  VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPR
  HTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL
  RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAF
  KYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASP
  LLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS
  ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHT
  HAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKK
  EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY
  TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS
  QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI
  WGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEM
  SRSLSQSNVAS

• Sequence length: 1091

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ADCY2-related disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANXIETY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORNEAL NEOVASCULARIZATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEPRESSION, BIPOLAR	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FEMALE INFERTILITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIXED BIPOLAR I DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OROPHARYNX CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL VESSEL STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	22982105, 38039290	Associate	★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	GWASCAT_DG	31116379		★☆☆☆☆ Found in Text Mining only
Arrhythmogenic Right Ventricular Dysplasia	Arrhythmogenic right ventricular cardiomyopathy	Pubtator	30664203	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	CTD_human_DG	21912604		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma	Asthma	Pubtator	21912604, 27901618, 34727921	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma	Asthma	BEFREE	27901618		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	GWASCAT_DG	27890468		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	BEFREE	24618891, 25943950		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	24618891, 27890468		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	GWASDB_DG	24618891		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	24618891		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	24618891, 27063557	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	CTD_human_DG	31043756		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Borderline Personality Disorder	Borderline personality disorder	BEFREE	27890468		★☆☆☆☆ Found in Text Mining only
Bronchopulmonary Dysplasia	Bronchopulmonary Dysplasia	BEFREE	27890468		★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	32788609, 32789468	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	27427220	Associate	★☆☆☆☆ Found in Text Mining only
Childhood asthma	Asthma	BEFREE	21912604		★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	22461431		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	21528083, 35545337	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Stenosis	Coronary Stenosis	BEFREE	10435047		★☆☆☆☆ Found in Text Mining only
Depression, Bipolar	Bipolar Disorder	CTD_human_DG	31043756		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma	Glioma	BEFREE	8836153		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	GWASCAT_DG	26252872		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15025724, 15770724		★☆☆☆☆ Found in Text Mining only
Manic	Manic Disorder	CTD_human_DG	31043756		★☆☆☆☆ Found in Text Mining only
Manic Disorder	Manic Disorder	CTD_human_DG	31043756		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	35871080	Associate	★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	32887903	Associate	★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	8836153		★☆☆☆☆ Found in Text Mining only
Neuroendocrine Tumors	Neuroendocrine Tumors	BEFREE	21853033, 28068084		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	31278444	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	22461431	Associate	★☆☆☆☆ Found in Text Mining only