WDR12 (WD repeat domain 12)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55759
• Gene name: WD repeat domain 12
• Gene symbol: WDR12
• Synonyms (NCBI Gene): YTM1
• Chromosome: 2
• Chromosome location: 2q33.2
• Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein com

miRNA Show/Hide all (242)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028635	hsa-miR-30a-5p	Proteomics	18668040
MIRT041501	hsa-miR-193b-3p	CLASH	23622248
MIRT707780	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707781	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707779	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT680445	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT680444	hsa-miR-764	HITS-CLIP	23824327
MIRT680443	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT649861	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT649860	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT680442	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT680441	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT649859	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT649858	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT680440	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT680439	hsa-miR-640	HITS-CLIP	23824327
MIRT649857	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT664814	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT664813	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT664812	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT621079	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621078	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT119354	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT621077	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT649861	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT649860	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT649859	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT649858	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT649857	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621085	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621084	hsa-miR-3649	HITS-CLIP	23824327
MIRT649856	hsa-miR-4279	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT649855	hsa-miR-3122	HITS-CLIP	23824327
MIRT649854	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621085	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621084	hsa-miR-3649	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT621081	hsa-miR-125b-1-3p	HITS-CLIP	23824327
MIRT621080	hsa-miR-3615	HITS-CLIP	23824327
MIRT621079	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621078	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT621077	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT542396	hsa-miR-4432	PAR-CLIP	21572407
MIRT542395	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT542394	hsa-miR-451b	PAR-CLIP	21572407
MIRT542393	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT542392	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542391	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542389	hsa-miR-4696	PAR-CLIP	21572407
MIRT542390	hsa-miR-3135a	PAR-CLIP	21572407
MIRT542388	hsa-miR-196a-3p	PAR-CLIP	21572407
MIRT542387	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542386	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT542388	hsa-miR-196a-3p	PAR-CLIP	27292025
MIRT542388	hsa-miR-196a-3p	PAR-CLIP	27292025
MIRT542390	hsa-miR-3135a	PAR-CLIP	27292025
MIRT542390	hsa-miR-3135a	PAR-CLIP	27292025
MIRT542396	hsa-miR-4432	PAR-CLIP	27292025
MIRT542396	hsa-miR-4432	PAR-CLIP	27292025
MIRT542394	hsa-miR-451b	PAR-CLIP	27292025
MIRT542394	hsa-miR-451b	PAR-CLIP	27292025
MIRT542389	hsa-miR-4696	PAR-CLIP	27292025
MIRT542389	hsa-miR-4696	PAR-CLIP	27292025
MIRT542395	hsa-miR-508-5p	PAR-CLIP	27292025
MIRT542393	hsa-miR-6501-3p	PAR-CLIP	27292025
MIRT542393	hsa-miR-6501-3p	PAR-CLIP	27292025
MIRT542387	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT542387	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT542386	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT542386	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT542391	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT542391	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT707780	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707781	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707779	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT680445	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT680444	hsa-miR-764	HITS-CLIP	23824327
MIRT680443	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT649861	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT649860	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT680442	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT680441	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT649859	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT649858	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT680440	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT680439	hsa-miR-640	HITS-CLIP	23824327
MIRT649857	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT664814	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT664813	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT664812	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT621079	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621078	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT119354	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT621077	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT649861	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT649860	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT649859	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT649858	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT649857	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621085	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621084	hsa-miR-3649	HITS-CLIP	23824327
MIRT649856	hsa-miR-4279	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT649855	hsa-miR-3122	HITS-CLIP	23824327
MIRT649854	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621085	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621084	hsa-miR-3649	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT621081	hsa-miR-125b-1-3p	HITS-CLIP	23824327
MIRT621080	hsa-miR-3615	HITS-CLIP	23824327
MIRT621079	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621078	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT621077	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT542396	hsa-miR-4432	PAR-CLIP	21572407
MIRT542395	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT542394	hsa-miR-451b	PAR-CLIP	21572407
MIRT542393	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT542392	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542391	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542389	hsa-miR-4696	PAR-CLIP	21572407
MIRT542390	hsa-miR-3135a	PAR-CLIP	21572407
MIRT542388	hsa-miR-196a-3p	PAR-CLIP	21572407
MIRT542387	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542386	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT1489724	hsa-miR-1297	CLIP-seq
MIRT1489725	hsa-miR-26a	CLIP-seq
MIRT1489726	hsa-miR-26b	CLIP-seq
MIRT1489727	hsa-miR-3064-3p	CLIP-seq
MIRT1489728	hsa-miR-3123	CLIP-seq
MIRT1489729	hsa-miR-3149	CLIP-seq
MIRT1489730	hsa-miR-340	CLIP-seq
MIRT1489731	hsa-miR-380	CLIP-seq
MIRT1489732	hsa-miR-3925-5p	CLIP-seq
MIRT1489733	hsa-miR-3976	CLIP-seq
MIRT1489734	hsa-miR-4328	CLIP-seq
MIRT1489735	hsa-miR-4465	CLIP-seq
MIRT1489736	hsa-miR-4495	CLIP-seq
MIRT1489737	hsa-miR-4714-3p	CLIP-seq
MIRT1489738	hsa-miR-4775	CLIP-seq
MIRT1489739	hsa-miR-498	CLIP-seq
MIRT1489740	hsa-miR-544	CLIP-seq
MIRT1489741	hsa-miR-568	CLIP-seq
MIRT2147680	hsa-miR-2117	CLIP-seq
MIRT2147681	hsa-miR-4684-5p	CLIP-seq
MIRT1489724	hsa-miR-1297	CLIP-seq
MIRT1489725	hsa-miR-26a	CLIP-seq
MIRT1489726	hsa-miR-26b	CLIP-seq
MIRT1489729	hsa-miR-3149	CLIP-seq
MIRT1489733	hsa-miR-3976	CLIP-seq
MIRT1489734	hsa-miR-4328	CLIP-seq
MIRT1489735	hsa-miR-4465	CLIP-seq
MIRT1489738	hsa-miR-4775	CLIP-seq
MIRT1489739	hsa-miR-498	CLIP-seq
MIRT1489741	hsa-miR-568	CLIP-seq
MIRT2147680	hsa-miR-2117	CLIP-seq
MIRT2661538	hsa-miR-216a	CLIP-seq
MIRT2661539	hsa-miR-216b	CLIP-seq
MIRT2661540	hsa-miR-3160-5p	CLIP-seq
MIRT2661541	hsa-miR-3179	CLIP-seq
MIRT2661542	hsa-miR-3675-3p	CLIP-seq
MIRT1489731	hsa-miR-380	CLIP-seq
MIRT2661543	hsa-miR-410	CLIP-seq
MIRT1489736	hsa-miR-4495	CLIP-seq
MIRT2661544	hsa-miR-4528	CLIP-seq
MIRT2147681	hsa-miR-4684-5p	CLIP-seq
MIRT2661545	hsa-miR-4729	CLIP-seq
MIRT1489740	hsa-miR-544	CLIP-seq
MIRT2661546	hsa-miR-570	CLIP-seq
MIRT2661547	hsa-miR-579	CLIP-seq
MIRT2147680	hsa-miR-2117	CLIP-seq
MIRT2661538	hsa-miR-216a	CLIP-seq
MIRT2661539	hsa-miR-216b	CLIP-seq
MIRT2661540	hsa-miR-3160-5p	CLIP-seq
MIRT2661541	hsa-miR-3179	CLIP-seq
MIRT1489731	hsa-miR-380	CLIP-seq
MIRT2661543	hsa-miR-410	CLIP-seq
MIRT1489736	hsa-miR-4495	CLIP-seq
MIRT2661544	hsa-miR-4528	CLIP-seq
MIRT2147681	hsa-miR-4684-5p	CLIP-seq
MIRT2661545	hsa-miR-4729	CLIP-seq
MIRT1489740	hsa-miR-544	CLIP-seq
MIRT2661546	hsa-miR-570	CLIP-seq
MIRT2661547	hsa-miR-579	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP	16043514, 17353269
GO:0000466	Process	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000466	Process	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0000466	Process	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP	16043514
GO:0005515	Function	Protein binding	IPI	16043514, 16738141, 17353269, 28514442, 30021884, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	16043514
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	16043514
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0030687	Component	Preribosome, large subunit precursor	IBA
GO:0030687	Component	Preribosome, large subunit precursor	IDA	17353269
GO:0030687	Component	Preribosome, large subunit precursor	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042273	Process	Ribosomal large subunit biogenesis	IC	16043514, 17353269
GO:0042273	Process	Ribosomal large subunit biogenesis	IEA
GO:0043021	Function	Ribonucleoprotein complex binding	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	16043514
GO:0070545	Component	PeBoW complex	IBA
GO:0070545	Component	PeBoW complex	IDA	16043514, 16738141, 17353269

Other IDs

• MIM: 616620
• HGNC: 14098
• e!Ensembl: ENSG00000138442

Protein

• UniProt ID: Q9GZL7
• Protein name: Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)
• Protein function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
• PDB: 6N31 , 6P0Q , 8FKY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	247 → 284	WD domain, G-beta repeat	Repeat
  PF00400	WD40	288 → 325	WD domain, G-beta repeat	Repeat
  PF00400	WD40	334 → 371	WD domain, G-beta repeat	Repeat
  PF00400	WD40	179 → 217	WD domain, G-beta repeat	Repeat
  PF00400	WD40	130 → 171	WD domain, G-beta repeat	Repeat
  PF08154	NLE	4 → 70	NLE (NUC135) domain	Domain

• Sequence:

  MAQLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKNEFHKHVEFDFLIKGQ
  FLRMPLDKHMEMENISSEEVVEIEYVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYD
  KTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVK
  ALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKT
  EQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVF
  NCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLIS
  GSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSH
  VGA

• Sequence length: 423

Pathways

Reactome Pathway:

Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (17)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	35379992, 37985413	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, DILATED	—	CTD, Disgenet CTD, Disgenet	25915632	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC BRONCHITIS	—	GWAS catalog	40155373	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	CTD, GWAS catalog CTD, GWAS catalog	21378990, 24262325, 28714975, 29212778, 32469254, 33020668, 33321069, 33910581, 35285134, 36474045, 39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ATHEROSCLEROSIS	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMOLYTIC ANEMIA	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	40155373	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LARGE ARTERY STROKE	—	GWAS catalog	24262325	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	27182965, 27322543, 34294844, 35115687, 35128049, 36939796	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	19198609, 19198609, 25915632, 33532862, 37947095, 38072966	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	36889626	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL VESSEL STROKE	—	GWAS catalog	35128049	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	24262325	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (29)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	39201500	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	31164008		★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Dilated	Cardiomyopathy	BEFREE	25915632		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiomyopathy, Dilated	Cardiomyopathy	CTD_human_DG	25915632		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiomyopathy, Familial Idiopathic	Cardiomyopathy	CTD_human_DG	25915632		★☆☆☆☆ Found in Text Mining only
Cerebral Small Vessel Diseases	Cerebral microangiopathy	Pubtator	31430377	Associate	★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	GWASCAT_DG	24262325		★☆☆☆☆ Found in Text Mining only
Chondrosarcoma	Chondrosarcoma	Pubtator	34797290	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29658574, 39969382	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	CTD_human_DG	21378990		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	25804320		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	CTD_human_DG	21378990		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	GWASDB_DG	24262325		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	BEFREE	25804320		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	Pubtator	28710368, 35379196, 39201500	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	28714975, 29212778		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease Autosomal Dominant 1	Coronary artery disease	Pubtator	22216278	Associate	★☆☆☆☆ Found in Text Mining only
CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1	Coronary artery disease	GWASDB_DG	23202125		★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	GWASDB_DG	21347282, 21378990		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary heart disease	Coronary Heart Disease	GWASCAT_DG	21378990, 24262325		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary heart disease	Coronary Heart Disease	BEFREE	25804320		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Liver carcinoma	Liver carcinoma	BEFREE	30310320		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	31164008		★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	GWASCAT_DG	27182965, 27322543		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	CTD_human_DG	19198609, 25915632		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	GWASCAT_DG	19198609		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	GWASDB_DG	19198609		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	BEFREE	25915632		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	GWASCAT_DG	31164008		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

NBEAL1 2 shared diseasesIschemic heart disease, Small vessel stroke 6 shared evidence sourcesDisgenet (Ischemic heart disease), Disgenet (Coronary artery disease), CTD (Coronary artery disease), GWAS catalog (Myocardial ischemia), GWAS catalog (Small vessel stroke), GWAS catalog (Stroke) Related via 2 shared diseases including Ischemic heart disease, Small vessel stroke — evidence mostly GWAS catalog. CARF 2 shared diseasesIschemic heart disease, Small vessel stroke 4 shared evidence sourcesDisgenet (Ischemic heart disease), Disgenet (Coronary artery disease), CTD (Coronary artery disease), GWAS catalog (Small vessel stroke) Related via 2 shared diseases including Ischemic heart disease, Small vessel stroke — evidence mostly Disgenet. ICA1L 2 shared diseasesBronchitis, Ischemic heart disease 5 shared evidence sourcesGWAS catalog (Bronchitis), Disgenet (Ischemic heart disease), Disgenet (Coronary artery disease), CTD (Coronary artery disease), GWAS catalog (Myocardial ischemia) Related via 2 shared diseases including Bronchitis, Ischemic heart disease — evidence mostly GWAS catalog. TCF21 2 shared diseasesIschemic heart disease, Large artery stroke 6 shared evidence sourcesDisgenet (Ischemic heart disease), Disgenet (Coronary artery disease), CTD (Coronary artery disease), GWAS catalog (Large artery stroke), GWAS catalog (Myocardial ischemia), GWAS catalog (Stroke) Related via 2 shared diseases including Ischemic heart disease, Large artery stroke — evidence mostly GWAS catalog. ZC3HC1 2 shared diseasesIschemic heart disease, Large artery stroke 6 shared evidence sourcesDisgenet (Ischemic heart disease), Disgenet (Coronary artery disease), CTD (Coronary artery disease), GWAS catalog (Large artery stroke), GWAS catalog (Myocardial ischemia), GWAS catalog (Stroke) Related via 2 shared diseases including Ischemic heart disease, Large artery stroke — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
NBEAL1	2	["Ischemic heart disease","Small vessel stroke"]	0	[]	6	["Disgenet (Ischemic heart disease)","Disgenet (Coronary artery disease)","CTD (Coronary artery disease)","GWAS catalog (Myocardial ischemia)","GWAS catalog (Small vessel stroke)","GWAS catalog (Stroke)"]
CARF	2	["Ischemic heart disease","Small vessel stroke"]	0	[]	4	["Disgenet (Ischemic heart disease)","Disgenet (Coronary artery disease)","CTD (Coronary artery disease)","GWAS catalog (Small vessel stroke)"]
ICA1L	2	["Bronchitis","Ischemic heart disease"]	0	[]	5	["GWAS catalog (Bronchitis)","Disgenet (Ischemic heart disease)","Disgenet (Coronary artery disease)","CTD (Coronary artery disease)","GWAS catalog (Myocardial ischemia)"]
TCF21	2	["Ischemic heart disease","Large artery stroke"]	0	[]	6	["Disgenet (Ischemic heart disease)","Disgenet (Coronary artery disease)","CTD (Coronary artery disease)","GWAS catalog (Large artery stroke)","GWAS catalog (Myocardial ischemia)","GWAS catalog (Stroke)"]
ZC3HC1	2	["Ischemic heart disease","Large artery stroke"]	0	[]	6	["Disgenet (Ischemic heart disease)","Disgenet (Coronary artery disease)","CTD (Coronary artery disease)","GWAS catalog (Large artery stroke)","GWAS catalog (Myocardial ischemia)","GWAS catalog (Stroke)"]

Diseases Linked via Similar Genes

Hypertension Linked via 3 of 5 related genesNBEAL1, TCF21, ZC3HC1 Heart disease Linked via 3 of 5 related genesICA1L, TCF21, ZC3HC1 Neurotic disorder Linked via 2 of 5 related genesNBEAL1, ICA1L Metabolic syndrome Linked via 2 of 5 related genesICA1L, ZC3HC1 Diabetes mellitus type 2 Linked via 2 of 5 related genesICA1L, ZC3HC1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Hypertension	3	["NBEAL1","TCF21","ZC3HC1"]
Heart disease	3	["ICA1L","TCF21","ZC3HC1"]
Neurotic disorder	2	["NBEAL1","ICA1L"]
Metabolic syndrome	2	["ICA1L","ZC3HC1"]
Diabetes mellitus type 2	2	["ICA1L","ZC3HC1"]