Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 12

24 diseases · 53 shared-gene connections
24 Diseases
124 Unique genes
0.229 Avg. similarity score
Glucose-6-phosphate dehydrogenase deficiency Most-connected disease (11 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Glucose-6-phosphate dehydrogenase deficiency 11 11 5
Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema 10 10 2
Autoinflammatory disease, systemic, x-linked 10 10 2
Bloch sulzberger syndrome 9 9 2
Congenital nonspherocytic hemolytic anemia 8 8 12
G6PD deficiency 6 6 1
Granulomatous disease 6 6 9
anemia, nonspherocytic hemolytic, due to G6PD deficiency 6 6 1
Hyper-igm immunodeficiency syndrome 5 5 7
IKBKG-related immunodeficiency with or without ectodermal dysplasia 5 5 1
incontinentia pigmenti 5 5 1
Hemolytic anemia 4 4 55
Hereditary hemolytic anemia 4 4 11
Pleural diseases 3 3 10
Coronary vessel anomalies 2 2 1
Uridine monophosphate hydrolase deficiency 2 2 1
Williams syndrome 2 2 24
inherited glutathione synthetase deficiency 2 2 1
Charcot-Marie-Tooth disease type 4B2 1 1 1
Endometrioid carcinoma 1 1 1
Occupational disease 1 1 13
Peritonitis 1 1 7
immunodeficiency, common variable, 2 1 1 1
leber-like hereditary optic neuropathy, autosomal recessive 1 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
G6PD 10 / 24 anemia, nonspherocytic hemolytic, due to G6PD deficiency, Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema, Autoinflammatory disease, systemic, x-linked, Bloch sulzberger syndrome and 6 more
IKBKG 8 / 24 Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema, Autoinflammatory disease, systemic, x-linked, Bloch sulzberger syndrome, Congenital nonspherocytic hemolytic anemia and 4 more
GCLC 4 / 24 Congenital nonspherocytic hemolytic anemia, Coronary vessel anomalies, Hemolytic anemia, Hereditary hemolytic anemia
IFNG 4 / 24 Glucose-6-phosphate dehydrogenase deficiency, Granulomatous disease, Peritonitis, Pleural diseases
GPI 3 / 24 Congenital nonspherocytic hemolytic anemia, Hemolytic anemia, Hereditary hemolytic anemia
GSS 3 / 24 Congenital nonspherocytic hemolytic anemia, Hereditary hemolytic anemia, inherited glutathione synthetase deficiency
HK1 3 / 24 Congenital nonspherocytic hemolytic anemia, Hemolytic anemia, Hereditary hemolytic anemia
NT5C3A 3 / 24 Congenital nonspherocytic hemolytic anemia, Hemolytic anemia, Uridine monophosphate hydrolase deficiency
AK1 2 / 24 Congenital nonspherocytic hemolytic anemia, Hemolytic anemia
BPGM 2 / 24 Hemolytic anemia, Hereditary hemolytic anemia
CARD8 2 / 24 Occupational disease, Pleural diseases
DNAJC30 2 / 24 leber-like hereditary optic neuropathy, autosomal recessive 1, Williams syndrome
GATA1 2 / 24 Congenital nonspherocytic hemolytic anemia, Hemolytic anemia
GSR 2 / 24 Congenital nonspherocytic hemolytic anemia, Hemolytic anemia
HBB 2 / 24 Hemolytic anemia, Hereditary hemolytic anemia
IL6 2 / 24 Glucose-6-phosphate dehydrogenase deficiency, Pleural diseases
MSLN 2 / 24 Endometrioid carcinoma, Pleural diseases
NCF1 2 / 24 Granulomatous disease, Williams syndrome
PKLR 2 / 24 Congenital nonspherocytic hemolytic anemia, Hemolytic anemia
RNF157 2 / 24 Granulomatous disease, Williams syndrome
SBF2 2 / 24 Charcot-Marie-Tooth disease type 4B2, Hemolytic anemia
TGFB1 2 / 24 Occupational disease, Pleural diseases
TIMP2 2 / 24 Occupational disease, Pleural diseases
TNFRSF13B 2 / 24 Hyper-igm immunodeficiency syndrome, immunodeficiency, common variable, 2
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Cross-presentation of particulate exogenous antigens (phagosomes)
CYBA, CYBB, NCF1, NCF2, NCF4
 Reactome 5 / 8 60.5× 5.91e-9 5.54e-7 ✓ sig.
Leishmaniasis
FCGR2A, CYBA, CYBB, IFNG, NCF1, NCF2, NCF4, IL10, TGFB1, IL4
 KEGG 10 / 78 12.4× 6.64e-9 6.12e-7 ✓ sig.
Intestinal immune network for IgA production
IL10, IL6, AICDA, CD40, CD40LG, TNFRSF13B, TGFB1, IL4
 KEGG 8 / 50 15.5× 3.84e-8 2.82e-6 ✓ sig.
Malaria
HBB, IFNG, IL10, IL6, CD40, CD40LG, TGFB1, CCL2
 KEGG 8 / 50 15.5× 3.84e-8 2.82e-6 ✓ sig.
Detoxification of Reactive Oxygen Species
GSR, CYBA, CYBB, NCF1, NCF2, NCF4, GPX1
 Reactome 7 / 34 19.9× 4.50e-8 3.25e-6 ✓ sig.
Lipid and atherosclerosis
IFNA2, IKBKG, CYBA, CYBB, NCF1, NCF2, NCF4, IL6, CYP2J2, CD40, CD40LG, CYP1A1
 KEGG 14 / 216 6.3× 4.62e-8 3.33e-6 ✓ sig.
RHO GTPases Activate NADPH Oxidases
CYBA, CYBB, NCF1, NCF2, NCF4, PRKCZ
 Reactome 6 / 24 24.2× 1.24e-7 7.89e-6 ✓ sig.
Glycolysis
PKLR, GPI, HK1, PGK1, TPI1, BPGM
 Reactome 6 / 28 20.8× 3.36e-7 1.89e-5 ✓ sig.
Primary immunodeficiency
IKBKG, AICDA, CD40, UNG, CD40LG, TNFRSF13B
 KEGG 6 / 38 15.3× 2.26e-6 9.78e-5 ✓ sig.
Fluid shear stress and atherosclerosis
HMOX1, IKBKG, CYBA, IFNG, NCF1, NCF2, PRKCZ, NQO1, CCL2
 KEGG 9 / 141 6.2× 1.48e-5 4.66e-4 ✓ sig.
ROS and RNS production in phagocytes
CYBA, CYBB, NCF1, NCF2, NCF4
 Reactome 5 / 34 14.2× 2.37e-5 6.85e-4 ✓ sig.
Allograft rejection
IFNG, IL10, CD40, CD40LG, IL4
 KEGG 5 / 39 12.4× 4.70e-5 1.21e-3 ✓ sig.
Diabetic cardiomyopathy
G6PD, GSR, CYBA, CYBB, NCF1, NCF2, NCF4, PRKCZ, TGFB1, GSK3B
 KEGG 10 / 205 4.7× 5.07e-5 1.29e-3 ✓ sig.
Cytokine-cytokine receptor interaction
EPO, IFNA2, IFNG, IL10, IL6, CD40, CD40LG, TNFRSF13B, TGFB1, CCL2, CXCR3, IL4
 KEGG 12 / 298 3.9× 5.83e-5 1.45e-3 ✓ sig.
Glycolysis / Gluconeogenesis
PKLR, GPI, HK1, PGK1, TPI1, BPGM
 KEGG 6 / 67 8.7× 6.40e-5 1.56e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
inflammatory response
HK1, HBB, HP, IFNA2, IKBKG, CYBA, CYBB, NCF1, IL6, PRKCZ, CD40, CD40LG
 GO:0006954 17 / 467 5.5× 1.28e-8 2.12e-6 ✓ sig.
respiratory burst
CYBA, CYBB, NCF1, NCF2, NCF4
 GO:0045730 5 / 15 50.2× 3.38e-8 4.85e-6 ✓ sig.
hydrogen peroxide biosynthetic process
CYBA, CYBB, NCF1, CYP1A1
 GO:0050665 4 / 11 54.8× 5.88e-7 5.37e-5 ✓ sig.
superoxide anion generation
CYBA, CYBB, NCF1, NCF2, NCF4
 GO:0042554 5 / 26 29.0× 6.98e-7 6.21e-5 ✓ sig.
glycolytic process
PKLR, GPI, HK1, PGK1, TPI1, BPGM
 GO:0006096 6 / 49 18.5× 8.37e-7 7.18e-5 ✓ sig.
erythrocyte development
GATA1, HBB, RHAG, SLC4A1, BPGM
 GO:0048821 5 / 32 23.5× 2.07e-6 1.48e-4 ✓ sig.
response to nutrient
PKLR, GCLC, EPO, ABCG5, ABCG8, CYBB
 GO:0007584 6 / 63 14.4× 3.77e-6 2.40e-4 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
IFNG, IL6, CD40, USP1, CCL2, IL4
 GO:0007259 6 / 67 13.5× 5.42e-6 3.20e-4 ✓ sig.
ammonium homeostasis
RHAG, RHCE, RHD
 GO:0097272 3 / 6 75.4× 5.62e-6 3.29e-4 ✓ sig.
response to xenobiotic stimulus
GCLC, ABCG5, ABCG8, CYBA, CYBB, IL10, GPX1, CYP1A1, TGFB1, FZD3
 GO:0009410 10 / 248 6.1× 6.14e-6 3.53e-4 ✓ sig.
positive regulation of interleukin-10 production
CD46, IL6, PRKCZ, CD40LG, IL4
 GO:0032733 5 / 43 17.5× 9.33e-6 4.95e-4 ✓ sig.
negative regulation of apoptotic process
GPI, GCLC, GATA1, EPO, RNF157, IL10, IL6, PRKCZ, SHH, UNG, CD40LG, MPO
 GO:0043066 14 / 524 4.0× 1.01e-5 5.25e-4 ✓ sig.
superoxide metabolic process
CYBA, CYBB, NCF1, NCF2
 GO:0006801 4 / 22 27.4× 1.23e-5 6.14e-4 ✓ sig.
canonical glycolysis
GPI, HK1, PGK1, TPI1
 GO:0061621 4 / 22 27.4× 1.23e-5 6.14e-4 ✓ sig.
positive regulation of T-helper 2 cell cytokine production
IL6, PRKCZ, IL4
 GO:2000553 3 / 9 50.2× 2.33e-5 1.01e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Congenital nonspherocytic hemolytic anemia Hemolytic anemia 0.153 9 1.04e-20 2.16e-19 ✓ sig.
Congenital nonspherocytic hemolytic anemia Hereditary hemolytic anemia 0.200 4 6.96e-11 7.45e-10 ✓ sig.
Hemolytic anemia Hereditary hemolytic anemia 0.081 5 2.19e-10 2.25e-9 ✓ sig.
Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema Autoinflammatory disease, systemic, x-linked 0.667 2 8.44e-9 7.20e-8 ✓ sig.
Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema Bloch sulzberger syndrome 0.667 2 8.44e-9 7.20e-8 ✓ sig.
Autoinflammatory disease, systemic, x-linked Bloch sulzberger syndrome 0.667 2 8.44e-9 7.20e-8 ✓ sig.
Occupational disease Pleural diseases 0.143 3 5.62e-8 4.33e-7 ✓ sig.
Autoinflammatory disease, systemic, x-linked Glucose-6-phosphate dehydrogenase deficiency 0.333 2 8.44e-8 6.27e-7 ✓ sig.
Bloch sulzberger syndrome Glucose-6-phosphate dehydrogenase deficiency 0.333 2 8.44e-8 6.27e-7 ✓ sig.
Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema Glucose-6-phosphate dehydrogenase deficiency 0.333 2 8.44e-8 6.27e-7 ✓ sig.
Autoinflammatory disease, systemic, x-linked Hyper-igm immunodeficiency syndrome 0.250 2 1.77e-7 1.25e-6 ✓ sig.
Bloch sulzberger syndrome Hyper-igm immunodeficiency syndrome 0.250 2 1.77e-7 1.25e-6 ✓ sig.
Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema Hyper-igm immunodeficiency syndrome 0.250 2 1.77e-7 1.25e-6 ✓ sig.
Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema Congenital nonspherocytic hemolytic anemia 0.154 2 5.57e-7 3.60e-6 ✓ sig.
Autoinflammatory disease, systemic, x-linked Congenital nonspherocytic hemolytic anemia 0.154 2 5.57e-7 3.60e-6 ✓ sig.
Bloch sulzberger syndrome Congenital nonspherocytic hemolytic anemia 0.154 2 5.57e-7 3.60e-6 ✓ sig.
Glucose-6-phosphate dehydrogenase deficiency Hyper-igm immunodeficiency syndrome 0.182 2 1.77e-6 1.05e-5 ✓ sig.
Glucose-6-phosphate dehydrogenase deficiency Granulomatous disease 0.154 2 3.03e-6 1.72e-5 ✓ sig.
Glucose-6-phosphate dehydrogenase deficiency Pleural diseases 0.143 2 3.79e-6 2.12e-5 ✓ sig.
anemia, nonspherocytic hemolytic, due to G6PD deficiency G6PD deficiency 0.500 1 6.49e-5 2.34e-4 ✓ sig.
IKBKG-related immunodeficiency with or without ectodermal dysplasia incontinentia pigmenti 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Granulomatous disease Williams syndrome 0.063 2 8.33e-5 2.99e-4 ✓ sig.
Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema IKBKG-related immunodeficiency with or without ectodermal dysplasia 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Autoinflammatory disease, systemic, x-linked IKBKG-related immunodeficiency with or without ectodermal dysplasia 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Bloch sulzberger syndrome IKBKG-related immunodeficiency with or without ectodermal dysplasia 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema incontinentia pigmenti 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Autoinflammatory disease, systemic, x-linked incontinentia pigmenti 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Bloch sulzberger syndrome incontinentia pigmenti 0.333 1 1.30e-4 3.90e-4 ✓ sig.
anemia, nonspherocytic hemolytic, due to G6PD deficiency Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Bloch sulzberger syndrome G6PD deficiency 0.333 1 1.30e-4 3.90e-4 ✓ sig.
anemia, nonspherocytic hemolytic, due to G6PD deficiency Autoinflammatory disease, systemic, x-linked 0.333 1 1.30e-4 3.90e-4 ✓ sig.
anemia, nonspherocytic hemolytic, due to G6PD deficiency Bloch sulzberger syndrome 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema G6PD deficiency 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Autoinflammatory disease, systemic, x-linked G6PD deficiency 0.333 1 1.30e-4 3.90e-4 ✓ sig.
G6PD deficiency Glucose-6-phosphate dehydrogenase deficiency 0.167 1 3.25e-4 7.58e-4 ✓ sig.
anemia, nonspherocytic hemolytic, due to G6PD deficiency Glucose-6-phosphate dehydrogenase deficiency 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Glucose-6-phosphate dehydrogenase deficiency incontinentia pigmenti 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Glucose-6-phosphate dehydrogenase deficiency IKBKG-related immunodeficiency with or without ectodermal dysplasia 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Hyper-igm immunodeficiency syndrome immunodeficiency, common variable, 2 0.125 1 4.55e-4 9.55e-4 ✓ sig.
anemia, nonspherocytic hemolytic, due to G6PD deficiency Granulomatous disease 0.100 1 5.84e-4 1.14e-3 ✓ sig.
G6PD deficiency Granulomatous disease 0.100 1 5.84e-4 1.14e-3 ✓ sig.
Endometrioid carcinoma Pleural diseases 0.091 1 6.49e-4 1.22e-3 ✓ sig.
Coronary vessel anomalies Hereditary hemolytic anemia 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Hereditary hemolytic anemia inherited glutathione synthetase deficiency 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Congenital nonspherocytic hemolytic anemia inherited glutathione synthetase deficiency 0.077 1 7.79e-4 1.39e-3 ✓ sig.
Congenital nonspherocytic hemolytic anemia Coronary vessel anomalies 0.077 1 7.79e-4 1.39e-3 ✓ sig.
Congenital nonspherocytic hemolytic anemia Uridine monophosphate hydrolase deficiency 0.077 1 7.79e-4 1.39e-3 ✓ sig.
Autoinflammatory disease, systemic, x-linked Granulomatous disease 0.091 1 1.17e-3 1.88e-3 ✓ sig.
Anhidrotic ectodermal dysplasia with immunodeficiency, osteopetrosis, and lymphedema Granulomatous disease 0.091 1 1.17e-3 1.88e-3 ✓ sig.
leber-like hereditary optic neuropathy, autosomal recessive 1 Williams syndrome 0.040 1 1.56e-3 2.36e-3 ✓ sig.
Glucose-6-phosphate dehydrogenase deficiency Peritonitis 0.083 1 2.27e-3 3.18e-3 ✓ sig.
Charcot-Marie-Tooth disease type 4B2 Hemolytic anemia 0.018 1 3.57e-3 4.59e-3 ✓ sig.
Hemolytic anemia Uridine monophosphate hydrolase deficiency 0.018 1 3.57e-3 4.59e-3 ✓ sig.