Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 28

19 diseases · 48 shared-gene connections
19 Diseases
2,887 Unique genes
0.168 Avg. similarity score
Crohn disease Most-connected disease (9 links)
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Disease Searched: Crohn disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Crohn disease 9 9 690
Inflammatory bowel disease 9 9 690
Psoriasis 9 9 731
Ulcerative colitis 8 8 611
Rheumatoid arthritis 7 7 662
Systemic lupus erythematosus 7 7 654
Ankylosing spondylitis 6 6 313
Diabetes mellitus type 1 6 6 477
Iga nephropathy 6 6 203
Sclerosing cholangitis 6 6 230
Hypothyroidism 5 5 374
Multiple sclerosis 5 5 576
Benign flecked retina 3 3 1
Sarcoidosis 3 3 163
neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 3 3 1
Autoinflammatory disease, systemic, with vasculitis 1 1 1
Autoinflammatory-pancytopenia syndrome 1 1 1
Ehrlich tumor carcinoma 1 1 1
Midline facial cleft 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
HLA-DQA1 13 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 9 more
HLA-DQB1 13 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 9 more
HLA-DRB1 13 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 9 more
ATXN2 12 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 8 more
ETS1 12 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 8 more
HLA-B 12 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 8 more
SH2B3 12 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 8 more
TAGAP 12 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 8 more
TYK2 12 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 8 more
ANKRD55 11 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Iga nephropathy and 7 more
BACH2 11 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 7 more
CCDC88B 11 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy and 7 more
CD226 11 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 7 more
CD28 11 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Iga nephropathy and 7 more
CTLA4 11 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 7 more
HLA-DQB3 11 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy and 7 more
HLA-DRA 11 / 19 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Inflammatory bowel disease and 7 more
IKZF1 11 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Iga nephropathy and 7 more
IL23R 11 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 7 more
IL2RA 11 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 7 more
TAP2 11 / 19 Ankylosing spondylitis, Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy and 7 more
TTC33 11 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Iga nephropathy and 7 more
ZMIZ1 11 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Iga nephropathy and 7 more
BTNL2 10 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease and 6 more
C1ORF141 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 6 more
CARD9 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Iga nephropathy and 6 more
HLA-DOB 10 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease and 6 more
IL10 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 6 more
IL21 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 6 more
IRF1 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 6 more
IRF5 10 / 19 Ankylosing spondylitis, Crohn disease, Hypothyroidism, Inflammatory bowel disease and 6 more
JAK2 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 6 more
JAZF1 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 6 more
KEAP1 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 6 more
NOD2 10 / 19 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 6 more
NOTCH4 10 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease and 6 more
PHTF1 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 6 more
PTPN2 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 6 more
PTPN22 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 6 more
RSBN1 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 6 more
STAT3 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 6 more
STAT4 10 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy and 6 more
TNF 10 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease and 6 more
TSBP1 10 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease and 6 more
UBASH3A 10 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 6 more
ATG16L1 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 5 more
ATG5 9 / 19 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 5 more
C2 9 / 19 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Inflammatory bowel disease and 5 more
CD40 9 / 19 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 5 more
CEP43 9 / 19 Ankylosing spondylitis, Crohn disease, Hypothyroidism, Iga nephropathy and 5 more
CFB 9 / 19 Crohn disease, Diabetes mellitus type 1, Iga nephropathy, Inflammatory bowel disease and 5 more
CLEC16A 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Multiple sclerosis and 5 more
FAP 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 5 more
FCGR2A 9 / 19 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 5 more
FUT2 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 5 more
IFIH1 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 5 more
IL19 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 5 more
IL2 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 5 more
IL6 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 5 more
NKD1 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 5 more
NKX2-3 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 5 more
PLCL1 9 / 19 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 5 more
PRDX5 9 / 19 Crohn disease, Hypothyroidism, Iga nephropathy, Inflammatory bowel disease and 5 more
RMI2 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 5 more
RPL3 9 / 19 Ankylosing spondylitis, Crohn disease, Hypothyroidism, Inflammatory bowel disease and 5 more
RUNX3 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 5 more
SKAP2 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 5 more
SLC25A28 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 5 more
TNFRSF14 9 / 19 Ankylosing spondylitis, Crohn disease, Hypothyroidism, Inflammatory bowel disease and 5 more
TNXB 9 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease and 5 more
ZPBP2 9 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 5 more
ADCY7 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 4 more
ASCL2 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 4 more
BANK1 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 4 more
CCL2 8 / 19 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 4 more
CCL20 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 4 more
CCR6 8 / 19 Ankylosing spondylitis, Crohn disease, Hypothyroidism, Inflammatory bowel disease and 4 more
CD6 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 4 more
EMSY 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 4 more
ERAP2 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 4 more
FAS 8 / 19 Ankylosing spondylitis, Crohn disease, Multiple sclerosis, Psoriasis and 4 more
GPR35 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 4 more
GSDMB 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 4 more
HIPK1 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Hypothyroidism and 4 more
HLA-DMB 8 / 19 Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease, Multiple sclerosis and 4 more
HLA-DOA 8 / 19 Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease, Multiple sclerosis and 4 more
HLA-DPA1 8 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease and 4 more
HLA-DRB5 8 / 19 Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease, Multiple sclerosis and 4 more
IFNGR2 8 / 19 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 4 more
IKZF3 8 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease and 4 more
IL12RB2 8 / 19 Ankylosing spondylitis, Crohn disease, Hypothyroidism, Inflammatory bowel disease and 4 more
IL6R 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Psoriasis and 4 more
IL7R 8 / 19 Ankylosing spondylitis, Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy and 4 more
INAVA 8 / 19 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 4 more
KSR1 8 / 19 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 4 more
LRRK2 8 / 19 Ankylosing spondylitis, Crohn disease, Diabetes mellitus type 1, Inflammatory bowel disease and 4 more
MUC22 8 / 19 Ankylosing spondylitis, Crohn disease, Hypothyroidism, Inflammatory bowel disease and 4 more
NCR3 8 / 19 Crohn disease, Diabetes mellitus type 1, Hypothyroidism, Inflammatory bowel disease and 4 more
NFATC1 8 / 19 Ankylosing spondylitis, Crohn disease, Hypothyroidism, Inflammatory bowel disease and 4 more
NFKB1 8 / 19 Ankylosing spondylitis, Crohn disease, Hypothyroidism, Iga nephropathy and 4 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Inflammatory bowel disease
HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IL12RB2, IL17A, IL18R1, IL18RAP, IL2, IL21
 KEGG 55 / 66 3.5× 3.51e-24 5.41e-21 ✓ sig.
Leishmaniasis
FCGR2A, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IRAK1, JAK2, MAPK3, NFKB1, NOS2
 KEGG 59 / 78 3.1× 8.27e-22 7.93e-19 ✓ sig.
Type I diabetes mellitus
CD28, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL12B, IL2, IFNG, FASLG, HLA-DPB1, HLA-DQA2
 KEGG 39 / 44 3.7× 1.71e-19 1.17e-16 ✓ sig.
Th17 cell differentiation
AHR, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL17A, IL1R1, IL2, IL21, IL23R, IL27, IL2RA
 KEGG 70 / 109 2.7× 4.68e-19 3.01e-16 ✓ sig.
Cytokine-cytokine receptor interaction
CCL2, CCL20, CCL21, CCR6, CD40, CSF2RB, CXCR1, CXCR2, FAS, IFNGR2, IFNLR1, IL10
 KEGG 141 / 298 2.0× 6.95e-19 4.39e-16 ✓ sig.
Viral protein interaction with cytokine and cytokine receptor
CCL2, CCL20, CCL21, CCR6, CXCR1, CXCR2, IL10, IL18R1, IL18RAP, IL19, IL2, IL2RA
 KEGG 65 / 100 2.7× 3.41e-18 1.99e-15 ✓ sig.
Allograft rejection
CD28, CD40, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL12B, IL2, CD40LG, IFNG
 KEGG 35 / 39 3.7× 5.26e-18 2.92e-15 ✓ sig.
Toxoplasmosis
CD40, HLA-DQA1, HLA-DQB1, HLA-DRB1, HSPA6, IFNGR2, IL10, IL12B, IRAK1, IRGM, JAK2, MAPK3
 KEGG 68 / 112 2.5× 1.13e-16 4.94e-14 ✓ sig.
Tuberculosis
CARD9, CORO1A, FCGR2A, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IL6, IRAK1, JAK2
 KEGG 94 / 181 2.2× 3.23e-16 1.29e-13 ✓ sig.
Th1 and Th2 cell differentiation
HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL12B, IL12RB2, IL2, IL2RA, JAK2, MAPK3, NFATC1, NFKB1
 KEGG 59 / 93 2.6× 6.56e-16 2.53e-13 ✓ sig.
Interleukin-10 signaling
CCL2, CCL20, IL10, IL12B, IL1R1, IL1R2, IL6, STAT3, TNFRSF1A, TNFRSF1B, TYK2, TIMP1
 Reactome 37 / 47 3.3× 3.86e-15 1.31e-12 ✓ sig.
Herpes simplex virus 1 infection
CARD9, CCL2, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFIH1, IFNGR2, IL12B, IL6, IRAK1
 KEGG 92 / 182 2.1× 5.95e-15 1.91e-12 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
CCL2, IL10, IL12B, IL17A, IL23R, IL6, IL6R, JAK2, NOS2, RORC, STAT3, TNFRSF1B
 Reactome 63 / 108 2.4× 2.20e-14 6.40e-12 ✓ sig.
Intestinal immune network for IgA production
CD28, CD40, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL15RA, IL2, IL6, LTBR, AICDA, CD40LG
 KEGG 37 / 50 3.1× 1.20e-13 3.00e-11 ✓ sig.
Graft-versus-host disease
CD28, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL2, IL6, IFNG, FASLG, HLA-DPB1, HLA-DQA2
 KEGG 34 / 45 3.1× 4.33e-13 9.93e-11 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
inflammatory response
CCL2, CCL20, CCL21, CD40, CXCR2, IL17A, IL18R1, IL18RAP, IL1R1, IL23R, IL27, IL2RA
 GO:0006954 190 / 467 2.6× 1.50e-40 1.43e-36 ✓ sig.
immune response
CCL2, CCL20, CCL21, CCR6, CD244, CD28, CTLA4, CXCR1, CXCR2, ETS1, FAS, HLA-B
 GO:0006955 203 / 543 2.4× 6.84e-37 5.62e-33 ✓ sig.
response to lipopolysaccharide
CD6, CSF2RB, CYP1A1, IL10, IL12RB2, IL23R, IRAK1, LITAF, MAPK3, NOS2, NOTCH1, PTPN22
 GO:0032496 77 / 161 3.1× 2.98e-22 6.50e-19 ✓ sig.
cytokine-mediated signaling pathway
CCL2, CSF2RB, IFNGR2, IFNLR1, IL12RB2, IL1R1, IL1R2, IL23R, IL6, IL6R, IL7R, IRAK1
 GO:0019221 72 / 145 3.2× 4.15e-22 8.78e-19 ✓ sig.
positive regulation of transcription by RNA polymerase II
ACTR2, AHR, ASCL2, CD28, CD40, CREM, CYTL1, EOMES, ETS1, GRHL3, HHEX, IGF2
 GO:0045944 310 / 1,208 1.7× 1.45e-21 2.87e-18 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
CCL2, CD40, CSF2RB, IL12B, IL15RA, IL23R, IL6, IL6R, JAK2, STAT3, TNFRSF1A, TYK2
 GO:0007259 43 / 67 4.2× 2.06e-19 2.92e-16 ✓ sig.
positive regulation of type II interferon production
CD226, CD244, IL12B, IL12RB2, IL18R1, IL1R1, IL2, IL21, IL23R, IL27, JAK2, PTPN22
 GO:0032729 44 / 77 3.7× 4.75e-17 4.71e-14 ✓ sig.
cellular response to lipopolysaccharide
CCL2, CD40, IL10, IL12B, IL6, IRAK1, IRGM, JAK2, LITAF, NFKB1, NOD2, NOS2
 GO:0071222 76 / 187 2.6× 6.84e-17 6.65e-14 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
CCL21, CD28, IGF2, IL17A, IL1R1, JAK2, PARK7, PDGFB, RELN, RPS6KB1, PECAM1, SIRT1
 GO:0051897 83 / 217 2.5× 1.92e-16 1.75e-13 ✓ sig.
positive regulation of cell migration
CCL2, CCL21, CEP43, JAK2, NOTCH1, PDGFB, PLAU, SMAD3, STAT3, COL1A1, IL4, PECAM1
 GO:0030335 101 / 292 2.2× 3.36e-16 2.93e-13 ✓ sig.
positive regulation of canonical NF-kappaB signal transduction
CARD9, CCL21, CD40, HLA-DRB1, IL1R1, INAVA, IRAK1, LITAF, LTBR, LURAP1L, NDFIP1, NOD2
 GO:0043123 85 / 232 2.4× 1.66e-15 1.27e-12 ✓ sig.
positive regulation of ERK1 and ERK2 cascade
ACTA2, CARD9, CCL21, HLA-DRB1, MAPK3, NOD2, NOTCH1, PDE8A, PDGFB, PTPN22, TLR4, ACKR3
 GO:0070374 77 / 201 2.5× 2.13e-15 1.60e-12 ✓ sig.
positive regulation of MAPK cascade
BANK1, CD40, HLA-DRB1, IGF2, IL6, IL6R, INAVA, JAK2, KSR1, LRRK2, NKD1, NOD2
 GO:0043410 82 / 224 2.4× 5.51e-15 3.83e-12 ✓ sig.
positive regulation of T cell proliferation
CD28, CD6, CORO1A, IL12B, IL2, IL21, IL23R, IL2RA, IL6, JAK2, NR5A2, TYK2
 GO:0042102 38 / 67 3.7× 9.08e-15 6.07e-12 ✓ sig.
positive regulation of cell population proliferation
CEP43, CXCR2, HIPK1, IGF2, IL12RB2, IL2, IL21, IL23R, IL6, IL6R, IL7R, JAK2
 GO:0008284 151 / 532 1.8× 9.88e-15 6.58e-12 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Crohn disease Inflammatory bowel disease 0.638 538 < 1e-300 < 1e-300 ✓ sig.
Crohn disease Ulcerative colitis 0.615 496 < 1e-300 < 1e-300 ✓ sig.
Inflammatory bowel disease Ulcerative colitis 0.534 453 < 1e-300 < 1e-300 ✓ sig.
Ankylosing spondylitis Sclerosing cholangitis 0.559 195 2.96e-323 4.41e-320 ✓ sig.
Ankylosing spondylitis Ulcerative colitis 0.327 228 1.73e-263 1.50e-260 ✓ sig.
Psoriasis Sclerosing cholangitis 0.272 206 1.03e-254 7.92e-252 ✓ sig.
Sclerosing cholangitis Ulcerative colitis 0.307 198 1.60e-254 1.19e-251 ✓ sig.
Ankylosing spondylitis Psoriasis 0.285 232 1.06e-249 7.64e-247 ✓ sig.
Ankylosing spondylitis Crohn disease 0.294 228 7.26e-249 5.04e-246 ✓ sig.
Crohn disease Sclerosing cholangitis 0.277 200 1.10e-246 7.13e-244 ✓ sig.
Crohn disease Psoriasis 0.255 289 7.25e-214 3.28e-211 ✓ sig.
Psoriasis Ulcerative colitis 0.253 271 2.80e-207 1.12e-204 ✓ sig.
Inflammatory bowel disease Sclerosing cholangitis 0.207 158 3.30e-162 7.09e-160 ✓ sig.
Inflammatory bowel disease Psoriasis 0.211 248 7.22e-161 1.47e-158 ✓ sig.
Ankylosing spondylitis Inflammatory bowel disease 0.205 171 8.80e-151 1.62e-148 ✓ sig.
Rheumatoid arthritis Systemic lupus erythematosus 0.196 216 1.66e-139 2.82e-137 ✓ sig.
Diabetes mellitus type 1 Rheumatoid arthritis 0.197 188 1.83e-136 3.03e-134 ✓ sig.
Psoriasis Rheumatoid arthritis 0.179 212 1.52e-123 2.26e-121 ✓ sig.
Diabetes mellitus type 1 Psoriasis 0.170 176 4.02e-113 5.44e-111 ✓ sig.
Hypothyroidism Rheumatoid arthritis 0.166 148 3.98e-106 4.96e-104 ✓ sig.
Inflammatory bowel disease Rheumatoid arthritis 0.164 191 4.56e-106 5.64e-104 ✓ sig.
Diabetes mellitus type 1 Systemic lupus erythematosus 0.163 159 9.62e-102 1.12e-99 ✓ sig.
Psoriasis Systemic lupus erythematosus 0.155 186 5.29e-97 5.59e-95 ✓ sig.
Multiple sclerosis Rheumatoid arthritis 0.142 154 1.07e-81 8.56e-80 ✓ sig.
Diabetes mellitus type 1 Hypothyroidism 0.144 107 1.44e-74 1.09e-72 ✓ sig.
Multiple sclerosis Systemic lupus erythematosus 0.130 142 1.27e-70 9.18e-69 ✓ sig.
Crohn disease Multiple sclerosis 0.124 140 1.59e-65 1.07e-63 ✓ sig.
Multiple sclerosis Ulcerative colitis 0.125 132 4.72e-65 3.16e-63 ✓ sig.
Hypothyroidism Systemic lupus erythematosus 0.118 109 9.63e-62 6.00e-60 ✓ sig.
Inflammatory bowel disease Multiple sclerosis 0.119 135 5.64e-61 3.48e-59 ✓ sig.
Rheumatoid arthritis Sarcoidosis 0.076 58 5.73e-38 2.26e-36 ✓ sig.
Diabetes mellitus type 1 Sarcoidosis 0.076 45 2.06e-30 6.32e-29 ✓ sig.
Iga nephropathy Systemic lupus erythematosus 0.059 48 6.13e-23 1.32e-21 ✓ sig.
Hypothyroidism Sarcoidosis 0.067 34 2.30e-22 4.84e-21 ✓ sig.
Iga nephropathy Ulcerative colitis 0.058 45 1.51e-21 3.07e-20 ✓ sig.
Diabetes mellitus type 1 Iga nephropathy 0.056 36 1.29e-17 2.18e-16 ✓ sig.
Iga nephropathy Sclerosing cholangitis 0.056 23 3.98e-14 5.31e-13 ✓ sig.
Ankylosing spondylitis Iga nephropathy 0.053 26 6.60e-14 8.66e-13 ✓ sig.
Autoinflammatory disease, systemic, with vasculitis Iga nephropathy 0.005 1 1.32e-2 1.47e-2 ✓ sig.
Hypothyroidism Midline facial cleft 0.003 1 2.43e-2 2.60e-2 ✓ sig.
neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties Ulcerative colitis 0.002 1 3.97e-2 4.15e-2 ✓ sig.
Autoinflammatory-pancytopenia syndrome Systemic lupus erythematosus 0.002 1 4.25e-2 4.43e-2 ✓ sig.
Crohn disease Ehrlich tumor carcinoma 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Inflammatory bowel disease neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Benign flecked retina Inflammatory bowel disease 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Benign flecked retina Crohn disease 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Crohn disease neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Benign flecked retina Psoriasis 0.001 1 4.75e-2 4.92e-2 ✓ sig.