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Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 2

143 diseases · 594 shared-gene connections
143 Diseases
7,021 Unique genes
0.439 Avg. similarity score
Plasma cell myeloma Most-connected disease (52 links)
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Disease Searched: Hypotaurinemic retinal degeneration and cardiomyopathy Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.
Hypotaurinemic retinal degeneration and cardiomyopathy Plasma cell myeloma Rectum adenocarcinoma Colon adenocarcinoma Bile duct cancer Transitional cell carcinoma

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Plasma cell myeloma 52 52 697
Rectum adenocarcinoma 51 51 704
Colon adenocarcinoma 46 44 738
Bile duct cancer 36 36 668
Transitional cell carcinoma 33 33 746
Superficial spreading melanoma 27 27 652
Gastric intestinal type adenocarcinoma 25 25 637
Nodular malignant melanoma 22 22 623
Ductal carcinoma of breast 21 21 630
Thyroid carcinoma 21 21 685
Cecum adenocarcinoma 18 18 631
Undifferentiated pleomorphic sarcoma 18 18 540
Duodenal adenocarcinoma 17 17 667
Central nervous system primitive neuroectodermal neoplasm 16 16 496
B-cell chronic lymphocytic leukemia 15 15 634
Gastric adenoma 14 14 431
Richter transformation 14 14 418
Meningioma 13 13 524
Small cell carcinoma 13 13 511
Peripheral primitive neuroectodermal tumor 12 12 405
Anaplastic astrocytoma 11 11 456
Brain stem glioblastoma 11 11 271
Carcinoma of the ampulla of vater 11 11 302
Ependymoma 11 11 211
Gastresophageal junction adenocarcinoma 11 11 562
Her2 positive breast carcinoma 11 11 363
Placental choriocarcinoma 11 11 368
Astrocytoma (excluding glioblastoma) 10 10 416
Mantle cell lymphoma 10 10 316
Lung cancer 10 9 1,333
Colorectal cancer 10 8 1,632
Acute myeloid leukemia 9 9 406
Angiosarcoma 9 9 436
B-cell prolymphocytic leukemia 9 9 122
Eccrine porocarcinoma 9 9 379
Extramammary paget disease 9 9 281
Pancreatic acinar cell carcinoma 9 9 293
Parathyroid carcinoma 9 9 239
Small intestinal tubulovillous adenoma 9 9 357
Glioblastoma 9 8 1,280
Anaplastic (malignant) meningioma 8 8 296
Gastric neuroendocrine tumor g1 8 8 383
Gastrointestinal stromal tumor 8 8 465
Large cell carcinoma 8 8 480
Lentigo maligna melanoma 8 8 344
Ovarian serous carcinoma 8 8 663
Squamous cell carcinoma 8 8 1,436
Carcinoma 8 7 850
Acral lentiginous melanoma 7 7 338
Astrocytoma 7 7 459
Basal cell carcinoma 7 7 1,002
Burkitt lymphoma 7 7 140
Childhood kidney wilms tumor 7 7 229
Colonic neoplasms 7 7 302
Diffuse large b-cell lymphoma 7 7 585
Endometrial hyperplasia 7 7 257
Hepatocellular carcinoma 7 7 1,124
Non-small cell lung carcinoma 7 7 889
Prostate cancer 7 7 1,520
Prostatic neoplasms 7 7 627
Rectal tubular adenoma 7 7 255
Retinoblastoma 7 7 133
Rhabdomyosarcoma 7 7 404
Skin cancer 7 7 657
T-cell large granular lymphocyte leukemia 7 7 231
Breast cancer 7 6 1,259
Central nervous system cancer 6 6 672
Chromophobe renal cell carcinoma 6 6 165
Clear cell renal cell carcinoma 6 6 720
Digestive system melanoma 6 6 312
Esophageal squamous cell carcinoma 6 6 772
Hemangioblastoma 6 6 390
Oral cavity carcinoma 6 6 662
Pancreatic ductal carcinoma 6 6 617
Papillary renal cell carcinoma 6 6 212
Polycystic ovary syndrome 6 6 227
Glioma 6 5 910
Melanoma 6 5 1,108
Acinar lung adenocarcinoma 5 5 126
Adenoid cystic carcinoma 5 5 426
Adenosquamous lung carcinoma 5 5 150
Anaplastic lung carcinoma 5 5 201
B-cell acute lymphoblastic leukemia 5 5 471
Breast neoplasms 5 5 529
Chondroblastoma 5 5 58
Diffuse gastric adenocarcinoma 5 5 209
Esophageal adenocarcinoma 5 5 559
Female breast carcinoma 5 5 274
Gallbladder neoplasms 5 5 600
Gastric cancer 5 5 687
Gliomatosis cerebri 5 5 188
Hodgkin lymphoma 5 5 585
Medulloblastoma 5 5 161
Osteosarcoma 5 5 561
Primary central nervous system lymphoma 5 5 184
Rectal tubulovillous adenoma 5 5 137
Renal pelvis urothelial carcinoma 5 5 218
Rhabdoid tumor 5 5 85
Skin neoplasms 5 5 272
Small cell lung carcinoma 5 5 744
T-cell acute lymphoblastic leukemia 5 5 247
T-cell leukemia-lymphoma 5 5 237
T-cell prolymphocytic leukemia 5 5 199
Urinary bladder cancer 5 5 431
Uterine fibroid 5 5 306
Desbuquois syndrome 5 4 567
Amelanotic skin melanoma 4 4 102
Cecum villous adenoma 4 4 145
Endometrial serous adenocarcinoma 4 4 130
Endometriosis 4 4 401
Gallbladder adenoma 4 4 128
Gallbladder biliary intraepithelial neoplasia 4 4 135
Liposarcoma 4 4 220
Lymphoblastic leukemia 4 4 312
Myelodysplastic syndrome 4 4 260
Oligodendroglioma 4 4 638
Osteoblastoma 4 4 40
Plasmacytoma 4 4 62
Stomach neoplasms 4 4 306
Villous adenoma of colon 4 4 83
Adrenal cortex adenoma 3 3 88
Androgenetic alopecia 3 3 408
Myeloid leukemia 3 3 248
Neoplasms 3 3 170
Prostatic adenoma 3 3 92
Signet ring cell gastric adenocarcinoma 3 3 81
Thyroid gland oncocytic follicular carcinoma 3 3 170
Systemic lupus erythematosus 18 3 1 1
Global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 2 2 1
Kidney cancer 2 2 81
Short stature, dauber-argente type 2 2 1
Acantholytic blistering of oral and laryngeal mucosa 2 1 1
Faundes-banka syndrome 2 1 1
C3hex olfactory ability 2 0 1
Neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities 2 0 2
colorectal adenocarcinoma 2 0 0
cutaneous melanoma 2 0 0
Guillouet-gordon syndrome 1 1 1
Hypotaurinemic retinal degeneration and cardiomyopathy 1 1 1
Intellectual developmental disorder seizures polymicrogyria 1 1 1
Isobutyryl-coa dehydrogenase deficiency 1 1 1
Neurodevelopmental disorder with hypotonia, neuropathy, and deafness 1 1 1
Microcornea, rod-cone dystrophy, cataract, and posterior staphyloma 1 1 0 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
TP53 109 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 105 more
LRP1B 107 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 103 more
ATM 104 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 100 more
CSMD3 104 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 100 more
KMT2C 103 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 99 more
ZFHX3 102 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma and 98 more
CTNNA2 100 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 96 more
KRAS 99 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 95 more
MUC16 99 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 95 more
KMT2D 98 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 94 more
APC 97 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 93 more
FAT3 97 / 143 Acinar lung adenocarcinoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 93 more
NRG1 97 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Anaplastic (malignant) meningioma and 93 more
DCC 95 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenosquamous lung carcinoma, Adrenal cortex adenoma and 91 more
MUC4 95 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 91 more
FAT4 94 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 90 more
NF1 94 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma and 90 more
ARID1A 93 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 89 more
BRAF 93 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 89 more
CREBBP 93 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 89 more
EP300 93 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 89 more
ERBB4 93 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma and 89 more
FAT1 93 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 89 more
MTOR 93 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 89 more
NBEA 93 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 89 more
NOTCH1 93 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 89 more
PTPRD 93 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 89 more
CNTNAP2 92 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Amelanotic skin melanoma and 88 more
EGFR 92 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 88 more
PIK3CA 92 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 88 more
TET2 92 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 88 more
BRCA2 91 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 87 more
CDKN2A 91 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 87 more
NCOR1 91 / 143 Acinar lung adenocarcinoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 87 more
PTEN 91 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Amelanotic skin melanoma and 87 more
PTPRT 91 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Anaplastic (malignant) meningioma, Anaplastic astrocytoma and 87 more
RB1 91 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 87 more
SETD2 91 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 87 more
ALK 90 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 86 more
NOTCH2 90 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 86 more
BCOR 89 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 85 more
CUX1 89 / 143 Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma, Amelanotic skin melanoma and 85 more
MET 89 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 85 more
NCOR2 89 / 143 Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma, Anaplastic astrocytoma and 85 more
ROS1 89 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 85 more
BIRC6 88 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 84 more
ASXL1 87 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma and 83 more
ERG 87 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Amelanotic skin melanoma, Anaplastic (malignant) meningioma and 83 more
FBXO11 87 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma and 83 more
KMT2A 87 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma and 83 more
POLE 87 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adrenal cortex adenoma, Anaplastic (malignant) meningioma and 83 more
SPEN 87 / 143 Acinar lung adenocarcinoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 83 more
CACNA1D 86 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Amelanotic skin melanoma and 82 more
CTNND2 86 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 82 more
ERBB2 86 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma and 82 more
GNAS 86 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma and 82 more
NTRK3 86 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 82 more
ROBO2 86 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenosquamous lung carcinoma, Anaplastic (malignant) meningioma and 82 more
TERT 86 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Anaplastic (malignant) meningioma, Anaplastic astrocytoma and 82 more
ARID1B 85 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Amelanotic skin melanoma and 81 more
ATRX 85 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma and 81 more
KDM6A 85 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 81 more
ESR1 84 / 143 Acute myeloid leukemia, Amelanotic skin melanoma, Anaplastic (malignant) meningioma, Anaplastic astrocytoma and 80 more
MECOM 84 / 143 Acral lentiginous melanoma, Adenosquamous lung carcinoma, Amelanotic skin melanoma, Anaplastic (malignant) meningioma and 80 more
SMARCA4 84 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma and 80 more
AR 83 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Adenosquamous lung carcinoma, Anaplastic (malignant) meningioma and 79 more
CTNNB1 83 / 143 Acral lentiginous melanoma, Adenoid cystic carcinoma, Adrenal cortex adenoma, Amelanotic skin melanoma and 79 more
ERBB3 83 / 143 Acral lentiginous melanoma, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma, Anaplastic astrocytoma and 79 more
FBXW7 83 / 143 Acute myeloid leukemia, Adenoid cystic carcinoma, Amelanotic skin melanoma, Anaplastic (malignant) meningioma and 79 more
PTPN13 83 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adrenal cortex adenoma and 79 more
TNRC18 83 / 143 Acral lentiginous melanoma, Adenoid cystic carcinoma, Adenosquamous lung carcinoma, Anaplastic astrocytoma and 79 more
CAMTA1 82 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Amelanotic skin melanoma and 78 more
FAM135B 82 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma and 78 more
MSH6 82 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma and 78 more
NTRK1 82 / 143 Acral lentiginous melanoma, Adenoid cystic carcinoma, Adenosquamous lung carcinoma, Amelanotic skin melanoma and 78 more
SETBP1 82 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Anaplastic (malignant) meningioma, Anaplastic astrocytoma and 78 more
TRRAP 82 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 78 more
AKAP9 81 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 77 more
ARID2 81 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma and 77 more
ATR 81 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Amelanotic skin melanoma and 77 more
BRCA1 81 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adenosquamous lung carcinoma and 77 more
CDK12 81 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 77 more
KAT6B 81 / 143 Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma, Amelanotic skin melanoma and 77 more
KDR 81 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma and 77 more
MUC6 81 / 143 Acinar lung adenocarcinoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma and 77 more
PLEC 81 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma and 77 more
PTPRK 81 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma and 77 more
TP63 81 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Adrenal cortex adenoma and 77 more
ASPM 80 / 143 Acral lentiginous melanoma, Adenoid cystic carcinoma, Anaplastic astrocytoma, B-cell chronic lymphocytic leukemia and 76 more
BCORL1 80 / 143 Acinar lung adenocarcinoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic astrocytoma and 76 more
CHD4 80 / 143 Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma, Anaplastic astrocytoma and 76 more
COL3A1 80 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenosquamous lung carcinoma, Anaplastic astrocytoma and 76 more
EPHA3 80 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Anaplastic (malignant) meningioma, Anaplastic astrocytoma and 76 more
FGFR3 80 / 143 Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic (malignant) meningioma, Anaplastic astrocytoma and 76 more
FLNA 80 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma and 76 more
KAT6A 80 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Amelanotic skin melanoma and 76 more
NSD1 80 / 143 Acinar lung adenocarcinoma, Acute myeloid leukemia, Adenoid cystic carcinoma, Anaplastic astrocytoma and 76 more
NTRK2 80 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Amelanotic skin melanoma, Anaplastic (malignant) meningioma and 76 more
PREX2 80 / 143 Acral lentiginous melanoma, Acute myeloid leukemia, Amelanotic skin melanoma, Anaplastic (malignant) meningioma and 76 more
PTCH1 80 / 143 Acinar lung adenocarcinoma, Acral lentiginous melanoma, Acute myeloid leukemia, Angiosarcoma and 76 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Prostate cancer
BRAF, AR, BCL2, CTNNB1, PDGFA, SRD5A2, FGFR1, KRAS, MMP3, MMP9, PDGFD, PTEN
 KEGG 91 / 98 1.6× 1.65e-14 4.50e-12 ✓ sig.
Pathways in cancer
CEBPA, RUNX1, TERT, BRAF, AR, AXIN1, BCL2, BMP4, COL4A2, CTNNB1, EDNRB, FGF5
 KEGG 387 / 533 1.2× 2.76e-12 4.72e-10 ✓ sig.
Pancreatic cancer
BRAF, SMAD3, TGFB1, KRAS, CDKN2A, TP53, BRCA2, PIK3R1, RAC1, BAK1, NFKB1, CCND1
 KEGG 72 / 77 1.6× 3.90e-12 6.50e-10 ✓ sig.
Colorectal cancer
BRAF, AREG, AXIN1, BCL2, CTNNB1, SMAD3, TGFB1, KRAS, APC, TP53, PIK3R1, RAC1
 KEGG 79 / 87 1.6× 2.00e-11 2.84e-9 ✓ sig.
EGFR tyrosine kinase inhibitor resistance
BRAF, BCL2, FGFR3, PDGFA, PRKCA, HGF, KRAS, MET, NF1, NRG2, PDGFD, PTEN
 KEGG 72 / 80 1.5× 4.44e-10 4.48e-8 ✓ sig.
Melanoma
BRAF, FGF5, PDGFA, FGFR1, HGF, KRAS, MET, PDGFD, CDKN2A, PTEN, TP53, PIK3R1
 KEGG 65 / 73 1.5× 9.20e-9 6.85e-7 ✓ sig.
Non-small cell lung cancer
BRAF, PRKCA, FHIT, HGF, KRAS, MET, RARB, CDKN2A, TP53, PIK3R1, BAK1, CCND1
 KEGG 65 / 73 1.5× 9.20e-9 6.85e-7 ✓ sig.
Transcriptional misregulation in cancer
CEBPA, ETV6, RUNX1, ATF1, CDKN2C, JUP, MAF, PAX3, PBX1, PDGFA, RUNX2, SUPT3H
 KEGG 153 / 198 1.3× 1.57e-8 1.11e-6 ✓ sig.
Chronic myeloid leukemia
RUNX1, BRAF, SMAD3, TGFB1, KRAS, PTPN11, CDKN2A, TP53, PIK3R1, BAK1, NFKB1, CCND1
 KEGG 67 / 77 1.5× 4.63e-8 2.85e-6 ✓ sig.
Acute myeloid leukemia
CEBPA, RUNX1, BRAF, JUP, KRAS, PIK3R1, CEBPE, CSF2, FLT3, NFKB1, CCND1, MAPK1
 KEGG 60 / 68 1.5× 7.64e-8 4.42e-6 ✓ sig.
Bladder cancer
BRAF, FGFR3, KRAS, MMP9, CDKN2A, TP53, CCND1, CDH1, MAPK1, CDKN1A, EGFR, ARAF
 KEGG 39 / 41 1.6× 1.18e-7 6.47e-6 ✓ sig.
Proteoglycans in cancer
BRAF, CTNNB1, GPC1, IQGAP1, ITPR1, MSN, PRKCA, SDC1, TGFB1, TWIST1, TWIST2, WNT10A
 KEGG 154 / 204 1.3× 2.15e-7 1.09e-5 ✓ sig.
Endocrine resistance
BRAF, BCL2, CDKN2C, DLL3, ESR1, ESR2, KRAS, MMP9, NCOA3, NOTCH1, NOTCH2, CDKN2A
 KEGG 81 / 99 1.4× 5.80e-7 2.59e-5 ✓ sig.
Endometrial cancer
BRAF, AXIN1, CTNNB1, CTNNA2, CTNNA3, KRAS, APC, PTEN, TP53, PIK3R1, BAK1, CCND1
 KEGG 52 / 59 1.5× 6.34e-7 2.81e-5 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications
BCL2, COL4A2, PRKCA, SMAD3, TGFB1, COL1A2, KRAS, NOX4, PIK3R1, RAC1, CCL2, NFKB1
 KEGG 82 / 101 1.4× 9.31e-7 3.92e-5 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of transcription by RNA polymerase II
CBFB, CEBPA, ETV6, GATA2, RUNX1, ALX4, AP3D1, AR, ATF1, ATXN1, AUTS2, BCL11A
 GO:0045944 726 / 1,208 1.6× 1.72e-60 6.55e-56 ✓ sig.
positive regulation of DNA-templated transcription
CEBPA, CHEK2, GATA2, RUNX1, AR, ATF7IP, BICRA, BMP4, BMP7, CASZ1, CITED4, CLOCK
 GO:0045893 458 / 778 1.6× 8.70e-35 6.49e-31 ✓ sig.
negative regulation of transcription by RNA polymerase II
CBFB, CEBPA, ETV6, GATA2, RUNX1, AR, ATF7IP, ATXN1, BCL11A, BHLHE40, BMP4, CBX5
 GO:0000122 544 / 1,002 1.4× 1.84e-28 9.62e-25 ✓ sig.
positive regulation of gene expression
CEBPA, GATA2, BRAF, AR, BCL11A, BMP4, BMP7, CTNNB1, DNMT3B, EDA, EDAR, MAF
 GO:0010628 310 / 504 1.6× 2.53e-28 1.27e-24 ✓ sig.
cell population proliferation
CEBPA, BCL2, BIRC6, BMP4, BMP7, BRINP1, BTC, CDKN2C, CTNNB1, FGFR3, NOG, PBX1
 GO:0008283 178 / 263 1.8× 2.27e-23 5.80e-20 ✓ sig.
negative regulation of apoptotic process
TERT, BRAF, ATG5, BABAM2, BCL2, BIRC6, CRYAA, CTNNB1, EDNRB, ITCH, PDE3A, SMAD3
 GO:0043066 307 / 524 1.6× 4.10e-23 1.01e-19 ✓ sig.
positive regulation of cell population proliferation
AR, AREG, BCAR3, BCL2, BICRA, BIRC6, BMP4, BTC, CTNNB1, EDNRB, FGF5, FGFR3
 GO:0008284 309 / 532 1.5× 1.98e-22 4.44e-19 ✓ sig.
negative regulation of DNA-templated transcription
CEBPA, ATF7IP, ATXN1, BHLHE40, BMP4, BMP7, CBX5, CDYL2, CIC, CLOCK, CTNNB1, EPC1
 GO:0045892 350 / 631 1.5× 1.39e-20 2.42e-17 ✓ sig.
skeletal system development
ALX4, BMP4, BMP7, CMKLR1, CTNNB1, FGFR3, GLI2, NOG, PAPSS1, PKDCC, PTHLH, RUNX2
 GO:0001501 111 / 151 2.0× 2.29e-19 3.34e-16 ✓ sig.
positive regulation of MAPK cascade
AR, BCAR3, CDON, CTNNB1, FGF5, FGFR3, HMGB1, INAVA, IQGAP1, KSR2, NTRK2, PDGFA
 GO:0043410 150 / 224 1.8× 3.11e-19 4.44e-16 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
FGFR3, FYN, NTRK2, PDGFA, PRKCA, PRKD1, TGFB1, ADRA2A, FGFR1, HGF, NTS, PDGFD
 GO:0051897 143 / 217 1.8× 1.84e-17 2.07e-14 ✓ sig.
cell migration
BCL2, FOXE1, GPC1, IQGAP1, JUP, KNSTRN, SDC1, CDH22, CTNNA2, CTNNA3, DOCK1, DOCK2
 GO:0016477 186 / 303 1.6× 2.33e-17 2.54e-14 ✓ sig.
intracellular signal transduction
SH2B3, ASB7, DCLK1, DLC1, DUSP22, FYN, LRRK1, PRKCA, PRKD1, RGS9, TRAF3IP2, AKAP11
 GO:0035556 266 / 471 1.5× 2.90e-17 3.09e-14 ✓ sig.
animal organ morphogenesis
BRAF, BCL2, BMP7, ELN, FOXF2, PAX3, PBX1, PDGFA, FAT3, NOTCH2, VDR, PTCH1
 GO:0009887 94 / 130 1.9× 7.66e-16 6.39e-13 ✓ sig.
embryonic limb morphogenesis
BMP4, BMP7, MBNL1, PBX1, TWIST1, FGFR1, NOTCH1, NOTCH2, PTCH1, GREM1, FBN2, TP63
 GO:0030326 52 / 59 2.3× 9.67e-16 7.95e-13 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Colon adenocarcinoma Transitional cell carcinoma 0.949 719 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Rectum adenocarcinoma 0.942 696 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Plasma cell myeloma 0.932 689 < 1e-300 < 1e-300 ✓ sig.
Rectum adenocarcinoma Transitional cell carcinoma 0.914 689 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Rectum adenocarcinoma 0.912 665 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Transitional cell carcinoma 0.902 681 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Thyroid carcinoma 0.898 670 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Colon adenocarcinoma 0.894 661 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Duodenal adenocarcinoma 0.892 659 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Thyroid carcinoma 0.884 645 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Transitional cell carcinoma 0.880 659 < 1e-300 < 1e-300 ✓ sig.
Rectum adenocarcinoma Thyroid carcinoma 0.875 645 < 1e-300 < 1e-300 ✓ sig.
Duodenal adenocarcinoma Plasma cell myeloma 0.874 633 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Superficial spreading melanoma 0.874 645 < 1e-300 < 1e-300 ✓ sig.
Rectum adenocarcinoma Superficial spreading melanoma 0.874 629 < 1e-300 < 1e-300 ✓ sig.
Thyroid carcinoma Transitional cell carcinoma 0.871 663 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Rectum adenocarcinoma 0.869 635 < 1e-300 < 1e-300 ✓ sig.
Duodenal adenocarcinoma Transitional cell carcinoma 0.867 653 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Plasma cell myeloma 0.867 631 < 1e-300 < 1e-300 ✓ sig.
Duodenal adenocarcinoma Rectum adenocarcinoma 0.863 632 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Superficial spreading melanoma 0.861 621 < 1e-300 < 1e-300 ✓ sig.
Superficial spreading melanoma Transitional cell carcinoma 0.857 642 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Gastric intestinal type adenocarcinoma 0.856 631 < 1e-300 < 1e-300 ✓ sig.
Cecum adenocarcinoma Colon adenocarcinoma 0.851 626 < 1e-300 < 1e-300 ✓ sig.
Clear cell renal cell carcinoma Colon adenocarcinoma 0.848 666 < 1e-300 < 1e-300 ✓ sig.
Cecum adenocarcinoma Rectum adenocarcinoma 0.844 608 < 1e-300 < 1e-300 ✓ sig.
Duodenal adenocarcinoma Thyroid carcinoma 0.842 615 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Colon adenocarcinoma 0.840 623 < 1e-300 < 1e-300 ✓ sig.
Clear cell renal cell carcinoma Plasma cell myeloma 0.838 643 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Superficial spreading melanoma 0.838 599 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Nodular malignant melanoma 0.837 617 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Plasma cell myeloma 0.836 603 < 1e-300 < 1e-300 ✓ sig.
Nodular malignant melanoma Rectum adenocarcinoma 0.836 601 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Rectum adenocarcinoma 0.836 606 < 1e-300 < 1e-300 ✓ sig.
Gastric intestinal type adenocarcinoma Rectum adenocarcinoma 0.835 607 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Ductal carcinoma of breast 0.829 617 < 1e-300 < 1e-300 ✓ sig.
Nodular malignant melanoma Plasma cell myeloma 0.829 595 < 1e-300 < 1e-300 ✓ sig.
Clear cell renal cell carcinoma Transitional cell carcinoma 0.828 661 < 1e-300 < 1e-300 ✓ sig.
Gastric intestinal type adenocarcinoma Plasma cell myeloma 0.828 601 < 1e-300 < 1e-300 ✓ sig.
Gastric intestinal type adenocarcinoma Transitional cell carcinoma 0.827 623 < 1e-300 < 1e-300 ✓ sig.
Nodular malignant melanoma Superficial spreading melanoma 0.827 574 < 1e-300 < 1e-300 ✓ sig.
Cecum adenocarcinoma Transitional cell carcinoma 0.824 619 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Transitional cell carcinoma 0.823 620 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Plasma cell myeloma 0.823 596 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Rectum adenocarcinoma 0.820 598 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Thyroid carcinoma 0.820 591 < 1e-300 < 1e-300 ✓ sig.
Oral cavity carcinoma Plasma cell myeloma 0.820 609 < 1e-300 < 1e-300 ✓ sig.
Clear cell renal cell carcinoma Rectum adenocarcinoma 0.819 638 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Cecum adenocarcinoma 0.819 582 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Oral cavity carcinoma 0.819 627 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Small cell lung carcinoma 0.818 664 < 1e-300 < 1e-300 ✓ sig.
Cecum adenocarcinoma Superficial spreading melanoma 0.815 573 < 1e-300 < 1e-300 ✓ sig.
Nodular malignant melanoma Transitional cell carcinoma 0.814 611 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Gastric intestinal type adenocarcinoma 0.812 582 < 1e-300 < 1e-300 ✓ sig.
Oral cavity carcinoma Rectum adenocarcinoma 0.810 608 < 1e-300 < 1e-300 ✓ sig.
Clear cell renal cell carcinoma Thyroid carcinoma 0.809 625 < 1e-300 < 1e-300 ✓ sig.
Carcinoma Colon adenocarcinoma 0.805 705 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Transitional cell carcinoma 0.804 610 < 1e-300 < 1e-300 ✓ sig.
Oral cavity carcinoma Transitional cell carcinoma 0.801 623 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Thyroid carcinoma 0.799 581 < 1e-300 < 1e-300 ✓ sig.
Small cell lung carcinoma Transitional cell carcinoma 0.797 658 < 1e-300 < 1e-300 ✓ sig.
Rectum adenocarcinoma Small cell lung carcinoma 0.796 639 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Esophageal squamous cell carcinoma 0.796 666 < 1e-300 < 1e-300 ✓ sig.
Esophageal squamous cell carcinoma Plasma cell myeloma 0.789 645 < 1e-300 < 1e-300 ✓ sig.
Carcinoma Transitional cell carcinoma 0.789 701 < 1e-300 < 1e-300 ✓ sig.
Esophageal squamous cell carcinoma Rectum adenocarcinoma 0.789 648 < 1e-300 < 1e-300 ✓ sig.
Duodenal adenocarcinoma Oral cavity carcinoma 0.789 583 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Small cell lung carcinoma 0.787 632 < 1e-300 < 1e-300 ✓ sig.
Carcinoma Rectum adenocarcinoma 0.778 677 < 1e-300 < 1e-300 ✓ sig.
Carcinoma Plasma cell myeloma 0.776 673 < 1e-300 < 1e-300 ✓ sig.
Esophageal squamous cell carcinoma Transitional cell carcinoma 0.776 660 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Pancreatic ductal carcinoma 0.774 589 < 1e-300 < 1e-300 ✓ sig.
Pancreatic ductal carcinoma Rectum adenocarcinoma 0.771 573 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Small cell lung carcinoma 0.768 611 < 1e-300 < 1e-300 ✓ sig.
Gallbladder neoplasms Rectum adenocarcinoma 0.765 562 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Gallbladder neoplasms 0.763 576 < 1e-300 < 1e-300 ✓ sig.
Pancreatic ductal carcinoma Transitional cell carcinoma 0.759 586 < 1e-300 < 1e-300 ✓ sig.
Esophageal squamous cell carcinoma Superficial spreading melanoma 0.758 611 < 1e-300 < 1e-300 ✓ sig.
Pancreatic ductal carcinoma Plasma cell myeloma 0.757 564 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Pancreatic ductal carcinoma 0.755 551 < 1e-300 < 1e-300 ✓ sig.
Thyroid carcinoma Undifferentiated pleomorphic sarcoma 0.753 523 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Gastresophageal junction adenocarcinoma 0.752 555 < 1e-300 < 1e-300 ✓ sig.
Carcinoma Thyroid carcinoma 0.750 655 < 1e-300 < 1e-300 ✓ sig.
Gallbladder neoplasms Plasma cell myeloma 0.746 551 < 1e-300 < 1e-300 ✓ sig.
Gastresophageal junction adenocarcinoma Plasma cell myeloma 0.744 534 < 1e-300 < 1e-300 ✓ sig.
Gallbladder neoplasms Superficial spreading melanoma 0.744 531 < 1e-300 < 1e-300 ✓ sig.
Gallbladder neoplasms Transitional cell carcinoma 0.741 570 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Undifferentiated pleomorphic sarcoma 0.735 521 < 1e-300 < 1e-300 ✓ sig.
Gastresophageal junction adenocarcinoma Rectum adenocarcinoma 0.732 532 < 1e-300 < 1e-300 ✓ sig.
Cecum adenocarcinoma Gastresophageal junction adenocarcinoma 0.729 500 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Gastresophageal junction adenocarcinoma 0.729 516 < 1e-300 < 1e-300 ✓ sig.
Rectum adenocarcinoma Skin cancer 0.727 570 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Skin cancer 0.726 584 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Undifferentiated pleomorphic sarcoma 0.725 534 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Skin cancer 0.722 553 < 1e-300 < 1e-300 ✓ sig.
Rectum adenocarcinoma Undifferentiated pleomorphic sarcoma 0.720 518 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Undifferentiated pleomorphic sarcoma 0.715 485 < 1e-300 < 1e-300 ✓ sig.
Skin cancer Thyroid carcinoma 0.714 556 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Skin cancer 0.712 560 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Non-small cell lung carcinoma 0.709 672 < 1e-300 < 1e-300 ✓ sig.
Central nervous system cancer Glioma 0.705 652 < 1e-300 < 1e-300 ✓ sig.
Esophageal adenocarcinoma Rectum adenocarcinoma 0.704 520 < 1e-300 < 1e-300 ✓ sig.
Non-small cell lung carcinoma Transitional cell carcinoma 0.703 672 < 1e-300 < 1e-300 ✓ sig.
Meningioma Thyroid carcinoma 0.700 495 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Diffuse large b-cell lymphoma 0.698 541 < 1e-300 < 1e-300 ✓ sig.
Diffuse large b-cell lymphoma Rectum adenocarcinoma 0.696 526 < 1e-300 < 1e-300 ✓ sig.
Basal cell carcinoma Colon adenocarcinoma 0.696 711 < 1e-300 < 1e-300 ✓ sig.
Esophageal adenocarcinoma Plasma cell myeloma 0.692 512 < 1e-300 < 1e-300 ✓ sig.
Meningioma Plasma cell myeloma 0.688 495 < 1e-300 < 1e-300 ✓ sig.
Esophageal adenocarcinoma Nodular malignant melanoma 0.688 480 < 1e-300 < 1e-300 ✓ sig.
Non-small cell lung carcinoma Rectum adenocarcinoma 0.685 645 < 1e-300 < 1e-300 ✓ sig.
Diffuse large b-cell lymphoma Plasma cell myeloma 0.684 518 < 1e-300 < 1e-300 ✓ sig.
Meningioma Rectum adenocarcinoma 0.684 496 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Esophageal adenocarcinoma 0.684 497 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Esophageal adenocarcinoma 0.684 525 < 1e-300 < 1e-300 ✓ sig.
Diffuse large b-cell lymphoma Transitional cell carcinoma 0.682 537 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Meningioma 0.682 509 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Small cell carcinoma 0.681 475 < 1e-300 < 1e-300 ✓ sig.
Diffuse large b-cell lymphoma Gastric intestinal type adenocarcinoma 0.681 492 < 1e-300 < 1e-300 ✓ sig.
Lung cancer Squamous cell carcinoma 0.680 1,118 < 1e-300 < 1e-300 ✓ sig.
Non-small cell lung carcinoma Plasma cell myeloma 0.680 639 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Small cell carcinoma 0.678 502 < 1e-300 < 1e-300 ✓ sig.
Rectum adenocarcinoma Small cell carcinoma 0.678 488 < 1e-300 < 1e-300 ✓ sig.
Meningioma Superficial spreading melanoma 0.677 472 < 1e-300 < 1e-300 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Plasma cell myeloma 0.677 479 < 1e-300 < 1e-300 ✓ sig.
Basal cell carcinoma Transitional cell carcinoma 0.676 702 < 1e-300 < 1e-300 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Rectum adenocarcinoma 0.675 481 < 1e-300 < 1e-300 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Ductal carcinoma of breast 0.674 451 < 1e-300 < 1e-300 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Duodenal adenocarcinoma 0.672 465 < 1e-300 < 1e-300 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Colon adenocarcinoma 0.671 493 < 1e-300 < 1e-300 ✓ sig.
Osteosarcoma Rectum adenocarcinoma 0.671 505 < 1e-300 < 1e-300 ✓ sig.
Basal cell carcinoma Rectum adenocarcinoma 0.671 682 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Small cell carcinoma 0.670 482 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Non-small cell lung carcinoma 0.670 622 < 1e-300 < 1e-300 ✓ sig.
Cecum adenocarcinoma Small cell carcinoma 0.667 454 < 1e-300 < 1e-300 ✓ sig.
Osteosarcoma Plasma cell myeloma 0.664 499 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Osteosarcoma 0.661 514 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Osteosarcoma 0.659 486 < 1e-300 < 1e-300 ✓ sig.
Basal cell carcinoma Plasma cell myeloma 0.659 672 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Melanoma 0.658 730 < 1e-300 < 1e-300 ✓ sig.
Osteosarcoma Thyroid carcinoma 0.652 489 < 1e-300 < 1e-300 ✓ sig.
Large cell carcinoma Rectum adenocarcinoma 0.648 463 < 1e-300 < 1e-300 ✓ sig.
Large cell carcinoma Nodular malignant melanoma 0.646 430 < 1e-300 < 1e-300 ✓ sig.
Large cell carcinoma Superficial spreading melanoma 0.645 441 < 1e-300 < 1e-300 ✓ sig.
Melanoma Transitional cell carcinoma 0.645 724 < 1e-300 < 1e-300 ✓ sig.
Basal cell carcinoma Bile duct cancer 0.641 650 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Large cell carcinoma 0.641 473 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Large cell carcinoma 0.641 446 < 1e-300 < 1e-300 ✓ sig.
Anaplastic astrocytoma Ductal carcinoma of breast 0.635 419 < 1e-300 < 1e-300 ✓ sig.
Anaplastic astrocytoma Nodular malignant melanoma 0.632 415 < 1e-300 < 1e-300 ✓ sig.
Melanoma Rectum adenocarcinoma 0.631 698 < 1e-300 < 1e-300 ✓ sig.
Anaplastic astrocytoma Superficial spreading melanoma 0.626 424 < 1e-300 < 1e-300 ✓ sig.
Melanoma Plasma cell myeloma 0.626 692 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Richter transformation 0.622 401 < 1e-300 < 1e-300 ✓ sig.
Anaplastic astrocytoma Cecum adenocarcinoma 0.619 413 < 1e-300 < 1e-300 ✓ sig.
Anaplastic astrocytoma Plasma cell myeloma 0.616 437 < 1e-300 < 1e-300 ✓ sig.
Melanoma Thyroid carcinoma 0.602 671 < 1e-300 < 1e-300 ✓ sig.
Angiosarcoma Plasma cell myeloma 0.602 423 < 1e-300 < 1e-300 ✓ sig.
Angiosarcoma Thyroid carcinoma 0.601 418 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Gastric adenoma 0.597 409 < 1e-300 < 1e-300 ✓ sig.
Angiosarcoma B-cell chronic lymphocytic leukemia 0.594 396 < 1e-300 < 1e-300 ✓ sig.
Angiosarcoma Meningioma 0.594 355 < 1e-300 < 1e-300 ✓ sig.
Angiosarcoma Duodenal adenocarcinoma 0.593 408 < 1e-300 < 1e-300 ✓ sig.
Cecum adenocarcinoma Gastric adenoma 0.593 393 < 1e-300 < 1e-300 ✓ sig.
Gastric adenoma Gastric intestinal type adenocarcinoma 0.592 395 < 1e-300 < 1e-300 ✓ sig.
Richter transformation Undifferentiated pleomorphic sarcoma 0.587 352 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Richter transformation 0.584 409 < 1e-300 < 1e-300 ✓ sig.
Gastric adenoma Rectum adenocarcinoma 0.583 416 < 1e-300 < 1e-300 ✓ sig.
Richter transformation Thyroid carcinoma 0.583 404 < 1e-300 < 1e-300 ✓ sig.
Gastric adenoma Plasma cell myeloma 0.583 413 < 1e-300 < 1e-300 ✓ sig.
Astrocytoma (excluding glioblastoma) Duodenal adenocarcinoma 0.573 392 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Richter transformation 0.572 379 < 1e-300 < 1e-300 ✓ sig.
Astrocytoma (excluding glioblastoma) Bile duct cancer 0.569 391 < 1e-300 < 1e-300 ✓ sig.
Hodgkin lymphoma Rectum adenocarcinoma 0.567 464 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Hodgkin lymphoma 0.566 476 < 1e-300 < 1e-300 ✓ sig.
Astrocytoma (excluding glioblastoma) Rectum adenocarcinoma 0.565 402 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Hodgkin lymphoma 0.564 450 < 1e-300 < 1e-300 ✓ sig.
Hodgkin lymphoma Plasma cell myeloma 0.564 460 < 1e-300 < 1e-300 ✓ sig.
Astrocytoma (excluding glioblastoma) Cecum adenocarcinoma 0.562 374 < 1e-300 < 1e-300 ✓ sig.
Duodenal adenocarcinoma Hodgkin lymphoma 0.561 448 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Glioblastoma 0.561 723 < 1e-300 < 1e-300 ✓ sig.
Gastrointestinal stromal tumor Plasma cell myeloma 0.561 415 < 1e-300 < 1e-300 ✓ sig.
Astrocytoma (excluding glioblastoma) Superficial spreading melanoma 0.560 381 < 1e-300 < 1e-300 ✓ sig.
Gastrointestinal stromal tumor Superficial spreading melanoma 0.559 398 < 1e-300 < 1e-300 ✓ sig.
Nodular malignant melanoma Peripheral primitive neuroectodermal tumor 0.556 365 < 1e-300 < 1e-300 ✓ sig.
Gastrointestinal stromal tumor Rectum adenocarcinoma 0.556 415 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Gastrointestinal stromal tumor 0.552 401 < 1e-300 < 1e-300 ✓ sig.
Peripheral primitive neuroectodermal tumor Rectum adenocarcinoma 0.552 392 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Hemangioblastoma 0.551 360 < 1e-300 < 1e-300 ✓ sig.
Glioblastoma Transitional cell carcinoma 0.551 717 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Gastrointestinal stromal tumor 0.549 424 < 1e-300 < 1e-300 ✓ sig.
Peripheral primitive neuroectodermal tumor Superficial spreading melanoma 0.549 372 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Peripheral primitive neuroectodermal tumor 0.548 364 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Peripheral primitive neuroectodermal tumor 0.546 377 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Lung cancer 0.546 729 < 1e-300 < 1e-300 ✓ sig.
Gastric intestinal type adenocarcinoma Hemangioblastoma 0.545 360 < 1e-300 < 1e-300 ✓ sig.
Nodular malignant melanoma Rhabdomyosarcoma 0.543 359 < 1e-300 < 1e-300 ✓ sig.
Glioblastoma Rectum adenocarcinoma 0.535 689 < 1e-300 < 1e-300 ✓ sig.
Eccrine porocarcinoma Nodular malignant melanoma 0.535 347 < 1e-300 < 1e-300 ✓ sig.
Hemangioblastoma Superficial spreading melanoma 0.533 360 < 1e-300 < 1e-300 ✓ sig.
B-cell acute lymphoblastic leukemia Colon adenocarcinoma 0.533 419 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Gastric cancer 0.533 493 < 1e-300 < 1e-300 ✓ sig.
Gastric intestinal type adenocarcinoma Rhabdomyosarcoma 0.532 359 < 1e-300 < 1e-300 ✓ sig.
Glioblastoma Plasma cell myeloma 0.531 683 < 1e-300 < 1e-300 ✓ sig.
Lung cancer Transitional cell carcinoma 0.530 718 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Rhabdomyosarcoma 0.530 379 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Hemangioblastoma 0.529 364 < 1e-300 < 1e-300 ✓ sig.
Hemangioblastoma Nodular malignant melanoma 0.529 348 < 1e-300 < 1e-300 ✓ sig.
Gastric intestinal type adenocarcinoma Gastric neuroendocrine tumor g1 0.528 350 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Gastric neuroendocrine tumor g1 0.528 361 < 1e-300 < 1e-300 ✓ sig.
Gastric neuroendocrine tumor g1 Rectum adenocarcinoma 0.528 373 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Rhabdomyosarcoma 0.527 356 < 1e-300 < 1e-300 ✓ sig.
Acute myeloid leukemia Duodenal adenocarcinoma 0.527 368 < 1e-300 < 1e-300 ✓ sig.
Rhabdomyosarcoma Superficial spreading melanoma 0.527 362 < 1e-300 < 1e-300 ✓ sig.
Acute myeloid leukemia Thyroid carcinoma 0.527 374 < 1e-300 < 1e-300 ✓ sig.
Eccrine porocarcinoma Gastric intestinal type adenocarcinoma 0.526 348 < 1e-300 < 1e-300 ✓ sig.
Gastresophageal junction adenocarcinoma Gastric neuroendocrine tumor g1 0.525 323 < 1e-300 < 1e-300 ✓ sig.
B-cell acute lymphoblastic leukemia Rectum adenocarcinoma 0.525 403 < 1e-300 < 1e-300 ✓ sig.
Gastric neuroendocrine tumor g1 Plasma cell myeloma 0.524 369 < 1e-300 < 1e-300 ✓ sig.
Cecum adenocarcinoma Eccrine porocarcinoma 0.524 345 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Eccrine porocarcinoma 0.523 358 < 1e-300 < 1e-300 ✓ sig.
Acute myeloid leukemia Superficial spreading melanoma 0.523 361 < 1e-300 < 1e-300 ✓ sig.
Acute myeloid leukemia Plasma cell myeloma 0.522 376 < 1e-300 < 1e-300 ✓ sig.
Lung cancer Rectum adenocarcinoma 0.522 696 < 1e-300 < 1e-300 ✓ sig.
Acute myeloid leukemia Bile duct cancer 0.521 366 < 1e-300 < 1e-300 ✓ sig.
Eccrine porocarcinoma Rectum adenocarcinoma 0.521 369 < 1e-300 < 1e-300 ✓ sig.
Gastric cancer Rectum adenocarcinoma 0.521 474 < 1e-300 < 1e-300 ✓ sig.
B-cell acute lymphoblastic leukemia Plasma cell myeloma 0.520 398 < 1e-300 < 1e-300 ✓ sig.
Gastric cancer Transitional cell carcinoma 0.519 487 < 1e-300 < 1e-300 ✓ sig.
B-cell acute lymphoblastic leukemia Transitional cell carcinoma 0.518 414 < 1e-300 < 1e-300 ✓ sig.
Glioblastoma Thyroid carcinoma 0.518 668 < 1e-300 < 1e-300 ✓ sig.
Lung cancer Plasma cell myeloma 0.515 688 < 1e-300 < 1e-300 ✓ sig.
Duodenal adenocarcinoma Placental choriocarcinoma 0.515 350 < 1e-300 < 1e-300 ✓ sig.
Placental choriocarcinoma Plasma cell myeloma 0.514 360 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Placental choriocarcinoma 0.513 350 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Her2 positive breast carcinoma 0.511 334 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Her2 positive breast carcinoma 0.511 347 < 1e-300 < 1e-300 ✓ sig.
Gastric intestinal type adenocarcinoma Placental choriocarcinoma 0.511 338 < 1e-300 < 1e-300 ✓ sig.
Oral cavity carcinoma Placental choriocarcinoma 0.510 346 < 1e-300 < 1e-300 ✓ sig.
B-cell acute lymphoblastic leukemia Thyroid carcinoma 0.508 388 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Squamous cell carcinoma 0.507 729 < 1e-300 < 1e-300 ✓ sig.
Duodenal adenocarcinoma Small intestinal tubulovillous adenoma 0.506 342 < 1e-300 < 1e-300 ✓ sig.
Her2 positive breast carcinoma Undifferentiated pleomorphic sarcoma 0.505 301 < 1e-300 < 1e-300 ✓ sig.
Her2 positive breast carcinoma Plasma cell myeloma 0.504 353 < 1e-300 < 1e-300 ✓ sig.
Gastric cancer Plasma cell myeloma 0.503 461 < 1e-300 < 1e-300 ✓ sig.
Her2 positive breast carcinoma Rectum adenocarcinoma 0.503 355 < 1e-300 < 1e-300 ✓ sig.
Gastric intestinal type adenocarcinoma Small intestinal tubulovillous adenoma 0.502 330 < 1e-300 < 1e-300 ✓ sig.
Lentigo maligna melanoma Superficial spreading melanoma 0.501 330 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Gastric cancer 0.499 449 < 1e-300 < 1e-300 ✓ sig.
Lentigo maligna melanoma Nodular malignant melanoma 0.495 318 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Small intestinal tubulovillous adenoma 0.495 347 < 1e-300 < 1e-300 ✓ sig.
Squamous cell carcinoma Transitional cell carcinoma 0.495 720 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Small intestinal tubulovillous adenoma 0.493 324 < 1e-300 < 1e-300 ✓ sig.
Nodular malignant melanoma Small intestinal tubulovillous adenoma 0.492 321 < 1e-300 < 1e-300 ✓ sig.
Acral lentiginous melanoma Nodular malignant melanoma 0.486 312 < 1e-300 < 1e-300 ✓ sig.
Lentigo maligna melanoma Small cell carcinoma 0.485 277 < 1e-300 < 1e-300 ✓ sig.
Rectum adenocarcinoma Squamous cell carcinoma 0.484 696 < 1e-300 < 1e-300 ✓ sig.
Basal cell carcinoma Squamous cell carcinoma 0.484 793 < 1e-300 < 1e-300 ✓ sig.
Glioblastoma Glioma 0.484 712 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Lentigo maligna melanoma 0.484 328 < 1e-300 < 1e-300 ✓ sig.
Plasma cell myeloma Urinary bladder cancer 0.481 364 < 1e-300 < 1e-300 ✓ sig.
Lentigo maligna melanoma Plasma cell myeloma 0.479 335 < 1e-300 < 1e-300 ✓ sig.
Acral lentiginous melanoma Gastric intestinal type adenocarcinoma 0.478 313 < 1e-300 < 1e-300 ✓ sig.
Nodular malignant melanoma Urinary bladder cancer 0.477 338 < 1e-300 < 1e-300 ✓ sig.
Superficial spreading melanoma Urinary bladder cancer 0.476 347 < 1e-300 < 1e-300 ✓ sig.
Ductal carcinoma of breast Mantle cell lymphoma 0.476 303 < 1e-300 < 1e-300 ✓ sig.
Gastric intestinal type adenocarcinoma Urinary bladder cancer 0.476 342 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Urinary bladder cancer 0.476 341 < 1e-300 < 1e-300 ✓ sig.
Acral lentiginous melanoma Cecum adenocarcinoma 0.475 310 < 1e-300 < 1e-300 ✓ sig.
Colorectal cancer Lung cancer 0.475 953 < 1e-300 < 1e-300 ✓ sig.
Acral lentiginous melanoma Superficial spreading melanoma 0.474 316 < 1e-300 < 1e-300 ✓ sig.
Anaplastic (malignant) meningioma Meningioma 0.472 261 < 1e-300 < 1e-300 ✓ sig.
Acral lentiginous melanoma Bile duct cancer 0.471 320 < 1e-300 < 1e-300 ✓ sig.
Adenoid cystic carcinoma Thyroid carcinoma 0.458 347 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Mantle cell lymphoma 0.457 296 < 1e-300 < 1e-300 ✓ sig.
Adenoid cystic carcinoma Cecum adenocarcinoma 0.456 329 < 1e-300 < 1e-300 ✓ sig.
Adenoid cystic carcinoma Duodenal adenocarcinoma 0.454 339 < 1e-300 < 1e-300 ✓ sig.
Anaplastic (malignant) meningioma Undifferentiated pleomorphic sarcoma 0.454 259 < 1e-300 < 1e-300 ✓ sig.
Adenoid cystic carcinoma Bile duct cancer 0.453 339 < 1e-300 < 1e-300 ✓ sig.
Adenoid cystic carcinoma Superficial spreading melanoma 0.451 333 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Colorectal cancer 0.451 734 < 1e-300 < 1e-300 ✓ sig.
Mantle cell lymphoma Meningioma 0.450 259 < 1e-300 < 1e-300 ✓ sig.
Colorectal cancer Squamous cell carcinoma 0.449 949 < 1e-300 < 1e-300 ✓ sig.
Mantle cell lymphoma Undifferentiated pleomorphic sarcoma 0.446 262 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Digestive system melanoma 0.440 288 < 1e-300 < 1e-300 ✓ sig.
Colorectal cancer Transitional cell carcinoma 0.439 723 < 1e-300 < 1e-300 ✓ sig.
Digestive system melanoma Gastric intestinal type adenocarcinoma 0.438 288 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Ovarian serous carcinoma 0.437 424 < 1e-300 < 1e-300 ✓ sig.
Digestive system melanoma Thyroid carcinoma 0.436 302 < 1e-300 < 1e-300 ✓ sig.
Digestive system melanoma Nodular malignant melanoma 0.434 282 < 1e-300 < 1e-300 ✓ sig.
Lung cancer Prostate cancer 0.432 859 < 1e-300 < 1e-300 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Digestive system melanoma 0.432 243 < 1e-300 < 1e-300 ✓ sig.
Ovarian serous carcinoma Plasma cell myeloma 0.430 407 < 1e-300 < 1e-300 ✓ sig.
Colorectal cancer Rectum adenocarcinoma 0.430 700 < 1e-300 < 1e-300 ✓ sig.
Ovarian serous carcinoma Transitional cell carcinoma 0.429 421 < 1e-300 < 1e-300 ✓ sig.
Anaplastic (malignant) meningioma Ductal carcinoma of breast 0.429 276 < 1e-300 < 1e-300 ✓ sig.
Carcinoma of the ampulla of vater Superficial spreading melanoma 0.426 283 < 1e-300 < 1e-300 ✓ sig.
Anaplastic (malignant) meningioma B-cell chronic lymphocytic leukemia 0.426 276 < 1e-300 < 1e-300 ✓ sig.
Carcinoma of the ampulla of vater Gastric intestinal type adenocarcinoma 0.425 278 < 1e-300 < 1e-300 ✓ sig.
Lung cancer Ovarian serous carcinoma 0.424 593 < 1e-300 < 1e-300 ✓ sig.
Ovarian serous carcinoma Rectum adenocarcinoma 0.424 405 < 1e-300 < 1e-300 ✓ sig.
Pancreatic acinar cell carcinoma Undifferentiated pleomorphic sarcoma 0.422 245 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Hepatocellular carcinoma 0.416 545 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Pancreatic acinar cell carcinoma 0.415 270 < 1e-300 < 1e-300 ✓ sig.
Cecum adenocarcinoma Pancreatic acinar cell carcinoma 0.415 269 < 1e-300 < 1e-300 ✓ sig.
Carcinoma of the ampulla of vater Rectum adenocarcinoma 0.415 293 < 1e-300 < 1e-300 ✓ sig.
Extramammary paget disease Gastresophageal junction adenocarcinoma 0.412 244 < 1e-300 < 1e-300 ✓ sig.
Nodular malignant melanoma Pancreatic acinar cell carcinoma 0.411 265 < 1e-300 < 1e-300 ✓ sig.
Hepatocellular carcinoma Rectum adenocarcinoma 0.411 530 < 1e-300 < 1e-300 ✓ sig.
Hepatocellular carcinoma Transitional cell carcinoma 0.409 541 < 1e-300 < 1e-300 ✓ sig.
Prostate cancer Squamous cell carcinoma 0.408 855 < 1e-300 < 1e-300 ✓ sig.
Cecum adenocarcinoma Extramammary paget disease 0.407 262 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Hepatocellular carcinoma 0.404 514 < 1e-300 < 1e-300 ✓ sig.
Hepatocellular carcinoma Plasma cell myeloma 0.402 520 < 1e-300 < 1e-300 ✓ sig.
Extramammary paget disease Gastric intestinal type adenocarcinoma 0.402 261 < 1e-300 < 1e-300 ✓ sig.
Central nervous system cancer Glioblastoma 0.400 556 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Prostate cancer 0.396 638 < 1e-300 < 1e-300 ✓ sig.
B-cell chronic lymphocytic leukemia Brain stem glioblastoma 0.393 254 < 1e-300 < 1e-300 ✓ sig.
Prostate cancer Transitional cell carcinoma 0.391 635 < 1e-300 < 1e-300 ✓ sig.
Colorectal cancer Prostate cancer 0.389 881 < 1e-300 < 1e-300 ✓ sig.
Brain stem glioblastoma Ductal carcinoma of breast 0.385 249 < 1e-300 < 1e-300 ✓ sig.
Nodular malignant melanoma Rectal tubular adenoma 0.375 238 < 1e-300 < 1e-300 ✓ sig.
Endometrial hyperplasia Gastric intestinal type adenocarcinoma 0.373 241 < 1e-300 < 1e-300 ✓ sig.
Colon adenocarcinoma Female breast carcinoma 0.371 273 < 1e-300 < 1e-300 ✓ sig.
Female breast carcinoma Plasma cell myeloma 0.366 259 < 1e-300 < 1e-300 ✓ sig.
Bile duct cancer Female breast carcinoma 0.363 250 < 1e-300 < 1e-300 ✓ sig.
Female breast carcinoma Rectum adenocarcinoma 0.360 258 < 1e-300 < 1e-300 ✓ sig.
Female breast carcinoma Transitional cell carcinoma 0.360 269 < 1e-300 < 1e-300 ✓ sig.
Brain stem glioblastoma Undifferentiated pleomorphic sarcoma 0.404 232 2.48e-319 2.38e-317 ✓ sig.
Mantle cell lymphoma Richter transformation 0.458 229 4.28e-317 4.08e-315 ✓ sig.
Carcinoma of the ampulla of vater Small cell carcinoma 0.417 237 6.61e-317 6.29e-315 ✓ sig.
Meningioma Pancreatic acinar cell carcinoma 0.409 235 4.73e-315 4.49e-313 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Extramammary paget disease 0.420 228 3.18e-314 3.01e-312 ✓ sig.
Duodenal adenocarcinoma T-cell acute lymphoblastic leukemia 0.339 230 2.86e-312 2.69e-310 ✓ sig.
Bile duct cancer T-cell acute lymphoblastic leukemia 0.336 229 3.47e-309 3.25e-307 ✓ sig.
Lymphoblastic leukemia Superficial spreading melanoma 0.355 251 2.37e-307 2.21e-305 ✓ sig.
Anaplastic (malignant) meningioma Angiosarcoma 0.435 220 3.63e-302 3.37e-300 ✓ sig.
Superficial spreading melanoma T-cell acute lymphoblastic leukemia 0.337 225 1.07e-301 9.87e-300 ✓ sig.
Endometrial hyperplasia Gastresophageal junction adenocarcinoma 0.374 221 8.29e-301 7.65e-299 ✓ sig.
Gastric intestinal type adenocarcinoma Lymphoblastic leukemia 0.353 246 1.39e-299 1.27e-297 ✓ sig.
Gastric intestinal type adenocarcinoma T-cell acute lymphoblastic leukemia 0.336 221 3.32e-294 3.03e-292 ✓ sig.
Ductal carcinoma of breast Liposarcoma 0.323 206 3.47e-287 3.15e-285 ✓ sig.
Extramammary paget disease Gastric adenoma 0.415 207 9.26e-283 8.34e-281 ✓ sig.
Rectal tubular adenoma Small cell carcinoma 0.377 208 1.62e-281 1.46e-279 ✓ sig.
Brain stem glioblastoma Central nervous system primitive neuroectodermal neoplasm 0.382 211 6.73e-280 6.03e-278 ✓ sig.
Gastresophageal junction adenocarcinoma Parathyroid carcinoma 0.350 206 9.02e-279 8.04e-277 ✓ sig.
Anaplastic lung carcinoma Rectum adenocarcinoma 0.283 199 4.15e-277 3.67e-275 ✓ sig.
Endometrial hyperplasia Small cell carcinoma 0.371 206 4.39e-276 3.88e-274 ✓ sig.
Ependymoma Undifferentiated pleomorphic sarcoma 0.345 191 1.12e-271 9.81e-270 ✓ sig.
Gastric intestinal type adenocarcinoma Renal pelvis urothelial carcinoma 0.307 199 2.86e-269 2.48e-267 ✓ sig.
Lymphoblastic leukemia Undifferentiated pleomorphic sarcoma 0.354 221 5.95e-268 5.15e-266 ✓ sig.
Carcinoma of the ampulla of vater Placental choriocarcinoma 0.418 196 5.64e-266 4.85e-264 ✓ sig.
Plasma cell myeloma T-cell leukemia-lymphoma 0.292 210 1.10e-265 9.43e-264 ✓ sig.
T-cell acute lymphoblastic leukemia Undifferentiated pleomorphic sarcoma 0.344 200 1.55e-262 1.32e-260 ✓ sig.
Gastrointestinal stromal tumor Renal pelvis urothelial carcinoma 0.371 183 8.82e-261 7.52e-259 ✓ sig.
Childhood kidney wilms tumor Undifferentiated pleomorphic sarcoma 0.339 193 5.17e-260 4.39e-258 ✓ sig.
Brain stem glioblastoma Richter transformation 0.384 190 1.66e-252 1.39e-250 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Ependymoma 0.345 180 9.84e-252 8.19e-250 ✓ sig.
Duodenal adenocarcinoma T-cell prolymphocytic leukemia 0.277 187 2.14e-251 1.78e-249 ✓ sig.
Liposarcoma Meningioma 0.333 184 1.25e-249 1.03e-247 ✓ sig.
Gastric adenoma Rectal tubular adenoma 0.376 186 1.26e-249 1.03e-247 ✓ sig.
Liposarcoma Undifferentiated pleomorphic sarcoma 0.326 185 4.64e-249 3.79e-247 ✓ sig.
Astrocytoma (excluding glioblastoma) Endometrial hyperplasia 0.382 184 1.40e-248 1.14e-246 ✓ sig.
Breast cancer Lung cancer 0.249 516 2.28e-248 1.86e-246 ✓ sig.
Acute myeloid leukemia Lymphoblastic leukemia 0.377 195 6.09e-248 4.92e-246 ✓ sig.
Gastric intestinal type adenocarcinoma T-cell leukemia-lymphoma 0.295 198 2.49e-247 2.01e-245 ✓ sig.
Acute myeloid leukemia Myelodysplastic syndrome 0.384 183 9.46e-247 7.60e-245 ✓ sig.
Large cell carcinoma Parathyroid carcinoma 0.350 185 3.24e-246 2.59e-244 ✓ sig.
Breast cancer Prostate cancer 0.245 545 7.19e-245 5.75e-243 ✓ sig.
Childhood kidney wilms tumor Small cell carcinoma 0.335 184 1.74e-244 1.39e-242 ✓ sig.
Cecum adenocarcinoma T-cell leukemia-lymphoma 0.294 196 8.21e-244 6.53e-242 ✓ sig.
Skin cancer Skin neoplasms 0.291 208 2.23e-242 1.76e-240 ✓ sig.
Anaplastic lung carcinoma Superficial spreading melanoma 0.276 184 2.44e-242 1.93e-240 ✓ sig.
Nodular malignant melanoma T-cell leukemia-lymphoma 0.293 194 1.17e-240 9.14e-239 ✓ sig.
Gastrointestinal stromal tumor Parathyroid carcinoma 0.350 181 2.13e-240 1.67e-238 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Childhood kidney wilms tumor 0.336 181 2.36e-240 1.85e-238 ✓ sig.
Astrocytoma (excluding glioblastoma) Parathyroid carcinoma 0.372 176 3.09e-240 2.40e-238 ✓ sig.
Anaplastic lung carcinoma Cecum adenocarcinoma 0.279 181 6.56e-238 5.07e-236 ✓ sig.
Anaplastic astrocytoma Parathyroid carcinoma 0.351 179 7.25e-238 5.58e-236 ✓ sig.
Anaplastic lung carcinoma Gastric intestinal type adenocarcinoma 0.277 181 4.96e-237 3.81e-235 ✓ sig.
Diffuse gastric adenocarcinoma Duodenal adenocarcinoma 0.269 185 9.83e-236 7.52e-234 ✓ sig.
Acute myeloid leukemia T-cell large granular lymphocyte leukemia 0.366 169 2.10e-231 1.59e-229 ✓ sig.
Nodular malignant melanoma T-cell prolymphocytic leukemia 0.274 176 1.00e-229 7.57e-228 ✓ sig.
Ependymoma Richter transformation 0.357 164 2.51e-229 1.89e-227 ✓ sig.
Eccrine porocarcinoma Rectal tubular adenoma 0.370 170 2.05e-227 1.54e-225 ✓ sig.
Gastresophageal junction adenocarcinoma T-cell leukemia-lymphoma 0.300 183 7.06e-227 5.29e-225 ✓ sig.
Gastric adenoma T-cell large granular lymphocyte leukemia 0.346 169 1.51e-225 1.13e-223 ✓ sig.
B-cell chronic lymphocytic leukemia Primary central nervous system lymphoma 0.260 168 2.48e-224 1.85e-222 ✓ sig.
Anaplastic astrocytoma Papillary renal cell carcinoma 0.332 165 2.32e-223 1.72e-221 ✓ sig.
Breast cancer Colorectal cancer 0.231 541 7.68e-223 5.68e-221 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Myelodysplastic syndrome 0.318 181 6.14e-222 4.53e-220 ✓ sig.
Myelodysplastic syndrome Small cell carcinoma 0.312 182 2.80e-221 2.06e-219 ✓ sig.
Her2 positive breast carcinoma Rectal tubular adenoma 0.368 165 9.73e-221 7.12e-219 ✓ sig.
Peripheral primitive neuroectodermal tumor T-cell large granular lymphocyte leukemia 0.349 163 2.96e-218 2.16e-216 ✓ sig.
Breast cancer Squamous cell carcinoma 0.230 503 6.49e-217 4.70e-215 ✓ sig.
Breast cancer Ovarian serous carcinoma 0.223 349 9.54e-215 6.88e-213 ✓ sig.
Diffuse gastric adenocarcinoma Gastresophageal junction adenocarcinoma 0.280 168 2.09e-212 1.50e-210 ✓ sig.
Angiosarcoma Liposarcoma 0.327 160 8.71e-212 6.24e-210 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Gliomatosis cerebri 0.298 156 1.25e-211 8.91e-210 ✓ sig.
Papillary renal cell carcinoma Peripheral primitive neuroectodermal tumor 0.340 155 4.46e-211 3.18e-209 ✓ sig.
Eccrine porocarcinoma T-cell large granular lymphocyte leukemia 0.350 157 7.75e-211 5.52e-209 ✓ sig.
Diffuse large b-cell lymphoma Primary central nervous system lymphoma 0.261 158 1.97e-206 1.38e-204 ✓ sig.
Gastric adenoma Papillary renal cell carcinoma 0.321 155 1.24e-205 8.66e-204 ✓ sig.
Anaplastic astrocytoma Gliomatosis cerebri 0.307 150 1.47e-204 1.02e-202 ✓ sig.
Basal cell carcinoma Skin neoplasms 0.200 211 4.48e-204 3.12e-202 ✓ sig.
Childhood kidney wilms tumor Peripheral primitive neuroectodermal tumor 0.328 155 5.19e-202 3.59e-200 ✓ sig.
Gastric adenoma Renal pelvis urothelial carcinoma 0.307 151 2.76e-194 1.88e-192 ✓ sig.
Peripheral primitive neuroectodermal tumor Renal pelvis urothelial carcinoma 0.316 148 3.97e-193 2.69e-191 ✓ sig.
Her2 positive breast carcinoma Papillary renal cell carcinoma 0.329 141 4.78e-189 3.22e-187 ✓ sig.
Anaplastic lung carcinoma Large cell carcinoma 0.282 149 7.67e-189 5.16e-187 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Diffuse gastric adenocarcinoma 0.276 152 1.92e-188 1.29e-186 ✓ sig.
Diffuse gastric adenocarcinoma Small cell carcinoma 0.270 152 2.90e-186 1.93e-184 ✓ sig.
Mantle cell lymphoma T-cell large granular lymphocyte leukemia 0.342 138 3.34e-185 2.21e-183 ✓ sig.
Gastrointestinal stromal tumor T-cell prolymphocytic leukemia 0.282 145 1.59e-184 1.05e-182 ✓ sig.
Gastric neuroendocrine tumor g1 Gliomatosis cerebri 0.307 133 1.43e-179 9.28e-178 ✓ sig.
Anaplastic (malignant) meningioma Ependymoma 0.346 129 5.62e-179 3.62e-177 ✓ sig.
Renal pelvis urothelial carcinoma Small intestinal tubulovillous adenoma 0.314 136 1.81e-177 1.15e-175 ✓ sig.
Childhood kidney wilms tumor Mantle cell lymphoma 0.327 133 1.73e-175 1.09e-173 ✓ sig.
Gastric adenoma T-cell prolymphocytic leukemia 0.282 138 2.53e-175 1.59e-173 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Chromophobe renal cell carcinoma 0.253 133 5.03e-175 3.14e-173 ✓ sig.
Retinoblastoma Undifferentiated pleomorphic sarcoma 0.226 123 1.17e-174 7.30e-173 ✓ sig.
Brain stem glioblastoma Ependymoma 0.350 124 3.03e-174 1.88e-172 ✓ sig.
Anaplastic astrocytoma Diffuse gastric adenocarcinoma 0.269 140 1.43e-170 8.74e-169 ✓ sig.
Gastric adenoma Primary central nervous system lymphoma 0.262 127 9.87e-161 5.80e-159 ✓ sig.
Small intestinal tubulovillous adenoma T-cell prolymphocytic leukemia 0.280 121 1.69e-153 9.58e-152 ✓ sig.
Astrocytoma Glioma 0.190 217 2.62e-149 1.47e-147 ✓ sig.
Carcinoma of the ampulla of vater Gliomatosis cerebri 0.293 110 2.38e-146 1.32e-144 ✓ sig.
Gastric neuroendocrine tumor g1 Primary central nervous system lymphoma 0.260 116 5.86e-146 3.25e-144 ✓ sig.
Chromophobe renal cell carcinoma Rhabdomyosarcoma 0.250 113 4.79e-145 2.64e-143 ✓ sig.
B-cell prolymphocytic leukemia Richter transformation 0.233 101 2.57e-144 1.41e-142 ✓ sig.
Adenosquamous lung carcinoma Her2 positive breast carcinoma 0.262 106 8.52e-144 4.67e-142 ✓ sig.
Astrocytoma (excluding glioblastoma) Rectal tubulovillous adenoma 0.236 105 6.29e-142 3.42e-140 ✓ sig.
Gastric neuroendocrine tumor g1 Thyroid gland oncocytic follicular carcinoma 0.252 110 5.59e-141 3.01e-139 ✓ sig.
Angiosarcoma Cecum villous adenoma 0.229 107 9.90e-141 5.33e-139 ✓ sig.
Angiosarcoma Retinoblastoma 0.226 104 1.71e-140 9.21e-139 ✓ sig.
Gallbladder adenoma Gallbladder biliary intraepithelial neoplasia 0.436 78 1.84e-140 9.85e-139 ✓ sig.
Retinoblastoma Richter transformation 0.229 102 4.52e-138 2.40e-136 ✓ sig.
Astrocytoma Gastric intestinal type adenocarcinoma 0.201 182 1.53e-137 8.08e-136 ✓ sig.
Burkitt lymphoma Richter transformation 0.228 103 5.53e-136 2.90e-134 ✓ sig.
Astrocytoma Ductal carcinoma of breast 0.198 179 1.60e-134 8.37e-133 ✓ sig.
Astrocytoma Hemangioblastoma 0.215 149 3.08e-132 1.60e-130 ✓ sig.
Cecum villous adenoma Richter transformation 0.224 102 3.58e-132 1.86e-130 ✓ sig.
Myelodysplastic syndrome Myeloid leukemia 0.270 107 2.76e-131 1.42e-129 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Medulloblastoma 0.203 110 5.15e-130 2.64e-128 ✓ sig.
Medulloblastoma Richter transformation 0.223 105 2.71e-129 1.38e-127 ✓ sig.
Lentigo maligna melanoma Thyroid gland oncocytic follicular carcinoma 0.249 101 1.14e-128 5.80e-127 ✓ sig.
Cecum villous adenoma Peripheral primitive neuroectodermal tumor 0.223 99 1.24e-127 6.32e-126 ✓ sig.
Gliomatosis cerebri Parathyroid carcinoma 0.286 94 2.08e-126 1.05e-124 ✓ sig.
Acute myeloid leukemia Myeloid leukemia 0.225 119 2.69e-126 1.36e-124 ✓ sig.
Adenosquamous lung carcinoma Eccrine porocarcinoma 0.226 97 7.38e-123 3.67e-121 ✓ sig.
Meningioma Skin neoplasms 0.197 130 5.28e-122 2.61e-120 ✓ sig.
Adenosquamous lung carcinoma Small intestinal tubulovillous adenoma 0.232 95 9.94e-122 4.90e-120 ✓ sig.
Astrocytoma Astrocytoma (excluding glioblastoma) 0.201 145 1.71e-121 8.40e-120 ✓ sig.
Adenosquamous lung carcinoma Placental choriocarcinoma 0.226 95 3.74e-120 1.83e-118 ✓ sig.
Placental choriocarcinoma Rectal tubulovillous adenoma 0.224 92 5.50e-120 2.69e-118 ✓ sig.
B-cell prolymphocytic leukemia Mantle cell lymphoma 0.241 84 2.60e-118 1.26e-116 ✓ sig.
Burkitt lymphoma Mantle cell lymphoma 0.242 88 7.55e-118 3.65e-116 ✓ sig.
Neoplasms Peripheral primitive neuroectodermal tumor 0.211 99 1.39e-116 6.67e-115 ✓ sig.
Large cell carcinoma Skin neoplasms 0.198 123 1.51e-116 7.24e-115 ✓ sig.
Chromophobe renal cell carcinoma Endometrial hyperplasia 0.263 87 1.02e-115 4.84e-114 ✓ sig.
Acinar lung adenocarcinoma Rhabdomyosarcoma 0.202 88 6.74e-115 3.19e-113 ✓ sig.
Acral lentiginous melanoma Endometrial serous adenocarcinoma 0.226 85 3.10e-114 1.46e-112 ✓ sig.
Gallbladder adenoma Placental choriocarcinoma 0.212 86 1.89e-113 8.85e-112 ✓ sig.
Acinar lung adenocarcinoma Eccrine porocarcinoma 0.208 86 2.46e-113 1.15e-111 ✓ sig.
Gallbladder adenoma Her2 positive breast carcinoma 0.213 85 4.60e-112 2.14e-110 ✓ sig.
Primary central nervous system lymphoma T-cell large granular lymphocyte leukemia 0.261 85 3.40e-111 1.57e-109 ✓ sig.
Gallbladder adenoma Pancreatic acinar cell carcinoma 0.240 80 1.40e-110 6.42e-109 ✓ sig.
Chromophobe renal cell carcinoma Papillary renal cell carcinoma 0.272 80 5.40e-110 2.47e-108 ✓ sig.
Extramammary paget disease Rectal tubulovillous adenoma 0.243 81 1.89e-109 8.62e-108 ✓ sig.
Peripheral primitive neuroectodermal tumor Skin neoplasms 0.201 112 3.16e-109 1.44e-107 ✓ sig.
Chromophobe renal cell carcinoma Parathyroid carcinoma 0.257 82 8.54e-109 3.86e-107 ✓ sig.
Brain stem glioblastoma Retinoblastoma 0.245 79 1.89e-108 8.51e-107 ✓ sig.
Adenosquamous lung carcinoma Carcinoma of the ampulla of vater 0.227 83 1.10e-105 4.88e-104 ✓ sig.
Gastric adenoma Villous adenoma of colon 0.165 72 3.07e-105 1.35e-103 ✓ sig.
Endometrial serous adenocarcinoma Extramammary paget disease 0.235 77 3.96e-105 1.74e-103 ✓ sig.
Amelanotic skin melanoma Lentigo maligna melanoma 0.204 75 4.30e-105 1.88e-103 ✓ sig.
Acinar lung adenocarcinoma Her2 positive breast carcinoma 0.201 81 8.11e-105 3.53e-103 ✓ sig.
Neoplasms Placental choriocarcinoma 0.203 90 2.79e-104 1.21e-102 ✓ sig.
Cecum villous adenoma Pancreatic acinar cell carcinoma 0.228 80 7.33e-104 3.17e-102 ✓ sig.
Gallbladder biliary intraepithelial neoplasia Pancreatic acinar cell carcinoma 0.227 78 3.51e-103 1.50e-101 ✓ sig.
Parathyroid carcinoma Thyroid gland oncocytic follicular carcinoma 0.244 79 2.53e-102 1.08e-100 ✓ sig.
Endometrial hyperplasia Rectal tubulovillous adenoma 0.238 75 8.06e-101 3.39e-99 ✓ sig.
Ductal carcinoma of breast Glioma 0.152 202 5.38e-99 2.24e-97 ✓ sig.
Lentigo maligna melanoma Medulloblastoma 0.202 84 8.44e-99 3.50e-97 ✓ sig.
Acral lentiginous melanoma Neoplasms 0.201 84 2.22e-97 9.11e-96 ✓ sig.
Rectal tubular adenoma Rectal tubulovillous adenoma 0.231 73 5.85e-97 2.38e-95 ✓ sig.
Glioma Superficial spreading melanoma 0.150 203 8.91e-97 3.62e-95 ✓ sig.
Anaplastic (malignant) meningioma Gallbladder biliary intraepithelial neoplasia 0.214 75 1.06e-96 4.31e-95 ✓ sig.
B-cell prolymphocytic leukemia Brain stem glioblastoma 0.223 71 1.35e-96 5.48e-95 ✓ sig.
Ependymoma Retinoblastoma 0.250 68 2.44e-95 9.78e-94 ✓ sig.
Rhabdoid tumor Richter transformation 0.158 68 7.12e-95 2.84e-93 ✓ sig.
Acinar lung adenocarcinoma Digestive system melanoma 0.202 73 3.38e-94 1.34e-92 ✓ sig.
Amelanotic skin melanoma Carcinoma of the ampulla of vater 0.201 67 2.16e-92 8.43e-91 ✓ sig.
Brain stem glioblastoma Gallbladder biliary intraepithelial neoplasia 0.215 71 5.63e-92 2.18e-90 ✓ sig.
B-cell prolymphocytic leukemia Ependymoma 0.242 64 7.13e-91 2.74e-89 ✓ sig.
Cecum adenocarcinoma Colonic neoplasms 0.150 121 1.05e-90 4.04e-89 ✓ sig.
Burkitt lymphoma Childhood kidney wilms tumor 0.229 68 2.45e-90 9.32e-89 ✓ sig.
Colonic neoplasms Nodular malignant melanoma 0.150 120 4.11e-90 1.56e-88 ✓ sig.
Acinar lung adenocarcinoma Carcinoma of the ampulla of vater 0.199 70 6.46e-90 2.45e-88 ✓ sig.
Her2 positive breast carcinoma Villous adenoma of colon 0.167 63 3.10e-89 1.17e-87 ✓ sig.
Brain stem glioblastoma Medulloblastoma 0.205 73 7.12e-88 2.67e-86 ✓ sig.
Burkitt lymphoma Ependymoma 0.226 64 2.85e-85 1.05e-83 ✓ sig.
Astrocytoma Central nervous system cancer 0.142 140 1.92e-82 6.94e-81 ✓ sig.
Central nervous system primitive neuroectodermal neoplasm Colonic neoplasms 0.151 104 6.03e-81 2.14e-79 ✓ sig.
Endometrial serous adenocarcinoma Papillary renal cell carcinoma 0.217 60 1.65e-80 5.83e-79 ✓ sig.
Adrenal cortex adenoma Placental choriocarcinoma 0.155 61 2.10e-80 7.43e-79 ✓ sig.
Astrocytoma (excluding glioblastoma) Colonic neoplasms 0.158 97 5.20e-80 1.83e-78 ✓ sig.
Anaplastic astrocytoma Colonic neoplasms 0.153 100 9.01e-80 3.17e-78 ✓ sig.
Ependymoma Medulloblastoma 0.203 62 1.51e-76 5.22e-75 ✓ sig.
Carcinoma of the ampulla of vater Villous adenoma of colon 0.166 54 7.49e-75 2.55e-73 ✓ sig.
Rectal tubular adenoma Villous adenoma of colon 0.185 52 7.58e-75 2.58e-73 ✓ sig.
Pancreatic acinar cell carcinoma Signet ring cell gastric adenocarcinoma 0.168 53 1.80e-74 6.13e-73 ✓ sig.
Anaplastic (malignant) meningioma Rhabdoid tumor 0.164 53 2.77e-72 9.24e-71 ✓ sig.
Carcinoma of the ampulla of vater Prostatic adenoma 0.164 55 3.78e-72 1.26e-70 ✓ sig.
Extramammary paget disease Signet ring cell gastric adenocarcinoma 0.163 50 3.33e-69 1.09e-67 ✓ sig.
Amelanotic skin melanoma Ependymoma 0.192 50 5.32e-68 1.72e-66 ✓ sig.
B-cell prolymphocytic leukemia Burkitt lymphoma 0.223 47 1.50e-67 4.81e-66 ✓ sig.
B-cell prolymphocytic leukemia Retinoblastoma 0.224 46 8.94e-67 2.86e-65 ✓ sig.
Adrenal cortex adenoma Parathyroid carcinoma 0.174 48 1.98e-65 6.26e-64 ✓ sig.
Endometrial hyperplasia Signet ring cell gastric adenocarcinoma 0.165 47 4.12e-65 1.30e-63 ✓ sig.
Brain stem glioblastoma Chondroblastoma 0.147 42 2.68e-62 8.23e-61 ✓ sig.
Chondroblastoma Ependymoma 0.171 39 1.78e-60 5.36e-59 ✓ sig.
Plasmacytoma Small intestinal tubulovillous adenoma 0.119 44 4.45e-60 1.34e-58 ✓ sig.
Prostatic adenoma T-cell large granular lymphocyte leukemia 0.164 45 4.39e-59 1.31e-57 ✓ sig.
Hepatocellular carcinoma Prostatic neoplasms 0.109 172 3.41e-57 9.87e-56 ✓ sig.
Childhood kidney wilms tumor Rhabdoid tumor 0.157 42 3.67e-56 1.06e-54 ✓ sig.
Burkitt lymphoma Rhabdoid tumor 0.201 37 1.55e-55 4.42e-54 ✓ sig.
Carcinoma Prostatic neoplasms 0.109 145 1.28e-53 3.58e-52 ✓ sig.
Extramammary paget disease Plasmacytoma 0.127 38 2.91e-52 8.02e-51 ✓ sig.
Breast neoplasms Hepatocellular carcinoma 0.100 150 1.19e-51 3.25e-50 ✓ sig.
Breast neoplasms Prostatic neoplasms 0.106 110 6.83e-49 1.81e-47 ✓ sig.
Non-small cell lung carcinoma Prostatic neoplasms 0.104 142 8.47e-49 2.24e-47 ✓ sig.
Breast neoplasms Non-small cell lung carcinoma 0.100 128 3.28e-47 8.51e-46 ✓ sig.
Glioblastoma Oligodendroglioma 0.098 171 5.20e-47 1.34e-45 ✓ sig.
Breast neoplasms Carcinoma 0.098 123 1.73e-45 4.38e-44 ✓ sig.
Esophageal squamous cell carcinoma Prostatic neoplasms 0.100 126 4.61e-44 1.15e-42 ✓ sig.
Meningioma Oligodendroglioma 0.099 104 1.64e-43 4.04e-42 ✓ sig.
Oligodendroglioma Skin cancer 0.099 116 3.39e-43 8.29e-42 ✓ sig.
Diffuse large b-cell lymphoma Oligodendroglioma 0.098 109 7.47e-43 1.82e-41 ✓ sig.
Adrenal cortex adenoma B-cell prolymphocytic leukemia 0.169 30 9.88e-43 2.40e-41 ✓ sig.
Amelanotic skin melanoma Prostatic adenoma 0.177 29 1.79e-42 4.35e-41 ✓ sig.
Clear cell renal cell carcinoma Kidney cancer 0.061 46 9.47e-41 2.25e-39 ✓ sig.
B-cell prolymphocytic leukemia Chondroblastoma 0.163 25 1.34e-38 3.08e-37 ✓ sig.
Chondroblastoma Retinoblastoma 0.152 25 1.88e-37 4.25e-36 ✓ sig.
Breast neoplasms Stomach neoplasms 0.085 65 6.76e-34 1.44e-32 ✓ sig.
Burkitt lymphoma Osteoblastoma 0.134 21 9.89e-34 2.10e-32 ✓ sig.
Chromophobe renal cell carcinoma Plasmacytoma 0.119 24 1.80e-32 3.74e-31 ✓ sig.
Prostatic neoplasms Stomach neoplasms 0.078 67 3.14e-31 6.30e-30 ✓ sig.
B-cell prolymphocytic leukemia Osteoblastoma 0.136 19 9.04e-31 1.79e-29 ✓ sig.
Endometrial serous adenocarcinoma Plasmacytoma 0.127 21 1.41e-29 2.73e-28 ✓ sig.
Bile duct cancer Desbuquois syndrome 0.077 88 1.12e-26 2.02e-25 ✓ sig.
Desbuquois syndrome Ductal carcinoma of breast 0.077 85 1.49e-26 2.68e-25 ✓ sig.
Desbuquois syndrome Pancreatic ductal carcinoma 0.077 84 2.02e-26 3.63e-25 ✓ sig.
Colonic neoplasms Stomach neoplasms 0.079 44 4.36e-26 7.68e-25 ✓ sig.
Chondroblastoma Osteoblastoma 0.167 14 2.75e-25 4.74e-24 ✓ sig.
Osteoblastoma Rhabdoid tumor 0.140 15 4.23e-25 7.26e-24 ✓ sig.
Endometriosis Meningioma 0.064 55 2.58e-19 3.68e-18 ✓ sig.
Anaplastic astrocytoma Endometriosis 0.062 50 1.93e-18 2.68e-17 ✓ sig.
Androgenetic alopecia Prostate cancer 0.052 96 1.45e-16 1.87e-15 ✓ sig.
Androgenetic alopecia Colorectal cancer 0.050 97 5.03e-15 6.08e-14 ✓ sig.
Androgenetic alopecia Ovarian serous carcinoma 0.055 56 6.82e-15 8.19e-14 ✓ sig.
Breast cancer Uterine fibroid 0.046 68 8.47e-15 1.01e-13 ✓ sig.
Kidney cancer Uterine fibroid 0.043 16 2.99e-12 3.12e-11 ✓ sig.
Ovarian serous carcinoma Uterine fibroid 0.044 41 6.24e-11 5.95e-10 ✓ sig.
Endometriosis Uterine fibroid 0.043 29 1.44e-9 1.23e-8 ✓ sig.
Polycystic ovary syndrome Undifferentiated pleomorphic sarcoma 0.035 26 8.80e-8 6.17e-7 ✓ sig.
Ductal carcinoma of breast Polycystic ovary syndrome 0.034 28 1.47e-7 1.01e-6 ✓ sig.
Mantle cell lymphoma Polycystic ovary syndrome 0.036 19 1.84e-7 1.23e-6 ✓ sig.
Gastric adenoma Polycystic ovary syndrome 0.035 22 3.47e-7 2.26e-6 ✓ sig.
Polycystic ovary syndrome Small cell carcinoma 0.034 24 4.44e-7 2.85e-6 ✓ sig.
Neurodevelopmental disorder with hypotonia, neuropathy, and deafness Polycystic ovary syndrome 0.004 1 1.47e-2 1.61e-2 ✓ sig.
Hypotaurinemic retinal degeneration and cardiomyopathy Myeloid leukemia 0.004 1 1.58e-2 1.72e-2 ✓ sig.
Acantholytic blistering of oral and laryngeal mucosa Colonic neoplasms 0.003 1 1.93e-2 2.08e-2 ✓ sig.
Isobutyryl-coa dehydrogenase deficiency Stomach neoplasms 0.003 1 1.96e-2 2.10e-2 ✓ sig.
Faundes-banka syndrome Uterine fibroid 0.003 1 1.97e-2 2.12e-2 ✓ sig.
Endometriosis Guillouet-gordon syndrome 0.003 1 2.58e-2 2.73e-2 ✓ sig.
Astrocytoma Global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 0.002 1 2.94e-2 3.09e-2 ✓ sig.
Desbuquois syndrome Short stature, dauber-argente type 0.002 1 3.65e-2 3.80e-2 ✓ sig.
Intellectual developmental disorder seizures polymicrogyria Prostatic neoplasms 0.002 1 4.02e-2 4.18e-2 ✓ sig.
Central nervous system cancer Global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 0.001 1 4.33e-2 4.48e-2 ✓ sig.
Central nervous system cancer Short stature, dauber-argente type 0.001 1 4.33e-2 4.48e-2 ✓ sig.
Central nervous system cancer Systemic lupus erythematosus 18 0.001 1 4.33e-2 4.48e-2 ✓ sig.
Carcinoma Faundes-banka syndrome 0.001 1 5.46e-2 5.62e-2
Glioma Systemic lupus erythematosus 18 0.001 1 5.85e-2 6.00e-2
Melanoma Microcornea, rod-cone dystrophy, cataract, and posterior staphyloma 1 0.001 1 7.13e-2 7.25e-2
Desbuquois syndrome Neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities 0.002 1 7.16e-2 7.28e-2
Breast cancer C3hex olfactory ability 0.001 1 8.11e-2 8.21e-2
Glioblastoma Systemic lupus erythematosus 18 0.001 1 8.24e-2 8.34e-2
C3hex olfactory ability Lung cancer 0.001 1 8.58e-2 8.67e-2
Acantholytic blistering of oral and laryngeal mucosa Colorectal cancer 0.001 1 1.05e-1 1.06e-1
Colorectal cancer Neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities 0.001 1 1.99e-1 1.99e-1
colorectal adenocarcinoma cutaneous melanoma 0.250 0 1.00e+0 1.00e+0
Colon adenocarcinoma colorectal adenocarcinoma 0.250 0 1.00e+0 1.00e+0
Colon adenocarcinoma cutaneous melanoma 0.250 0 1.00e+0 1.00e+0