Gene Gene information from NCBI Gene database.
Entrez ID 2152
Gene name Coagulation factor III, tissue factor
Gene symbol F3
Synonyms (NCBI Gene)
CD142TFTFA
Chromosome 1
Chromosome location 1p21.3
Summary This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provi
miRNA miRNA information provided by mirtarbase database.
777
miRTarBase ID miRNA Experiments Reference
MIRT019927 hsa-miR-375 Microarray 20215506
MIRT020315 hsa-miR-130b-3p Sequencing 20371350
MIRT022817 hsa-miR-124-3p Microarray 18668037
MIRT028146 hsa-miR-93-5p Sequencing 20371350
MIRT029798 hsa-miR-26b-5p Microarray 19088304
Transcription factors Transcription factors information provided by TRRUST V2 database.
7
Transcription factor Regulation Reference
EGR1 Unknown 10707957;8576248
JUN Unknown 11057875
JUND Unknown 11057875
NFKB1 Unknown 11057875;11157486;19167713;9867853
REL Unknown 11057875
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0001938 Process Positive regulation of endothelial cell proliferation IDA 17898544
GO:0002020 Function Protease binding IPI 3455766
GO:0002541 Process Activation of plasma proteins involved in acute inflammatory response IDA 17469850
GO:0002543 Process Activation of blood coagulation via clotting cascade IDA 17469850
GO:0004252 Function Serine-type endopeptidase activity IDA 24998411
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
134390 3541 ENSG00000117525
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P13726
Protein name Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)
Protein function Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly a
PDB 1AHW , 1BOY , 1DAN , 1FAK , 1J9C , 1JPS , 1O5D , 1TFH , 1UJ3 , 1W0Y , 1W2K , 1WQV , 1WSS , 1WTG , 1WUN , 1WV7 , 1Z6J , 2A2Q , 2AEI , 2AER , 2B7D , 2B8O , 2C4F , 2CEF , 2CEH , 2CEZ , 2CFJ , 2EC9 , 2F9B , 2FIR , 2FLB , 2FLR , 2HFT , 2PUQ , 2ZP0 , 2ZWL , 2ZZU , 3ELA , 3TH2 , 3TH3 , 3TH4 , 4IBL , 4M7L , 4YLQ , 4Z6A , 4ZMA , 5W06 , 6R2W , 6Z9W , 8CN9 , 8QOD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01108 Tissue_fac 17 118 Tissue factor Family
PF09294 Interfer-bind 138 245 Interferon-alpha/beta receptor, fibronectin type III Domain
Tissue specificity TISSUE SPECIFICITY: Lung, placenta and pancreas. {ECO:0000269|PubMed:12652293}.
Sequence
Sequence length 295
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
14
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISSECTION, SPONTANEOUS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Activated Protein C Resistance Activated Protein C Resistance BEFREE 10769107, 10871461, 11165549, 11943934, 12520697, 12571435, 12680634, 15650545, 16479199, 18854273, 19105233, 22882730, 23188048, 25407022, 8735142
View all (3 more)
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome BEFREE 16239598, 16461845, 18292391, 21557685, 25056722, 25963480
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome LHGDN 16239598, 16324758, 18217146, 18292391
★☆☆☆☆
Found in Text Mining only
Acute fatty liver of pregnancy Fatty Liver BEFREE 29297090
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 27605400, 31090597
★☆☆☆☆
Found in Text Mining only
Acute Megakaryocytic Leukemias Megakaryocytic Leukemia BEFREE 15474155
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 27923687
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 10480290, 11775254, 11779431, 14597990, 18802482, 20133705, 26374632, 28343272, 30234545, 31434194, 7949172, 8289480, 8555488, 9269772, 9639510
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia CTD_human_DG 16206674
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 12174921, 21693061, 28055955, 29539580
★☆☆☆☆
Found in Text Mining only