NEK10 (NIMA related kinase 10)

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Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 152110
• Gene name: NIMA related kinase 10
• Gene symbol: NEK10
• Synonyms (NCBI Gene): CILD44
• Chromosome: 3
• Chromosome location: 3p24.1

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs766982731	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, genic downstream transcript variant, missense variant
rs1253689023	C>G	Pathogenic	Genic upstream transcript variant, 5 prime UTR variant, intron variant
rs1575215909	G>A	Pathogenic	Non coding transcript variant, missense variant, genic downstream transcript variant, coding sequence variant
rs1575588483	->A	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant, genic upstream transcript variant

miRNA Show/Hide all (34)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT1180073	hsa-miR-24	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180075	hsa-miR-3914	CLIP-seq
MIRT1180076	hsa-miR-4284	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180080	hsa-miR-873	CLIP-seq
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180075	hsa-miR-3914	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180080	hsa-miR-873	CLIP-seq
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT2281433	hsa-miR-23a	CLIP-seq
MIRT2281434	hsa-miR-23b	CLIP-seq
MIRT2281435	hsa-miR-23c	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180071	hsa-miR-1184	CLIP-seq
MIRT1180072	hsa-miR-1205	CLIP-seq
MIRT1180074	hsa-miR-3158-5p	CLIP-seq
MIRT1180077	hsa-miR-4700-3p	CLIP-seq
MIRT1180078	hsa-miR-4718	CLIP-seq
MIRT1180079	hsa-miR-544	CLIP-seq
MIRT1180080	hsa-miR-873	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IDA	20956560
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0006468	Process	Protein phosphorylation	IDA	20956560
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031954	Process	Positive regulation of protein autophosphorylation	IDA	20956560
GO:0043406	Process	Positive regulation of MAP kinase activity	IMP	20956560
GO:0046872	Function	Metal ion binding	IEA
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IMP	20956560
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0120197	Process	Mucociliary clearance	IMP	31959991
GO:1902749	Process	Regulation of cell cycle G2/M phase transition	IBA
GO:1902749	Process	Regulation of cell cycle G2/M phase transition	IMP	20956560
GO:1902911	Component	Protein kinase complex	IDA	20956560

Other IDs

• MIM: 618726
• HGNC: 18592
• e!Ensembl: ENSG00000163491

Protein

• UniProt ID: Q6ZWH5
• Protein name: Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10)
• Protein function: Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	519 → 783	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the lung. {ECO:0000269|PubMed:31959991}.
• Sequence:

  MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKS
  EPAIRAGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLIS
  REWVNRAPSIHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVANEYLGYGEEQH
  TVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAESQ
  ECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLL
  HSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSA
  NAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKL
  ILPNKQKNAAKSNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISA
  YEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHS
  GQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRL
  YIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNN
  IMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCILY
  QMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDIVEVS
  SMISDVMMKYLDNLSTSQLSLEKKLERERRRTQRYFMEANRNTVTCHHELAVLSHETFEK
  ASLSSSSSGAASLKSELSESADLPPEGFQASYGKDEDRACDEILSDDNFNLENAEKDTYS
  EVDDELDISDNSSSSSSSPLKESTFNILKRSFSASGGERQSQTRDFTGGTGSRPRPALLP
  LDLLLKVPPHMLRAHIKEIEAELVTGWQSHSLPAVILRNLKDHGPQMGTFLWQASAGIAV
  SQRKVRQISDPIQQILIQLHKIIYITQLPPALHHNLKRRVIERFKKSLFSQQSNPCNLKS
  EIKKLSQGSPEPIEPNFFTADYHLLHRSSGGNSLSPNDPTGLPTSIELEEGITYEQMQTV
  IEEVLEESGYYNFTSNRYHSYPWGTKNHPTKR

• Sequence length: 1172

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Ciliary dyskinesia, primary, 44	Pathogenic; Likely pathogenic	rs2472395615, rs764245230, rs1253689023, rs1575588483, rs1575215909, rs766982731	RCV002283668 RCV003989019 RCV001004051 RCV001004052 RCV001004053 RCV001004054	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (30)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ASTHMA	—	GWAS catalog	32514122	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	19330027, 24493630, 29059683, 32808324, 32887889, 34290314, 34594039, 37340002, 38538606, 39789286	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	19330027, 24493630, 27197191, 29059683, 32808324, 32887889, 34290314, 34594039, 37340002, 38538606, 39789286	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANCER	—	GWAS catalog	27197191, 32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANNABIS DEPENDENCE	—	GWAS catalog	37985822	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CATARACT	—	GWAS catalog	36009466	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CILIARY MOTILITY DISORDERS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	27197191, 32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	39046104	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	27197191, 32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR POSITIVE BREAST CANCER	—	GWAS catalog	35803233	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HOARDING DISORDER	—	GWAS catalog	36379924	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	27770636	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	27197191, 32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	27197191, 32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALIGNANT EPITHELIAL TUMOR OF OVARY	—	GWAS catalog	30898391	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEK10-related disorder	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	27197191, 30898391, 32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN ENDOMETRIOID CARCINOMA	—	GWAS catalog	27197191, 32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN SEROUS CARCINOMA	—	GWAS catalog	27197191, 32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERICARDITIS	—	GWAS catalog	40465716	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERICARDIUM DISORDER	—	GWAS catalog	40465716	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY CILIARY DYSKINESIA	—	Disgenet, GWAS catalog, Orphanet Disgenet, GWAS catalog, Orphanet Disgenet, GWAS catalog, Orphanet	31959991, 31959991	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	27197191, 32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	27197191, 32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	37985822	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	30194396	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (24)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of large intestine	Colorectal Cancer	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	GWASCAT_DG	19330027, 24493630, 27197191, 29059683		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	19330027, 24943594, 25881232, 29898891	Associate	★☆☆☆☆ Found in Text Mining only
Bronchiectasis	Bronchiectasis	Pubtator	31959991	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Ciliary Motility Disorders	Ciliary dyskinesia	Pubtator	32414360, 37998386	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ciliopathies	Ciliopathy	Pubtator	31959991	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Endometrioid carcinoma ovary	Ovarian endometrioid carcinoma	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	GWASDB_DG	19330027		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of large intestine	Colorectal Neoplasms	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Metastatic melanoma	Metastatic Melanoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30474248		★☆☆☆☆ Found in Text Mining only
Ovarian Mucinous Adenocarcinoma	Ovarian adenocarcinoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Ovarian Serous Adenocarcinoma	Ovarian serous adenocarcinoma	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Plexiform leiomyoma	Plexiform leiomyoma	GWASCAT_DG	30194396		★☆☆☆☆ Found in Text Mining only
Primary ciliary dyskinesia	Ciliary dyskinesia	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate carcinoma	Prostate cancer	GWASCAT_DG	27197191		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of lung	Lung carcinoma	GWASCAT_DG	27197191		★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	GWASCAT_DG	30194396		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

LRRC3B 5 shared diseasesCannabis abuse, Hoarding disorder, Ovarian epithelial cancer, Pericarditis, Pericardium disorder 5 shared evidence sourcesGWAS catalog (Cannabis abuse), GWAS catalog (Hoarding disorder), GWAS catalog (Ovarian epithelial cancer), GWAS catalog (Pericarditis), GWAS catalog (Pericardium disorder) Related via 5 shared diseases including Cannabis abuse, Hoarding disorder — evidence mostly GWAS catalog. NSF 5 shared diseasesCancer, Estrogen-receptor negative breast cancer, Hypertrophic cardiomyopathy, Ovarian epithelial cancer, Ovarian serous carcinoma 5 shared evidence sourcesGWAS catalog (Cancer), GWAS catalog (Estrogen-receptor negative breast cancer), GWAS catalog (Hypertrophic cardiomyopathy), GWAS catalog (Ovarian epithelial cancer), GWAS catalog (Ovarian serous carcinoma) Related via 5 shared diseases including Cancer, Estrogen-receptor negative breast cancer — evidence mostly GWAS catalog. SMIM38 4 shared diseasesCancer, Cataract, Estrogen-receptor negative breast cancer, Ovarian serous carcinoma 4 shared evidence sourcesGWAS catalog (Cancer), GWAS catalog (Cataract), GWAS catalog (Estrogen-receptor negative breast cancer), GWAS catalog (Ovarian serous carcinoma) Related via 4 shared diseases including Cancer, Cataract — evidence mostly GWAS catalog. CFAP74 2 shared diseasesCiliary dyskinesia, Estrogen-receptor negative breast cancer 6 shared evidence sourcesHPO (Ciliary dyskinesia), Disgenet (Ciliary dyskinesia), ClinGen (Ciliary dyskinesia), ClinVar (Ciliary dyskinesia), GWAS catalog (Estrogen-receptor negative breast cancer), Orphanet (Ciliary dyskinesia) Related via 2 shared diseases including Ciliary dyskinesia, Estrogen-receptor negative breast cancer — evidence mostly HPO. LMTK2 3 shared diseasesCancer, Estrogen-receptor negative breast cancer, Ovarian serous carcinoma 3 shared evidence sourcesGWAS catalog (Cancer), GWAS catalog (Estrogen-receptor negative breast cancer), GWAS catalog (Ovarian serous carcinoma) Related via 3 shared diseases including Cancer, Estrogen-receptor negative breast cancer — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
LRRC3B	5	["Cannabis abuse","Hoarding disorder","Ovarian epithelial cancer","Pericarditis","Pericardium disorder"]	0	[]	5	["GWAS catalog (Cannabis abuse)","GWAS catalog (Hoarding disorder)","GWAS catalog (Ovarian epithelial cancer)","GWAS catalog (Pericarditis)","GWAS catalog (Pericardium disorder)"]
NSF	5	["Cancer","Estrogen-receptor negative breast cancer","Hypertrophic cardiomyopathy","Ovarian epithelial cancer","Ovarian serous carcinoma"]	0	[]	5	["GWAS catalog (Cancer)","GWAS catalog (Estrogen-receptor negative breast cancer)","GWAS catalog (Hypertrophic cardiomyopathy)","GWAS catalog (Ovarian epithelial cancer)","GWAS catalog (Ovarian serous carcinoma)"]
SMIM38	4	["Cancer","Cataract","Estrogen-receptor negative breast cancer","Ovarian serous carcinoma"]	0	[]	4	["GWAS catalog (Cancer)","GWAS catalog (Cataract)","GWAS catalog (Estrogen-receptor negative breast cancer)","GWAS catalog (Ovarian serous carcinoma)"]
CFAP74	2	["Ciliary dyskinesia","Estrogen-receptor negative breast cancer"]	0	[]	6	["HPO (Ciliary dyskinesia)","Disgenet (Ciliary dyskinesia)","ClinGen (Ciliary dyskinesia)","ClinVar (Ciliary dyskinesia)","GWAS catalog (Estrogen-receptor negative breast cancer)","Orphanet (Ciliary dyskinesia)"]
LMTK2	3	["Cancer","Estrogen-receptor negative breast cancer","Ovarian serous carcinoma"]	0	[]	3	["GWAS catalog (Cancer)","GWAS catalog (Estrogen-receptor negative breast cancer)","GWAS catalog (Ovarian serous carcinoma)"]

Diseases Linked via Similar Genes

Diabetes mellitus type 2 Linked via 3 of 5 related genesSMIM38, CFAP74, LMTK2 Neurotic disorder Linked via 2 of 5 related genesNSF, LMTK2 Breast neoplasms Linked via 1 of 5 related genesLRRC3B Colorectal neoplasms Linked via 1 of 5 related genesLRRC3B Stomach neoplasms Linked via 1 of 5 related genesLRRC3B

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetes mellitus type 2	3	["SMIM38","CFAP74","LMTK2"]
Neurotic disorder	2	["NSF","LMTK2"]
Breast neoplasms	1	["LRRC3B"]
Colorectal neoplasms	1	["LRRC3B"]
Stomach neoplasms	1	["LRRC3B"]