Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

Log in to save this analysis

Save This Analysis

What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Autoimmune hepatitis Sjogren syndrome
10 genes
Show details
7 of 10 corroborated by 2+ sources
HLA-DQA1(2), HLA-DRB1(2), IL10(2), ATXN2(1), IL6(2), HLA-DQB1(2), HLA-DPB1(2), CTLA4(1), STAT4(3), TSBP1(1)
0.100 0.263 9.58e-16 1.44e-14 ✓ sig. —
Hemophilia a Thrombophilia
7 genes
Show details
5 of 7 corroborated by 2+ sources
HLA-DQA1(1), F2(6), MTHFR(3), PLAT(3), F8(7), TFPI(1), F9(6)
0.167 0.438 9.35e-16 1.40e-14 ✓ sig. Cluster 55 →
Cardiomegaly Fatty liver, alcoholic
13 genes
Show details
13 of 13 corroborated by 2+ sources
LEP(2), PPARA(2), SOD2(2), TNF(2), POMC(2), AKT1(2), CYP1B1(2), CYP2E1(2), HTR2B(2), PPARD(2), UCP2(2), CEBPB(2) +1 more
0.082 0.155 9.10e-16 1.37e-14 ✓ sig. —
Thrombosis Venous thrombosis
8 genes
Show details
PLAU(1), EPO(1), F2(1), PLAT(1), SERPINC1(1), F5(1), PROC(1), F3(1)
0.133 0.364 8.55e-16 1.28e-14 ✓ sig. Cluster 55 →
Age-related macular degeneration C3 glomerulonephritis
7 genes
Show details
7 of 7 corroborated by 2+ sources
CFHR1(4), CFI(5), C3(4), CFB(4), CFH(4), CFHR5(6), CFHR3(3)
0.082 0.875 8.13e-16 1.22e-14 ✓ sig. —
Anophthalmia Colobomatous microphthalmia
6 genes
Show details
6 of 6 corroborated by 2+ sources
SOX2(3), STRA6(3), OTX2(2), RAX(3), VSX2(2), RBP4(2)
0.250 0.429 8.09e-16 1.22e-14 ✓ sig. Cluster 56 →
Colonic neoplasms Liver neoplasms
21 genes
Show details
1 of 21 corroborated by 2+ sources
TP53(1), GRIK2(1), IGF2(1), MACIR(1), PPARG(1), STAT3(1), TNF(1), CTNNB1(1), TRMT11(1), KRAS(1), APC(1), CDKN1A(1) +9 more
0.063 0.138 7.85e-16 1.18e-14 ✓ sig. Cluster 5 →
Cleft palate Orofacial cleft
14 genes
Show details
11 of 14 corroborated by 2+ sources
MEIS2(1), TBX22(1), COL2A1(2), TP63(5), FGF10(2), IRF6(4), MSX1(4), FGFR1(2), CDH1(2), DLG1(2), RYK(2), ARHGAP29(3) +2 more
0.069 0.233 7.71e-16 1.16e-14 ✓ sig. Cluster 63 →
Anemia Beta thalassemia
9 genes
Show details
8 of 9 corroborated by 2+ sources
HBA2(2), HFE(2), EPO(3), TNF(2), HBS1L(2), GATA1(4), GH1(1), HAMP(2), HBB(8)
0.093 0.429 7.67e-16 1.16e-14 ✓ sig. —
Carcinoma Urinary bladder neoplasms
19 genes
Show details
TP53(1), EGFR(1), ESR2(1), RHOA(1), BCL2(1), ESR1(1), GSTP1(1), SOD2(1), STAT3(1), PTGS2(1), HIF1A(1), CSF3(1) +7 more
0.066 0.134 7.64e-16 1.15e-14 ✓ sig. Cluster 5 →
Color vision deficiency Pelvic organ prolapse
39 genes
Show details
WT1(1), SOX5(1), WWOX(1), CACNA2D3(1), CAMK1D(1), DISC1(1), FARP1(1), GLIS3(1), NAALADL2(1), NRP1(1), PSD3(1), RBFOX1(1) +27 more
0.037 0.281 7.13e-16 1.08e-14 ✓ sig. —
Crest syndrome Diffuse cutaneous systemic sclerosis
7 genes
Show details
4 of 7 corroborated by 2+ sources
HLA-DRB1(1), CAV1(2), CCR6(2), IRF5(3), STAT4(2), TNPO3(1), CCN2(1)
0.184 0.333 6.92e-16 1.05e-14 ✓ sig. Cluster 25 →
Irritable bowel syndrome Obstructive pulmonary disease
30 genes
Show details
RERE(1), RREB1(1), ASCC2(1), CADM2(1), CELF4(1), EMSY(1), FOXP2(1), GLIS3(1), HEYL(1), HLA-C(1), MECOM(1), MPHOSPH9(1) +18 more
0.045 0.224 6.27e-16 9.49e-15 ✓ sig. —
Distal arthrogryposis Sheldon-hall syndrome
5 genes
Show details
5 of 5 corroborated by 2+ sources
MYH3(5), TPM2(6), NALCN(2), TNNI2(5), TNNT3(5)
0.294 1.000 6.06e-16 9.17e-15 ✓ sig. Cluster 202 →
Brain injuries Rhinitis
12 genes
Show details
12 of 12 corroborated by 2+ sources
BDNF(2), IL10(2), IL1B(2), IL2(2), TLR4(2), TNF(2), PTGS2(2), ALB(2), IL1RN(2), CD14(2), TLR2(2), OCLN(2)
0.090 0.185 5.29e-16 8.01e-15 ✓ sig. —
Cor pulmonale Thrombophilia
7 genes
Show details
4 of 7 corroborated by 2+ sources
FGA(4), F2(6), ABO(1), SLC19A2(1), F5(6), FGG(3), F11(1)
0.171 0.467 5.27e-16 7.98e-15 ✓ sig. —
Necrosis Ventricular dysfunction
10 genes
Show details
AGT(1), DMD(1), FAS(1), NFE2L2(1), SOD2(1), TNF(1), IL6(1), CAST(1), TNNT2(1), METTL14(1)
0.109 0.217 5.26e-16 7.98e-15 ✓ sig. —
Jeune syndrome Majewski syndrome
7 genes
Show details
5 of 7 corroborated by 2+ sources
NEK1(1), IFT80(5), DYNC2H1(5), DYNC2LI1(3), IFT172(3), TTC21B(6), WDR35(1)
0.146 0.583 5.20e-16 7.90e-15 ✓ sig. Cluster 22 →
Peripheral arterial disease Vascular disease
14 genes
Show details
1 of 14 corroborated by 2+ sources
HDAC9(1), NFAT5(1), TCF7L2(1), MTHFR(2), ATXN2(1), CHRNA3(1), TWIST1(1), ABO(1), CELSR2(1), LPA(1), F5(1), FRMD4A(1) +2 more
0.065 0.269 5.06e-16 7.69e-15 ✓ sig. Cluster 307 →
Androgenetic alopecia Obstructive pulmonary disease
53 genes
Show details
KANSL1(1), CASZ1(1), RERE(1), RREB1(1), HDAC4(1), FGFR3(1), AFF3(1), CCDC91(1), FADS2(1), GLIS3(1), HDAC9(1), L3MBTL3(1) +41 more
0.058 0.130 4.92e-16 7.47e-15 ✓ sig. —
Hyperlipidemia Hypertriglyceridemia
11 genes
Show details
9 of 11 corroborated by 2+ sources
APOB(3), LPL(6), PPARA(2), ZPR1(2), GCKR(3), CETP(2), PLTP(3), TDRD15(1), ANGPTL4(3), APOA5(4), HAVCR1(1)
0.069 0.393 4.80e-16 7.31e-15 ✓ sig. Cluster 254 →
Lamellar cataract Nuclear cataract
6 genes
Show details
6 of 6 corroborated by 2+ sources
CRYAA(2), CRYGC(2), CRYAB(2), CRYGD(2), MIP(2), CRYBA1(2)
0.250 0.545 4.62e-16 7.04e-15 ✓ sig. Cluster 43 →
Nasal disorder Upper respiratory tract disorder
7 genes
Show details
NEK6(1), SMAD3(1), IL18R1(1), IL7R(1), IL1RL1(1), RANBP6(1), FBXO33(1)
0.189 0.350 4.62e-16 7.04e-15 ✓ sig. Cluster 137 →
Paraganglioma Pheochromocytoma/paraganglioma syndrome
5 genes
Show details
5 of 5 corroborated by 2+ sources
SDHB(5), SDHD(5), SDHA(5), SDHC(4), SDHAF2(4)
0.417 0.625 4.35e-16 6.63e-15 ✓ sig. Cluster 81 →
Ap-4 deficiency syndrome Ap4-related intellectual disability and spastic paraplegia
4 genes
Show details
4 of 4 corroborated by 2+ sources
AP4M1(2), AP4B1(2), AP4E1(2), AP4S1(2)
0.800 1.000 4.27e-16 6.52e-15 ✓ sig. —

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.