Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
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Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Diabetes mellitus ketosis prone Idiopathic diabetes
6 genes
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INS(1), CTLA4(1), IL2RA(1), CCR5(1), HNF1A(1), SUMO4(1)
0.750 1.000 3.79e-22 7.87e-21 ✓ sig. —
Cushing syndrome Cushing's disease
8 genes
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8 of 8 corroborated by 2+ sources
TP53(2), ATRX(2), BRAF(2), USP8(2), POMC(2), USP48(2), NR3C1(2), CDH23(2)
0.320 0.727 4.28e-22 8.89e-21 ✓ sig. —
Heart disease Large artery stroke
19 genes
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ABCG8(1), HDAC9(1), IL6R(1), JCAD(1), SMARCA4(1), ATXN2(1), ABO(1), CELSR2(1), LPA(1), PSRC1(1), ZPR1(1), PLG(1) +7 more
0.092 0.244 4.56e-22 9.46e-21 ✓ sig. Cluster 139 →
Melas syndrome Mitochondrial complex deficiency
12 genes
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7 of 12 corroborated by 2+ sources
ND1(2), ND2(1), ATP6(1), COX3(2), ATP8(1), COX1(2), ND5(2), NDUFS1(5), COX2(2), ND3(1), ND4(1), CYTB(2)
0.095 0.667 4.59e-22 9.51e-21 ✓ sig. —
Joubert syndrome Orofaciodigital syndrome
12 genes
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11 of 12 corroborated by 2+ sources
KIF7(3), CPLANE1(8), TMEM216(6), TMEM231(5), IFT140(1), KIAA0753(6), TBC1D32(4), OFD1(6), TCTN3(6), TMEM107(4), FAM149B1(4), PDE6D(5)
0.152 0.375 5.16e-22 1.07e-20 ✓ sig. Cluster 8 →
Congenital nasopharyngeal atresia Polynesian bronchiectasis
8 genes
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DNAH5(1), CCDC40(1), DNAH11(1), DNAI1(1), DNAAF3(1), DNAAF19(1), DNAAF4(1), DRC1(1)
0.250 0.889 6.72e-22 1.39e-20 ✓ sig. Cluster 9 →
Benign hereditary chorea Chorea
7 genes
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4 of 7 corroborated by 2+ sources
HLA-DQA1(1), HLA-DRB1(1), HLA-DQB1(1), CACNA2D2(2), ADCY5(2), NKX2-1(5), VPS13A(3)
0.368 1.000 7.83e-22 1.62e-20 ✓ sig. Cluster 1 →
Cutis laxa Rothmund-thomson syndrome
8 genes
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8 of 8 corroborated by 2+ sources
ALDH18A1(6), ATP6V0A2(8), ELN(7), EFEMP2(7), FBLN5(6), ATP6V1A(8), ATP6V1E1(7), PYCR1(7)
0.320 0.667 7.95e-22 1.64e-20 ✓ sig. Cluster 80 →
Cerebellar ataxia Cleft palate and bilateral cleft lip
11 genes
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ND1(1), ND2(1), ATP6(1), COX3(1), ATP8(1), COX1(1), ND5(1), COX2(1), ND3(1), ND4(1), ND4L(1)
0.093 0.786 7.98e-22 1.65e-20 ✓ sig. —
Gastric ulcer Peptic ulcer disease
16 genes
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1 of 16 corroborated by 2+ sources
CCKBR(1), FUT2(1), MECOM(1), PRKAA1(1), TTC33(1), IL1B(2), ABO(1), JRK(1), PSCA(1), PLCL2(1), MUC1(1), LY6K(1) +4 more
0.101 0.302 8.83e-22 1.82e-20 ✓ sig. —
Kidney disease Myocardial infarction
64 genes
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33 of 64 corroborated by 2+ sources
APOA1(1), SPI1(1), COL4A4(2), ACE(2), AGT(2), BCAS3(1), CLU(2), COL6A3(2), CUX2(1), L3MBTL3(1), LAMB2(2), NYAP2(1) +52 more
0.068 0.151 9.05e-22 1.86e-20 ✓ sig. —
Eye disease Glaucoma
23 genes
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6 of 23 corroborated by 2+ sources
ABCA1(1), ANTXR1(1), CADM2(1), HERC2(1), ME3(1), PDZD2(1), PTCD2(1), RARB(1), RBFOX1(1), TCF7L2(1), RPE65(3), EFEMP1(6) +11 more
0.075 0.245 9.72e-22 2.00e-20 ✓ sig. —
Hereditary sensory and autonomic neuropathy Sensory neuropathy
8 genes
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7 of 8 corroborated by 2+ sources
NTRK1(4), NGF(5), DNMT1(3), FLVCR1(1), WNK1(7), KIF1A(6), SCN11A(6), RETREG1(7)
0.320 0.615 1.24e-21 2.55e-20 ✓ sig. Cluster 169 →
Cutaneous mastocytosis Mastocytosis
9 genes
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1 of 9 corroborated by 2+ sources
RPTN(1), HBE1(1), HBG2(1), KIT(6), ABCA2(1), CYP2B6(1), OR51B5(1), OR51Q1(1), PDE4DIP(1)
0.243 0.529 1.24e-21 2.55e-20 ✓ sig. Cluster 235 →
Focal segmental glomerulosclerosis Idiopathic steroid-resistant nephrotic syndrome
10 genes
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10 of 10 corroborated by 2+ sources
NUP107(2), ACTN4(4), ARHGAP24(2), CD2AP(6), MYO1E(5), PAX2(5), TRPC6(5), ANLN(4), CRB2(5), INF2(5)
0.208 0.357 1.25e-21 2.57e-20 ✓ sig. Cluster 30 →
Coronary artery disease Open angle glaucoma
85 genes
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18 of 85 corroborated by 2+ sources
NFIA(1), PRDM16(3), ZFPM2(1), TP53(1), ABCA1(2), ALCAM(1), APOE(3), ARHGAP20(1), BCAS3(1), BNC2(1), CDKN2B(3), CLIC5(1) +73 more
0.060 0.230 1.26e-21 2.58e-20 ✓ sig. —
Hypertension Migraine
90 genes
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27 of 90 corroborated by 2+ sources
CASZ1(1), PRDM16(3), RERE(1), RUNX1(1), ATP1A2(5), ACTN4(1), ASCC1(1), C1GALT1(1), CAMK1D(1), CDH13(1), CDH4(1), CTNNA3(1) +78 more
0.061 0.223 1.27e-21 2.60e-20 ✓ sig. Cluster 78 →
Bone disease Osteoporosis
19 genes
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7 of 19 corroborated by 2+ sources
BMP2(2), AXIN1(1), HLA-DQA1(1), HLA-DRB1(1), RSPO3(1), CYP19A1(3), ESR1(2), ZBTB40(1), PTH(2), ALDH7A1(3), CCDC170(1), DDN(1) +7 more
0.090 0.232 1.30e-21 2.65e-20 ✓ sig. —
Atrial septal defect Tetralogy of fallot
14 genes
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13 of 14 corroborated by 2+ sources
GATA4(6), ROBO1(2), SMARCA4(2), TBX5(2), TLL1(6), CHD7(2), MYH6(6), TBX20(6), NKX2-5(7), ACTC1(5), TPM1(1), CITED2(6) +2 more
0.103 0.400 1.33e-21 2.71e-20 ✓ sig. —
Cardiomegaly Ventricular dysfunction
14 genes
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ATP2A2(1), AGT(1), DMD(1), SOD2(1), TNF(1), AKT1(1), IDH2(1), NPPB(1), MYH6(1), TNNT2(1), PLPP3(1), FNDC5(1) +2 more
0.120 0.304 1.38e-21 2.82e-20 ✓ sig. —
Anophthalmia Microphthalmos
9 genes
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3 of 9 corroborated by 2+ sources
RARB(1), PAX6(1), SOX2(2), STRA6(2), OTX2(1), RAX(2), VSX2(1), ARHGAP35(1), RBP4(1)
0.214 0.643 1.40e-21 2.85e-20 ✓ sig. Cluster 56 →
Cataract Lamellar cataract
11 genes
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11 of 11 corroborated by 2+ sources
BFSP2(5), CRYAA(5), CRYBA4(6), CRYGC(6), CRYAB(6), CRYGD(6), CRYGS(6), HSF4(5), MIP(6), CRYBA1(4), CRYGB(6)
0.054 1.000 1.42e-21 2.90e-20 ✓ sig. Cluster 43 →
Cataract Posterior subcapsular cataract
11 genes
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11 of 11 corroborated by 2+ sources
CRYBB2(5), PITX3(5), EPHA2(6), CHMP4B(5), CRYAB(5), UNC45B(5), MIP(6), PANK4(4), CRYBA1(4), GJA3(4), LEMD2(6)
0.054 1.000 1.42e-21 2.90e-20 ✓ sig. Cluster 43 →
Ciliopathy Nephronophthisis
13 genes
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12 of 13 corroborated by 2+ sources
ZNF423(6), CC2D2A(3), RPGRIP1L(3), TMEM67(5), IFT172(4), WDR19(6), ADAMTS9(4), DCDC2(7), SDCCAG8(2), BBS9(1), IQCB1(4), CEP164(4) +1 more
0.131 0.325 1.46e-21 2.96e-20 ✓ sig. Cluster 8 →
Cardiomegaly Ventricular remodeling
12 genes
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GATA4(1), AGT(1), LEP(1), AKT1(1), MFN2(1), NPPB(1), MYH6(1), TBX20(1), NPPA(1), HAND2(1), ROCK2(1), SIRT6(1)
0.122 0.480 1.50e-21 3.05e-20 ✓ sig. —

Showing 25 of 20813 pairs, sorted by significance (ascending). Click a column header to sort.