Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 103

12 diseases · 21 shared-gene connections
12 Diseases
1,039 Unique genes
0.130 Avg. similarity score
Autoimmune disease Most-connected disease (6 links)
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Disease Searched: Immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Autoimmune disease 6 6 202
Autoimmune thyroid disease 6 6 144
Diabetes mellitus type 1 6 6 479
Celiac disease 5 5 193
Common variable immunodeficiency 5 5 79
Hypothyroidism 5 5 377
Isolated sulfite oxidase deficiency 3 3 1
Sarcoidosis 2 2 163
Autoinflammation with pulmonary and cutaneous vasculitis 1 1 1
Immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias 1 1 1
Midline facial cleft 1 1 1
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
CTLA4 7 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more
HLA-DQB1 7 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more
ADCY7 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
C1ORF141 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
ICOS 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
IL23R 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
IL2RA 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
KEAP1 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
NKX2-3 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
PHTF1 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
PTPN2 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
RSBN1 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
SH2B3 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 2 more
SLC25A28 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
SUOX 6 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
ADGRL2 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
ANKRD55 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
ATG16L1 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
ATXN2 5 / 12 Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 1 more
ATXN2L 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
BACH2 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 1 more
BTNL2 5 / 12 Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 1 more
CARD9 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
CRB1 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
CYTL1 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
DAG1 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
DCTD 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
ERAP2 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
FNBP1 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
FUT2 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
GPR35 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
GSDMB 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
HLA-B 5 / 12 Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 1 more
HLA-DQA1 5 / 12 Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 1 more
HLA-DRA 5 / 12 Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 1 more
HLA-DRB1 5 / 12 Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 1 more
IGF2 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
IL10 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
IL18RAP 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
INS-IGF2 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
IRF1 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
IRF4 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 1 more
JAK2 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
LRRK2 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
LURAP1L 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
NKD1 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
NPIPB6 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
PDE4A 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
PPARG 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 1 more
PSMB9 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 1 more
SBK1 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
SLC9A4 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
SMAD3 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
STAT4 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 1 more
STMN3 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
TENM3 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
TNFSF15 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
TSBP1 5 / 12 Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 1 more
TTC33 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
TYK2 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 1 more
UBASH3A 5 / 12 Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 1 more
ZMIZ1 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
ZPBP2 5 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
BANF2 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
C1QTNF6 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
CAMK4 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
CBLB 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
CCDC88B 4 / 12 Autoimmune disease, Diabetes mellitus type 1, Hypothyroidism, Sarcoidosis
CD226 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
ELMO1 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Hypothyroidism
ERBB3 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
FAM76B 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
HLA-DMB 4 / 12 Autoimmune disease, Diabetes mellitus type 1, Hypothyroidism, Sarcoidosis
HLA-DOA 4 / 12 Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism
HLA-DOB 4 / 12 Celiac disease, Diabetes mellitus type 1, Hypothyroidism, Sarcoidosis
HLA-DPA1 4 / 12 Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism
HLA-DPB1 4 / 12 Celiac disease, Diabetes mellitus type 1, Hypothyroidism, Sarcoidosis
HLA-DQB3 4 / 12 Autoimmune disease, Diabetes mellitus type 1, Hypothyroidism, Sarcoidosis
IL21 4 / 12 Celiac disease, Common variable immunodeficiency, Diabetes mellitus type 1, Hypothyroidism
LPP 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Hypothyroidism
NCR3 4 / 12 Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism, Sarcoidosis
NOTCH4 4 / 12 Celiac disease, Diabetes mellitus type 1, Hypothyroidism, Sarcoidosis
PLEKHA1 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
PTPN22 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
RASGRP1 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
RHOH 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
RNASET2 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
TAGAP 4 / 12 Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism
TAP1 4 / 12 Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism
TAP2 4 / 12 Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism, Sarcoidosis
TNFRSF14 4 / 12 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Hypothyroidism
ACAP1 3 / 12 Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
ACE 3 / 12 Celiac disease, Diabetes mellitus type 1, Sarcoidosis
AFF3 3 / 12 Autoimmune disease, Celiac disease, Diabetes mellitus type 1
ARID5B 3 / 12 Autoimmune disease, Autoimmune thyroid disease, Hypothyroidism
BCL2L15 3 / 12 Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism
BRD2 3 / 12 Celiac disease, Diabetes mellitus type 1, Sarcoidosis
C12ORF42 3 / 12 Autoimmune disease, Autoimmune thyroid disease, Hypothyroidism
C2 3 / 12 Diabetes mellitus type 1, Hypothyroidism, Sarcoidosis
C6ORF15 3 / 12 Celiac disease, Diabetes mellitus type 1, Sarcoidosis
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Inflammatory bowel disease
GATA3, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL10, IL18RAP, IL23R, SMAD3, STAT4, STAT3, IFNG
 KEGG 44 / 66 7.7× 2.06e-31 6.76e-28 ✓ sig.
Type I diabetes mellitus
CD28, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, FAS, IFNG, CD86, HLA-DQA1, HLA-DRA
 KEGG 34 / 44 8.9× 4.67e-28 1.07e-24 ✓ sig.
Intestinal immune network for IgA production
CD28, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, ICOS, IL10, AICDA, CD40LG, IL4, IL6, CD86
 KEGG 34 / 50 7.9× 5.56e-25 7.98e-22 ✓ sig.
Th17 cell differentiation
GATA3, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL23R, IL2RA, IRF4, JAK1, JAK2, SMAD3, TYK2
 KEGG 49 / 109 5.2× 5.10e-24 6.35e-21 ✓ sig.
Allograft rejection
CD28, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL10, CD40LG, FAS, IFNG, IL4
 KEGG 29 / 39 8.6× 2.84e-23 3.29e-20 ✓ sig.
Autoimmune thyroid disease
CD28, CTLA4, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL10, TG, TPO, CD40LG
 KEGG 33 / 54 7.1× 4.57e-22 4.41e-19 ✓ sig.
Graft-versus-host disease
CD28, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, FAS, IFNG, IL6, CD86, HLA-DQA1
 KEGG 29 / 45 7.4× 1.73e-20 1.31e-17 ✓ sig.
Rheumatoid arthritis
CD28, CTLA4, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IFNG, IL17A, IL6, TGFB2, CD86, HLA-DQA1
 KEGG 40 / 95 4.9× 1.41e-18 7.87e-16 ✓ sig.
Th1 and Th2 cell differentiation
GATA3, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL2RA, JAK1, JAK2, STAT4, TYK2, ZAP70, IFNG
 KEGG 39 / 93 4.8× 4.53e-18 2.34e-15 ✓ sig.
Cytokine-cytokine receptor interaction
CCL21, CXCR5, FASLG, IL10, IL18RAP, IL23R, IL2RA, TNFRSF11B, TNFRSF14, TNFSF15, CD40LG, CXCR3
 KEGG 75 / 298 2.9× 6.73e-18 3.31e-15 ✓ sig.
Viral protein interaction with cytokine and cytokine receptor
CCL21, CXCR5, IL10, IL18RAP, IL2RA, TNFRSF14, CXCR3, IL6, PF4, TNFRSF1A, CX3CR1, CCR2
 KEGG 37 / 100 4.3× 4.18e-15 1.22e-12 ✓ sig.
Leishmaniasis
HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL10, JAK1, JAK2, IFNG, IL4, TGFB2, HLA-DQA1, HLA-DRA
 KEGG 31 / 78 4.6× 7.26e-14 1.66e-11 ✓ sig.
Hematopoietic cell lineage
FLT3, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL2RA, ITGB3, IL4, IL6, HLA-DQA1, IL7R, HLA-DRA
 KEGG 35 / 100 4.0× 1.61e-13 3.41e-11 ✓ sig.
Herpes simplex virus 1 infection
CARD9, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, ITGB3, JAK1, JAK2, TAP1, TICAM1
 KEGG 49 / 182 3.1× 2.66e-13 5.35e-11 ✓ sig.
Interleukin-10 signaling
IL10, JAK1, TYK2, STAT3, IL6, TIMP1, TNFRSF1A, CD86, CCR2, CD80, CXCL10, CCR5
 Reactome 23 / 47 5.7× 6.03e-13 1.13e-10 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
CBLB, CCL21, CD28, CTLA4, CTSH, CXCR5, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1
 GO:0006955 115 / 543 3.8× 7.34e-37 6.98e-33 ✓ sig.
immune system process
CAMK4, CARD9, CD28, CTLA4, ERAP2, GATA3, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL18RAP
 GO:0002376 128 / 943 2.4× 1.56e-21 3.27e-18 ✓ sig.
inflammatory response
CAMK4, CCL21, GATA3, IL18RAP, IL23R, IL2RA, IRF5, MACIR, TICAM1, TNFAIP3, TNIP1, STAT3
 GO:0006954 83 / 467 3.2× 1.91e-21 3.93e-18 ✓ sig.
peptide antigen assembly with MHC class II protein complex
HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, B2M, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DPB1, HLA-DQB2, HLA-DQA2
 GO:0002503 14 / 16 15.7× 2.68e-16 2.45e-13 ✓ sig.
positive regulation of transcription by RNA polymerase II
CD28, CYTL1, EAF2, GATA3, IGF2, IL10, IRF1, IRF4, IRF5, JAK2, LHX2, NKX2-3
 GO:0045944 136 / 1,208 2.0× 9.68e-16 7.99e-13 ✓ sig.
positive regulation of type II interferon production
CD226, HLA-DPA1, IL23R, JAK2, PTPN22, TYK2, TLR3, CCR2, CD14, HLA-DPB1, IL18R1, IL2
 GO:0032729 27 / 77 6.3× 2.84e-15 2.17e-12 ✓ sig.
positive regulation of T cell activation
CCDC88B, CD28, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, B2M, HLA-DQA1, HLA-DRA, HLA-DRB1, CCR2, HLA-DOB
 GO:0050870 21 / 45 8.4× 3.83e-15 2.84e-12 ✓ sig.
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DPB1, HLA-DQB2, HLA-DQA2, HLA-DRB5
 GO:0002504 13 / 15 15.6× 4.27e-15 3.14e-12 ✓ sig.
positive regulation of T cell proliferation
CCDC88B, CD28, HLA-DMB, HLA-DPA1, IL23R, IL2RA, JAK2, TYK2, CD274, CD40LG, IL4, IL6
 GO:0042102 25 / 67 6.7× 5.66e-15 4.07e-12 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
CCL21, CD28, ERBB3, FLT3, GATA3, IGF2, JAK2, NTRK1, SIRT1, VAV3, IL17A, PECAM1
 GO:0051897 44 / 217 3.6× 5.19e-14 3.18e-11 ✓ sig.
positive regulation of tumor necrosis factor production
CARD9, JAK2, LRRK2, TICAM1, STAT3, FCGR2B, IFNG, IL17A, IL6, PF4, IFIH1, TLR3
 GO:0032760 30 / 113 4.8× 3.72e-13 1.93e-10 ✓ sig.
T cell receptor signaling pathway
CBLB, CD28, CTLA4, GATA3, HLA-DQB1, PTPN22, ZAP70, BTNL2, CD247, FYN, HLA-DRB1, CSK
 GO:0050852 31 / 121 4.6× 4.29e-13 2.19e-10 ✓ sig.
cytokine-mediated signaling pathway
FLT3, IL23R, IRF5, JAK1, JAK2, SOCS1, SOCS4, STAT4, TYK2, STAT3, HCK, IL6
 GO:0019221 34 / 145 4.2× 5.08e-13 2.55e-10 ✓ sig.
antigen processing and presentation
CTSH, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, RAB5B, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DPB1
 GO:0019882 19 / 48 7.1× 3.02e-12 1.32e-9 ✓ sig.
positive regulation of MAPK cascade
ERBB3, FLT3, IGF2, JAK2, LRRK2, NKD1, ZAP70, IL6, PECAM1, BANK1, HLA-DRB1, CD36
 GO:0043410 42 / 224 3.4× 3.03e-12 1.32e-9 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Autoimmune disease Autoimmune thyroid disease 0.335 87 1.75e-133 9.14e-132 ✓ sig.
Autoimmune thyroid disease Hypothyroidism 0.206 89 3.62e-109 1.64e-107 ✓ sig.
Autoimmune thyroid disease Diabetes mellitus type 1 0.175 93 3.16e-106 1.41e-104 ✓ sig.
Autoimmune disease Celiac disease 0.249 79 3.83e-102 1.63e-100 ✓ sig.
Autoimmune disease Diabetes mellitus type 1 0.172 100 6.21e-98 2.56e-96 ✓ sig.
Celiac disease Diabetes mellitus type 1 0.164 95 1.39e-92 5.46e-91 ✓ sig.
Autoimmune thyroid disease Celiac disease 0.229 63 3.16e-84 1.16e-82 ✓ sig.
Autoimmune thyroid disease Common variable immunodeficiency 0.280 49 1.31e-82 4.75e-81 ✓ sig.
Autoimmune disease Common variable immunodeficiency 0.221 51 1.19e-78 4.16e-77 ✓ sig.
Autoimmune disease Hypothyroidism 0.158 79 1.65e-75 5.67e-74 ✓ sig.
Celiac disease Common variable immunodeficiency 0.219 49 2.75e-75 9.40e-74 ✓ sig.
Diabetes mellitus type 1 Hypothyroidism 0.143 107 3.25e-74 1.10e-72 ✓ sig.
Diabetes mellitus type 1 Sarcoidosis 0.075 45 1.94e-30 3.82e-29 ✓ sig.
Hypothyroidism Sarcoidosis 0.067 34 2.49e-22 3.91e-21 ✓ sig.
Common variable immunodeficiency Immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias 0.013 1 5.10e-3 6.10e-3 ✓ sig.
Common variable immunodeficiency Isolated sulfite oxidase deficiency 0.013 1 5.10e-3 6.10e-3 ✓ sig.
Autoimmune thyroid disease Isolated sulfite oxidase deficiency 0.007 1 9.30e-3 1.05e-2 ✓ sig.
Celiac disease Isolated sulfite oxidase deficiency 0.005 1 1.25e-2 1.38e-2 ✓ sig.
Autoimmune disease Autoinflammation with pulmonary and cutaneous vasculitis 0.005 1 1.30e-2 1.44e-2 ✓ sig.
Hypothyroidism Midline facial cleft 0.003 1 2.43e-2 2.59e-2 ✓ sig.
Diabetes mellitus type 1 Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies 0.002 1 3.09e-2 3.25e-2 ✓ sig.