Subtype of: Breast cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HER2 positive breast carcinoma	MONDO_0006244	A1CF	Unknown	27406316	Open Targets	mRNA Editing: C to U Conversion Formation of the Editosome
		ABI1	Unknown	28027327	Open Targets	Pathogenic Escherichia coli infection Salmonella infection Regulation of actin dynamics for phagocytic cup formation +3 more
		ABL1	Unknown	27406316	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		ABL2	Unknown	27406316 20668451	Open Targets	ErbB signaling pathway Ras signaling pathway Chemical carcinogenesis - reactive oxygen species +2 more
		ACSL3	Unknown	27406316	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +8 more
		ACSL6	Unknown	27406316	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +7 more
		ACVR1	Unknown	21493686	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +2 more
		ACVR1B	Unknown	22722202	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +1 more
		AFDN	Unknown	27406316	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		AFF3	Unknown	25591616	Open Targets	—
		AKAP9	Unknown	27406316 20668451	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		AKT2	Unknown	22722202	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +122 more
		ALDH2	Unknown	28027327	Open Targets	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ALK	Unknown	25591616 30062102	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AMER1	Unknown	27406316	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		APC	Unknown	27406316 25591616 20668451 21493686	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AR	Unknown	28027327 20668451	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARHGAP26	Unknown	27406316	Open Targets	Rho GTPase cycle
		ARHGAP35	Unknown	27406316	Open Targets	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ARHGAP5	Unknown	27406316 28027327 22722201	Open Targets	Focal adhesion Leukocyte transendothelial migration Rho GTPase cycle
		ARHGEF12	Unknown	20668451	Open Targets	Vascular smooth muscle contraction Axon guidance Platelet activation +12 more
		ARID1A	Unknown	27406316 22101766 30205045 22722201 25850943	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	27406316 30062102	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	27406316 28027327	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ASPM	Unknown	27406316	Open Targets	—
		ASXL1	Unknown	28027327 25591616	Open Targets	Polycomb repressive complex UCH proteinases
		ATF1	Unknown	27406316	Open Targets	Aldosterone synthesis and secretion Transcriptional misregulation in cancer CREB phosphorylation +1 more
		ATIC	Unknown	27406316 28027327	Open Targets	Purine metabolism One carbon pool by folate Metabolic pathways +2 more
		ATM	Unknown	22722201 30062102 26527317 25850943 28027327 21493686 25591616 22722202	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP2B3	Unknown	27406316	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +9 more
		ATR	Unknown	28027327 22722202 33004031 30062102 30205045	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		ATRX	Unknown	27406316 38970069	Open Targets	Cell cycle
		AXIN1	Unknown	20668451	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN2	Unknown	27406316	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		BARD1	Unknown	38970069	Open Targets	Homologous recombination HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +11 more
		BCL11A	Unknown	27406316	Open Targets	—
		BCL11B	Unknown	25591616	Open Targets	Transcriptional misregulation in cancer
		BCL2	Unknown	30062102	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
		BCL6	Unknown	27406316	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCL9	Unknown	28027327 20668451	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCOR	Unknown	30205045 22722202	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	27406316 22722202	Open Targets	Polycomb repressive complex
		BIRC6	Unknown	27406316 22722202 22722201	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BLM	Unknown	28027327	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		BMP5	Unknown	28027327	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway
		BMPR1A	Unknown	20668451	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +4 more
		BRAF	Unknown	27406316 28027327 20668451	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	20668451 25850943	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	27406316	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BRD3	Unknown	25591616	Open Targets	—

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Her2 positive breast carcinoma

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