Subtype of: Breast cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HER2 positive breast carcinoma	MONDO_0006244	CACNA1D	Unknown	27406316	Open Targets	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +35 more
		CAMTA1	Unknown	27406316	Open Targets	—
		CARD11	Unknown	27406316	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CASP8	Unknown	27406316 20668451 25850943	Open Targets	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CBFB	Unknown	20668451	Open Targets	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
		CBL	Unknown	25591616	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CBLB	Unknown	38970069	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CCDC6	Unknown	27406316	Open Targets	Pathways in cancer Thyroid cancer
		CCNC	Unknown	27406316	Open Targets	PPARA activates gene expression Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription +3 more
		CCND2	Unknown	22722202	Open Targets	FoxO signaling pathway Cell cycle p53 signaling pathway +18 more
		CDC73	Unknown	20668451 30205045	Open Targets	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state +3 more
		CDH1	Unknown	27406316 21512767 22722202	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDK12	Unknown	27406316 20668451	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDK4	Unknown	20668451	Open Targets	Endocrine resistance Cell cycle p53 signaling pathway +40 more
		CDKN1B	Unknown	27406316	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	28027327 19372580	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CEP43	Unknown	21493686	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		CHD2	Unknown	27406316 28027327	Open Targets	—
		CHD4	Unknown	27406316 22722202 30062102	Open Targets	ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis +5 more
		CHEK2	Unknown	27406316	Open Targets	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CIC	Unknown	27406316	Open Targets	Spinocerebellar ataxia
		CLIP1	Unknown	27406316 21493686	Open Targets	mTOR signaling pathway Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		CLTC	Unknown	27406316 22722201	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +18 more
		CNBD1	Unknown	27406316 22722202	Open Targets	—
		CNOT3	Unknown	27406316	Open Targets	RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
		COL1A1	Unknown	25591616	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +26 more
		COL3A1	Unknown	27406316	Open Targets	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
		CREBBP	Unknown	27406316 25591616 22722202	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CRTC1	Unknown	27406316	Open Targets	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CSF1R	Unknown	27406316	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CSMD3	Unknown	27406316 22722202 22722201	Open Targets	—
		CTCF	Unknown	27406316	Open Targets	—
		CTNNA1	Unknown	27406316	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +9 more
		CTNNA2	Unknown	28027327	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		CTNNB1	Unknown	27406316 29807833	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		CTNND2	Unknown	28027327	Open Targets	Wnt signaling pathway
		DDB2	Unknown	27406316	Open Targets	Nucleotide excision repair p53 signaling pathway Ubiquitin mediated proteolysis +23 more
		DDR2	Unknown	20668451	Open Targets	Non-integrin membrane-ECM interactions
		DDX10	Unknown	27406316	Open Targets	—
		DDX3X	Unknown	27406316 25850943	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		DICER1	Unknown	27406316 21493686 30062102	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		DROSHA	Unknown	22722201	Open Targets	Ribosome biogenesis in eukaryotes Proteoglycans in cancer MicroRNA (miRNA) biogenesis
		EBF1	Unknown	22722201	Open Targets	—
		EGFR	Unknown	28750640 22722202 31905165 30023006	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EIF4A2	Unknown	22722202	Open Targets	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA +4 more
		ELF3	Unknown	22722201	Open Targets	Pre-NOTCH Transcription and Translation
		EML4	Unknown	27406316	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		EP300	Unknown	27406316 33004031 30205045 28027327 25591616 20668451	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPHA3	Unknown	27406316	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPHA7	Unknown	28027327 22722202	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more

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Her2 positive breast carcinoma

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