Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 32

18 diseases · 39 shared-gene connections
18 Diseases
59 Unique genes
0.234 Avg. similarity score
atypical hemolytic-uremic syndrome Most-connected disease (10 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
atypical hemolytic-uremic syndrome 10 10 3
C3 glomerulonephritis 7 7 8
Mesangiocapillary glomerulonephritis 7 7 8
Thrombotic microangiopathy 7 7 3
Factor h deficiency 6 6 1
Genetic hemolytic uremic syndrome 6 6 1
Atypical hemolytic uremic syndrome 5 5 2
Factor i deficiency 5 5 1
Hemolytic uremic syndrome 5 5 33
Central serous retinopathy 4 4 11
Macular and posterior pole degeneration 4 4 13
Doyne honeycomb retinal dystrophy 3 3 4
Panuveitis 3 3 2
atypical hemolytic-uremic syndrome with B factor anomaly 2 2 1
DDX41-related hematologic malignancy predisposition syndrome 1 1 1
Intellectual developmental disorder seizures cerebellar 1 1 1
Throat disease 1 1 3
hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
CFH 12 / 18 Atypical hemolytic uremic syndrome, atypical hemolytic-uremic syndrome, C3 glomerulonephritis, Central serous retinopathy and 8 more
CFI 8 / 18 atypical hemolytic-uremic syndrome, C3 glomerulonephritis, Doyne honeycomb retinal dystrophy, Factor i deficiency and 4 more
CD46 5 / 18 Atypical hemolytic uremic syndrome, atypical hemolytic-uremic syndrome, Hemolytic uremic syndrome, Macular and posterior pole degeneration and 1 more
C3 4 / 18 C3 glomerulonephritis, Hemolytic uremic syndrome, Macular and posterior pole degeneration, Mesangiocapillary glomerulonephritis
CFB 4 / 18 atypical hemolytic-uremic syndrome with B factor anomaly, C3 glomerulonephritis, Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
CFHR1 3 / 18 C3 glomerulonephritis, Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
CFHR5 3 / 18 C3 glomerulonephritis, Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
C1GALT1C1 2 / 18 Hemolytic uremic syndrome, hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature
CFHR3 2 / 18 C3 glomerulonephritis, Hemolytic uremic syndrome
DDX41 2 / 18 DDX41-related hematologic malignancy predisposition syndrome, Thrombotic microangiopathy
DGKE 2 / 18 Hemolytic uremic syndrome, Mesangiocapillary glomerulonephritis
GATA5 2 / 18 Central serous retinopathy, Throat disease
RORA 2 / 18 Central serous retinopathy, Intellectual developmental disorder seizures cerebellar
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Complement and coagulation cascades
C3, CD46, CFB, CFH, CFHR1, CFHR3, CFHR5, CFI, PLG, THBD, CFHR4, CFHR2
 KEGG 14 / 88 32.4× 4.46e-18 2.63e-15 ✓ sig.
Regulation of Complement cascade
C3, CD46, CFB, CFH, CFHR1, CFHR3, CFHR5, CFI, CFHR4, CFHR2, C9
 Reactome 11 / 47 47.6× 2.28e-16 9.89e-14 ✓ sig.
Interleukin-10 signaling
IL1A, IL1B, IL1RN, IL6, TNF, IL10
 Reactome 6 / 47 26.0× 9.95e-8 6.50e-6 ✓ sig.
Malaria
HBB, CD36, IL1B, IL6, TNF, IL10
 KEGG 6 / 50 24.4× 1.46e-7 9.06e-6 ✓ sig.
Staphylococcus aureus infection
C3, CFB, CFH, CFI, PLG, MBL2, IL10
 KEGG 7 / 99 14.4× 5.02e-7 2.69e-5 ✓ sig.
Inflammatory bowel disease
RORA, IL1A, IL1B, IL6, TNF, IL10
 KEGG 6 / 66 18.5× 7.83e-7 3.94e-5 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
RORA, CD36, IL1A, IL1B, IL6, TNF, IL10
 Reactome 7 / 108 13.2× 9.08e-7 4.48e-5 ✓ sig.
African trypanosomiasis
HBB, IL1B, IL6, TNF, IL10
 KEGG 5 / 37 27.5× 9.30e-7 4.57e-5 ✓ sig.
Pertussis
C3, IL1A, IL1B, IL6, TNF, IL10
 KEGG 6 / 78 15.7× 2.12e-6 9.22e-5 ✓ sig.
Hematopoietic cell lineage
CD36, EPO, IL1A, IL1B, IL6, TNF
 KEGG 6 / 100 12.2× 9.04e-6 3.09e-4 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications
COL4A5, THBD, IL1A, IL1B, IL6, TNF
 KEGG 6 / 101 12.1× 9.57e-6 3.24e-4 ✓ sig.
Amoebiasis
COL4A5, C9, IL1B, IL6, TNF, IL10
 KEGG 6 / 103 11.9× 1.07e-5 3.56e-4 ✓ sig.
Coronavirus disease - COVID-19
C3, CFB, C9, RPL3, IL1B, IL6, MBL2, TNF
 KEGG 8 / 238 6.8× 1.96e-5 5.89e-4 ✓ sig.
Leishmaniasis
C3, IL1A, IL1B, TNF, IL10
 KEGG 5 / 78 13.0× 3.86e-5 1.03e-3 ✓ sig.
Fluid shear stress and atherosclerosis
THBD, PDGFB, IL1A, IL1B, NQO1, TNF
 KEGG 6 / 141 8.7× 6.36e-5 1.55e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
complement activation
C3, CFB, CFH, CFHR1, CFHR3, CFHR5, CFI, CFHR4, CFHR2, C9, MBL2
 GO:0006956 11 / 35 99.5× 4.55e-20 7.58e-17 ✓ sig.
complement activation, alternative pathway
C3, CFB, CFH, CFHR5, C9
 GO:0006957 5 / 16 99.0× 1.12e-9 2.48e-7 ✓ sig.
positive regulation of vascular endothelial growth factor production
C3, RORA, IL1A, IL1B, IL6
 GO:0010575 5 / 32 49.5× 4.98e-8 6.76e-6 ✓ sig.
complement activation, classical pathway
C3, CD46, CFI, C9, MBL2
 GO:0006958 5 / 37 42.8× 1.06e-7 1.27e-5 ✓ sig.
cellular response to lipopolysaccharide
ADAMTS13, SLC7A5, CD36, IL1A, IL1B, IL6, TNF, IL10
 GO:0071222 8 / 187 13.5× 1.24e-7 1.44e-5 ✓ sig.
vascular endothelial growth factor production
IL1B, IL6, TNF
 GO:0010573 3 / 6 158× 5.94e-7 5.41e-5 ✓ sig.
positive regulation of glial cell proliferation
SLC7A5, IL1B, IL6, TNF
 GO:0060252 4 / 22 57.6× 6.28e-7 5.67e-5 ✓ sig.
positive regulation of mitotic nuclear division
PDGFB, IL1A, IL1B, TNF
 GO:0045840 4 / 29 43.7× 2.01e-6 1.45e-4 ✓ sig.
liver regeneration
SLC7A5, IL6, TNF, IL10
 GO:0097421 4 / 29 43.7× 2.01e-6 1.45e-4 ✓ sig.
negative regulation of heterotypic cell-cell adhesion
WNK1, IL1RN, IL10
 GO:0034115 3 / 11 86.4× 4.84e-6 2.93e-4 ✓ sig.
cytolysis by host of symbiont cells
CFHR1, CFHR5, CFHR2
 GO:0051838 3 / 11 86.4× 4.84e-6 2.93e-4 ✓ sig.
acute-phase response
EPO, IL1RN, IL6, MBL2
 GO:0006953 4 / 37 34.2× 5.48e-6 3.23e-4 ✓ sig.
activation of membrane attack complex
C3, CFB, MBL2
 GO:0001905 3 / 13 73.1× 8.36e-6 4.54e-4 ✓ sig.
positive regulation of heterotypic cell-cell adhesion
IL1B, TNF, IL10
 GO:0034116 3 / 13 73.1× 8.36e-6 4.54e-4 ✓ sig.
positive regulation of nitric oxide biosynthetic process
HBB, CD36, IL1B, TNF
 GO:0045429 4 / 42 30.2× 9.17e-6 4.89e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Hemolytic uremic syndrome Mesangiocapillary glomerulonephritis 0.235 8 1.77e-22 3.98e-21 ✓ sig.
C3 glomerulonephritis Mesangiocapillary glomerulonephritis 0.545 6 4.24e-20 8.58e-19 ✓ sig.
C3 glomerulonephritis Hemolytic uremic syndrome 0.200 7 8.39e-19 1.58e-17 ✓ sig.
Macular and posterior pole degeneration Mesangiocapillary glomerulonephritis 0.222 4 2.13e-11 2.40e-10 ✓ sig.
atypical hemolytic-uremic syndrome Mesangiocapillary glomerulonephritis 0.333 3 9.21e-11 9.69e-10 ✓ sig.
atypical hemolytic-uremic syndrome Macular and posterior pole degeneration 0.214 3 4.70e-10 4.65e-9 ✓ sig.
atypical hemolytic-uremic syndrome Hemolytic uremic syndrome 0.088 3 8.97e-9 7.62e-8 ✓ sig.
Hemolytic uremic syndrome Macular and posterior pole degeneration 0.093 4 1.23e-8 1.04e-7 ✓ sig.
Atypical hemolytic uremic syndrome atypical hemolytic-uremic syndrome 0.500 2 2.53e-8 2.03e-7 ✓ sig.
C3 glomerulonephritis Macular and posterior pole degeneration 0.158 3 2.63e-8 2.11e-7 ✓ sig.
atypical hemolytic-uremic syndrome Thrombotic microangiopathy 0.400 2 7.59e-8 5.72e-7 ✓ sig.
atypical hemolytic-uremic syndrome Doyne honeycomb retinal dystrophy 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Doyne honeycomb retinal dystrophy Thrombotic microangiopathy 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Atypical hemolytic uremic syndrome Mesangiocapillary glomerulonephritis 0.222 2 2.36e-7 1.64e-6 ✓ sig.
C3 glomerulonephritis Thrombotic microangiopathy 0.200 2 7.08e-7 4.51e-6 ✓ sig.
atypical hemolytic-uremic syndrome C3 glomerulonephritis 0.200 2 7.08e-7 4.51e-6 ✓ sig.
Factor h deficiency Genetic hemolytic uremic syndrome 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Atypical hemolytic uremic syndrome Factor h deficiency 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Genetic hemolytic uremic syndrome Panuveitis 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Factor h deficiency Panuveitis 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Atypical hemolytic uremic syndrome Genetic hemolytic uremic syndrome 0.333 1 1.30e-4 3.90e-4 ✓ sig.
DDX41-related hematologic malignancy predisposition syndrome Thrombotic microangiopathy 0.250 1 1.95e-4 5.28e-4 ✓ sig.
atypical hemolytic-uremic syndrome Factor i deficiency 0.250 1 1.95e-4 5.28e-4 ✓ sig.
atypical hemolytic-uremic syndrome Genetic hemolytic uremic syndrome 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Genetic hemolytic uremic syndrome Thrombotic microangiopathy 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Factor i deficiency Thrombotic microangiopathy 0.250 1 1.95e-4 5.28e-4 ✓ sig.
atypical hemolytic-uremic syndrome Factor h deficiency 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Factor h deficiency Thrombotic microangiopathy 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Atypical hemolytic uremic syndrome Panuveitis 0.250 1 2.60e-4 6.40e-4 ✓ sig.
Doyne honeycomb retinal dystrophy Factor i deficiency 0.200 1 2.60e-4 6.40e-4 ✓ sig.
C3 glomerulonephritis Factor i deficiency 0.111 1 5.20e-4 1.04e-3 ✓ sig.
Factor i deficiency Mesangiocapillary glomerulonephritis 0.111 1 5.20e-4 1.04e-3 ✓ sig.
atypical hemolytic-uremic syndrome with B factor anomaly Mesangiocapillary glomerulonephritis 0.111 1 5.20e-4 1.04e-3 ✓ sig.
atypical hemolytic-uremic syndrome with B factor anomaly C3 glomerulonephritis 0.111 1 5.20e-4 1.04e-3 ✓ sig.
Central serous retinopathy Factor h deficiency 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Central serous retinopathy Intellectual developmental disorder seizures cerebellar 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Central serous retinopathy Genetic hemolytic uremic syndrome 0.083 1 7.14e-4 1.31e-3 ✓ sig.
Central serous retinopathy Throat disease 0.071 1 2.14e-3 3.03e-3 ✓ sig.
Hemolytic uremic syndrome hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature 0.029 1 2.14e-3 3.03e-3 ✓ sig.