CDK2 (cyclin dependent kinase 2)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1017
• Gene name: Cyclin dependent kinase 2
• Gene symbol: CDK2
• Synonyms (NCBI Gene): CDKN2, p33(CDK2)
• Chromosome: 12
• Chromosome location: 12q13.2
• Summary: This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell

miRNA Show/Hide all (288)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004283	hsa-miR-124-3p	Luciferase reporter assay, Western blot	19404929
MIRT004764	hsa-miR-103a-3p	Luciferase reporter assay, qRT-PCR, Western blot	20886090
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assay, Microarray, Northern blot, Western blot	21062975
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assay, Microarray, Northern blot, Western blot	21062975
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assay, Microarray, Northern blot, Western blot	21062975
MIRT005461	hsa-miR-885-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21233845
MIRT006766	hsa-miR-372-3p	FACS, GFP reporter assay, qRT-PCR, Western blot	21646351
MIRT006766	hsa-miR-372-3p	FACS, GFP reporter assay, qRT-PCR, Western blot	21646351
MIRT007019	hsa-miR-376a-3p	Luciferase reporter assay	21556037
MIRT007019	hsa-miR-376a-3p	Luciferase reporter assay	21556037
MIRT020948	hsa-miR-155-5p	Proteomics	18668040
MIRT004283	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT030063	hsa-miR-26b-5p	Microarray	19088304
MIRT047445	hsa-miR-10b-5p	CLASH	23622248
MIRT046257	hsa-miR-23b-3p	CLASH	23622248
MIRT044112	hsa-miR-361-5p	CLASH	23622248
MIRT053070	hsa-miR-223-3p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24137330
MIRT006766	hsa-miR-372-3p	Luciferase reporter assay, Western blot, qRT-PCR	23479742
MIRT053775	hsa-miR-302a-3p	ChIP-seq, Flow, Microarray, qRT-PCR, Western blot	24861464
MIRT054309	hsa-miR-29a-3p	qRT-PCR, Western blot	25889078
MIRT054309	hsa-miR-29a-3p	qRT-PCR, Western blot	25889078
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT054309	hsa-miR-29a-3p	qRT-PCR, Western blot	25889078
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT659646	hsa-miR-622	HITS-CLIP	23824327
MIRT659644	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT659645	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT659643	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT659642	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT659641	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659640	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659638	hsa-miR-7977	HITS-CLIP	23824327
MIRT659639	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT570129	hsa-miR-4492	PAR-CLIP	20371350
MIRT570128	hsa-miR-4498	PAR-CLIP	20371350
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT570126	hsa-miR-762	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	23446348
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	23446348
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	23446348
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	23446348
MIRT513340	hsa-miR-5186	PAR-CLIP	23446348
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	23446348
MIRT513338	hsa-miR-4784	PAR-CLIP	23446348
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT513336	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT513334	hsa-miR-765	PAR-CLIP	23446348
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	23446348
MIRT513331	hsa-miR-2909	PAR-CLIP	23446348
MIRT479490	hsa-miR-3125	PAR-CLIP	23592263
MIRT479489	hsa-miR-3916	PAR-CLIP	23592263
MIRT479488	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT479487	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT479486	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT479485	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT479484	hsa-miR-4257	PAR-CLIP	23592263
MIRT479483	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT479481	hsa-miR-4270	PAR-CLIP	23592263
MIRT479482	hsa-miR-4441	PAR-CLIP	23592263
MIRT479480	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT479479	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT479478	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT479477	hsa-miR-4772-5p	PAR-CLIP	23592263
MIRT479476	hsa-miR-8071	PAR-CLIP	23592263
MIRT479475	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT479474	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT732203	hsa-miR-200c-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26248649
MIRT732203	hsa-miR-200c-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26248649
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	26701625
MIRT513331	hsa-miR-2909	PAR-CLIP	26701625
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	26701625
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	26701625
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	26701625
MIRT570129	hsa-miR-4492	PAR-CLIP	26701625
MIRT570128	hsa-miR-4498	PAR-CLIP	26701625
MIRT513338	hsa-miR-4784	PAR-CLIP	26701625
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	26701625
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	26701625
MIRT513340	hsa-miR-5186	PAR-CLIP	26701625
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	26701625
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	26701625
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	26701625
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	26701625
MIRT570126	hsa-miR-762	PAR-CLIP	26701625
MIRT513334	hsa-miR-765	PAR-CLIP	26701625
MIRT513336	hsa-miR-766-5p	PAR-CLIP	26701625
MIRT735447	hsa-miR-335-3p	qRT-PCR	32165872
MIRT659646	hsa-miR-622	HITS-CLIP	23824327
MIRT659644	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT659645	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT659643	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT659642	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT659641	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659640	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659638	hsa-miR-7977	HITS-CLIP	23824327
MIRT659639	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT570129	hsa-miR-4492	PAR-CLIP	20371350
MIRT570128	hsa-miR-4498	PAR-CLIP	20371350
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT570126	hsa-miR-762	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	23446348
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	23446348
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	23446348
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	23446348
MIRT513340	hsa-miR-5186	PAR-CLIP	23446348
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	23446348
MIRT513338	hsa-miR-4784	PAR-CLIP	23446348
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT513336	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT513334	hsa-miR-765	PAR-CLIP	23446348
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	23446348
MIRT513331	hsa-miR-2909	PAR-CLIP	23446348
MIRT479490	hsa-miR-3125	PAR-CLIP	23592263
MIRT479489	hsa-miR-3916	PAR-CLIP	23592263
MIRT479488	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT479487	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT479486	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT479485	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT479484	hsa-miR-4257	PAR-CLIP	23592263
MIRT479483	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT479481	hsa-miR-4270	PAR-CLIP	23592263
MIRT479482	hsa-miR-4441	PAR-CLIP	23592263
MIRT479480	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT479479	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT479478	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT479477	hsa-miR-4772-5p	PAR-CLIP	23592263
MIRT479476	hsa-miR-8071	PAR-CLIP	23592263
MIRT479475	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT479474	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT755832	hsa-miR-646	Western blotting, qRT-PCR, in vitro cullelar assays, Flow cytometry	37155307
MIRT880948	hsa-miR-18a	CLIP-seq
MIRT880949	hsa-miR-18b	CLIP-seq
MIRT880950	hsa-miR-4717-3p	CLIP-seq
MIRT880951	hsa-miR-4735-3p	CLIP-seq
MIRT880952	hsa-miR-4761-5p	CLIP-seq
MIRT880953	hsa-miR-520d-5p	CLIP-seq
MIRT880954	hsa-miR-616	CLIP-seq
MIRT880955	hsa-miR-1293	CLIP-seq
MIRT880956	hsa-miR-3129-3p	CLIP-seq
MIRT880957	hsa-miR-3153	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT880959	hsa-miR-3165	CLIP-seq
MIRT880960	hsa-miR-3179	CLIP-seq
MIRT880961	hsa-miR-3199	CLIP-seq
MIRT880962	hsa-miR-3612	CLIP-seq
MIRT880963	hsa-miR-3942-5p	CLIP-seq
MIRT880964	hsa-miR-3975	CLIP-seq
MIRT880965	hsa-miR-4443	CLIP-seq
MIRT880966	hsa-miR-4483	CLIP-seq
MIRT880967	hsa-miR-4515	CLIP-seq
MIRT880968	hsa-miR-4652-5p	CLIP-seq
MIRT880969	hsa-miR-4703-5p	CLIP-seq
MIRT880970	hsa-miR-4716-3p	CLIP-seq
MIRT880971	hsa-miR-548t	CLIP-seq
MIRT880972	hsa-miR-625	CLIP-seq
MIRT880973	hsa-miR-650	CLIP-seq
MIRT880974	hsa-miR-660	CLIP-seq
MIRT1960974	hsa-miR-1224-3p	CLIP-seq
MIRT1960975	hsa-miR-1263	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT1960976	hsa-miR-3622a-3p	CLIP-seq
MIRT1960977	hsa-miR-3622b-3p	CLIP-seq
MIRT1960978	hsa-miR-3651	CLIP-seq
MIRT1960979	hsa-miR-4756-3p	CLIP-seq
MIRT1960980	hsa-miR-4762-5p	CLIP-seq
MIRT1960981	hsa-miR-509-3p	CLIP-seq
MIRT1960982	hsa-miR-548al	CLIP-seq
MIRT2197677	hsa-miR-124	CLIP-seq
MIRT2197678	hsa-miR-200b	CLIP-seq
MIRT2197679	hsa-miR-200c	CLIP-seq
MIRT2197680	hsa-miR-214	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT2197681	hsa-miR-3188	CLIP-seq
MIRT2197682	hsa-miR-3619-5p	CLIP-seq
MIRT2197683	hsa-miR-3652	CLIP-seq
MIRT2197684	hsa-miR-3659	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197686	hsa-miR-3714	CLIP-seq
MIRT2197687	hsa-miR-3910	CLIP-seq
MIRT2197688	hsa-miR-3926	CLIP-seq
MIRT2197689	hsa-miR-3938	CLIP-seq
MIRT2197690	hsa-miR-429	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197692	hsa-miR-4430	CLIP-seq
MIRT2197693	hsa-miR-4459	CLIP-seq
MIRT2197694	hsa-miR-4477b	CLIP-seq
MIRT2197695	hsa-miR-451b	CLIP-seq
MIRT2197696	hsa-miR-4658	CLIP-seq
MIRT2197697	hsa-miR-4695-5p	CLIP-seq
MIRT2197698	hsa-miR-4713-3p	CLIP-seq
MIRT2197699	hsa-miR-4715-5p	CLIP-seq
MIRT880950	hsa-miR-4717-3p	CLIP-seq
MIRT2197700	hsa-miR-4722-5p	CLIP-seq
MIRT2197701	hsa-miR-4724-5p	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197703	hsa-miR-4742-3p	CLIP-seq
MIRT2197704	hsa-miR-506	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197706	hsa-miR-519a	CLIP-seq
MIRT2197707	hsa-miR-519b-3p	CLIP-seq
MIRT2197708	hsa-miR-519c-3p	CLIP-seq
MIRT2197709	hsa-miR-548s	CLIP-seq
MIRT2197710	hsa-miR-571	CLIP-seq
MIRT2197711	hsa-miR-574-5p	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq
MIRT2197713	hsa-miR-630	CLIP-seq
MIRT2197714	hsa-miR-647	CLIP-seq
MIRT2197715	hsa-miR-761	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq

Transcription factors Show/Hide all (9)

Transcription factor	Regulation	Reference
ARNT	Repression	21544813
DDIT3	Unknown	20017906
E2F4	Unknown	22447046
GLI1	Activation	20647328
IRF1	Repression	22200613
KAT2B	Repression	19525977
MITF	Unknown	15607961
MYC	Unknown	21384303
TP53	Repression	12732645

Gene ontology (GO) Show/Hide all (99)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IBA
GO:0000082	Process	G1/S transition of mitotic cell cycle	IEA
GO:0000082	Process	G1/S transition of mitotic cell cycle	NAS	9840943, 15838514
GO:0000086	Process	G2/M transition of mitotic cell cycle	NAS	1653904
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IBA
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IDA	1312467, 8692841
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IEA
GO:0000723	Process	Telomere maintenance	IDA	28216226
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0000793	Component	Condensed chromosome	IEA
GO:0000805	Component	X chromosome	IEA
GO:0000806	Component	Y chromosome	IEA
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11953320
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IGI	26996940
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IBA
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IDA	21596315, 28216226
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IEA
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	2227411, 7630397, 8242750, 8521818, 8601310, 8684460, 8756328, 8756624, 9840943, 10330164, 11463386, 11980914, 12244298, 12361598, 12839962, 12941338, 15107404, 15178429, 15189033, 15232106, 15239650, 15530371, 15611625, 15890360, 16061792, 16209941, 16326706, 16327805, 16431923, 167
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10767298
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IEA
GO:0005654	Component	Nucleoplasm	IDA	8245034
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10767298
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IDA	21262353
GO:0005768	Component	Endosome	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	TAS	19238148
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006260	Process	DNA replication	TAS	19238148
GO:0006281	Process	DNA repair	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006468	Process	Protein phosphorylation	IDA	12944431, 28666995
GO:0006468	Process	Protein phosphorylation	IMP	29203878
GO:0006813	Process	Potassium ion transport	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0007099	Process	Centriole replication	IMP	26297806
GO:0007165	Process	Signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	IEP	9054499
GO:0007346	Process	Regulation of mitotic cell cycle	TAS
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	10767298
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	IBA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0015030	Component	Cajal body	IDA	10995387
GO:0015030	Component	Cajal body	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	23184662
GO:0019904	Function	Protein domain specific binding	IPI	8876165, 15024385
GO:0030332	Function	Cyclin binding	IBA
GO:0030332	Function	Cyclin binding	IDA	1653904, 23781148
GO:0030332	Function	Cyclin binding	IEA
GO:0030332	Function	Cyclin binding	IPI	1312467, 15024385
GO:0031453	Process	Positive regulation of heterochromatin formation	IDA	20935635
GO:0031571	Process	Mitotic G1 DNA damage checkpoint signaling	TAS	21319273
GO:0031848	Process	Protection from non-homologous end joining at telomere	IDA	28216226
GO:0032298	Process	Positive regulation of DNA-templated DNA replication initiation	IEA
GO:0035173	Function	Histone kinase activity	IDA	8692841
GO:0043247	Process	Telomere maintenance in response to DNA damage	IDA	28216226
GO:0043247	Process	Telomere maintenance in response to DNA damage	IDA	28216226
GO:0043687	Process	Post-translational protein modification	IDA	11746698
GO:0045740	Process	Positive regulation of DNA replication	TAS
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051298	Process	Centrosome duplication	TAS	19238148
GO:0051301	Process	Cell division	IEA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051321	Process	Meiotic cell cycle	TAS	19238148
GO:0071732	Process	Cellular response to nitric oxide	TAS	20079829
GO:0090398	Process	Cellular senescence	TAS
GO:0097123	Component	Cyclin A1-CDK2 complex	IEA
GO:0097123	Component	Cyclin A1-CDK2 complex	NAS	12244298
GO:0097124	Component	Cyclin A2-CDK2 complex	IDA	1312467, 8684460, 8876165, 11746698, 15024385
GO:0097124	Component	Cyclin A2-CDK2 complex	IEA
GO:0097124	Component	Cyclin A2-CDK2 complex	IPI	12244298
GO:0097134	Component	Cyclin E1-CDK2 complex	IEA
GO:0097134	Component	Cyclin E1-CDK2 complex	IPI	8756624
GO:0097135	Component	Cyclin E2-CDK2 complex	IEA
GO:0097135	Component	Cyclin E2-CDK2 complex	IPI	15232106
GO:0097472	Function	Cyclin-dependent protein kinase activity	IDA	1312467, 24670654, 28666995
GO:0097472	Function	Cyclin-dependent protein kinase activity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1905784	Process	Regulation of anaphase-promoting complex-dependent catabolic process	TAS

Other IDs

• MIM: 116953
• HGNC: 1771
• e!Ensembl: ENSG00000123374

Protein

• UniProt ID: P24941
• Protein name: Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
• Protein function: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431,
• PDB: 1AQ1 , 1B38 , 1B39 , 1BUH , 1CKP , 1DI8 , 1DM2 , 1E1V , 1E1X , 1E9H , 1F5Q , 1FIN , 1FQ1 , 1FVT , 1FVV , 1G5S , 1GIH , 1GII , 1GIJ , 1GY3 , 1GZ8 , 1H00 , 1H01 , 1H07 , 1H08 , 1H0V , 1H0W , 1H1P , 1H1Q , 1H1R , 1H1S , 1H24 , 1H25 , 1H26 , 1H27 , 1H28 , 1HCK , 1HCL , 1JST , 1JSU , 1JSV , 1JVP , 1KE5 , 1KE6 , 1KE7 , 1KE8 , 1KE9 , 1OGU , 1OI9 , 1OIQ , 1OIR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	4 → 286	Protein kinase domain	Domain

• Sequence:

  MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
  HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
  STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
  PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

• Sequence length: 298

Pathways

KEGG Pathway	Reactome Pathway
FoxO signaling pathway	G0 and Early G1
Cell cycle	Activation of ATR in response to replication stress
Oocyte meiosis	Regulation of APC/C activators between G1/S and early anaphase
p53 signaling pathway	SCF(Skp2)-mediated degradation of p27/p21
PI3K-Akt signaling pathway	Senescence-Associated Secretory Phenotype (SASP)
Cellular senescence	DNA Damage/Telomere Stress Induced Senescence
Progesterone-mediated oocyte maturation	Processing of DNA double-strand break ends
Cushing syndrome	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Hepatitis C	Regulation of TP53 Activity through Phosphorylation
Hepatitis B	Regulation of TP53 Degradation
Measles	G2 Phase
Human papillomavirus infection	Orc1 removal from chromatin
Human T-cell leukemia virus 1 infection	Activation of the pre-replicative complex
Epstein-Barr virus infection	CDK-mediated phosphorylation and removal of Cdc6
Pathways in cancer	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Viral carcinogenesis	Cyclin E associated events during G1/S transition
Prostate cancer	Cyclin A/B1/B2 associated events during G2/M transition
Small cell lung cancer	p53-Dependent G1 DNA Damage Response
Gastric cancer	Cyclin A:Cdk2-associated events at S phase entry
	PTK6 Regulates Cell Cycle
	Transcriptional regulation of granulopoiesis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ASTHMA	—	GWAS catalog	21804548	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	CTD	21559390	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA OF HEAD AND NECK	—	CTD	29464035	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TRIPLE NEGATIVE BREAST NEOPLASMS	—	CTD	33727089	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (295)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	7544647, 7630190, 8547131, 8618438, 8637233, 8704231, 9258663, 9355972		★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	29720484		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	10601379, 10713684, 31788115, 8589035, 8621247, 8934532, 9155671, 9873831		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	28423618, 8609061		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma, Endometrioid	Endometrial Cancer	BEFREE	15213599		★☆☆☆☆ Found in Text Mining only
Adenoid Cystic Carcinoma	Adenocarcinoma	BEFREE	17912431		★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	BEFREE	14612924, 30196178		★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	7544647, 8618438, 8637233, 8704231		★☆☆☆☆ Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma	B-cell Lymphoma	CGI_DG			★☆☆☆☆ Found in Text Mining only
Adult Medulloblastoma	Medulloblastoma	BEFREE	29511348		★☆☆☆☆ Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia	T-Cell Lymphoma/Leukemia	BEFREE	7742529, 8826890, 9638973		★☆☆☆☆ Found in Text Mining only
Agenesis of corpus callosum	Agenesis Of Corpus Callosum	BEFREE	17912431, 31529315		★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	25410660		★☆☆☆☆ Found in Text Mining only
Anaplastic astrocytoma	Anaplastic Astrocytoma	BEFREE	7987821, 8548755		★☆☆☆☆ Found in Text Mining only
Anaplastic Oligodendroglioma	Anaplastic Oligodendroglioma	BEFREE	10359140		★☆☆☆☆ Found in Text Mining only
Anaplastic thyroid carcinoma	Anaplastic thyroid cancer	BEFREE	8561866		★☆☆☆☆ Found in Text Mining only
Aneuploidy	Aneuploidy	Pubtator	23321641	Associate	★☆☆☆☆ Found in Text Mining only
Anophthalmia with pulmonary hypoplasia	Anophthalmia	Pubtator	39358545	Associate	★☆☆☆☆ Found in Text Mining only
Aortic Dissection	Aortic dissection	Pubtator	36818541	Associate	★☆☆☆☆ Found in Text Mining only
Aortic Valve Insufficiency	Aortic Valve Insufficiency	BEFREE	23130941		★☆☆☆☆ Found in Text Mining only
Aplasia Cutis Congenita	Aplasia Cutis Congenita	BEFREE	17912431, 31529315		★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	29567075		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	19404929, 21676922	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	GWASCAT_DG	21804548		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma	Asthma	GWASDB_DG	21804548		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Astrocytoma	Astrocytoma	BEFREE	10359140, 7849711, 8548755, 8674005, 8857999, 9291941, 9454886		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	27172220	Associate	★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	17163457		★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia telangiectasia	Pubtator	26429916	Associate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	29567075		★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	BEFREE	18941885		★☆☆☆☆ Found in Text Mining only
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1	Lymphoblastic Leukemia	BEFREE	27090891		★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	10397744, 29655853, 30218747, 31155753, 7670111		★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	BEFREE	8934532, 9155671, 9834265		★☆☆☆☆ Found in Text Mining only
Benign Rolandic Epilepsy	Benign Rolandic Epilepsy	BEFREE	27733185		★☆☆☆☆ Found in Text Mining only
Biliary Tract Cancer	Biliary Tract Cancer	BEFREE	7796400		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	10022125, 10938379, 11410506, 28693160, 31455378, 7553622, 8541841, 9171998, 9738978		★☆☆☆☆ Found in Text Mining only
Blast Phase	Blast phase chronic myelogenous leukemia	BEFREE	8555065		★☆☆☆☆ Found in Text Mining only
Bone Marrow Diseases	Bone marrow diseases	Pubtator	19201832	Associate	★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	10536183, 8689637		★☆☆☆☆ Found in Text Mining only
Brain Tumor, Primary	Brain Neoplasms	BEFREE	26124340		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	10995786, 15572662, 16020661, 16740735, 19239702, 21150326, 21385896, 22828875, 23185313, 23285007, 23390492, 23390529, 23494890, 23955388, 24956567, 26282201, 27101368, 27410227, 27496804, 29137354, 29137393, 29330290, 29853338, 30106443, 30286765, 7547249, 7796417, 7923151, 8867812, 9259969, 9990866		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	10757805, 10991938, 10995786, 11337496, 12379472, 17055492, 17671085, 18060053, 18236071, 19242061, 21821547, 22108518, 22948662, 23185313, 23285007, 23321641, 23390492, 23390529, 23446853, 24444383, 26771717, 27410227, 27496804, 29328377, 30286765, 31078043, 33098638, 33466812, 35383130, 36539893, 9215124, 9528753	Associate	★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt`s Lymphoma	BEFREE	7849311		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	11884622, 12684894, 24386425, 26701206, 28760857	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoid Tumor	Carcinoid tumor	Pubtator	26008974	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	26008974, 7553622, 7614482, 8621247, 8640773, 8797888, 8835820, 8980248, 9072554, 9764589, 9815578		★☆☆☆☆ Found in Text Mining only
Carcinoma Embryonal	Embryonal carcinoma	Pubtator	19259937	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	10884382, 15298730, 25292023, 27782152, 28333141, 28742201, 29782647, 35694386, 35958019, 36047102, 36069218	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Large Cell	Large cell carcinoma	Pubtator	9736045	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Merkel Cell	Merkel cell carcinoma	Pubtator	31694959	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	10022125, 10938379, 11223676, 11410506, 28693160, 30237499, 31455378, 8541841, 8631601, 9171998		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	15743317, 19854217, 25754817, 25808870, 26304236, 28376145, 29541172, 7551956, 7563154, 7566983, 8589032, 9673367, 9891228		★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	35445726	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	19473483, 25443276, 30675171, 34595849, 37464398, 39199428	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Small Cell	Small cell carcinoma	Pubtator	9736045	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	11710944, 27356570, 34738627, 9736045	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Transitional Cell	Transitional cell carcinoma	Pubtator	10408858	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	10329035, 11992549, 17466040, 23787073, 24004674, 26828990, 7591208, 7743516, 9426687		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	30361442		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	32196466, 32631246	Associate	★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	10675486, 21646351		★☆☆☆☆ Found in Text Mining only
Cervical Intraepithelial Neoplasia	Cervical Intraepithelial Neoplasia	BEFREE	30504376		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	21646351		★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	11426564, 7544647, 7630190, 8618438, 8637233, 8704231, 9089742, 9324282		★☆☆☆☆ Found in Text Mining only
Childhood Medulloblastoma	Medulloblastoma	BEFREE	29511348		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	10718212, 26572808, 31746435		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	22972485	Associate	★☆☆☆☆ Found in Text Mining only
Chondrosarcoma	Chondrosarcoma	Pubtator	26555773	Associate	★☆☆☆☆ Found in Text Mining only
Chondrosarcoma	Chondrosarcoma	BEFREE	8689636, 8689637		★☆☆☆☆ Found in Text Mining only
Chromosomal Instability	Chromosomal instability	Pubtator	28760857	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	15902296, 7670111		★☆☆☆☆ Found in Text Mining only
Classical Lissencephalies and Subcortical Band Heterotopias	Lissencephaly	Pubtator	26121641	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	12810668, 26028036, 27819669, 28492347, 28827110, 29063678, 29345391		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	16177568	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	15806176, 17689689, 23777425, 23867993, 26398439, 29435174, 30131854, 7601562, 7779716		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	16437675, 24550143, 29386092, 35039060, 37919073, 7779716	Associate	★☆☆☆☆ Found in Text Mining only
Congenital chromosomal disease	Congenital Chromosomal Disease	BEFREE	29357072, 7849311		★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	24935000, 26248649, 29482572		★☆☆☆☆ Found in Text Mining only
Cutaneous Melanoma	Melanoma	BEFREE	8562340, 8631588, 9221801		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	29899865		★☆☆☆☆ Found in Text Mining only
Deuteranomaly	Deuteranomaly	BEFREE	31349651		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	28100774		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	28100774		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	29700214		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	30300385, 30914061		★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	16704435, 18156799, 9591637		★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	CGI_DG			★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	10757805, 30763715	Associate	★☆☆☆☆ Found in Text Mining only
Endocrine System Diseases	Endocrine system disease	Pubtator	33098638	Associate	★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	7646759		★☆☆☆☆ Found in Text Mining only
Endometrial Hyperplasia	Endometrial Hyperplasia	BEFREE	10682682		★☆☆☆☆ Found in Text Mining only
Endometrial Hyperplasia	Endometrial hyperplasia	Pubtator	19631369	Stimulate	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	12684894	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy Idiopathic Generalized	Epilepsy	Pubtator	26537625	Stimulate	★☆☆☆☆ Found in Text Mining only
Epilepsy Idiopathic Generalized	Epilepsy	Pubtator	30675171	Associate	★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	11992549, 17466040		★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	24297335, 31354907, 7614482		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	24297335, 31354907, 7614482, 9808520		★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	10390005, 27496804	Associate	★☆☆☆☆ Found in Text Mining only
Ewings sarcoma	Ewing sarcoma	BEFREE	31649026		★☆☆☆☆ Found in Text Mining only
Ewings sarcoma-primitive neuroectodermal tumor (PNET)	Ewing sarcoma	BEFREE	7791990		★☆☆☆☆ Found in Text Mining only
Familial Atypical Mole Melanoma Syndrome	Atypical Mole Melanoma Syndrome	BEFREE	7640518		★☆☆☆☆ Found in Text Mining only
Fibroid Tumor	Leiomyoma	BEFREE	12634633		★☆☆☆☆ Found in Text Mining only
Gallbladder Carcinoma	Gallbladder cancer	BEFREE	25218593		★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Gallbladder neoplasm	Pubtator	29513793	Associate	★☆☆☆☆ Found in Text Mining only
Gastric Adenocarcinoma	Gastric Cancer	BEFREE	9139866		★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	BEFREE	18438954, 25707496		★☆☆☆☆ Found in Text Mining only
Germ cell tumor	Tumor	BEFREE	11358847, 9554401		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	10359140, 24704824, 26151768, 26678675, 7987821, 8548755, 9217972		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	17960384, 32678261, 32781747, 34716726, 35982032, 37936247	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	24704824, 24967941, 26151768, 26678675, 7887443, 8548755, 8857999, 9217972		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	10651484, 11496313, 17565152, 26124340, 27733185, 30272277, 7728764, 7867008, 8548755, 8552379, 9247304, 9366522		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	18492260, 27613831, 32851798, 37936247	Associate	★☆☆☆☆ Found in Text Mining only
Glomerulonephritis IGA	Iga nephropathy	Pubtator	15208647	Associate	★☆☆☆☆ Found in Text Mining only
Glomerulonephritis Membranous	Membranous glomerulonephritis	Pubtator	28760550	Associate	★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	23461792, 29229598		★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	29229598	Associate	★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	39351221	Associate	★☆☆☆☆ Found in Text Mining only
hemangiopericytoma	Hemangiopericytoma	BEFREE	8834533		★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	7544647, 9086436		★☆☆☆☆ Found in Text Mining only
Hematopoietic Neoplasms	Hematopoietic Neoplasms	BEFREE	29541172		★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome	BEFREE	24395243		★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	26598692, 28678584	Associate	★☆☆☆☆ Found in Text Mining only
Hereditary gingival fibromatosis	Hereditary Gingival Fibromatosis	BEFREE	18004740		★☆☆☆☆ Found in Text Mining only
Hereditary Melanoma	Hereditary cutaneous melanoma	BEFREE	8570179, 9667525		★☆☆☆☆ Found in Text Mining only
Hereditary pancreatitis	Hereditary Pancreatitis	BEFREE	8834533		★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin disease	Pubtator	12393683	Associate	★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	7544647, 9086436, 9309120		★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	CGI_DG			★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	Pubtator	12379472	Stimulate	★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	12401721		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	10471034	Inhibit	★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	14511370	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Breast Carcinoma	Breast Cancer	BEFREE	28107181		★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral disc disease	Pubtator	32271397	Associate	★☆☆☆☆ Found in Text Mining only
Intervertebral disc disorder	Intervertebral Disc Disorder	BEFREE	29700214		★☆☆☆☆ Found in Text Mining only
Intestinal Neoplasms	Intestinal Neoplasms	BEFREE	17631145		★☆☆☆☆ Found in Text Mining only
Keratocystic Odontogenic Tumor	Keratocystic Odontogenic Tumor	BEFREE	28512636		★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	15208647	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Failure, Acute	Kidney Failure	BEFREE	27470679, 28566468		★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	24272084	Associate	★☆☆☆☆ Found in Text Mining only
Laryngeal Neoplasms	Laryngeal neoplasm	Pubtator	28269752	Associate	★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	10854234, 30015921	Associate	★☆☆☆☆ Found in Text Mining only
Leiomyosarcoma	Leiomyosarcoma	Pubtator	10854234	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	24520316, 25451924, 8704231	Associate	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	25451924, 7630199, 7849311, 7882348, 8547131, 8618438, 8689637, 8704231, 9258663		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	16115123	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	25844667	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	11212263, 25451924, 28656088, 29720484, 31692040, 7544647		★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	BEFREE	7742529		★☆☆☆☆ Found in Text Mining only
Li-Fraumeni Syndrome	Li-Fraumeni Syndrome	BEFREE	10389970		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	10374394, 10575317, 18350604, 19885547, 20512928, 22002319, 22610972, 24336329, 29782647, 30150405, 30444001, 30779474, 30842588, 30947664, 31597595, 31804459, 9407351, 9464511, 9873831		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	LHGDN	12531694, 16036217		★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	24671051	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	19633068, 27356570, 33148075, 9708810, 9736045	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	24151513	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	24386425	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoid leukemia	Lymphoid leukemia	BEFREE	7882348		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	10851086	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	11291051, 7849311, 7882348, 9258663		★☆☆☆☆ Found in Text Mining only
Lymphoma, Large-Cell, Follicular	Lymphoma	BEFREE	7849311		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	7670111, 7849311, 9591637		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	7849311, 9591637		★☆☆☆☆ Found in Text Mining only
Lymphoma, T-Cell, Cutaneous	Lymphoma	BEFREE	26244872		★☆☆☆☆ Found in Text Mining only
Lymphoproliferative Disorders	Lymphoproliferative syndrome	Pubtator	16449999	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoproliferative Disorders	Lymphoproliferative Disorder	BEFREE	31743514		★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	10536183, 12883667, 7987825, 8895506		★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	23461792, 29229598		★☆☆☆☆ Found in Text Mining only
Malignant mesothelioma	Malignant Mesothelioma	BEFREE	7494231		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	10995786, 15572662, 16020661, 16740735, 18953433, 19239702, 21150326, 21385896, 22433433, 22828875, 23185313, 23285007, 23390492, 23390529, 23494890, 23955388, 24956567, 25218592, 26282201, 27101368, 27410227, 27496804, 29137354, 29137393, 29330290, 29853338, 30106443, 30286765, 7547249, 7796417, 8867812		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	24297335, 31354907, 7614482, 9212218		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gallbladder	Gallbladder cancer	BEFREE	25218593		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of kidney	Kidney Cancer	BEFREE	24272084		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	20512928, 27782152, 29858084, 9873831		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	19854217, 25754817, 25808870, 26304236, 26774155, 28376145, 29541172, 29559545, 7551956, 7563154, 7566983, 8589032, 8988029, 9645340, 9673367, 9816274, 9873831, 9891228		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	11992549, 23787073, 24004674, 26828990, 7591208, 7743516, 9426687		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	19639215, 8640773, 9046882, 9364657, 9841966		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	10383161, 12954644, 19286570, 27819669, 29323532, 7559077, 9171999, 9815578		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	26028036		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	27496804, 28465245, 29853970, 30029874, 9139866		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	24289643, 8561866		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	10022125, 10938379, 11223676, 11410506, 28693160, 30772267, 31455378, 7834615, 8541841, 9171998		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	10359140, 10634406, 12659774, 12676582, 12726855, 14510182, 15048079, 15112280, 15159402, 15882169, 17079443, 17210692, 17804714, 19829063, 19966300, 20399812, 20423616, 22467868, 22474407, 22623710, 23461792, 24004674, 25149358, 26398439, 26685215, 26828990, 27819669, 28056778, 28723151, 28760857, 28947566, 29063678, 29357072, 29511348, 29708285, 30197029, 30423939, 30516105, 30599108, 30613863, 30864522, 31513938, 31839441, 31847444, 7547637, 7563154, 7585513, 7640518, 7705923, 7743516, 7849311, 7882348, 8555065, 8689636, 8934532, 9086436, 9149259, 9221801, 9231912, 9328469, 9407351, 9495360, 9834265		★☆☆☆☆ Found in Text Mining only
Malignant Squamous Cell Neoplasm	Neoplasm	BEFREE	21769424		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	21646351		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	12676582, 26028036, 27819669, 28492347, 28827110, 29063678, 29345391, 7553622		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	10995786, 21321214, 22479189, 23955388, 9811471, 9888465		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	16912201		★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	26022239, 9377576		★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	Pubtator	29511348, 29984917, 30678435	Associate	★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	BEFREE	29511348		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	10651484, 11479422, 15607961, 16032697, 16204058, 21649464, 24395243, 25832654, 25980496, 29063678, 29507054, 30385854, 7478563, 7589260, 7624155, 7640518, 7700630, 7743501, 7923152, 8562340, 8570179, 8595405, 8611425, 8631588, 8727306, 8834170, 8917541, 8970585, 9036865, 9046882, 9328469, 9810513		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Melanoma	Pubtator	11253137, 11442760, 15607961, 21559390, 23349796, 25980496, 27903987, 29507054, 30385854, 30792348, 33450548, 7589260, 8562340, 9579547	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
melanoma	Melanoma	LHGDN	15607961, 17013093		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
melanoma	Melanoma	CTD_human_DG	21559390		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma Cutaneous Malignant	Melanoma	Pubtator	11253137	Stimulate	★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Melanoma	Pubtator	37401304, 8562340	Associate	★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	BEFREE	8834533		★☆☆☆☆ Found in Text Mining only
Mesothelioma	Mesothelioma	BEFREE	12643444, 26680231, 7494231		★☆☆☆☆ Found in Text Mining only
Metastatic Prostate Carcinoma	Metastatic Prostate Carcinoma	BEFREE	9171999		★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	Pubtator	26297806	Stimulate	★☆☆☆☆ Found in Text Mining only
Microphthalmos	Microphthalmos	BEFREE	10585280		★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	11267947	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	10851086, 27319807, 32060401, 37012388, 9207463	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	10851086, 29039521		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	LHGDN	19201832		★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy Duchenne	Duchenne muscular dystrophy	Pubtator	34922439	Associate	★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	29312515		★☆☆☆☆ Found in Text Mining only
Myelofibrosis	Myelofibrosis	BEFREE	17912431		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	10973491, 8555065, 9086436		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	18925945	Associate	★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	35303867	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10210535, 10221342, 10329596, 10389970, 10446997, 10469971, 10490845, 10534174, 10575317, 10602500, 10634406, 10640976, 10696248, 10741713, 10854145, 11332612, 11358847, 11410506, 11479232, 12136424, 12352662, 12466360, 12615717, 15075339, 15161057, 15317660, 15475449, 15492825, 15743317, 17122514, 17434927, 17631145, 17951406, 18345036, 19239702, 19724860, 19885547, 20423997, 20512928, 20713526, 21150326, 21321214, 21368870, 21385896, 21411222, 21695458, 22610972, 23321641, 23378270, 24107632, 24289130, 24531709, 24694877, 25149358, 25707496, 26095675, 26416455, 26714930, 27098147, 27819669, 28056778, 28368414, 28947566, 29372687, 29540837, 29896817, 30181387, 30444001, 30543440, 30675171, 30947664, 31329165, 31529315, 31692040, 31797046, 31839441, 7478563, 7494231, 7563154, 7566983, 7591208, 7630199, 7640224, 7640518, 7700630, 7705923, 7718873, 7791990, 7796417, 7867008, 7882335, 7887443, 7923151, 7923152, 7987825, 8547131, 8548755, 8555065, 8589032, 8589035, 8595153, 8618438, 8625287, 8625319, 8640773, 8689636, 8689637, 8690521, 8727306, 8752149, 8834170, 8857999, 8917541, 8980248, 8988029, 9036865, 9046882, 9047388, 9086436, 9139866, 9166859, 9171998, 9171999, 9196251, 9221801, 9231912, 9244358, 9291941, 9309120, 9345058, 9378820, 9436977, 9441131, 9484941, 9620022, 9638973, 9738978, 9815578, 9816274, 9834265, 9851876, 9861348, 9891228, 9990866		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	12839982, 16155345, 19525400, 24967941, 26202950, 27378523, 28253714, 29328425, 7743501		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	17273780, 19525400, 28246384, 33016930, 33277872, 35655142, 37813883	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	30197029		★☆☆☆☆ Found in Text Mining only
Neuroectodermal Tumor, Primitive	Neuroectodermal Tumors	BEFREE	7791990		★☆☆☆☆ Found in Text Mining only
Non-Functioning Pituitary Gland Neoplasm	Pituitary adenoma	BEFREE	31223310		★☆☆☆☆ Found in Text Mining only
Non-obstructive azoospermia	Non-obstructive azoospermia	BEFREE	29373224		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	10375610, 11212263, 16452236, 21616632, 30218747, 7551956, 7563154, 8589032, 8988029, 9846966, 9873831		★☆☆☆☆ Found in Text Mining only
oligodendroglioma	Oligodendroglioma	BEFREE	10359140, 11550302		★☆☆☆☆ Found in Text Mining only
Oligospermia	Oligospermia	BEFREE	29373224		★☆☆☆☆ Found in Text Mining only
Osteoarthritis, Knee	Knee osteoarthritis	BEFREE	28859619		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	10234573, 12676582, 30389712, 33963544	Associate	★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	27898692, 31106479, 31548420		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	10329035, 11992549, 23787073, 24004674, 26828990, 7591208, 7743516, 8855976, 8980248, 9426687		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	LHGDN	18202766		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	15075339, 19258477, 21424700, 32415712, 32622365, 35843311	Associate	★☆☆☆☆ Found in Text Mining only
PACHYONYCHIA CONGENITA 3	Pachyonychia Congenita	BEFREE	20574166		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	10210535, 15112280, 19639215, 7640518, 8640773, 9841966		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma, familial	Pancreatic carcinoma	BEFREE	9364657		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	19460940, 21898405, 9579547	Associate	★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	27452523		★☆☆☆☆ Found in Text Mining only
Pemphigus Vulgaris	Pemphigus Vulgaris	BEFREE	18199752		★☆☆☆☆ Found in Text Mining only
Pineal Gland Neoplasm	Pineal Gland Neoplasm	BEFREE	25149358		★☆☆☆☆ Found in Text Mining only
Poikiloderma of Kindler	Poikiloderma Of Kindler	BEFREE	31260568		★☆☆☆☆ Found in Text Mining only
Polycystic Kidney, Autosomal Dominant	Polycystic kidney disease	BEFREE	18721488		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	19631369	Associate	★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	GWASDB_DG	22885925		★☆☆☆☆ Found in Text Mining only
Polyostotic fibrous dysplasia	Polyostotic Fibrous Dysplasia	BEFREE	30621175		★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	7630190		★☆☆☆☆ Found in Text Mining only
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	7630190		★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	7630190, 7882348, 9258663		★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	17507663, 9345058		★☆☆☆☆ Found in Text Mining only
Proliferative vitreoretinopathy	Proliferative Vitreoretinopathy	BEFREE	25421815		★☆☆☆☆ Found in Text Mining only
PROPERDIN DEFICIENCY, X-LINKED	Properdin Deficiency, X-Linked	BEFREE	30621175		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	12954644, 19286570, 27819669, 28350121, 29323532, 7559077, 9171999, 9815578		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	19017637, 20147522, 21867506, 29767250, 31300540, 35430569	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	19738602, 9794232, 9815578		★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	31145809		★☆☆☆☆ Found in Text Mining only
Refractory anemias	Anemia	BEFREE	9259311		★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	24272084		★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	24935000, 26248649, 29482572		★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	11358847, 12352662, 15161057, 15666088, 17079443, 17951406, 18236071, 19286570, 22523071, 24550143, 28859059, 29856829, 31043741, 31817413, 8674005, 8697435, 9149259, 9168007, 9620022, 9713590, 9861348		★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	LHGDN	18236071		★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	Pubtator	8641969	Associate	★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	Pubtator	16899113	Associate	★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	21339227, 9259311		★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	20017906	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	7640224		★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Sarcoma	Pubtator	18271016, 31649026	Associate	★☆☆☆☆ Found in Text Mining only
Seminoma	Seminoma	BEFREE	15734211		★☆☆☆☆ Found in Text Mining only
Severe Combined Immunodeficiency	Severe combined immunodeficiency disease	BEFREE	11291051, 7849311		★☆☆☆☆ Found in Text Mining only
Skin Neoplasms	Skin neoplasm	Pubtator	33450548	Associate	★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	26008974, 30244948, 7551956, 7563154		★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	26008974	Stimulate	★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	9421477	Associate	★☆☆☆☆ Found in Text Mining only
Spastic paraplegia 11 autosomal recessive	Spastic paraplegia	Pubtator	10408858	Associate	★☆☆☆☆ Found in Text Mining only
Sporadic Breast Carcinoma	Breast Carcinoma	BEFREE	8889502		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	11782570, 20541561, 21411222, 21769424, 7547637, 7923115, 8621247, 9108451, 9403727, 9713590, 9716179		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	11295092, 11304781, 26670461, 27496804, 8752149, 9815619		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	17217620, 19596857, 24386425, 25275298, 27285764, 29229598, 30468474, 34599215, 36768994, 37178584	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of lung	Lung carcinoma	BEFREE	31239782		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	23461792, 7542912, 7923115, 9378820		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	CTD_human_DG	29464035		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	27496804, 28465245, 29853970, 30029874, 9139866		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	22320960, 27465546, 27496804, 27983933, 29896817, 31399040, 37848946, 8797888	Associate	★☆☆☆☆ Found in Text Mining only
TARSAL-CARPAL COALITION SYNDROME	Tarsal-Carpal Coalition Syndrome	BEFREE	10048962, 10408858, 7553622		★☆☆☆☆ Found in Text Mining only
Thymic Carcinoma	Thymic Carcinoma	BEFREE	9398039		★☆☆☆☆ Found in Text Mining only
Thymoma	Thymoma	BEFREE	9398039		★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	10510327, 24289643, 8561866, 8625287		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	24289643		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	10510327, 24289643, 35968508	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	24970653, 36998242	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	28606920, 29137393, 29144137, 30181387		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Tumors of Adrenal Cortex	Tumors Of Adrenal Cortex	BEFREE	10634406		★☆☆☆☆ Found in Text Mining only
Undifferentiated carcinoma	Carcinoma	BEFREE	8625287		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	25136960, 30145203, 30237499, 9738978	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	12676582, 21646351, 26041102, 34284793, 35246013	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	BEFREE	12634633, 22850687		★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal Melanoma	BEFREE	8631588		★☆☆☆☆ Found in Text Mining only
Well Differentiated Oligodendroglioma	Oligodendroglioma	BEFREE	10359140, 11550302		★☆☆☆☆ Found in Text Mining only
Wilms Tumor	Wilms tumor	Pubtator	32214060	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

CCNE1 22 shared pathwaysCell cycle, Oocyte meiosis, p53 signaling pathway, Cellular senescence, Cushing syndrome, Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Viral carcinogenesis, Prostate cancer, Small cell lung cancer +10 more 1 shared evidence sourceCTD (Squamous cell carcinoma) Related via 22 shared pathways including Cell cycle, Oocyte meiosis — evidence mostly CTD. CCNE2 21 shared pathwaysCell cycle, Oocyte meiosis, p53 signaling pathway, Cellular senescence, Cushing syndrome, Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Viral carcinogenesis, Prostate cancer, Small cell lung cancer +9 more 1 shared evidence sourceCTD (Squamous cell carcinoma) Related via 21 shared pathways including Cell cycle, Oocyte meiosis — evidence mostly CTD. CCNA2 22 shared pathwaysCell cycle, Cellular senescence, Progesterone-mediated oocyte maturation, Hepatitis B, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Viral carcinogenesis, Regulation of TP53 Degradation, Cyclin A:Cdk2-associated events at S phase entry, DNA Damage/Telomere Stress Induced Senescence, Processing of DNA double-strand break ends, Regulation of TP53 Activity through Phosphorylation +10 more 1 shared evidence sourceCTD (Squamous cell carcinoma) Related via 22 shared pathways including Cell cycle, Cellular senescence — evidence mostly CTD. CCNA1 22 shared pathwaysCell cycle, Cellular senescence, Progesterone-mediated oocyte maturation, Hepatitis B, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Viral carcinogenesis, Regulation of TP53 Degradation, Cyclin A:Cdk2-associated events at S phase entry, DNA Damage/Telomere Stress Induced Senescence, Processing of DNA double-strand break ends, Regulation of TP53 Activity through Phosphorylation +10 more 1 shared evidence sourceCTD (Squamous cell carcinoma) Related via 22 shared pathways including Cell cycle, Cellular senescence — evidence mostly CTD. CDK4 1 shared diseaseBreast neoplasms 14 shared pathwaysCell cycle, p53 signaling pathway, Cellular senescence, Cushing syndrome, Hepatitis C, Measles, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Viral carcinogenesis, Small cell lung cancer, SCF(Skp2)-mediated degradation of p27/p21, Senescence-Associated Secretory Phenotype (SASP) +2 more 3 shared evidence sourcesCTD (Squamous cell carcinoma), CTD (Melanoma), CTD (Breast neoplasms ) Related via 14 shared pathways including Cell cycle, p53 signaling pathway — evidence mostly CTD.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
CCNE1	0	[]	22	["Cell cycle","Oocyte meiosis","p53 signaling pathway","Cellular senescence","Cushing syndrome","Hepatitis B","Measles","Human T-cell leukemia virus 1 infection","Epstein-Barr virus infection","Viral carcinogenesis","Prostate cancer","Small cell lung cancer"]	1	["CTD (Squamous cell carcinoma)"]
CCNE2	0	[]	21	["Cell cycle","Oocyte meiosis","p53 signaling pathway","Cellular senescence","Cushing syndrome","Hepatitis B","Measles","Human T-cell leukemia virus 1 infection","Epstein-Barr virus infection","Viral carcinogenesis","Prostate cancer","Small cell lung cancer"]	1	["CTD (Squamous cell carcinoma)"]
CCNA2	0	[]	22	["Cell cycle","Cellular senescence","Progesterone-mediated oocyte maturation","Hepatitis B","Human T-cell leukemia virus 1 infection","Epstein-Barr virus infection","Viral carcinogenesis","Regulation of TP53 Degradation","Cyclin A:Cdk2-associated events at S phase entry","DNA Damage\/Telomere Stress Induced Senescence","Processing of DNA double-strand break ends","Regulation of TP53 Activity through Phosphorylation"]	1	["CTD (Squamous cell carcinoma)"]
CCNA1	0	[]	22	["Cell cycle","Cellular senescence","Progesterone-mediated oocyte maturation","Hepatitis B","Human T-cell leukemia virus 1 infection","Epstein-Barr virus infection","Viral carcinogenesis","Regulation of TP53 Degradation","Cyclin A:Cdk2-associated events at S phase entry","DNA Damage\/Telomere Stress Induced Senescence","Processing of DNA double-strand break ends","Regulation of TP53 Activity through Phosphorylation"]	1	["CTD (Squamous cell carcinoma)"]
CDK4	1	["Breast neoplasms "]	14	["Cell cycle","p53 signaling pathway","Cellular senescence","Cushing syndrome","Hepatitis C","Measles","Human T-cell leukemia virus 1 infection","Epstein-Barr virus infection","Viral carcinogenesis","Small cell lung cancer","SCF(Skp2)-mediated degradation of p27\/p21","Senescence-Associated Secretory Phenotype (SASP)"]	3	["CTD (Squamous cell carcinoma)","CTD (Melanoma)","CTD (Breast neoplasms )"]

Diseases Linked via Similar Genes

Hepatocellular carcinoma Linked via 3 of 5 related genesCCNE1, CCNA1, CDK4 Diabetes mellitus type 2 Linked via 2 of 5 related genesCCNE1, CDK4 Breast cancer Linked via 1 of 5 related genesCCNE1 Breast neoplasms Linked via 1 of 5 related genesCCNE1 Cancer Linked via 1 of 5 related genesCCNE1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Hepatocellular carcinoma	3	["CCNE1","CCNA1","CDK4"]
Diabetes mellitus type 2	2	["CCNE1","CDK4"]
Breast cancer	1	["CCNE1"]
Breast neoplasms	1	["CCNE1"]
Cancer	1	["CCNE1"]