Subtype of: Breast cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HER2 positive breast carcinoma	MONDO_0006244	ERBB2	Unknown	27406316 31905165 20668451 22722202 30023006	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	27406316 28750640 30062102 28027327 25591616 22722202 30023006	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERBB4	Unknown	27406316 28027327 28750640 30023006	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERCC3	Unknown	27406316	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC4	Unknown	27406316 28027327 30205045	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		ERCC5	Unknown	27406316 21493686	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		ERG	Unknown	22722202	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ESR1	Unknown	27406316	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		ETV5	Unknown	27406316	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ETV6	Unknown	27406316	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EZH2	Unknown	27406316	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FAM135B	Unknown	27406316	Open Targets	—
		FAM47C	Unknown	22722202	Open Targets	—
		FANCA	Unknown	27406316 25591616	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCD2	Unknown	28027327	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FAT1	Unknown	27406316 28027327	Open Targets	—
		FAT3	Unknown	27406316 28027327	Open Targets	—
		FAT4	Unknown	27406316 28027327 22722202	Open Targets	Hippo signaling pathway - multiple species
		FBXO11	Unknown	20668451	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	30062102	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FCGR2B	Unknown	27406316	Open Targets	Virion - Ebolavirus, Lyssavirus and Morbillivirus Phagosome Osteoclast differentiation +6 more
		FCRL4	Unknown	27406316	Open Targets	—
		FGFR1	Unknown	28027327	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR3	Unknown	22722202 30062102	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FGFR4	Unknown	25591616	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		FLNA	Unknown	27406316 22722202	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		FLT3	Unknown	27406316 25591616 22722202	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		FLT4	Unknown	27406316 20668451 22722202 25850943	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FNBP1	Unknown	28027327	Open Targets	Shigellosis Clathrin-mediated endocytosis
		FOXA1	Unknown	29807833	Open Targets	Estrogen-dependent gene expression
		FOXL2	Unknown	27406316	Open Targets	SUMOylation of transcription factors
		FSTL3	Unknown	28027327	Open Targets	Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
		GAS7	Unknown	22722202	Open Targets	—
		GATA1	Unknown	27406316 25591616	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA2	Unknown	25591616	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA3	Unknown	27406316 28027327 22722201 30062102	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action +6 more
		GLI1	Unknown	28027327 22302350	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GNAS	Unknown	27406316	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GOLGA5	Unknown	28027327	Open Targets	Intra-Golgi traffic
		GPC5	Unknown	22722201	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GRIN2A	Unknown	27406316	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		H3C2	Unknown	27406316	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		HEY1	Unknown	27406316	Open Targets	Notch signaling pathway Human papillomavirus infection Pathways in cancer +4 more
		HIP1	Unknown	28027327	Open Targets	Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis
		HOOK3	Unknown	22722202	Open Targets	Motor proteins
		HOXA11	Unknown	20668451	Open Targets	Transcriptional misregulation in cancer
		HOXC13	Unknown	20668451	Open Targets	—
		HSP90AA1	Unknown	27406316 20668451	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		HSP90AB1	Unknown	27406316	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IDH1	Unknown	27406316	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more

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Her2 positive breast carcinoma

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