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Cluster 9

34 diseases · 71 shared-gene connections
34 Diseases
102 Unique genes
0.063 Avg. similarity score
Ciliary dyskinesia Most-connected disease (29 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
DNAH11 6 / 34 Bone remodeling disease, Ciliary dyskinesia, Ciliary dyskinesia, with or without situs inversus, Congenital nasopharyngeal atresia and 2 more
CCDC40 5 / 34 Ciliary dyskinesia, Ciliary dyskinesia, with or without situs inversus, Congenital nasopharyngeal atresia, Polynesian bronchiectasis and 1 more
DNAAF19 5 / 34 Ciliary dyskinesia, Ciliary dyskinesia, with or without situs inversus, Congenital nasopharyngeal atresia, Polynesian bronchiectasis and 1 more
DNAAF3 5 / 34 Ciliary dyskinesia, Ciliary dyskinesia, with or without situs inversus, Congenital nasopharyngeal atresia, Polynesian bronchiectasis and 1 more
DNAAF4 5 / 34 Ciliary dyskinesia, Ciliary dyskinesia, with or without situs inversus, Congenital nasopharyngeal atresia, Polynesian bronchiectasis and 1 more
DNAH5 5 / 34 Ciliary dyskinesia, Ciliary dyskinesia, with or without situs inversus, Congenital nasopharyngeal atresia, Polynesian bronchiectasis and 1 more
DNAI1 5 / 34 Ciliary dyskinesia, Ciliary dyskinesia, with or without situs inversus, Congenital nasopharyngeal atresia, Polynesian bronchiectasis and 1 more
DRC1 5 / 34 Ciliary dyskinesia, Ciliary dyskinesia, with or without situs inversus, Congenital nasopharyngeal atresia, Polynesian bronchiectasis and 1 more
ODAD3 4 / 34 Ciliary dyskinesia, Ciliary dyskinesia, with or without situs inversus, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 30
RSPH4A 4 / 34 Ciliary dyskinesia, Ciliary dyskinesia, with or without situs inversus, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 11
CCNO 3 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 29
DNAAF2 3 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 10
DNAAF5 3 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 18
DNAI2 3 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 9
DNAL1 3 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 16
ODAD2 3 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 23
RSPH1 3 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 24
RSPH3 3 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 32
RSPH9 3 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 12
ZMYND10 3 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia, primary ciliary dyskinesia 22
CCDC39 2 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia
CCDC65 2 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia
CFAP298 2 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia
CFAP74 2 / 34 Ciliary dyskinesia, ciliary dyskinesia, primary, 49, without situs inversus
CLXN 2 / 34 Ciliary dyskinesia, ciliary dyskinesia, primary, 53
DNAAF1 2 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia
DNAAF11 2 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia
DNAAF6 2 / 34 Ciliary dyskinesia, ciliary dyskinesia, primary, 36, x-linked
DNAJB13 2 / 34 Ciliary dyskinesia, primary ciliary dyskinesia 34
DRC2 2 / 34 Ciliary dyskinesia, primary ciliary dyskinesia 27
DRC4 2 / 34 Ciliary dyskinesia, primary ciliary dyskinesia 33
FOXJ1 2 / 34 Ciliary dyskinesia, ciliary dyskinesia, primary, 43
GAS8 2 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia
HYDIN 2 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia
MBL2 2 / 34 Ciliary dyskinesia, with or without situs inversus, Polynesian bronchiectasis
MCIDAS 2 / 34 Ciliary dyskinesia, ciliary dyskinesia, primary, 42
NME5 2 / 34 Ciliary dyskinesia, ciliary dyskinesia, primary, 48, without situs inversus
NME8 2 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia
ODAD1 2 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia
SPAG1 2 / 34 Ciliary dyskinesia, Congenital nasopharyngeal atresia
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Motor proteins KEGG 13 / 194 7.9× 9.06e-9 8.01e-7 ✓ sig.
Huntington disease KEGG 13 / 308 5.0× 1.94e-6 8.58e-5 ✓ sig.
Pathways of neurodegeneration - multiple diseases KEGG 14 / 480 3.4× 5.18e-5 1.32e-3 ✓ sig.
Amyotrophic lateral sclerosis KEGG 12 / 368 3.8× 6.46e-5 1.57e-3 ✓ sig.
Hedgehog 'off' state Reactome 4 / 56 8.4× 1.28e-3 1.64e-2 ✓ sig.
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Reactome 2 / 20 11.8× 1.23e-2 7.75e-2
CD209 (DC-SIGN) signaling Reactome 2 / 21 11.2× 1.35e-2 8.17e-2
Glycogen storage disease type II (GAA) Reactome 1 / 2 58.9× 1.69e-2 9.38e-2
ARL13B-mediated ciliary trafficking of INPP5E Reactome 1 / 3 39.2× 2.53e-2 1.17e-1
Antifolate resistance KEGG 2 / 30 7.8× 2.66e-2 1.21e-1
Hyaluronan biosynthesis and export Reactome 1 / 5 23.5× 4.18e-2 1.55e-1
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Reactome 1 / 5 23.5× 4.18e-2 1.55e-1
CLEC7A/inflammasome pathway Reactome 1 / 6 19.6× 4.99e-2 1.71e-1
IkBA variant leads to EDA-ID Reactome 1 / 7 16.8× 5.80e-2 1.85e-1
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Reactome 1 / 7 16.8× 5.80e-2 1.85e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
cilium movement GO:0003341 24 / 48 91.6× 7.67e-43 9.94e-39 ✓ sig.
outer dynein arm assembly GO:0036158 17 / 22 142× 2.14e-35 1.63e-31 ✓ sig.
epithelial cilium movement involved in extracellular fluid movement GO:0003351 15 / 26 106× 2.85e-28 1.35e-24 ✓ sig.
cilium movement involved in cell motility GO:0060294 14 / 27 95.0× 1.56e-25 5.19e-22 ✓ sig.
cell projection organization GO:0030030 24 / 214 20.5× 4.37e-25 1.39e-21 ✓ sig.
axonemal dynein complex assembly GO:0070286 12 / 16 137× 6.40e-25 2.02e-21 ✓ sig.
inner dynein arm assembly GO:0036159 11 / 18 112× 2.27e-21 4.41e-18 ✓ sig.
cilium assembly GO:0060271 22 / 237 17.0× 3.40e-21 6.53e-18 ✓ sig.
determination of left/right symmetry GO:0007368 16 / 83 35.3× 6.98e-21 1.28e-17 ✓ sig.
cerebrospinal fluid circulation GO:0090660 10 / 18 102× 6.30e-19 8.57e-16 ✓ sig.
motile cilium assembly GO:0044458 11 / 28 72.0× 1.46e-18 1.92e-15 ✓ sig.
axoneme assembly GO:0035082 11 / 33 61.1× 1.29e-17 1.48e-14 ✓ sig.
epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 8 / 13 113× 7.49e-16 5.98e-13 ✓ sig.
flagellated sperm motility GO:0030317 15 / 142 19.4× 1.52e-15 1.14e-12 ✓ sig.
mucociliary clearance GO:0120197 7 / 12 107× 9.07e-14 5.01e-11 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Ciliary dyskinesia Congenital nasopharyngeal atresia 0.330 30 4.37e-70 3.30e-68 ✓ sig.
Ciliary dyskinesia, with or without situs inversus Polynesian bronchiectasis 0.750 9 4.11e-31 1.37e-29 ✓ sig.
Ciliary dyskinesia, with or without situs inversus Congenital nasopharyngeal atresia 0.313 10 1.60e-27 4.70e-26 ✓ sig.
Ciliary dyskinesia Ciliary dyskinesia, with or without situs inversus 0.109 10 3.04e-22 6.75e-21 ✓ sig.
Congenital nasopharyngeal atresia Polynesian bronchiectasis 0.250 8 6.72e-22 1.47e-20 ✓ sig.
Ciliary dyskinesia Polynesian bronchiectasis 0.087 8 8.87e-18 1.59e-16 ✓ sig.
Polynesian bronchiectasis primary ciliary dyskinesia 2 0.100 1 5.84e-4 1.14e-3 ✓ sig.
Polynesian bronchiectasis primary ciliary dyskinesia 21 0.100 1 5.84e-4 1.14e-3 ✓ sig.
Polynesian bronchiectasis primary ciliary dyskinesia 17 0.100 1 5.84e-4 1.14e-3 ✓ sig.
Polynesian bronchiectasis primary ciliary dyskinesia 25 0.100 1 5.84e-4 1.14e-3 ✓ sig.
Polynesian bronchiectasis primary ciliary dyskinesia 1 0.100 1 5.84e-4 1.14e-3 ✓ sig.
Polynesian bronchiectasis primary ciliary dyskinesia 15 0.100 1 5.84e-4 1.14e-3 ✓ sig.
Polynesian bronchiectasis primary ciliary dyskinesia 3 0.100 1 5.84e-4 1.14e-3 ✓ sig.
Polynesian bronchiectasis primary ciliary dyskinesia 7 0.100 1 5.84e-4 1.14e-3 ✓ sig.
Ciliary dyskinesia, with or without situs inversus primary ciliary dyskinesia 21 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Ciliary dyskinesia, with or without situs inversus primary ciliary dyskinesia 2 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Ciliary dyskinesia, with or without situs inversus primary ciliary dyskinesia 1 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Ciliary dyskinesia, with or without situs inversus primary ciliary dyskinesia 30 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Ciliary dyskinesia, with or without situs inversus primary ciliary dyskinesia 15 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Ciliary dyskinesia, with or without situs inversus primary ciliary dyskinesia 11 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Ciliary dyskinesia, with or without situs inversus primary ciliary dyskinesia 25 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Ciliary dyskinesia, with or without situs inversus primary ciliary dyskinesia 7 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Ciliary dyskinesia, with or without situs inversus primary ciliary dyskinesia 3 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Ciliary dyskinesia, with or without situs inversus primary ciliary dyskinesia 17 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Bone remodeling disease primary ciliary dyskinesia 7 0.077 1 7.79e-4 1.39e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 9 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 7 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 24 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 2 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 18 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 21 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 22 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 23 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 25 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 29 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 3 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 32 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 30 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 10 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 17 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 1 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 16 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 15 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 11 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Congenital nasopharyngeal atresia primary ciliary dyskinesia 12 0.032 1 1.95e-3 2.81e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 33 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 1 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia ciliary dyskinesia, primary, 53 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 30 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia ciliary dyskinesia, primary, 49, without situs inversus 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 32 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 25 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 34 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia ciliary dyskinesia, primary, 48, without situs inversus 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia ciliary dyskinesia, primary, 43 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia ciliary dyskinesia, primary, 42 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia ciliary dyskinesia, primary, 36, x-linked 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 9 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 29 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 27 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 18 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 10 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 11 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 24 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 23 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 12 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 22 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 21 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 16 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 2 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Ciliary dyskinesia primary ciliary dyskinesia 17 0.011 1 5.84e-3 7.05e-3 ✓ sig.