Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
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Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Endometrial cancer Endometrial neoplasms
50 genes
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8 of 50 corroborated by 2+ sources
NF1(1), HNF1B(2), BPTF(1), SH2B3(1), BCL11A(1), CACNA2D3(1), H4C8(1), LINGO2(1), MSH6(2), NTM(1), TAFA5(1), CYP19A1(1) +38 more
0.195 0.379 7.87e-65 5.23e-63 ✓ sig. Cluster 67 →
Barrett esophagus Esophageal adenocarcinoma
29 genes
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1 of 29 corroborated by 2+ sources
ALDH1A2(1), APOB(1), BCL3(1), CRTC1(1), FOXP1(2), KHDRBS2(1), MSRA(1), OR5V1(1), PLCL1(1), TMOD1(1), DPYSL2(1), DPP6(1) +17 more
0.367 0.829 6.08e-65 4.06e-63 ✓ sig. —
Multiple sclerosis Ulcerative colitis
132 genes
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50 of 132 corroborated by 2+ sources
WWOX(1), GLI3(1), SH2B3(1), CEBPA(1), RBPJ(3), ANKRD55(1), BTNL2(2), ELMO1(1), ERN1(3), ETS1(1), FOXP1(1), FUT2(1) +120 more
0.125 0.229 4.72e-65 3.16e-63 ✓ sig. Cluster 28 →
Heart disease Myocardial ischemia
65 genes
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39 of 65 corroborated by 2+ sources
ABCG8(2), AGT(2), APOC1(1), APOE(2), CDH13(1), ELL(1), ENSA(3), HDAC9(1), ICA1L(2), IL6R(1), JCAD(2), KCNE2(2) +53 more
0.137 0.445 3.63e-65 2.44e-63 ✓ sig. Cluster 139 →
Crohn disease Multiple sclerosis
140 genes
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48 of 140 corroborated by 2+ sources
WWOX(1), GLI3(1), SH2B3(1), CEBPA(1), RBPJ(3), ANKRD55(1), BTNL2(1), CDHR3(1), CSMD1(1), ELMO1(1), ERN1(3), ETS1(1) +128 more
0.124 0.243 1.59e-65 1.07e-63 ✓ sig. Cluster 28 →
Autism Tourette syndrome
131 genes
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29 of 131 corroborated by 2+ sources
SOX5(3), RERE(2), ATP2A2(1), AKAP6(1), ANK3(2), BANK1(1), BRAF(1), C8orf90(1), CACNB2(2), CSMD1(3), CSMD3(3), CTNND1(1) +119 more
0.082 0.508 1.14e-65 7.70e-64 ✓ sig. —
Osteogenesis imperfecta Osteoporosis-pseudoglioma syndrome
28 genes
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28 of 28 corroborated by 2+ sources
ALPL(2), BMP1(6), CCDC134(5), SERPINF1(6), TENT5A(6), COL1A1(7), PLOD2(2), FKBP10(6), COL1A2(7), CRTAP(7), KDELR2(5), WNT1(7) +16 more
0.459 0.718 1.14e-65 7.70e-64 ✓ sig. Cluster 68 →
Bone fragility with contractures, arterial rupture, and deafness Osteogenesis imperfecta
28 genes
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28 of 28 corroborated by 2+ sources
ALPL(2), BMP1(6), CCDC134(5), SERPINF1(6), TENT5A(6), COL1A1(7), PLOD2(2), FKBP10(6), COL1A2(7), CRTAP(7), KDELR2(5), WNT1(7) +16 more
0.459 0.718 1.14e-65 7.70e-64 ✓ sig. Cluster 68 →
Epilepsy Generalized epilepsy
44 genes
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7 of 44 corroborated by 2+ sources
CHRNA7(3), AUTS2(3), CHRM3(1), CUX2(1), GABRA2(1), GRM3(1), HTR1A(1), OGA(1), PCDH7(1), RBFOX1(3), RPH3A(1), TRIM36(1) +32 more
0.173 0.677 5.37e-66 3.67e-64 ✓ sig. —
Diabetes mellitus Diabetic retinopathy
63 genes
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14 of 63 corroborated by 2+ sources
INS(2), APOB(2), APOE(2), BMP8A(1), CDKAL1(2), GIPR(2), HMG20A(1), JAZF1(1), KLHL42(1), MACF1(1), MACIR(1), MAU2(1) +51 more
0.158 0.384 2.67e-66 1.83e-64 ✓ sig. Cluster 73 →
Coronary artery disease Heart failure
161 genes
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57 of 161 corroborated by 2+ sources
NFIA(1), CASZ1(1), ZFPM2(1), SH2B3(3), ANKRD26(1), AMPD1(1), TP53(1), ACE(2), AGT(3), ALDH1A2(1), ANKRD31(1), APOB(3) +149 more
0.111 0.343 1.56e-66 1.07e-64 ✓ sig. —
Hypertension Myocardial infarction
180 genes
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78 of 180 corroborated by 2+ sources
CYP17A1(1), PRDM16(1), GATA4(3), ZFPM2(1), APOA1(2), CAT(2), ATP2A2(2), SH2B3(3), RUNX1(1), TP53(2), SPI1(1), COL4A4(2) +168 more
0.116 0.310 1.55e-66 1.07e-64 ✓ sig. Cluster 78 →
Cardiomyopathy Left ventricular noncompaction cardiomyopathy
37 genes
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15 of 37 corroborated by 2+ sources
PRDM16(1), ACTN2(1), CTNNA3(1), DMD(2), DSG2(1), EYA4(1), JUP(1), MYPN(1), PKP2(1), RBM20(1), DSP(1), MYH6(3) +25 more
0.150 0.974 5.50e-67 3.81e-65 ✓ sig. —
Marfan syndrome Thoracic aortic aneurysm and aortic dissection
28 genes
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27 of 28 corroborated by 2+ sources
FBN1(8), NOTCH1(2), JAG1(2), COL5A1(2), FBN2(4), PRKG1(5), SLC2A10(2), TGFB2(5), THSD4(3), FLNA(3), BGN(5), SMAD3(6) +16 more
0.491 0.683 4.65e-67 3.22e-65 ✓ sig. Cluster 12 →
Asthma Psoriasis
197 genes
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54 of 197 corroborated by 2+ sources
RERE(1), COLEC10(1), CAT(2), RUNX1(1), BLTP1(1), APOE(3), BTNL2(1), CSMD1(3), CTNND2(1), EMSY(1), ERBB3(1), ETS1(1) +185 more
0.123 0.269 3.43e-67 2.38e-65 ✓ sig. —
Diabetic eye disease Diabetic retinopathy
38 genes
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4 of 38 corroborated by 2+ sources
APOE(2), CDKAL1(2), HMG20A(1), JAZF1(1), KLHL42(1), MACF1(1), MACIR(1), NRXN3(1), NYAP2(1), TCF7L2(1), TRPS1(1), PPARG(1) +26 more
0.217 0.792 6.59e-68 4.60e-66 ✓ sig. Cluster 73 →
Combined oxidative phosphorylation deficiency Mitochondrial disease
46 genes
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45 of 46 corroborated by 2+ sources
MICOS13(5), MRPS22(5), AARS2(7), MRPL39(4), MTRFR(7), NARS2(6), ATP5F1A(5), TRIT1(5), MRPS23(4), SLC25A26(6), EARS2(4), FARS2(7) +34 more
0.174 0.676 3.61e-68 2.53e-66 ✓ sig. Cluster 50 →
Developmental and epileptic encephalopathy genetic developmental and epileptic encephalopathy
36 genes
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36 of 36 corroborated by 2+ sources
WWOX(6), ABAT(3), CACNA1E(6), CUX2(6), PACS2(6), SIK1(6), SYNJ1(6), SZT2(7), GLUL(6), RYR3(3), ITPA(6), GABRB3(6) +24 more
0.163 1.000 1.90e-68 1.34e-66 ✓ sig. —
Lissencephaly Macrogyria
27 genes
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6 of 27 corroborated by 2+ sources
PAFAH1B1(5), CTNNA2(2), DYNC1H1(1), CASK(1), ARL3(1), NDE1(5), TMEM216(1), TMEM237(1), SEPSECS(1), KIAA0586(1), KIAA0753(1), CHMP1A(1) +15 more
0.509 0.931 4.23e-69 2.98e-67 ✓ sig. Cluster 110 →
Ankylosing spondylitis Common variable immunodeficiency
51 genes
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7 of 51 corroborated by 2+ sources
ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), IGF2(1), IKZF1(4), LRRK2(1), TENM3(1), TTC33(1), IL10(1), CRB1(1) +39 more
0.151 0.680 1.29e-69 9.13e-68 ✓ sig. —
Liver cirrhosis Nonalcoholic fatty liver disease
78 genes
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37 of 78 corroborated by 2+ sources
CAT(2), PTEN(2), CDH2(1), SERPINA1(3), ACE(2), APOC1(1), APOE(1), COMMD1(3), CYP1A2(2), FARP1(1), HLA-DQA1(2), HLA-DRB1(2) +66 more
0.155 0.295 9.78e-70 6.94e-68 ✓ sig. Cluster 226 →
Ciliary dyskinesia Congenital nasopharyngeal atresia
30 genes
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28 of 30 corroborated by 2+ sources
DNAI2(6), HYDIN(7), NME8(8), DNAH5(7), DNAAF2(7), RSPH3(6), CCDC39(7), CCDC40(6), DNAAF1(6), DNAH11(7), DNAI1(5), ODAD1(7) +18 more
0.330 1.000 4.37e-70 3.11e-68 ✓ sig. Cluster 9 →
Hearing loss Hereditary hearing loss
46 genes
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46 of 46 corroborated by 2+ sources
ESRRB(3), EYA4(3), MYO15A(3), OTOF(3), PCDH15(4), TMC1(2), HGF(2), RDX(3), GSDME(3), DIAPH1(2), MYO1A(2), GJB6(4) +34 more
0.117 0.920 3.59e-70 2.57e-68 ✓ sig. Cluster 26 →
Autoimmune thyroid disease Juvenile idiopathic arthritis
61 genes
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11 of 61 corroborated by 2+ sources
RERE(2), ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), HLA-DQA1(2), HLA-DRA(2), HLA-DRB1(2), IGF2(1), LRRK2(1), RHOH(1) +49 more
0.174 0.424 1.80e-70 1.29e-68 ✓ sig. —
Colorectal adenoma Colorectal cancer
88 genes
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1 of 88 corroborated by 2+ sources
BMP2(1), RTEL1(1), TERT(1), FAM193A(1), FMN1(1), HLA-DQA1(1), HLA-DRB1(1), MAP2K5(1), NALF1(1), NXN(1), PLCL1(1), PREX1(1) +76 more
0.086 0.633 1.38e-70 9.95e-69 ✓ sig. Cluster 20 →

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.