Hyperlipidemia

mRNA Editing: C to U Conversion Formation of the Editosome

ABC transporters Fat digestion and absorption Bile secretion Cholesterol metabolism ABC transporters in lipid homeostasis Defective ABCG8 causes gallbladder disease 4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +5 more

Transcriptional misregulation in cancer

Retinol metabolism Metabolic pathways RA biosynthesis pathway

PPAR signaling pathway Cholesterol metabolism PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes +2 more

Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism Lipid and atherosclerosis Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance LDL clearance LDL remodeling VLDL clearance Retinoid metabolism and transport +20 more

Cholesterol metabolism VLDL assembly VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +1 more

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +2 more

Autophagy - other Autophagy - animal Macroautophagy

Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +3 more

C-type lectin receptor signaling pathway TNF signaling pathway

Ubiquitin mediated proteolysis Endocytosis

Sphingolipid de novo biosynthesis

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Metabolic pathways Chondroitin sulfate biosynthesis

Retinol metabolism Metabolic pathways Vitamins RA biosynthesis pathway +1 more

Primary bile acid biosynthesis Steroid hormone biosynthesis Metabolic pathways PPAR signaling pathway Bile secretion Cholesterol metabolism Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols +8 more

Spliceosome Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination +2 more

MET activates RAP1 and RAC1 Factors involved in megakaryocyte development and platelet production

Platinum drug resistance Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway +5 more

Mucin type O-glycan biosynthesis Other types of O-glycan biosynthesis Metabolic pathways COPI-independent Golgi-to-ER retrograde traffic O-linked glycosylation of mucins +2 more

EGFR tyrosine kinase inhibitor resistance Efferocytosis Platelet degranulation Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +5 more

Regulation of Glucokinase by Glucokinase Regulatory Protein Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Virion - Flavivirus and Alphavirus Efferocytosis

MET Receptor Activation

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +24 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Terpenoid backbone biosynthesis Metabolic pathways AMPK signaling pathway Bile secretion Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination +5 more

Virion - Herpesvirus Lysosome Endocytosis Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +5 more

RNA polymerase II transcribes snRNA genes

Virion - Hepatitis viruses Endocytosis Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Bile secretion Cholesterol metabolism Toxoplasmosis Hepatitis C Lipid and atherosclerosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance +12 more

Glycerolipid metabolism Metabolic pathways Cholesterol metabolism Assembly of active LPL and LIPC lipase complexes Chylomicron clearance +2 more

Cholesterol metabolism

Glycerolipid metabolism PPAR signaling pathway Cholesterol metabolism Alzheimer disease Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport +5 more

Parathyroid hormone synthesis, secretion and action

Insulin resistance Non-alcoholic fatty liver disease PKA-mediated phosphorylation of key metabolic factors ChREBP activates metabolic gene expression +1 more

ABC transporters Fat digestion and absorption Bile secretion Cholesterol metabolism ABC transporters in lipid homeostasis Defective ABCG8 causes gallbladder disease 4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +5 more

Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism Lipid and atherosclerosis Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance LDL clearance LDL remodeling VLDL clearance Retinoid metabolism and transport +20 more

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

Sphingolipid de novo biosynthesis

Retinol metabolism Metabolic pathways Vitamins RA biosynthesis pathway +1 more

Primary bile acid biosynthesis Steroid hormone biosynthesis Metabolic pathways PPAR signaling pathway Bile secretion Cholesterol metabolism Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols +8 more

MET activates RAP1 and RAC1 Factors involved in megakaryocyte development and platelet production

Regulation of Glucokinase by Glucokinase Regulatory Protein Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Virion - Flavivirus and Alphavirus Efferocytosis

MET Receptor Activation

Terpenoid backbone biosynthesis Metabolic pathways AMPK signaling pathway Bile secretion Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination +5 more

Virion - Hepatitis viruses Endocytosis Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Bile secretion Cholesterol metabolism Toxoplasmosis Hepatitis C Lipid and atherosclerosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance +12 more

Glycerolipid metabolism Metabolic pathways Cholesterol metabolism Assembly of active LPL and LIPC lipase complexes Chylomicron clearance +2 more

Cholesterol metabolism

Glycerolipid metabolism PPAR signaling pathway Cholesterol metabolism Alzheimer disease Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport +5 more

Glycerolipid metabolism Metabolic pathways Cholesterol metabolism Assembly of active LPL and LIPC lipase complexes Chylomicron clearance +2 more

Glycerolipid metabolism Metabolic pathways Cholesterol metabolism Assembly of active LPL and LIPC lipase complexes Chylomicron clearance +2 more

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

Glycerolipid metabolism Metabolic pathways Cholesterol metabolism Assembly of active LPL and LIPC lipase complexes Chylomicron clearance +2 more

Glycerolipid metabolism PPAR signaling pathway Cholesterol metabolism Alzheimer disease Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport +5 more

Glycerolipid metabolism PPAR signaling pathway Cholesterol metabolism Alzheimer disease Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport +5 more

Glycerolipid metabolism PPAR signaling pathway Cholesterol metabolism Alzheimer disease Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport +5 more

Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism Lipid and atherosclerosis Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance LDL clearance LDL remodeling VLDL clearance Retinoid metabolism and transport +20 more

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

Virion - Hepatitis viruses Endocytosis Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Bile secretion Cholesterol metabolism Toxoplasmosis Hepatitis C Lipid and atherosclerosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance +12 more

Glycerolipid metabolism Metabolic pathways Cholesterol metabolism Assembly of active LPL and LIPC lipase complexes Chylomicron clearance +2 more

Glycerolipid metabolism PPAR signaling pathway Cholesterol metabolism Alzheimer disease Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport +5 more