Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
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Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Autoimmune hepatitis Giant cell arteritis
5 genes
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5 of 5 corroborated by 2+ sources
HLA-DRB1(2), IL4(2), IFNG(2), CCL2(2), IL18(2)
0.096 0.278 5.83e-10 5.39e-9 ✓ sig. —
Developmental delay Melas syndrome
5 genes
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3 of 5 corroborated by 2+ sources
ND2(1), COX3(2), ND5(2), ND4(1), CYTB(2)
0.096 0.278 5.83e-10 5.39e-9 ✓ sig. Cluster 32 →
Oral submucous fibrosis Sepsis
5 genes
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5 of 5 corroborated by 2+ sources
TNF(2), IL6(2), TGFB1(2), IFNG(2), MMP9(2)
0.100 0.250 5.85e-10 5.40e-9 ✓ sig. —
Liver failure Necrosis
7 genes
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7 of 7 corroborated by 2+ sources
FAS(2), TNF(2), POMC(2), ATG7(2), CAST(2), IL1RN(2), KRT18(2)
0.069 0.135 5.90e-10 5.45e-9 ✓ sig. —
Congenital microcephaly Lissencephaly
6 genes
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FOXG1(1), CASK(1), ASPM(1), CPAP(1), TUBA3E(1), MZT2B(1)
0.079 0.194 5.95e-10 5.49e-9 ✓ sig. —
Congenital communicating hydrocephalus Congenital hydrocephalus
3 genes
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3 of 3 corroborated by 2+ sources
MPDZ(6), WDR81(4), TRIM71(5)
0.200 1.000 5.98e-10 5.52e-9 ✓ sig. Cluster 293 →
Gestational diabetes Hyperglycemia
8 genes
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8 of 8 corroborated by 2+ sources
INSR(2), LEP(2), IL6(2), ADIPOQ(2), PAX4(2), LEPR(3), GCK(2), HNF1A(2)
0.059 0.154 6.05e-10 5.58e-9 ✓ sig. —
Dermatomyositis Polymyositis
5 genes
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3 of 5 corroborated by 2+ sources
IL1A(2), IL1B(2), TNF(2), STAT4(1), PMS1(1)
0.102 0.227 6.06e-10 5.59e-9 ✓ sig. Cluster 25 →
Hyperalgesia Temporal lobe epilepsy
7 genes
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7 of 7 corroborated by 2+ sources
PDYN(2), BDKRB2(2), CNR1(2), TRPV1(2), SLC12A5(2), GAL(3), BDKRB1(2)
0.060 0.212 6.41e-10 5.91e-9 ✓ sig. —
Diabetes mellitus type 1 Periodontitis
23 genes
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4 of 23 corroborated by 2+ sources
GATA4(1), ZFPM2(1), CAMK4(1), CCR7(1), LRP1B(1), RBFOX1(1), TCF7L2(1), TSEN2(1), IGF2R(2), PPARG(1), IL6(3), GSTM1(1) +11 more
0.038 0.146 6.45e-10 5.94e-9 ✓ sig. —
Hyperalgesia Peripheral nervous system disease
8 genes
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GFAP(1), CACNA1H(1), MMP3(1), IGF1(1), IL6(1), NGF(1), PRKCE(1), ALOX12(1)
0.059 0.151 6.48e-10 5.96e-9 ✓ sig. —
Endometrial hyperplasia Nasopharyngeal carcinoma
4 genes
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4 of 4 corroborated by 2+ sources
PTEN(2), TP53(4), KRAS(2), CDKN2A(2)
0.138 0.400 6.52e-10 6.00e-9 ✓ sig. Cluster 3 →
Deep vein thrombosis Venous thrombosis
4 genes
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4 of 4 corroborated by 2+ sources
PLAT(2), SERPINC1(2), PLG(2), PROC(2)
0.138 0.400 6.52e-10 6.00e-9 ✓ sig. —
Cerebrooculofacioskeletal syndrome Cockayne syndrome
3 genes
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2 of 3 corroborated by 2+ sources
ERCC1(5), ERCC6(7), PGBD3(1)
0.300 0.500 6.57e-10 6.04e-9 ✓ sig. —
Bethlem myopathy Collagen vi-related myopathy
3 genes
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3 of 3 corroborated by 2+ sources
COL6A3(7), COL6A1(7), COL6A2(7)
0.300 0.500 6.57e-10 6.04e-9 ✓ sig. —
Cognition disorder Disruptive impulse-control and conduct disorder
4 genes
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4 of 4 corroborated by 2+ sources
DRD2(2), DRD3(2), FOSB(2), OXTR(2)
0.071 0.800 6.74e-10 6.19e-9 ✓ sig. —
Dental caries Diabetes mellitus type 1
28 genes
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5 of 28 corroborated by 2+ sources
ADGRL2(1), FUT2(1), GLIS3(3), H4C8(1), HLA-DQA1(3), HLA-DRB5(1), MAF(1), MOG(1), OR5V1(1), TCF7L2(1), TLL1(1), TNXB(1) +16 more
0.041 0.121 6.87e-10 6.31e-9 ✓ sig. —
Pancreatic diseases Proteinuria
4 genes
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SPP1(1), POMC(1), ALB(1), LEPR(1)
0.089 0.667 7.14e-10 6.55e-9 ✓ sig. —
Bronchiectasis Pseudohypoparathyroidism
4 genes
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3 of 4 corroborated by 2+ sources
LTBR(1), SCNN1A(7), SCNN1B(7), SCNN1G(6)
0.148 0.308 7.22e-10 6.63e-9 ✓ sig. Cluster 95 →
Anemia Neutropenia
8 genes
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7 of 8 corroborated by 2+ sources
MTHFR(2), TNF(2), CSF2(2), CSF3(2), HOXD13(2), IFNA2(1), NUP98(2), TNFRSF10A(2)
0.060 0.140 7.42e-10 6.81e-9 ✓ sig. —
Diabetic polyneuropathy Gestational diabetes
5 genes
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2 of 5 corroborated by 2+ sources
CDKAL1(2), TCF7L2(2), HLA-DQB1(1), KCNQ1(1), IGF2BP2(1)
0.053 0.556 7.54e-10 6.91e-9 ✓ sig. Cluster 73 →
Hyperalgesia Non-neoplastic peripheral nervous system disease
8 genes
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8 of 8 corroborated by 2+ sources
GFAP(2), CACNA1H(2), MMP3(2), IGF1(2), IL6(2), NGF(2), PRKCE(2), ALOX12(2)
0.059 0.148 7.57e-10 6.93e-9 ✓ sig. —
Dyslipidemias Hyperlipoproteinemia
5 genes
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5 of 5 corroborated by 2+ sources
LDLR(2), LPL(4), PPARA(2), LEPR(2), NEIL1(2)
0.093 0.278 7.63e-10 6.98e-9 ✓ sig. Cluster 141 →
Henoch schoenlein purpura Interstitial cystitis
5 genes
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1 of 5 corroborated by 2+ sources
HLA-DQA1(2), HLA-DQB3(1), HLA-DRA(1), HLA-DRB1(1), HLA-DQB1(1)
0.093 0.278 7.63e-10 6.98e-9 ✓ sig. Cluster 1 →
Atopic dermatitis Bronchopulmonary dysplasia
7 genes
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1 of 7 corroborated by 2+ sources
GSTP1(1), GSTT1(1), IL1B(2), MBL2(1), TNF(1), GSTM1(1), VDR(1)
0.067 0.156 7.65e-10 7.00e-9 ✓ sig. —

Showing 25 of 20813 pairs, sorted by significance (ascending). Click a column header to sort.