Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5151
Gene name	Phosphodiesterase 8A
Gene symbol	PDE8A
Synonyms (NCBI Gene)	HsT19550
Chromosome	15
Chromosome location	15q25.3
Summary	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular sign

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miRTarBase ID	miRNA	Experiments	Reference
MIRT047034	hsa-miR-183-5p	CLASH	23622248
MIRT438310	hsa-miR-33a-5p	ImmunoprecipitaionmicroarrayqRT-PCR	25202981
MIRT438310	hsa-miR-33a-5p	ImmunoprecipitaionmicroarrayqRT-PCR	25202981
MIRT1221046	hsa-miR-1233	CLIP-seq
MIRT1221047	hsa-miR-149	CLIP-seq
MIRT1221048	hsa-miR-1537	CLIP-seq
MIRT1221049	hsa-miR-1827	CLIP-seq
MIRT1221050	hsa-miR-203	CLIP-seq
MIRT1221051	hsa-miR-28-5p	CLIP-seq
MIRT1221052	hsa-miR-3064-5p	CLIP-seq
MIRT1221053	hsa-miR-3139	CLIP-seq
MIRT1221054	hsa-miR-3646	CLIP-seq
MIRT1221055	hsa-miR-3662	CLIP-seq
MIRT1221056	hsa-miR-3664-3p	CLIP-seq
MIRT1221057	hsa-miR-3942-3p	CLIP-seq
MIRT1221058	hsa-miR-4290	CLIP-seq
MIRT1221059	hsa-miR-4292	CLIP-seq
MIRT1221060	hsa-miR-4470	CLIP-seq
MIRT1221061	hsa-miR-4649-3p	CLIP-seq
MIRT1221062	hsa-miR-4738-3p	CLIP-seq
MIRT1221063	hsa-miR-4794	CLIP-seq
MIRT1221064	hsa-miR-604	CLIP-seq
MIRT1221065	hsa-miR-647	CLIP-seq
MIRT1221066	hsa-miR-708	CLIP-seq
MIRT1221067	hsa-miR-873	CLIP-seq
MIRT2063773	hsa-miR-1207-5p	CLIP-seq
MIRT2063774	hsa-miR-145	CLIP-seq
MIRT2063775	hsa-miR-1909	CLIP-seq
MIRT2063776	hsa-miR-3121-5p	CLIP-seq
MIRT2063777	hsa-miR-3180-5p	CLIP-seq
MIRT2063778	hsa-miR-3611	CLIP-seq
MIRT1221056	hsa-miR-3664-3p	CLIP-seq
MIRT2063779	hsa-miR-3671	CLIP-seq
MIRT2063780	hsa-miR-4272	CLIP-seq
MIRT1221058	hsa-miR-4290	CLIP-seq
MIRT2063781	hsa-miR-4686	CLIP-seq
MIRT2063782	hsa-miR-4688	CLIP-seq
MIRT2063783	hsa-miR-4699-5p	CLIP-seq
MIRT2063784	hsa-miR-4736	CLIP-seq
MIRT2063785	hsa-miR-4761-5p	CLIP-seq
MIRT2063786	hsa-miR-4763-3p	CLIP-seq
MIRT2063787	hsa-miR-4775	CLIP-seq
MIRT2063788	hsa-miR-508-5p	CLIP-seq
MIRT2063789	hsa-miR-590-3p	CLIP-seq
MIRT2063790	hsa-miR-607	CLIP-seq
MIRT2063791	hsa-miR-668	CLIP-seq
MIRT1221067	hsa-miR-873	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IBA
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IEA
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IMP	9618252
GO:0005829	Component	Cytosol	TAS
GO:0006198	Process	CAMP catabolic process	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019900	Function	Kinase binding	IPI	23509299
GO:0030295	Function	Protein kinase activator activity	IMP	23509299
GO:0046872	Function	Metal ion binding	IEA
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IBA
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IDA	9618252
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IBA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	23509299
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	IBA
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	IEA
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	IMP	23509299
GO:0141162	Process	Negative regulation of cAMP/PKA signal transduction	IBA

MIM	HGNC	e!Ensembl
602972	8793	ENSG00000073417

O60658

Protein name

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)

Protein function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell developme

PDB

3ECM , 3ECN , 7CWA , 7CWF , 7CWG , 7VSL , 7VTV , 7VTW , 7VTX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00233	PDEase_I	555 → 807		Domain
PF00989	PAS	216 → 325	PAS fold	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Sequence

MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSG
KKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACF
LDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGF
TRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYA
NPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNI
QQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSL
DVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE
ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS
LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS
WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH
PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG
IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM
LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS
FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE

Sequence length

829

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Purine metabolism	G alpha (s) signalling events
Metabolic pathways
Cortisol synthesis and secretion
Cushing syndrome
Morphine addiction

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (9)
ALZHEIMER DISEASE	—	GWAS catalog	35589863	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANKYLOSING SPONDYLITIS	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BULIMIA NERVOSA	—	GWAS catalog	23568457	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	37359372	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	39406924	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROLITHIASIS	—	GWAS catalog	37787550, 40216741	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	39885523, 40021644	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TESTICULAR CARCINOMA	—	GWAS catalog	28604728	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TESTICULAR GERM CELL TUMOR	—	GWAS catalog	28604728	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (16)
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	29709702		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aphakia congenital primary	Congenital primary aphakia	Pubtator	32875319	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	36810794	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26022351		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder	Major depressive disorder	Pubtator	31332697	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus	Lupus Erythematosus	BEFREE	31332697		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	31332697	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	30770787		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26022351		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	29709702		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	30909892		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29709702		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	29709702		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	19482904		★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Testicular Germ Cell Tumor	GWASCAT_DG	28604728		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Turner Syndrome	Turner syndrome	Pubtator	24324027	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PDE8A (phosphodiesterase 8A)

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