Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 23
19
Diseases
1,021
Unique genes
0.129
Avg. similarity score
Keratinocyte carcinoma
Most-connected disease (11 links)
Disease
Searched: optic atrophy 13 with retinal and foveal abnormalities
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optic atrophy 13 with retinal and foveal abnormalities
Keratinocyte carcinoma
Skin cancer
Skin neoplasms
Cutaneous squamous cell carcinoma
Basal cell carcinoma
Non-melanoma skin carcinoma
Seborrheic keratosis
Skin disease
Non-small cell lung carcinoma
histidinemia
Melanoma
Chromosome 20q11-q12 deletion syndrome
Congenital posterior urethral valves
Dermatologic disorder
progressive essential tremor-speech impairment-facial dysmorphism-intellectual disability-abnormal behavior syndrome
Acromelic frontonasal dysostosis
Woolly hair-skin fragility syndrome
hyper-IgE recurrent infection syndrome 3, autosomal recessive
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Keratinocyte carcinoma | 11 | 11 | 77 |
| Skin cancer | 9 | 9 | 83 |
| Skin neoplasms | 9 | 9 | 145 |
| Cutaneous squamous cell carcinoma | 8 | 8 | 38 |
| Basal cell carcinoma | 7 | 7 | 327 |
| Non-melanoma skin carcinoma | 7 | 7 | 169 |
| Seborrheic keratosis | 7 | 7 | 31 |
| Skin disease | 6 | 6 | 177 |
| Non-small cell lung carcinoma | 5 | 5 | 115 |
| histidinemia | 5 | 5 | 1 |
| Melanoma | 3 | 3 | 435 |
| Chromosome 20q11-q12 deletion syndrome | 2 | 2 | 1 |
| Congenital posterior urethral valves | 2 | 2 | 1 |
| Dermatologic disorder | 2 | 2 | 68 |
| optic atrophy 13 with retinal and foveal abnormalities | 2 | 2 | 1 |
| progressive essential tremor-speech impairment-facial dysmorphism-intellectual disability-abnormal behavior syndrome | 2 | 2 | 1 |
| Acromelic frontonasal dysostosis | 1 | 1 | 1 |
| Woolly hair-skin fragility syndrome | 1 | 1 | 1 |
| hyper-IgE recurrent infection syndrome 3, autosomal recessive | 1 | 1 | 1 |
Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| BNC2 | 11 / 19 | Basal cell carcinoma, Congenital posterior urethral valves, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma and 7 more |
| CASP8 | 10 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more |
| IRF4 | 10 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more |
| KRT5 | 10 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more |
| LPP | 10 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more |
| RALY | 10 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more |
| SLC45A2 | 10 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more |
| TYR | 10 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more |
| BACH2 | 9 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more |
| BRCA2 | 9 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more |
| CPVL | 9 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more |
| FLACC1 | 9 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more |
| HLA-DQA1 | 9 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more |
| MC1R | 9 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more |
| FOXP1 | 8 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 4 more |
| HERC2 | 8 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 4 more |
| HLA-DRB1 | 8 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 4 more |
| MICA | 8 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma and 4 more |
| OCA2 | 8 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Melanoma, Non-melanoma skin carcinoma and 4 more |
| TERT | 8 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-small cell lung carcinoma and 4 more |
| CLPTM1L | 7 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 3 more |
| CTLA4 | 7 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 3 more |
| HAL | 7 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, histidinemia, Keratinocyte carcinoma and 3 more |
| HLA-B | 7 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 3 more |
| TRPS1 | 7 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Non-small cell lung carcinoma and 3 more |
| CUX1 | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 2 more |
| CYP1B1 | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more |
| DEF8 | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-small cell lung carcinoma and 2 more |
| EPB41L1 | 6 / 19 | Basal cell carcinoma, Chromosome 20q11-q12 deletion syndrome, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma and 2 more |
| ICOS | 6 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more |
| MYL10 | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 2 more |
| PHTF1 | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 2 more |
| PTPN22 | 6 / 19 | Basal cell carcinoma, Melanoma, Seborrheic keratosis, Skin cancer and 2 more |
| RCC2 | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more |
| RHOU | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more |
| RSBN1 | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 2 more |
| TGM3 | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more |
| TICAM1 | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more |
| TP53 | 6 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more |
| AHR | 5 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Melanoma, Skin disease and 1 more |
| ANKRD11 | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 1 more |
| ATP11A | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Skin cancer and 1 more |
| BCAS4 | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more |
| CCDC88B | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more |
| CCR6 | 5 / 19 | Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma, Skin cancer and 1 more |
| CEP43 | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Skin cancer and 1 more |
| CYRIA | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more |
| JDP2 | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more |
| PARD6B | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more |
| RGS22 | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more |
| SMC2 | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more |
| THNSL2 | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more |
| ZNF276 | 5 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 1 more |
| ADGRV1 | 4 / 19 | Basal cell carcinoma, Melanoma, Skin cancer, Skin neoplasms |
| ASIP | 4 / 19 | Basal cell carcinoma, Melanoma, Non-melanoma skin carcinoma, Skin neoplasms |
| ATP8B4 | 4 / 19 | Basal cell carcinoma, Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms |
| CTSS | 4 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Melanoma, Non-melanoma skin carcinoma |
| CTXND2 | 4 / 19 | Cutaneous squamous cell carcinoma, Melanoma, Skin cancer, Skin neoplasms |
| EMSY | 4 / 19 | Basal cell carcinoma, Skin cancer, Skin disease, Skin neoplasms |
| EXOC2 | 4 / 19 | Basal cell carcinoma, Melanoma, Non-melanoma skin carcinoma, Skin disease |
| FADS2 | 4 / 19 | Basal cell carcinoma, Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms |
| FANCA | 4 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma |
| HLA-DQB3 | 4 / 19 | Basal cell carcinoma, Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms |
| IL2RA | 4 / 19 | Basal cell carcinoma, Skin cancer, Skin disease, Skin neoplasms |
| KANK1 | 4 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Skin cancer, Skin neoplasms |
| KRT6A | 4 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Seborrheic keratosis, Skin disease |
| PPARGC1B | 4 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma |
| PRDX5 | 4 / 19 | Basal cell carcinoma, Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms |
| PTGS2 | 4 / 19 | Dermatologic disorder, Melanoma, Skin disease, Skin neoplasms |
| SCAF1 | 4 / 19 | Basal cell carcinoma, Melanoma, Skin cancer, Skin neoplasms |
| SLC24A5 | 4 / 19 | Melanoma, Skin cancer, Skin disease, Skin neoplasms |
| SPMIP7 | 4 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin disease |
| TP63 | 4 / 19 | Cutaneous squamous cell carcinoma, Non-small cell lung carcinoma, Seborrheic keratosis, Skin disease |
| TPCN2 | 4 / 19 | Basal cell carcinoma, Melanoma, Skin cancer, Skin neoplasms |
| TPRG1 | 4 / 19 | Cutaneous squamous cell carcinoma, Non-small cell lung carcinoma, Seborrheic keratosis, Skin disease |
| TRPC4AP | 4 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Melanoma, Non-melanoma skin carcinoma |
| ZBTB10 | 4 / 19 | Basal cell carcinoma, Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms |
| AQP3 | 3 / 19 | Melanoma, Non-small cell lung carcinoma, Skin neoplasms |
| BCL2L12 | 3 / 19 | Basal cell carcinoma, Skin cancer, Skin neoplasms |
| CBFA2T2 | 3 / 19 | Basal cell carcinoma, Melanoma, Non-melanoma skin carcinoma |
| CCRL2 | 3 / 19 | Dermatologic disorder, Non-melanoma skin carcinoma, Skin disease |
| CFL1 | 3 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma |
| DCST1 | 3 / 19 | Basal cell carcinoma, Skin cancer, Skin neoplasms |
| DLGAP4 | 3 / 19 | Basal cell carcinoma, Melanoma, Non-melanoma skin carcinoma |
| DUSP22 | 3 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Non-melanoma skin carcinoma |
| EDEM2 | 3 / 19 | Basal cell carcinoma, Cutaneous squamous cell carcinoma, Non-melanoma skin carcinoma |
| ERCC2 | 3 / 19 | Dermatologic disorder, Skin disease, Skin neoplasms |
| FAM76B | 3 / 19 | Basal cell carcinoma, Skin cancer, Skin neoplasms |
| GPX4 | 3 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma |
| GRM5 | 3 / 19 | Basal cell carcinoma, Melanoma, Non-melanoma skin carcinoma |
| HLA-DPA1 | 3 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma |
| IL1A | 3 / 19 | Dermatologic disorder, Skin disease, Skin neoplasms |
| IL6 | 3 / 19 | Basal cell carcinoma, Dermatologic disorder, Skin disease |
| IRF3 | 3 / 19 | Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms |
| JAZF1 | 3 / 19 | Basal cell carcinoma, Skin cancer, Skin neoplasms |
| KIAA0930 | 3 / 19 | Melanoma, Skin cancer, Skin neoplasms |
| MITF | 3 / 19 | Melanoma, Skin cancer, Skin neoplasms |
| MTAP | 3 / 19 | Basal cell carcinoma, Melanoma, Non-small cell lung carcinoma |
| NOX4 | 3 / 19 | Basal cell carcinoma, Melanoma, Skin disease |
| OVOL1 | 3 / 19 | Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Pathways in cancer | KEGG | 97 / 533 | 2.1× | 2.36e-13 | 5.16e-11 ✓ sig. |
| Human cytomegalovirus infection | KEGG | 52 / 226 | 2.7× | 1.83e-11 | 2.90e-9 ✓ sig. |
| Graft-versus-host disease | KEGG | 20 / 45 | 5.2× | 1.31e-10 | 1.75e-8 ✓ sig. |
| Hepatitis B | KEGG | 41 / 163 | 3.0× | 1.41e-10 | 1.86e-8 ✓ sig. |
| Human T-cell leukemia virus 1 infection | KEGG | 49 / 224 | 2.6× | 4.60e-10 | 5.32e-8 ✓ sig. |
| Allograft rejection | KEGG | 18 / 39 | 5.4× | 5.18e-10 | 5.94e-8 ✓ sig. |
| Type I diabetes mellitus | KEGG | 19 / 44 | 5.1× | 7.01e-10 | 7.72e-8 ✓ sig. |
| Bladder cancer | KEGG | 18 / 41 | 5.2× | 1.42e-9 | 1.45e-7 ✓ sig. |
| Inflammatory bowel disease | KEGG | 23 / 66 | 4.1× | 1.87e-9 | 1.85e-7 ✓ sig. |
| Autoimmune thyroid disease | KEGG | 20 / 54 | 4.4× | 6.33e-9 | 5.55e-7 ✓ sig. |
| Kaposi sarcoma-associated herpesvirus infection | KEGG | 42 / 196 | 2.5× | 1.54e-8 | 1.20e-6 ✓ sig. |
| Viral myocarditis | KEGG | 22 / 70 | 3.7× | 3.67e-8 | 2.61e-6 ✓ sig. |
| Herpes simplex virus 1 infection | KEGG | 39 / 182 | 2.5× | 5.02e-8 | 3.44e-6 ✓ sig. |
| Chronic myeloid leukemia | KEGG | 23 / 77 | 3.5× | 5.25e-8 | 3.58e-6 ✓ sig. |
| Rheumatoid arthritis | KEGG | 26 / 95 | 3.2× | 5.27e-8 | 3.59e-6 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| positive regulation of gene expression | GO:0010628 | 70 / 504 | 2.5× | 5.14e-13 | 2.45e-10 ✓ sig. |
| response to lipopolysaccharide | GO:0032496 | 33 / 161 | 3.8× | 3.50e-11 | 1.13e-8 ✓ sig. |
| positive regulation of miRNA transcription | GO:1902895 | 18 / 56 | 5.9× | 4.78e-10 | 1.17e-7 ✓ sig. |
| negative regulation of transcription by RNA polymerase II | GO:0000122 | 101 / 1,002 | 1.8× | 1.37e-9 | 2.96e-7 ✓ sig. |
| positive regulation of cell population proliferation | GO:0008284 | 64 / 532 | 2.2× | 2.32e-9 | 4.68e-7 ✓ sig. |
| antigen processing and presentation | GO:0019882 | 16 / 48 | 6.1× | 2.42e-9 | 4.85e-7 ✓ sig. |
| positive regulation of transcription by RNA polymerase II | GO:0045944 | 115 / 1,208 | 1.7× | 2.66e-9 | 5.27e-7 ✓ sig. |
| liver development | GO:0001889 | 21 / 87 | 4.4× | 6.04e-9 | 1.08e-6 ✓ sig. |
| melanin biosynthetic process | GO:0042438 | 9 / 14 | 11.8× | 6.54e-9 | 1.16e-6 ✓ sig. |
| regulation of gene expression | GO:0010468 | 52 / 402 | 2.4× | 6.65e-9 | 1.18e-6 ✓ sig. |
| negative regulation of apoptotic process | GO:0043066 | 62 / 524 | 2.2× | 7.87e-9 | 1.37e-6 ✓ sig. |
| cell population proliferation | GO:0008283 | 39 / 263 | 2.7× | 1.28e-8 | 2.10e-6 ✓ sig. |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | GO:0002504 | 9 / 15 | 11.0× | 1.56e-8 | 2.49e-6 ✓ sig. |
| positive regulation of nitric oxide biosynthetic process | GO:0045429 | 14 / 42 | 6.1× | 2.43e-8 | 3.63e-6 ✓ sig. |
| peptide antigen assembly with MHC class II protein complex | GO:0002503 | 9 / 16 | 10.3× | 3.38e-8 | 4.79e-6 ✓ sig. |