SLC22A10 (solute carrier family 22 member 10 (gene/pseudogene))

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Gene Gene information from NCBI Gene database.
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Entrez ID 387775
Gene name Solute carrier family 22 member 10 (gene/pseudogene)
Gene symbol SLC22A10
Synonyms (NCBI Gene)
OAT5hOAT5
Chromosome 11
Chromosome location 11q12.3
miRNA miRNA information provided by mirtarbase database.
9 Show/Hide all (9)
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miRTarBase ID miRNA Experiments Reference
MIRT2104818 hsa-miR-4282 CLIP-seq
MIRT2690933 hsa-miR-133a CLIP-seq
MIRT2690934 hsa-miR-133b CLIP-seq
MIRT2690935 hsa-miR-2113 CLIP-seq
MIRT2690936 hsa-miR-3908 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
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Transcription factor Regulation Reference
HNF1A Activation 20829431
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0015711 Process Organic anion transport IBA
GO:0016020 Component Membrane IEA
GO:0022857 Function Transmembrane transporter activity IEA
GO:0055085 Process Transmembrane transport IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
607580 18057 ENSG00000184999
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q63ZE4
Protein name Solute carrier family 22 member 10 (Organic anion transporter 5)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00083 Sugar_tr 102 → 527 Sugar (and other) transporter Family
Tissue specificity TISSUE SPECIFICITY: Detected in fetal and adult liver, and in adult kidney. {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:12372408}.
Sequence 
MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS
GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW
VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL
LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA
LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR
KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN
TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI
LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA
ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK
A
Sequence length 541
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (6)
Phenotype Name Clinical Significance Source Reference Evidence Score
CARCINOMA, HEPATOCELLULAR — CTD 28284560, 30705370
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, NON-SMALL-CELL LUNG — CTD 30705370
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONOTRUNCAL HEART MALFORMATIONS — GWAS catalog 34356046
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA — CTD 30705370
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LYMPHATIC METASTASIS — CTD 30705370
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (12)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 35173266 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Conotruncal defect Conotruncal defect GWASDB_DG 24800985
★★★★★
★☆☆☆☆
Found in Text Mining only
CONOTRUNCAL HEART MALFORMATIONS (disorder) Conotruncal heart defect GWASCAT_DG 24800985
★★★★★
★☆☆☆☆
Found in Text Mining only
Dementia Dementia Pubtator 35173266 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Giant Cell Glioblastoma Giant Cell Glioblastoma CTD_human_DG 30705370
★★★★★
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma CTD_human_DG 30705370
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Glioblastoma Multiforme Glioblastoma CTD_human_DG 30705370
★★★★★
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma CTD_human_DG 28284560, 30705370
★★★★★
★☆☆☆☆
Found in Text Mining only
Lymphatic Metastasis Lymphatic Metastasis CTD_human_DG 30705370
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of ovary Ovarian cancer CTD_human_DG 30705370
★★★★★
★☆☆☆☆
Found in Text Mining only
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LRRC59 3 shared diseasesOvarian neoplasms, Non-small-cell lung carcinoma, Lymphatic metastasis 4 shared evidence sourcesCTD (Non-small-cell lung carcinoma), CTD (Glioblastoma), CTD (Lymphatic metastasis), CTD (Ovarian neoplasms) Related via 3 shared diseases including Ovarian neoplasms, Non-small-cell lung carcinoma — evidence mostly CTD. TP53BP1 3 shared diseasesOvarian neoplasms, Non-small-cell lung carcinoma, Lymphatic metastasis 4 shared evidence sourcesCTD (Non-small-cell lung carcinoma), CTD (Glioblastoma), CTD (Lymphatic metastasis), CTD (Ovarian neoplasms) Related via 3 shared diseases including Ovarian neoplasms, Non-small-cell lung carcinoma — evidence mostly CTD. TRMT11 3 shared diseasesOvarian neoplasms, Non-small-cell lung carcinoma, Lymphatic metastasis 4 shared evidence sourcesCTD (Non-small-cell lung carcinoma), CTD (Glioblastoma), CTD (Lymphatic metastasis), CTD (Ovarian neoplasms) Related via 3 shared diseases including Ovarian neoplasms, Non-small-cell lung carcinoma — evidence mostly CTD. CCNH 3 shared diseasesOvarian neoplasms, Non-small-cell lung carcinoma, Lymphatic metastasis 4 shared evidence sourcesCTD (Non-small-cell lung carcinoma), CTD (Glioblastoma), CTD (Lymphatic metastasis), CTD (Ovarian neoplasms) Related via 3 shared diseases including Ovarian neoplasms, Non-small-cell lung carcinoma — evidence mostly CTD. MACIR 3 shared diseasesOvarian neoplasms, Non-small-cell lung carcinoma, Lymphatic metastasis 4 shared evidence sourcesCTD (Non-small-cell lung carcinoma), CTD (Glioblastoma), CTD (Lymphatic metastasis), CTD (Ovarian neoplasms) Related via 3 shared diseases including Ovarian neoplasms, Non-small-cell lung carcinoma — evidence mostly CTD.
Breast neoplasms Linked via 4 of 5 related genesTP53BP1, TRMT11, CCNH, MACIR Colonic neoplasms Linked via 4 of 5 related genesTP53BP1, TRMT11, CCNH, MACIR Esophageal neoplasms Linked via 3 of 5 related genesTRMT11, CCNH, MACIR Liver neoplasms Linked via 3 of 5 related genesTRMT11, CCNH, MACIR Prostatic neoplasms Linked via 2 of 5 related genesCCNH, MACIR