Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Biliary cirrhosis Sjogren syndrome
15 genes
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7 of 15 corroborated by 2+ sources
DGKQ(3), HLA-DQA1(2), HLA-DRA(1), ATXN2(1), HLA-DQB1(2), ATG5(1), HLA-DPB1(1), CTLA4(2), IRF5(1), STAT4(3), TNPO3(1), CXCR5(2) +3 more
0.081 0.211 1.67e-17 2.80e-16 ✓ sig. —
Hereditary spastic paraplegia Spastic ataxia
14 genes
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4 of 14 corroborated by 2+ sources
SETX(1), SPG11(1), PNPLA6(2), CYP7B1(2), KIF1C(4), SACS(3), SPG7(1), SPAST(1), KIF1A(1), AMPD2(1), FA2H(1), C19orf12(1) +2 more
0.089 0.200 1.53e-17 2.58e-16 ✓ sig. —
Interstitial lung disease Pulmonary fibrosis
14 genes
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8 of 14 corroborated by 2+ sources
RTEL1(1), TERT(4), ARL17B(1), DSP(3), MUC5B(4), IL1RN(2), MUC5AC(1), SFTPC(4), SPDL1(1), FAM13A(3), LRRC34(1), SFTPA1(5) +2 more
0.088 0.212 1.46e-17 2.46e-16 ✓ sig. —
Complete unilateral cleft lip Orofacial cleft
13 genes
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9 of 13 corroborated by 2+ sources
ABCA4(2), TP63(4), FGF10(1), IRF6(4), MTHFR(1), BMP4(5), NOG(2), MSX1(4), FGFR1(1), CDH1(2), MAFB(2), SUMO1(5) +1 more
0.072 0.361 1.35e-17 2.27e-16 ✓ sig. Cluster 63 →
Atrial septal defect Congenital heart septal defect
8 genes
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5 of 8 corroborated by 2+ sources
GATA4(6), ROBO1(1), MYH6(6), NKX2-5(6), HSPBAP1(1), PARP14(1), CITED2(6), PQBP1(2)
0.174 0.444 1.30e-17 2.19e-16 ✓ sig. Cluster 364 →
Diabetes mellitus type 1 Iga nephropathy
36 genes
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12 of 36 corroborated by 2+ sources
NOTCH2(2), ACE(1), AFF3(1), ANKRD55(1), ASAP1(1), ETS1(2), HLA-DQA1(3), HLA-DQB3(1), HLA-DRA(1), HLA-DRB1(3), IKZF1(1), INPP5B(1) +24 more
0.056 0.177 1.29e-17 2.18e-16 ✓ sig. Cluster 28 →
Epiphyseal dysplasia Osteochondrodysplasias
7 genes
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7 of 7 corroborated by 2+ sources
SLC26A2(3), COL2A1(3), COMP(3), COL9A1(5), COL9A2(5), COL9A3(5), MATN3(3)
0.189 0.700 1.26e-17 2.12e-16 ✓ sig. —
Lymphatic metastasis Non-small-cell lung carcinoma
12 genes
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GRIK2(1), MACIR(1), SOD2(1), STAT3(1), TRMT11(1), MET(1), CDKN2A(1), CCNH(1), MTOR(1), TP53BP1(1), LRRC59(1), SLC22A10(1)
0.077 0.400 1.14e-17 1.92e-16 ✓ sig. Cluster 5 →
Deep vein thrombosis Thrombophilia
7 genes
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6 of 7 corroborated by 2+ sources
FGA(3), PLAT(3), PLG(1), PROC(5), PROS1(5), FGB(2), SERPIND1(2)
0.194 0.700 9.89e-18 1.67e-16 ✓ sig. —
Ciliary dyskinesia Polynesian bronchiectasis
8 genes
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8 of 8 corroborated by 2+ sources
DNAH5(7), CCDC40(6), DNAH11(7), DNAI1(5), DNAAF3(6), DNAAF19(7), DNAAF4(7), DRC1(6)
0.087 0.889 8.87e-18 1.50e-16 ✓ sig. Cluster 9 →
Ciliary dyskinesia primary ciliary dyskinesia
8 genes
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8 of 8 corroborated by 2+ sources
SPEF2(4), DNAH10(3), CFAP221(4), CFAP43(2), DNAH7(5), CFAP57(3), DNAH1(6), DAW1(6)
0.087 0.889 8.87e-18 1.50e-16 ✓ sig. —
Bipolar depression Psychotic disorders
17 genes
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9 of 17 corroborated by 2+ sources
ANK3(1), GCH1(1), BDNF(2), MAOA(1), NTRK1(2), CACNA1C(1), TENM4(1), TRPM2(1), NR3C1(2), TPH2(1), GRIK4(1), HTR2A(2) +5 more
0.079 0.162 8.50e-18 1.44e-16 ✓ sig. —
Glomerulonephritis Hypersensitivity
14 genes
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14 of 14 corroborated by 2+ sources
HLA-DQA1(2), IL10(2), IL1B(2), MTHFR(2), TNF(2), IL6(2), ALB(2), IFNG(2), CCL2(2), CXCR3(2), IL18(2), CCL3(2) +2 more
0.091 0.200 8.48e-18 1.44e-16 ✓ sig. Cluster 16 →
Ischemic heart disease Large artery stroke
17 genes
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17 of 17 corroborated by 2+ sources
SH2B3(2), ABCG8(2), JCAD(2), MMP12(2), MMP3(2), WDR12(2), TWIST1(2), ABO(2), CELSR2(2), PSRC1(2), FURIN(2), PHACTR1(2) +5 more
0.073 0.218 8.36e-18 1.42e-16 ✓ sig. Cluster 139 →
Hypertension Osteoarthritis
122 genes
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37 of 122 corroborated by 2+ sources
HMGA2(1), TBX4(1), CYP11B2(2), PIK3R1(1), ADK(1), AMPD3(1), ALDH1A2(2), APOC1(1), APOE(3), ARL17B(1), BANK1(1), BCAS3(1) +110 more
0.069 0.167 8.16e-18 1.39e-16 ✓ sig. —
Beta thalassemia Sickle cell anemia
8 genes
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6 of 8 corroborated by 2+ sources
BCL11A(2), GSTT1(1), TNF(2), HLA-DQB1(1), HBB(8), CAD(2), UMPS(2), DHODH(2)
0.190 0.381 7.96e-18 1.36e-16 ✓ sig. —
Angioedema Urticaria
11 genes
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1 of 11 corroborated by 2+ sources
BANK1(1), HLA-DRB1(1), RIMS1(1), HLA-DQB1(1), ALB(1), RAD51B(1), ABI3BP(1), HLA-DPB1(1), HLF(1), IFT43(1), F12(3)
0.118 0.239 7.76e-18 1.32e-16 ✓ sig. Cluster 16 →
Cerebrovascular disorder Thrombosis
12 genes
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12 of 12 corroborated by 2+ sources
FGA(2), AGT(2), PLAU(2), F2(2), TNF(2), PLAT(2), PTGS2(2), PDE3A(2), F5(2), CRP(2), VKORC1(2), P2RY12(2)
0.102 0.267 7.63e-18 1.30e-16 ✓ sig. —
Arima syndrome Joubert syndrome
7 genes
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7 of 7 corroborated by 2+ sources
ZNF423(3), CC2D2A(5), CEP290(6), TMEM138(6), TMEM216(6), TMEM231(5), TMEM237(6)
0.119 1.000 7.39e-18 1.26e-16 ✓ sig. Cluster 8 →
Generalized lipodystrophy Lipodystrophy
6 genes
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6 of 6 corroborated by 2+ sources
PPARG(4), CAV1(5), BSCL2(5), CAVIN1(5), AGPAT2(5), PCYT1A(3)
0.300 0.857 7.02e-18 1.20e-16 ✓ sig. Cluster 71 →
Intellectual disability Nonsyndromic intellectual disability
16 genes
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14 of 16 corroborated by 2+ sources
CRBN(3), GRIN2B(2), KDM5B(4), SCN8A(2), ST3GAL3(2), TCF4(3), TUSC3(3), ZC3H14(4), ZNF292(1), JARID2(1), RAB11A(2), STXBP1(2) +4 more
0.079 0.211 6.95e-18 1.19e-16 ✓ sig. Cluster 6 →
Lymphoid leukemia Multiple myeloma
12 genes
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1 of 12 corroborated by 2+ sources
GRAMD1B(1), GRIP1(1), HLA-DQB1(1), EXOC2(1), IRF4(2), SP140(1), IRF8(1), ACOXL(1), MYNN(1), ACTRT3(1), BMF(1), SP140L(1)
0.075 0.429 6.90e-18 1.18e-16 ✓ sig. Cluster 225 →
Lymphocytic leukemia Non-hodgkins lymphoma
18 genes
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TERT(1), GRAMD1B(1), HLA-DQA1(1), HLA-DRB1(1), RHOU(1), BCL2(1), HLA-DQB1(1), EXOC2(1), IRF4(1), EOMES(1), SP140(1), IRF8(1) +6 more
0.077 0.157 6.80e-18 1.16e-16 ✓ sig. —
Nephrotic syndrome Proteinuria
14 genes
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14 of 14 corroborated by 2+ sources
AGT(2), HLA-DQA1(2), HLA-DRB1(3), NCK2(2), REN(2), SOD1(2), ALB(2), TGFB1(2), IL1RN(2), MUC16(2), LMX1B(2), NCK1(2) +2 more
0.072 0.333 6.69e-18 1.15e-16 ✓ sig. Cluster 30 →
Autoimmune thyroid disease Oligoarticular juvenile idiopathic arthritis
21 genes
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14 of 21 corroborated by 2+ sources
RERE(2), ANKRD55(2), HLA-DQA1(2), HLA-DRB1(1), ATXN2(1), HLA-DQB1(2), IRF1(1), SMAD3(2), ADCY7(2), CTLA4(2), IL2RA(3), PHTF1(1) +9 more
0.071 0.146 6.35e-18 1.09e-16 ✓ sig. —

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.