PRKCZ (protein kinase C zeta)

Gene Gene information from NCBI Gene database.
Gene SNPs Other IDs Associated diseases
Entrez ID 5590
Gene name Protein kinase C zeta
Gene symbol PRKCZ
Synonyms (NCBI Gene)
PKC-ZETAPKC2
Chromosome 1
Chromosome location 1p36.33
Summary Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-depende
miRNA miRNA information provided by mirtarbase database.
12
Gene SNPs Other IDs Associated diseases
Show/Hide all (12)
miRTarBase ID miRNA Experiments Reference
MIRT2457169 hsa-miR-1207-5p CLIP-seq
MIRT2457170 hsa-miR-127-3p CLIP-seq
MIRT2457171 hsa-miR-15a CLIP-seq
MIRT2457172 hsa-miR-15b CLIP-seq
MIRT2457173 hsa-miR-16 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
80
Gene SNPs Other IDs Associated diseases
Show/Hide all (80)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000226 Process Microtubule cytoskeleton organization IEA
GO:0004672 Function Protein kinase activity IDA 10770950
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Other IDs Associated diseases
MIM HGNC e!Ensembl
176982 9412 ENSG00000067606
Protein Protein information from UniProt database.
Gene SNPs Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q05513
Protein name Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Protein function Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signal
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00564 PB1 15 → 98 PB1 domain Domain
PF00130 C1_1 131 → 183 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00069 Pkinase 252 → 518 Protein kinase domain Domain
PF00433 Pkinase_C 539 → 580 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in brain, and to a lesser extent in lung, kidney and testis.
Sequence
Sequence length 592
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
12
Gene SNPs Other IDs Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (12)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
1P36 DELETION SYNDROME — Orphanet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (110)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma LHGDN 12920244
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 26374103
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 29158810, 29220829
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer UNIPROT_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 25118570, 28983601, 31412817
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 29220829
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 21946537
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 18336728, 37833700 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder PSYGENET_DG 22231931
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Carcinoma Breast Carcinoma BEFREE 20844151, 26218882, 28218902, 28518146, 30052635, 30675210
★★★★★
★☆☆☆☆
Found in Text Mining only