Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 205

9 diseases · 17 shared-gene connections
9 Diseases
1,430 Unique genes
0.121 Avg. similarity score
Crohn disease Most-connected disease (7 links)
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Disease Searched: Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Crohn disease 7 7 704
Inflammatory bowel disease 6 6 694
Ulcerative colitis 6 6 701
Multiple sclerosis 4 4 576
Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities 3 3 1
Neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction 3 3 1
Neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 3 3 1
Ehrlich tumor carcinoma 1 1 1
Neurodevelopmental disorder with microcephaly and congenital malformations 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
ADCY3 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
ANKRD55 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
ARHGAP26 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
ATXN2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
BACH2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
BTNL2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CAMK2G 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CCDC88B 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CCL2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CCL20 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CCL7 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CD226 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CD28 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CD40 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CD6 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CDC37 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CDH3 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CEBPA 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CIITA 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CSF2RB 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
CXCR5 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
DNMT3A 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
DPH5 4 / 9 Crohn disease, Inflammatory bowel disease, Neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties, Ulcerative colitis
ELMO1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
ETS1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
EXOC6 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
FOXP1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
FUT2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
GALC 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
GLI3 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
GRB7 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
GSTM1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
GSTT1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
HLA-B 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
HLA-DQA1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
HLA-DQB1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
HLA-DRB1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
HORMAD1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
ICAM1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
IFNGR2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
IKZF1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
IKZF3 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
IL10 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
IL21R 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
IL23R 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
IL2RA 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
IL4R 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
INAVA 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
INTS11 4 / 9 Crohn disease, Inflammatory bowel disease, Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities, Ulcerative colitis
IRF1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
IRF5 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
JAK2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
JAZF1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
KEAP1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
LITAF 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
LPP 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
LTBR 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
MAMSTR 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
MICB 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
MOG 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
NAB1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
NCF4 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
NDFIP1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
NOD2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
NOTCH4 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
PCSK5 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
PDE4A 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
PHACTR2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
PHTF1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
PRDX5 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
PRR5L 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
PRXL2B 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
PTPRC 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
PTPRK 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
PUS10 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
RBPJ 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
RGS14 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
RMI2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
RORA 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
RSBN1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
RUNX3 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
SH2B3 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
SKAP2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
SLC11A1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
SLC7A10 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
SNAPC4 4 / 9 Crohn disease, Inflammatory bowel disease, Neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction, Ulcerative colitis
SP140 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
SPMIP7 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
SPRED2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
SPRY4 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
STAT3 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
STAT4 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
TAGAP 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
TET2 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
TGFBR3 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
THEMIS 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
TNF 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
TNFRSF14 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
TSBP1 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
TTC33 4 / 9 Crohn disease, Inflammatory bowel disease, Multiple sclerosis, Ulcerative colitis
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Th17 cell differentiation
HLA-DQB1, HLA-DRB1, IL1B, IL23R, IRF4, JAK2, RELA, STAT3, IFNG, IL2RA, IL6, PRKCQ
 KEGG 61 / 109 4.7× 9.77e-29 2.66e-25 ✓ sig.
Inflammatory bowel disease
HLA-DQB1, HLA-DRB1, IL10, IL12B, IL18RAP, IL1B, IL23R, RELA, STAT3, TNF, NOD2, IFNG
 KEGG 46 / 66 5.9× 5.91e-28 1.45e-24 ✓ sig.
Pathways in cancer
ADCY7, CASP3, CDH1, GNA12, GSTM1, GSTT1, IL12B, IL23R, IL7R, JAK2, LAMB1, MMP9
 KEGG 150 / 533 2.4× 1.76e-25 3.08e-22 ✓ sig.
Th1 and Th2 cell differentiation
HLA-DQB1, HLA-DRB1, IL12B, JAK2, RELA, IFNG, IL2RA, PRKCQ, TYK2, CD3E, FOS, HLA-DOB
 KEGG 50 / 93 4.5× 1.03e-22 1.26e-19 ✓ sig.
Allograft rejection
HLA-DQB1, HLA-DRB1, IL10, IL12B, TNF, IFNG, CD28, CD40, FAS, HLA-B, HLA-DOB, HLA-DQA1
 KEGG 31 / 39 6.7× 3.95e-22 4.28e-19 ✓ sig.
Toxoplasmosis
CASP3, HLA-DQB1, HLA-DRB1, IL10, IL12B, IRGM, JAK2, LAMB1, RELA, STAT3, TNF, HSPA1L
 KEGG 53 / 112 4.0× 1.23e-20 1.02e-17 ✓ sig.
Leishmaniasis
C3, FCGR2A, HLA-DQB1, HLA-DRB1, IL10, IL12B, IL1B, JAK2, RELA, TNF, IFNG, NCF4
 KEGG 43 / 78 4.6× 2.79e-20 2.16e-17 ✓ sig.
Human T-cell leukemia virus 1 infection
ADCY7, HLA-DQB1, HLA-DRB1, ICAM1, IL1R2, RELA, TNF, IL2RA, IL6, SMAD3, ADCY3, CCND3
 KEGG 79 / 224 3.0× 3.43e-20 2.60e-17 ✓ sig.
Herpes simplex virus 1 infection
C3, CARD9, CASP3, HLA-DQB1, HLA-DRB1, IL12B, IL1B, JAK2, RELA, TNF, CCL2, IFNG
 KEGG 67 / 182 3.1× 1.96e-18 1.15e-15 ✓ sig.
Type I diabetes mellitus
HLA-DQB1, HLA-DRB1, IL12B, IL1B, TNF, IFNG, CD28, FAS, HLA-B, HLA-DOB, HLA-DQA1, HLA-DQB2
 KEGG 30 / 44 5.7× 3.07e-18 1.72e-15 ✓ sig.
Tuberculosis
C3, CARD9, CASP3, FCGR2A, HLA-DQB1, HLA-DRB1, IL10, IL12B, IL1B, JAK2, LSP1, RELA
 KEGG 66 / 181 3.1× 6.29e-18 3.37e-15 ✓ sig.
JAK-STAT signaling pathway
IL10, IL12B, IL23R, IL7R, JAK2, PTPN2, STAT3, IFNG, IL10RA, IL2RA, IL6, LEP
 KEGG 62 / 168 3.1× 3.26e-17 1.52e-14 ✓ sig.
Cytokine-cytokine receptor interaction
CCL20, CCR6, CXCR1, CXCR2, IL10, IL12B, IL18RAP, IL1B, IL1R2, IL1RN, IL23R, IL7R
 KEGG 88 / 298 2.5× 1.06e-16 4.44e-14 ✓ sig.
Graft-versus-host disease
HLA-DQB1, HLA-DRB1, IL1B, TNF, IFNG, IL6, CD28, FAS, HLA-B, HLA-DOB, HLA-DQA1, HLA-DQB2
 KEGG 29 / 45 5.4× 1.16e-16 4.84e-14 ✓ sig.
Influenza A
CASP3, HLA-DQB1, HLA-DRB1, ICAM1, IL12B, IL1B, JAK2, RELA, TNF, CXCL8, CCL2, IFNG
 KEGG 62 / 173 3.0× 1.70e-16 6.77e-14 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
C3, CCL20, CCR6, CXCR1, CXCR2, GPR65, HLA-DQB1, HLA-DRB1, ICAM1, IL10, IL18RAP, IL1B
 GO:0006955 137 / 543 3.3× 2.50e-37 2.50e-33 ✓ sig.
positive regulation of transcription by RNA polymerase II
HNF4A, IL10, IL1B, IRF4, IRF5, JAK2, RELA, RIPK2, SLC11A1, STAT3, TNF, NKX2-3
 GO:0045944 200 / 1,208 2.2× 9.82e-27 3.89e-23 ✓ sig.
inflammatory response
BCL6, C3, CCL20, CXCR2, DPEP1, ECM1, HP, IL18RAP, IL1B, IL1RN, IL23R, IRF5
 GO:0006954 108 / 467 3.0× 4.08e-26 1.51e-22 ✓ sig.
cytokine-mediated signaling pathway
IL1B, IL1R2, IL23R, IL7R, IRF5, JAK2, RELA, RIPK2, STAT3, IL17REL, CCL2, IL10RA
 GO:0019221 53 / 145 4.8× 4.15e-23 1.01e-19 ✓ sig.
response to lipopolysaccharide
ABCB1, CASP3, IL10, IL1B, IL23R, MPO, RELA, SLC11A1, TNF, VCAM1, CCR7, IL10RA
 GO:0032496 55 / 161 4.5× 2.72e-22 6.03e-19 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
IL12B, IL23R, JAK2, STAT3, TNF, CCL2, IFNG, IL6, LEP, TYK2, BRD2, CAMK2A
 GO:0007259 34 / 67 6.6× 9.16e-21 1.67e-17 ✓ sig.
cellular response to lipopolysaccharide
ABCB1, IL10, IL12B, IL1B, IRGM, JAK2, MMP9, RELA, RIPK2, TNF, CXCL8, NOD2
 GO:0071222 56 / 187 3.9× 1.40e-19 2.12e-16 ✓ sig.
regulation of gene expression
CDH1, IL10, SPHK1, DNMT3A, IGF1, PHOX2B, PPARA, AHR, BRD2, CD40, CSF2, DNMT3B
 GO:0010468 83 / 402 2.7× 4.23e-17 4.39e-14 ✓ sig.
positive regulation of T cell activation
HLA-DQB1, HLA-DRB1, CCL2, PRKCQ, CCDC88B, CD28, CD3E, CORO1A, HLA-DOB, HLA-DQA1, HLA-DQB2, NR5A2
 GO:0050870 25 / 45 7.3× 7.23e-17 7.28e-14 ✓ sig.
positive regulation of canonical NF-kappaB signal transduction
CARD9, ECM1, HLA-DRB1, IL1B, LTF, RELA, RIPK2, STAT3, TNF, TNFSF15, NOD2, ADIPOQ
 GO:0043123 59 / 232 3.3× 8.10e-17 8.11e-14 ✓ sig.
positive regulation of T cell proliferation
BTNL2, IL12B, IL1B, IL23R, JAK2, VCAM1, IL2RA, IL6, LEP, TYK2, CCDC88B, CD28
 GO:0042102 30 / 67 5.9× 1.51e-16 1.43e-13 ✓ sig.
positive regulation of type II interferon production
IL12B, IL1B, IL23R, JAK2, RIPK2, SLC11A1, TNF, TLR4, TLR9, TYK2, CD226, CD244
 GO:0032729 32 / 77 5.4× 2.15e-16 1.96e-13 ✓ sig.
peptide antigen assembly with MHC class II protein complex
HLA-DQB1, HLA-DRB1, HLA-DOB, HLA-DQA1, HLA-DQB2, HLA-DPA1, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DQA2, HLA-DRA, HLA-DRB5
 GO:0002503 15 / 16 12.3× 2.51e-16 2.26e-13 ✓ sig.
positive regulation of miRNA transcription
IL10, RELA, STAT3, TNF, IL6, PPARG, SMAD3, ETS1, FOS, NOTCH2, PDGFB, GATA3
 GO:1902895 27 / 56 6.3× 4.84e-16 4.17e-13 ✓ sig.
B cell differentiation
BCL6, IL10, PTPN2, VCAM1, NKX2-3, FOSL2, HHEX, IKZF3, ITGA4, KLF6, PIK3R1, PLCG2
 GO:0030183 32 / 80 5.2× 8.13e-16 6.76e-13 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Crohn disease Inflammatory bowel disease 0.632 541 < 1e-300 < 1e-300 ✓ sig.
Crohn disease Ulcerative colitis 0.558 502 < 1e-300 < 1e-300 ✓ sig.
Inflammatory bowel disease Ulcerative colitis 0.490 458 < 1e-300 < 1e-300 ✓ sig.
Crohn disease Multiple sclerosis 0.125 142 1.16e-66 3.71e-65 ✓ sig.
Multiple sclerosis Ulcerative colitis 0.120 137 2.00e-62 6.15e-61 ✓ sig.
Inflammatory bowel disease Multiple sclerosis 0.119 135 5.97e-61 1.81e-59 ✓ sig.
Multiple sclerosis Neurodevelopmental disorder with microcephaly and congenital malformations 0.002 1 3.72e-2 3.88e-2 ✓ sig.
Inflammatory bowel disease Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities 0.001 1 4.48e-2 4.64e-2 ✓ sig.
Inflammatory bowel disease Neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 0.001 1 4.48e-2 4.64e-2 ✓ sig.
Inflammatory bowel disease Neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction 0.001 1 4.48e-2 4.64e-2 ✓ sig.
Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities Ulcerative colitis 0.001 1 4.51e-2 4.66e-2 ✓ sig.
Neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction Ulcerative colitis 0.001 1 4.51e-2 4.66e-2 ✓ sig.
Neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties Ulcerative colitis 0.001 1 4.51e-2 4.66e-2 ✓ sig.
Crohn disease Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities 0.001 1 4.53e-2 4.69e-2 ✓ sig.
Crohn disease Neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction 0.001 1 4.53e-2 4.69e-2 ✓ sig.
Crohn disease Ehrlich tumor carcinoma 0.001 1 4.53e-2 4.69e-2 ✓ sig.
Crohn disease Neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 0.001 1 4.53e-2 4.69e-2 ✓ sig.