FAM193A (family with sequence similarity 193 member A)

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Gene miRNA Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8603
• Gene name: Family with sequence similarity 193 member A
• Gene symbol: FAM193A
• Synonyms (NCBI Gene): C4orf8, RES4-22
• Chromosome: 4
• Chromosome location: 4p16.3

miRNA Show/Hide all (117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030136	hsa-miR-26b-5p	Microarray	19088304
MIRT720772	hsa-miR-6856-3p	HITS-CLIP	19536157
MIRT720771	hsa-miR-29a-3p	HITS-CLIP	19536157
MIRT720770	hsa-miR-29b-3p	HITS-CLIP	19536157
MIRT720769	hsa-miR-29c-3p	HITS-CLIP	19536157
MIRT720768	hsa-miR-129-1-3p	HITS-CLIP	19536157
MIRT720767	hsa-miR-129-2-3p	HITS-CLIP	19536157
MIRT720766	hsa-miR-212-5p	HITS-CLIP	19536157
MIRT720765	hsa-miR-6741-3p	HITS-CLIP	19536157
MIRT720764	hsa-miR-326	HITS-CLIP	19536157
MIRT720763	hsa-miR-330-5p	HITS-CLIP	19536157
MIRT720762	hsa-miR-4667-5p	HITS-CLIP	19536157
MIRT720761	hsa-miR-4700-5p	HITS-CLIP	19536157
MIRT720760	hsa-miR-8089	HITS-CLIP	19536157
MIRT720759	hsa-miR-637	HITS-CLIP	19536157
MIRT720758	hsa-miR-7155-5p	HITS-CLIP	19536157
MIRT720757	hsa-miR-31-5p	HITS-CLIP	19536157
MIRT720756	hsa-miR-6809-5p	HITS-CLIP	19536157
MIRT720755	hsa-miR-760	HITS-CLIP	19536157
MIRT720754	hsa-miR-3180	HITS-CLIP	19536157
MIRT720753	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT720752	hsa-miR-3196	HITS-CLIP	19536157
MIRT720751	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT720750	hsa-miR-182-5p	HITS-CLIP	19536157
MIRT720749	hsa-miR-6090	HITS-CLIP	19536157
MIRT720772	hsa-miR-6856-3p	HITS-CLIP	19536157
MIRT720771	hsa-miR-29a-3p	HITS-CLIP	19536157
MIRT720770	hsa-miR-29b-3p	HITS-CLIP	19536157
MIRT720769	hsa-miR-29c-3p	HITS-CLIP	19536157
MIRT720768	hsa-miR-129-1-3p	HITS-CLIP	19536157
MIRT720767	hsa-miR-129-2-3p	HITS-CLIP	19536157
MIRT720766	hsa-miR-212-5p	HITS-CLIP	19536157
MIRT720765	hsa-miR-6741-3p	HITS-CLIP	19536157
MIRT720764	hsa-miR-326	HITS-CLIP	19536157
MIRT720763	hsa-miR-330-5p	HITS-CLIP	19536157
MIRT720762	hsa-miR-4667-5p	HITS-CLIP	19536157
MIRT720761	hsa-miR-4700-5p	HITS-CLIP	19536157
MIRT720760	hsa-miR-8089	HITS-CLIP	19536157
MIRT720759	hsa-miR-637	HITS-CLIP	19536157
MIRT720758	hsa-miR-7155-5p	HITS-CLIP	19536157
MIRT720757	hsa-miR-31-5p	HITS-CLIP	19536157
MIRT720756	hsa-miR-6809-5p	HITS-CLIP	19536157
MIRT720755	hsa-miR-760	HITS-CLIP	19536157
MIRT720754	hsa-miR-3180	HITS-CLIP	19536157
MIRT720753	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT720752	hsa-miR-3196	HITS-CLIP	19536157
MIRT720751	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT720750	hsa-miR-182-5p	HITS-CLIP	19536157
MIRT720749	hsa-miR-6090	HITS-CLIP	19536157
MIRT983229	hsa-miR-4525	CLIP-seq
MIRT983230	hsa-miR-4716-3p	CLIP-seq
MIRT1991405	hsa-miR-1909	CLIP-seq
MIRT1991406	hsa-miR-3160-3p	CLIP-seq
MIRT1991407	hsa-miR-4688	CLIP-seq
MIRT1991408	hsa-miR-4765	CLIP-seq
MIRT1991409	hsa-miR-4768-3p	CLIP-seq
MIRT2387811	hsa-miR-1293	CLIP-seq
MIRT2387812	hsa-miR-4483	CLIP-seq
MIRT2529172	hsa-miR-1255a	CLIP-seq
MIRT2529173	hsa-miR-1255b	CLIP-seq
MIRT2529174	hsa-miR-1322	CLIP-seq
MIRT2529175	hsa-miR-2467-3p	CLIP-seq
MIRT2529176	hsa-miR-3126-3p	CLIP-seq
MIRT2529177	hsa-miR-3176	CLIP-seq
MIRT2529178	hsa-miR-3177-5p	CLIP-seq
MIRT2529179	hsa-miR-320e	CLIP-seq
MIRT2529180	hsa-miR-3678-3p	CLIP-seq
MIRT2529181	hsa-miR-3691-5p	CLIP-seq
MIRT2529182	hsa-miR-3922-3p	CLIP-seq
MIRT2529183	hsa-miR-3941	CLIP-seq
MIRT2529184	hsa-miR-4434	CLIP-seq
MIRT2529185	hsa-miR-4436a	CLIP-seq
MIRT2529186	hsa-miR-4516	CLIP-seq
MIRT983229	hsa-miR-4525	CLIP-seq
MIRT2529187	hsa-miR-4531	CLIP-seq
MIRT2529188	hsa-miR-4645-3p	CLIP-seq
MIRT2529189	hsa-miR-4650-5p	CLIP-seq
MIRT2529190	hsa-miR-466	CLIP-seq
MIRT2529191	hsa-miR-4672	CLIP-seq
MIRT2529192	hsa-miR-4700-3p	CLIP-seq
MIRT2529193	hsa-miR-4701-5p	CLIP-seq
MIRT983230	hsa-miR-4716-3p	CLIP-seq
MIRT2529194	hsa-miR-4731-3p	CLIP-seq
MIRT2529195	hsa-miR-4752	CLIP-seq
MIRT2529196	hsa-miR-4794	CLIP-seq
MIRT2529197	hsa-miR-4801	CLIP-seq
MIRT2529198	hsa-miR-588	CLIP-seq
MIRT2529199	hsa-miR-936	CLIP-seq
MIRT2529172	hsa-miR-1255a	CLIP-seq
MIRT2529173	hsa-miR-1255b	CLIP-seq
MIRT2529174	hsa-miR-1322	CLIP-seq
MIRT2529175	hsa-miR-2467-3p	CLIP-seq
MIRT2529176	hsa-miR-3126-3p	CLIP-seq
MIRT2529177	hsa-miR-3176	CLIP-seq
MIRT2529178	hsa-miR-3177-5p	CLIP-seq
MIRT2529179	hsa-miR-320e	CLIP-seq
MIRT2529180	hsa-miR-3678-3p	CLIP-seq
MIRT2529181	hsa-miR-3691-5p	CLIP-seq
MIRT2529182	hsa-miR-3922-3p	CLIP-seq
MIRT2529183	hsa-miR-3941	CLIP-seq
MIRT2529184	hsa-miR-4434	CLIP-seq
MIRT2529185	hsa-miR-4436a	CLIP-seq
MIRT2529186	hsa-miR-4516	CLIP-seq
MIRT983229	hsa-miR-4525	CLIP-seq
MIRT2529187	hsa-miR-4531	CLIP-seq
MIRT2529188	hsa-miR-4645-3p	CLIP-seq
MIRT2529190	hsa-miR-466	CLIP-seq
MIRT2529191	hsa-miR-4672	CLIP-seq
MIRT2529192	hsa-miR-4700-3p	CLIP-seq
MIRT2529193	hsa-miR-4701-5p	CLIP-seq
MIRT983230	hsa-miR-4716-3p	CLIP-seq
MIRT2529194	hsa-miR-4731-3p	CLIP-seq
MIRT2529195	hsa-miR-4752	CLIP-seq
MIRT2529196	hsa-miR-4794	CLIP-seq
MIRT2529197	hsa-miR-4801	CLIP-seq
MIRT2529198	hsa-miR-588	CLIP-seq
MIRT2529199	hsa-miR-936	CLIP-seq

Other IDs

• MIM: 620037
• HGNC: 16822
• e!Ensembl: ENSG00000125386

Protein

• UniProt ID: P78312
• Protein name: Protein FAM193A (Protein IT14)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15914	FAM193_C	1208 → 1264	FAM193 family C-terminal	Family

• Sequence:

  MKVRLLRQLSAAAKVKAPSGLQGPPQAHQFISLLLEEYGALCQAARSISTFLGTLENEHL
  KKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCSEDTYSTLLQRYQR
  SEEELRRVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWELFKQRRFIEEQLTNKKAVT
  GENNFTDTMRHMLSSRLSMPDCPNCNYRRRCACDDCSLSHILTCGIMDPPVTDDIHIHQL
  PLQVDPAPDYLAERSPPSVSSASSGSGSSSPITIQQHPRLILTDSGSAPTFCSDDEDVAP
  LSAKFADIYPLSNYDDTEVVANMNGIHSELNGGGENMALKDESPQISSTSSSSSEADDEE
  ADGESSGEPPGAPKEDGVLGSRSPRTEESKADSPPPSYPTQQAEQAPNTCECHVCKQEAS
  GLTPSAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYATP
  PFTHSKALPPAPVQNHTNKHQVFNASLQDHIYPSCFGNTPEWNSSKFISLWGSEVMNDKN
  WNPGTFLPDTISGSEILGPTLSETRPEALPPPSSNETPAVSDSKEKKNAAKKKCLYNFQD
  AFMEANKVVMATSSATSSVSCTATTVQSSNSQFRVSSKRPPSVGDVFHGISKEDHRHSAP
  AAPRNSPTGLAPLPALSPAALSPAALSPASTPHLANLAAPSFPKTATTTPGFVDTRKSFC
  PAPLPPATDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTS
  TNQKEGKYCDCCYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMDQISERE
  SVVDHRRVEDLLQFINSSETKPVSSTRAAKRARHKQRKLEEKARLEAEARAREHLHLQEE
  QRRREEEEDEEEEEDRFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTRNFQAATE
  SVPNSGNIHNGSLEQTEEPETSSHSPSRHMNHSEPRPGLGADGDAADPVDTRDSKFLLPK
  EVNGKQHEPLSFFFDIMQHHKEGNGKQKLRQTSKASSEPARRPTEPPKATEGQSKPRAQT
  ESKAKVVDLMSITEQKREERKVNSNNNNKKQLNHIKDEKSNPTPMEPTSPGEHQQNSKLV
  LAESPQPKGKNKKNKKKKGDRVNNSIDGVSLLLPSLGYNGAILAHCNLRLPGSSDCAASA
  SQVVGITDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQTRQRLSINWSNFSLKKA
  TFAAH

• Sequence length: 1265

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (11)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	39998322	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	35764056	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	35764056	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL ADENOMA	—	GWAS catalog	29228715	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	29228715	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONNECTIVE TISSUE DISEASE	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	36333501	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	33272962	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (9)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of large intestine	Colorectal Cancer	GWASCAT_DG	29228715		★☆☆☆☆ Found in Text Mining only
Brain Ischemia	Brain ischemia	Pubtator	11169226	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	GWASCAT_DG	29228715		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	GWASCAT_DG	29228715		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	11169226, 9734812		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	11169226, 9734812	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of large intestine	Colorectal Neoplasms	GWASCAT_DG	29228715		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	GWASCAT_DG	29228715		★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	31747953	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

HLA-B 2 shared diseasesColorectal adenoma, Connective tissue disease 2 shared evidence sourcesGWAS catalog (Colorectal adenoma), GWAS catalog (Connective tissue disease) Related via 2 shared diseases including Colorectal adenoma, Connective tissue disease — evidence mostly GWAS catalog. SMAD3 2 shared diseasesColorectal adenoma, Connective tissue disease 1 shared evidence sourceGWAS catalog (Colorectal adenoma) Related via 2 shared diseases including Colorectal adenoma, Connective tissue disease — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
HLA-B	2	["Colorectal adenoma","Connective tissue disease"]	0	[]	2	["GWAS catalog (Colorectal adenoma)","GWAS catalog (Connective tissue disease)"]
SMAD3	2	["Colorectal adenoma","Connective tissue disease"]	0	[]	1	["GWAS catalog (Colorectal adenoma)"]

Diseases Linked via Similar Genes

Ankylosing spondylitis Linked via 2 of 2 related genesHLA-B, SMAD3 Asthma Linked via 2 of 2 related genesHLA-B, SMAD3 Eczema Linked via 2 of 2 related genesHLA-B, SMAD3 Autoimmune disease Linked via 2 of 2 related genesHLA-B, SMAD3 Basal cell carcinoma Linked via 2 of 2 related genesHLA-B, SMAD3

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Ankylosing spondylitis	2	["HLA-B","SMAD3"]
Asthma	2	["HLA-B","SMAD3"]
Eczema	2	["HLA-B","SMAD3"]
Autoimmune disease	2	["HLA-B","SMAD3"]
Basal cell carcinoma	2	["HLA-B","SMAD3"]