Digestive system melanoma

mRNA Editing: C to U Conversion Formation of the Editosome

ErbB signaling pathway Ras signaling pathway Cell cycle Axon guidance Neurotrophin signaling pathway Pathogenic Escherichia coli infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Chronic myeloid leukemia Viral myocarditis Regulation of actin dynamics for phagocytic cup formation Role of ABL in ROBO-SLIT signaling Myogenesis RHO GTPases Activate WASPs and WAVEs HDR through Single Strand Annealing (SSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Cyclin D associated events in G1 RUNX1 regulates transcription of genes involved in differentiation of HSCs FCGR3A-mediated phagocytosis +17 more

Fatty acid biosynthesis Fatty acid degradation Metabolic pathways Fatty acid metabolism PPAR signaling pathway Peroxisome Ferroptosis Thermogenesis Adipocytokine signaling pathway Intracellular metabolism of fatty acids regulates insulin secretion Synthesis of very long-chain fatty acyl-CoAs +8 more

Fatty acid biosynthesis Fatty acid degradation Metabolic pathways Fatty acid metabolism PPAR signaling pathway Peroxisome Ferroptosis Thermogenesis Adipocytokine signaling pathway Synthesis of very long-chain fatty acyl-CoAs +7 more

Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells Fluid shear stress and atherosclerosis +2 more

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells Signaling by Activin +1 more

Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Adherens junction Tight junction Leukocyte transendothelial migration Adherens junctions interactions +4 more

Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation +1 more

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2 +7 more

Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions COPI-mediated anterograde transport +1 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway FoxO signaling pathway Vascular smooth muscle contraction Natural killer cell mediated cytotoxicity Long-term potentiation Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Parathyroid hormone synthesis, secretion and action Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Hepatitis C Hepatitis B Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +41 more

Focal adhesion Leukocyte transendothelial migration Rho GTPase cycle

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Vascular smooth muscle contraction Axon guidance Platelet activation C-type lectin receptor signaling pathway Regulation of actin cytoskeleton Pathogenic Escherichia coli infection Yersinia infection Tuberculosis Human cytomegalovirus infection Pathways in cancer Proteoglycans in cancer NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse +12 more

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +2 more

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +2 more

Transcriptional misregulation in cancer

Aldosterone synthesis and secretion Transcriptional misregulation in cancer CREB phosphorylation NGF-stimulated transcription +1 more

Purine metabolism One carbon pool by folate Metabolic pathways Antifolate resistance Purine ribonucleoside monophosphate biosynthesis +2 more

Platinum drug resistance Homologous recombination NF-kappa B signaling pathway FoxO signaling pathway Cell cycle p53 signaling pathway Apoptosis Cellular senescence Shigellosis Human papillomavirus infection Human T-cell leukemia virus 1 infection Human immunodeficiency virus 1 infection Transcriptional misregulation in cancer MicroRNAs in cancer DNA Damage/Telomere Stress Induced Senescence Regulation of HSF1-mediated heat shock response Autodegradation of the E3 ubiquitin ligase COP1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Caspase Activators and Caspases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Pexophagy +33 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Adrenergic signaling in cardiomyocytes Aldosterone synthesis and secretion Endocrine and other factor-regulated calcium reabsorption Salivary secretion Pancreatic secretion Mineral absorption Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +9 more

Fanconi anemia pathway Cell cycle p53 signaling pathway Cellular senescence Human papillomavirus infection Human T-cell leukemia virus 1 infection Human immunodeficiency virus 1 infection Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +13 more

Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer Colorectal cancer Endometrial cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases +15 more

ATP-dependent chromatin remodeling

Transcriptional misregulation in cancer

C-type lectin receptor signaling pathway TNF signaling pathway

Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex

Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex

Polycomb repressive complex

Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway

Platinum drug resistance Homologous recombination Fanconi anemia pathway Ubiquitin mediated proteolysis PI3K-Akt signaling pathway MicroRNAs in cancer Breast cancer SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 +19 more

Purine metabolism Pyrimidine metabolism Metabolic pathways Nucleotide metabolism Neutrophil degranulation +2 more

Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation

Platinum drug resistance p53 signaling pathway PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species VEGF signaling pathway Thyroid hormone signaling pathway Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Legionellosis Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Colorectal cancer Pancreatic cancer Endometrial cancer Prostate cancer Small cell lung cancer Non-small cell lung cancer Viral myocarditis Lipid and atherosclerosis Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity +39 more

ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis Insulin signaling pathway Bacterial invasion of epithelial cells Pathways in cancer Proteoglycans in cancer Chronic myeloid leukemia Interleukin-6 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Spry regulation of FGF signaling Regulation of KIT signaling EGFR downregulation TGF-beta receptor signaling activates SMADs Constitutive Signaling by EGFRvIII Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Negative regulation of MET activity PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Regulation of signaling by CBL +22 more

Ubiquitin mediated proteolysis Endocytosis

Pathways in cancer Thyroid cancer

FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Wnt signaling pathway Hedgehog signaling pathway Hippo signaling pathway Focal adhesion JAK-STAT signaling pathway Prolactin signaling pathway Measles Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity +18 more

Cell cycle p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Wnt signaling pathway Hippo signaling pathway Focal adhesion JAK-STAT signaling pathway Measles Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity +17 more

Cell cycle Oocyte meiosis p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Cushing syndrome Hepatitis B Measles Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Prostate cancer Small cell lung cancer Gastric cancer G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle +24 more

Adherens junctions interactions

Gastric cancer Adherens junctions interactions

TP53 Regulates Transcription of DNA Repair Genes