Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	22828
Gene name	SR-related CTD associated factor 8
Gene symbol	SCAF8
Synonyms (NCBI Gene)	RBM16
Chromosome	6
Chromosome location	6q25.2

65 Show/Hide all (65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052039	hsa-let-7b-5p	CLASH	23622248
MIRT049583	hsa-miR-92a-3p	CLASH	23622248
MIRT048359	hsa-miR-29b-3p	CLASH	23622248
MIRT037053	hsa-miR-877-3p	CLASH	23622248
MIRT1327762	hsa-miR-103a	CLIP-seq
MIRT1327763	hsa-miR-107	CLIP-seq
MIRT1327764	hsa-miR-1184	CLIP-seq
MIRT1327765	hsa-miR-1205	CLIP-seq
MIRT1327766	hsa-miR-1284	CLIP-seq
MIRT1327767	hsa-miR-223	CLIP-seq
MIRT1327768	hsa-miR-300	CLIP-seq
MIRT1327769	hsa-miR-3158-5p	CLIP-seq
MIRT1327770	hsa-miR-3613-5p	CLIP-seq
MIRT1327771	hsa-miR-3660	CLIP-seq
MIRT1327772	hsa-miR-381	CLIP-seq
MIRT1327773	hsa-miR-3921	CLIP-seq
MIRT1327774	hsa-miR-4282	CLIP-seq
MIRT1327775	hsa-miR-4476	CLIP-seq
MIRT1327776	hsa-miR-4526	CLIP-seq
MIRT1327777	hsa-miR-4653-5p	CLIP-seq
MIRT1327778	hsa-miR-4666-3p	CLIP-seq
MIRT1327779	hsa-miR-4744	CLIP-seq
MIRT1327780	hsa-miR-4796-5p	CLIP-seq
MIRT1327781	hsa-miR-544	CLIP-seq
MIRT1327782	hsa-miR-593	CLIP-seq
MIRT1327783	hsa-miR-944	CLIP-seq
MIRT1327771	hsa-miR-3660	CLIP-seq
MIRT1327773	hsa-miR-3921	CLIP-seq
MIRT1327776	hsa-miR-4526	CLIP-seq
MIRT1327777	hsa-miR-4653-5p	CLIP-seq
MIRT2097293	hsa-miR-520d-5p	CLIP-seq
MIRT2097294	hsa-miR-524-5p	CLIP-seq
MIRT2097295	hsa-miR-548m	CLIP-seq
MIRT1327782	hsa-miR-593	CLIP-seq
MIRT2097296	hsa-miR-664	CLIP-seq
MIRT1327767	hsa-miR-223	CLIP-seq
MIRT1327768	hsa-miR-300	CLIP-seq
MIRT1327770	hsa-miR-3613-5p	CLIP-seq
MIRT2321632	hsa-miR-3658	CLIP-seq
MIRT1327772	hsa-miR-381	CLIP-seq
MIRT2321633	hsa-miR-3915	CLIP-seq
MIRT2321634	hsa-miR-3928	CLIP-seq
MIRT1327778	hsa-miR-4666-3p	CLIP-seq
MIRT2321635	hsa-miR-579	CLIP-seq
MIRT2097296	hsa-miR-664	CLIP-seq
MIRT1327783	hsa-miR-944	CLIP-seq
MIRT2617975	hsa-miR-186	CLIP-seq
MIRT2617976	hsa-miR-3149	CLIP-seq
MIRT2617977	hsa-miR-361-5p	CLIP-seq
MIRT2617978	hsa-miR-4667-5p	CLIP-seq
MIRT2617979	hsa-miR-4700-5p	CLIP-seq
MIRT2617980	hsa-miR-4781-3p	CLIP-seq
MIRT2617981	hsa-miR-502-5p	CLIP-seq
MIRT2617982	hsa-miR-578	CLIP-seq
MIRT2321635	hsa-miR-579	CLIP-seq
MIRT2617983	hsa-miR-637	CLIP-seq
MIRT2097296	hsa-miR-664	CLIP-seq
MIRT2617984	hsa-miR-889	CLIP-seq
MIRT2617975	hsa-miR-186	CLIP-seq
MIRT2617978	hsa-miR-4667-5p	CLIP-seq
MIRT2617979	hsa-miR-4700-5p	CLIP-seq
MIRT2617981	hsa-miR-502-5p	CLIP-seq
MIRT2321635	hsa-miR-579	CLIP-seq
MIRT2617983	hsa-miR-637	CLIP-seq
MIRT2097296	hsa-miR-664	CLIP-seq

20 Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000993	Function	RNA polymerase II complex binding	IBA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IDA	31104839
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	31104839
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005849	Component	MRNA cleavage factor complex	IBA
GO:0006369	Process	Termination of RNA polymerase II transcription	IBA
GO:0016363	Component	Nuclear matrix	IEA
GO:0016363	Component	Nuclear matrix	ISS
GO:0032786	Process	Positive regulation of DNA-templated transcription, elongation	IDA	31104839
GO:0043175	Function	RNA polymerase core enzyme binding	IPI	18550522
GO:1990269	Function	RNA polymerase II C-terminal domain phosphoserine binding	IDA	31104839
GO:1990269	Function	RNA polymerase II C-terminal domain phosphoserine binding	IEA
GO:2000805	Process	Negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled	IDA	31104839
GO:2000805	Process	Negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled	IEA

MIM	HGNC	e!Ensembl
616024	20959	ENSG00000213079

Q9UPN6

Protein name

SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16)

Protein function

Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functiona

PDB

2DIW , 3D9I , 3D9J , 3D9K , 3D9L , 3D9M , 3D9N , 3D9O , 3D9P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	479 → 545	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF04818	CID	5 → 131	CID domain	Domain

Sequence

MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKV
PGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKN
NVFKSEIIQPLLDMAAGIPPPVVTPVLASTTTAMSNTPGTPVTPVTPANVVQGLPDPWVS
QITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQL
TAAAAAANTLTPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIF
HQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEV
NLDDSIDIQQQDMDIDEGQDGVEEEVFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRS
GSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLW
VGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIG
SKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWE
TVKSSEPVKETVQTTQSPTPVEKETVVTTQAEVFPPPVAMLQIPVAPAVPTVSLVPPAFP
VSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPSL
SMTPETVKDVGFGSLVIPGGSVASNLATSALPAGNVFNAPTKQAEPEEKVPHLIDHQISS
GENTRSVIPNDISSNAAILGGQPPNVTSNSGILGVQRPNVSSNSEILGVRPSNVSSSSGI
IAAQPPNILNNSGILGIQPPSVSNSSGLLGVLPPNIPNNSGLVGVQPPNVPNTPGLLGTQ
PPAGPQNLPPLSIPNQRMPTMPMLDIRPGLIPQAPGPRFPLIQPGIPPQRGIPPPSVLDS
ALHPPPRGPFPPGDIFSQPERPFLAPGRQSVDNVTNPEKRIPLGNDNIQQEGDRDYRFPP
IETRESISRPPPVDVRDVVGRPIDPREGPGRPPLDGRDHFGRPPVDIRENLVRPGIDHLG
RRDHFGFNPEKPWGHRGDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRG
FGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWVPPPHARVFDYFE
GATSQRKGDNVPQVNGENTERHAQPPPIPVQNDPELYEKLTSSNEINKEKSDTVADIESE
PVVESTETEGT

Sequence length

1271

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (8)
ASTHMA	—	GWAS catalog	31361310, 32296059	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	40164604	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATYPICAL FEMORAL FRACTURE	—	GWAS catalog	31006051	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism spectrum disorder	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	26621817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	26305897	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	26621817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESPIRATORY SYSTEM DISEASE	—	GWAS catalog	38965376	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (12)
Adenocarcinoma of large intestine	Colorectal Cancer	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	28401168	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	28401168		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	28401168		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic retinopathy	Pubtator	28401168	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Duane Retraction Syndrome	Duane retraction syndrome	Pubtator	28401168	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial Neoplasms	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	33883344	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of large intestine	Colorectal Neoplasms	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only

SCAF8 (SR-related CTD associated factor 8)

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