Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Hereditary hearing loss nonsyndromic genetic hearing loss
39 genes
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39 of 39 corroborated by 2+ sources
ESRRB(2), EYA4(2), MYO15A(2), OTOF(2), PCDH15(2), TMC1(2), HGF(2), RDX(2), GSDME(2), COL11A2(2), MYO6(2), CDH23(2) +27 more
0.415 0.780 1.46e-83 1.21e-81 ✓ sig. Cluster 20 →
Coronary artery disease Hypertension
285 genes
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92 of 285 corroborated by 2+ sources
CYP17A1(1), CASZ1(1), PRDM16(3), MAP3K1(1), ZFPM2(1), APOA1(2), CELA2A(2), BMPR1B(1), SH2B3(3), TERT(3), ARHGAP31(2), TP53(2) +273 more
0.142 0.249 7.57e-83 6.26e-81 ✓ sig. Cluster 6 →
Ankylosing spondylitis Celiac disease
78 genes
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21 of 78 corroborated by 2+ sources
SH2B3(1), ACE(2), ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), ETS1(3), FUT2(1), HLA-DQA1(4), HLA-DRB1(2), IGF2(1), LRRK2(1) +66 more
0.182 0.404 1.27e-82 1.05e-80 ✓ sig. —
Hereditary steroid-resistant nephrotic syndrome Idiopathic steroid-resistant nephrotic syndrome
28 genes
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26 of 28 corroborated by 2+ sources
WT1(2), NUP107(2), ACTN4(2), ARHGAP24(2), CD2AP(2), MYO1E(2), NUP160(2), NUP85(2), PAX2(2), PTPRO(2), TRPC6(2), PLCE1(2) +16 more
0.800 1.000 2.37e-82 1.93e-80 ✓ sig. Cluster 24 →
Genetic steroid-resistant nephrotic syndrome Idiopathic steroid-resistant nephrotic syndrome
28 genes
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22 of 28 corroborated by 2+ sources
WT1(2), NUP107(2), ACTN4(2), ARHGAP24(2), CD2AP(2), MYO1E(2), NUP160(2), NUP85(2), PAX2(2), PTPRO(1), TRPC6(2), PLCE1(1) +16 more
0.800 1.000 2.37e-82 1.93e-80 ✓ sig. Cluster 24 →
Attention deficit hyperactivity disorder Metabolic syndrome
299 genes
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12 of 299 corroborated by 2+ sources
SOX5(1), BPTF(1), RERE(1), COMT(3), JMJD1C(1), ZFPM2(1), ATP2A2(1), BMPR1B(1), GBE1(1), BRWD1(1), CACNA1D(1), ADARB1(1) +287 more
0.142 0.271 2.43e-82 1.97e-80 ✓ sig. Cluster 2 →
Diabetes mellitus type 2 Schizophrenia
882 genes
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346 of 882 corroborated by 2+ sources
SOX5(2), HMGA2(1), RAI1(2), HNF1B(6), KANSL1(1), NFIX(1), DPYD(3), HSPG2(2), RERE(1), ARVCF(2), COMT(3), HDAC4(2) +870 more
0.186 0.347 2.65e-82 2.15e-80 ✓ sig. Cluster 2 →
Charcot-marie-tooth disease Roussy-levy syndrome
38 genes
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36 of 38 corroborated by 2+ sources
DHTKD1(5), AARS1(7), VCP(5), SLC12A6(4), EGR2(8), KIF1B(6), MME(8), TRPV4(5), DYNC1H1(5), FIG4(7), MFN2(7), NEFL(7) +26 more
0.286 1.000 8.10e-82 6.49e-80 ✓ sig. Cluster 12 →
Charcot-marie-tooth disease Hypertrophic neuropathy
38 genes
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36 of 38 corroborated by 2+ sources
DHTKD1(5), AARS1(7), VCP(5), SLC12A6(4), EGR2(8), KIF1B(6), MME(8), TRPV4(5), DYNC1H1(5), FIG4(7), MFN2(7), NEFL(7) +26 more
0.286 1.000 8.10e-82 6.49e-80 ✓ sig. Cluster 12 →
Charcot-marie-tooth disease Dejerine-sottas disease
38 genes
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36 of 38 corroborated by 2+ sources
DHTKD1(5), AARS1(7), VCP(5), SLC12A6(4), EGR2(8), KIF1B(6), MME(8), TRPV4(5), DYNC1H1(5), FIG4(7), MFN2(7), NEFL(7) +26 more
0.286 1.000 8.10e-82 6.49e-80 ✓ sig. Cluster 12 →
Multiple sclerosis Rheumatoid arthritis
154 genes
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62 of 154 corroborated by 2+ sources
SH2B3(1), RBPJ(3), ABT1(1), ANKRD55(3), BTNL2(2), ELMO1(1), ETS1(1), FAM76B(1), GPC5(1), HLA-DQA1(2), HLA-DQB3(1), HLA-DRA(3) +142 more
0.142 0.267 1.07e-81 8.56e-80 ✓ sig. —
Heart valve disease Heart valve prolapse
29 genes
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27 of 29 corroborated by 2+ sources
NOTCH1(2), ACE(1), COL18A1(2), SPP1(2), CASP3(2), IL1B(2), PCDHA9(2), JAK2(2), CCL2(2), COL1A1(2), TIMP1(2), FGFR1(2) +17 more
0.690 1.000 2.62e-81 2.09e-79 ✓ sig. Cluster 370 →
Charcot-marie-tooth disease Peroneal muscle atrophy
38 genes
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36 of 38 corroborated by 2+ sources
DHTKD1(5), AARS1(7), VCP(5), SLC12A6(4), EGR2(8), KIF1B(6), MME(8), TRPV4(5), DYNC1H1(5), FIG4(7), MFN2(7), NEFL(7) +26 more
0.284 0.974 3.14e-80 2.49e-78 ✓ sig. Cluster 12 →
Intellectual developmental disorder Nonsyndromic intellectual disability
90 genes
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88 of 90 corroborated by 2+ sources
CDH15(7), CLIP1(4), CRADD(6), CRBN(6), CUX1(3), DEAF1(4), EPB41L1(4), FMN2(6), GABBR1(2), GRIA1(6), GRIK2(6), GRIN2B(5) +78 more
0.105 0.638 3.83e-80 3.02e-78 ✓ sig. Cluster 5 →
Coronary artery disease Diabetes mellitus type 2
498 genes
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116 of 498 corroborated by 2+ sources
WT1(1), SOX5(1), CYP17A1(1), RAI1(1), DPYD(1), CASZ1(1), SKI(1), ARVCF(1), JMJD1C(1), COLEC11(1), MAP3K1(1), ZFPM2(1) +486 more
0.134 0.436 7.27e-80 5.72e-78 ✓ sig. —
Autoimmune thyroid disease Common variable immunodeficiency
47 genes
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2 of 47 corroborated by 2+ sources
ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), ICOS(4), IGF2(1), LRRK2(1), TENM3(1), TTC33(1), IL10(1), MBL2(1) +35 more
0.272 0.627 2.53e-79 1.98e-77 ✓ sig. Cluster 39 →
Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy
47 genes
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36 of 47 corroborated by 2+ sources
ABCC9(7), ACTN2(7), CDH2(5), CACNB2(1), CTNNA3(7), DMD(6), DSG2(8), JUP(5), PKP2(7), PLEC(1), PRKAG2(1), RBM20(8) +35 more
0.168 0.904 1.89e-78 1.47e-76 ✓ sig. Cluster 3 →
Keratinocyte carcinoma Skin neoplasms
47 genes
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3 of 47 corroborated by 2+ sources
TERT(1), TP53(2), BNC2(1), CUX1(1), FOXP1(1), HERC2(1), HLA-DQA1(1), HLA-DRB1(1), MYL10(1), RHOU(1), SMC2(1), TRPS1(1) +35 more
0.267 0.610 2.48e-78 1.93e-76 ✓ sig. Cluster 23 →
Diabetes mellitus Diabetic eye disease
46 genes
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5 of 46 corroborated by 2+ sources
RREB1(1), APOE(2), AUTS2(1), CDKAL1(2), HLA-DQB3(1), HMG20A(1), JAZF1(1), KLHL42(1), MACF1(1), MACIR(1), NRXN3(1), NYAP2(1) +34 more
0.154 0.958 3.32e-78 2.57e-76 ✓ sig. Cluster 155 →
Autism Intellectual developmental disorder
261 genes
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185 of 261 corroborated by 2+ sources
SOX5(3), CHD8(3), FOXG1(2), UBE3A(2), CHRNA7(2), SIN3A(2), ANKRD11(2), RAI1(2), NF1(2), KANSL1(3), NFIX(2), JMJD1C(3) +249 more
0.130 0.323 7.32e-78 5.64e-76 ✓ sig. —
Congenital myasthenic syndrome Myasthenic syndrome
28 genes
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28 of 28 corroborated by 2+ sources
CHD8(2), SCN4A(5), ALG2(7), AGRN(6), CHRNE(6), COLQ(4), GFPT1(7), GMPPB(5), PLEC(2), RAPSN(5), RPH3A(2), CHAT(6) +16 more
0.667 0.966 2.85e-77 2.19e-75 ✓ sig. Cluster 30 →
Leigh syndrome Mitochondrial complex deficiency
48 genes
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45 of 48 corroborated by 2+ sources
NDUFA10(6), NDUFA12(5), NDUFA9(5), NDUFAF2(5), NDUFAF6(6), ND2(1), NDUFS3(6), NDUFS2(6), TTC19(7), LRPPRC(5), NDUFA2(6), TIMMDC1(5) +36 more
0.268 0.449 3.86e-76 2.95e-74 ✓ sig. Cluster 50 →
Autoimmune disease Hypothyroidism
79 genes
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7 of 79 corroborated by 2+ sources
SH2B3(1), C12orf42(1), CAMK4(1), ELMO1(1), ERBB3(1), FAM76B(1), GIGYF1(1), HLA-DQB3(1), ICOS(1), ITGB3(1), MACIR(1), MB21D2(1) +67 more
0.159 0.391 1.31e-75 9.96e-74 ✓ sig. Cluster 39 →
Insomnia Major depressive disorder
360 genes
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56 of 360 corroborated by 2+ sources
SOX5(1), PAFAH1B1(1), BPTF(1), WWOX(1), PER2(2), BLTP1(1), ADARB1(1), ADCK1(1), AKAP6(1), APOE(1), ARHGAP15(1), ARHGEF10L(1) +348 more
0.134 0.334 1.38e-75 1.05e-73 ✓ sig. Cluster 2 →
Bladder calculus Nephrolithiasis
36 genes
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3 of 36 corroborated by 2+ sources
KANSL1(1), ALPL(1), BCAS3(1), GIPR(1), PRKAG2(1), STC1(1), VEGFA(1), SLC30A10(1), PDILT(1), AP1S3(1), TFAP2B(1), ABCG2(1) +24 more
0.290 0.923 3.37e-75 2.55e-73 ✓ sig. Cluster 176 →

Showing 25 of 20825 pairs, sorted by significance (ascending). Click a column header to sort.