Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	APC	Causal	26650777 29665843 9083931 19378335 29069792 18849522 16959974 31336886 20544848 21837511 16258065 19679059 27756406 28465371 19503063 18977219 15507235 22895193 12524418 12408524 24470207 29438965 36142641 31226844 24755471 29237421 12110635 38725616 29420467 20951698 26071483 7927902 27302369 26336987 11746989 19527492 15375009 24005794 38023256 28978093 32375028 28548127 9330602 25617745 27816598 18602395 30038269 28243320 26416732 29316426 28120820 27087592 11821507 30962964 23856246 28939743 21901162 29937994 23354438 9482574 25344691 27004155 9589476 30239619 24699064 9566701 24943349 27612425 30631260 25589621 22810696 29967250 28145097 10074927 19684041 27245685 26109429 22287596 25695693 29844865 25623536 27566247 31400926 10737795 25957691 22864938 26764183 20176655 28551381 27023146 9419979 11920497 19026650 22014273 28546418 15449173 9869603 28481359 17932254	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		BRCA2	Causal	22810696 29967250 34680263 26071483 27023146 31400926 26764183 29937994 26416732 26336987 23856246 28465371 25957691 29316426 25344691 38725616 24755471 22895193 28481359	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CHEK2	Causal	18186519 27023146 27612425 29937994 26416732 17145815 25957691 26109429 25344691 29844865 22895193 28481359	Open Targets	Cell cycle p53 signaling pathway Cellular senescence +9 more
		EP300	Causal	22810696 29967250 8622873 26764183 29937994 12385008 29316426 23856246 25957691 30239619 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		ERCC2	Causal	22810696 26071483 26764183 29937994 26416732 29316426 25957691 26109429 25344691 38725616 24755471 22895193 28481359	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		EXT1	Causal	22810696 29967250 29937994 23856246 25957691 25344691 24755471 22895193	Open Targets	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis +2 more
		FANCD2	Causal	22810696 27023146 29967250 26071483 26764183 29937994 26416732 26336987 25957691 25344691 29844865 24755471 22895193	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		KRAS	Causal	30036146 26650777 23606169 32944848 21478103 21704278 12039935 21474505 32561076 19378335 8157747 8187064 22586484 29069792 22259183 9778456 11289281 19223544 37448961 24594115 27154293 29998005 16959974 31336886 18544172 22467075 20604919 7872685 22740893 20959826 21837511 21603900 26018827 27929064 21193546 16699497 19679059 27756406 9797369 9191543 28465371 25673644 22392911 8394730 9816002 22617127 26968814 22895193 20473912 17150185 8486427 18669174 11290569 19832985 20979647 9777938 24470207 12524418 21536390 7657384 15674332 9328563 11051374 36142641 2194896 2203688 18628094 23341527 11106095 19479711 14688025 23125007 19934290 24755471 1396073 21726664 21445971 10220498 22722830 21103049 25313410 22494971 1627381 12093899 12110635 21369707 28936923 37158138 8421601 21931273 8621253 38725616 12012008 24498230 29420467 8033106 21036746 26071483 27302369 18757341 22675560 3587348 19955118 20361188 23542178 23755925 19527492 26336987 19574674 2649235 24005794 8804161 9097993 9592195 21659424 20008640 8283788 22402123 37113399 24990411 38023256 23680147 28978093 32375028 28548127 8039618 8160776 8778329 20485143 25617745 18398843 18022911 9568504 22722843 1973170 18602395 30038269 10510729 12068308 28243320 26416732 28120820 29316426 20049979 8450652 21354055 18186519 19686742 24726492 37434969 20664172 1566048 22252179 23856246 1453686 9075750 28939743 24519090 22089345 10362137 9834286 21901162 11390535 29937994 2648401 19637313 9036876 23430953 28951457 14633673 3021699 25344691 29842994 27004155 12110640 9097977 8622495 18042066 15729718 20924129 9589476 22586653 24841357 30239619 23569465 8514605 7567931 21206494 24943349 27612425 7890240 21203531 30631260 21884216 19661358 25574089 23355298 25694286 27155048 25675084 22810696 29967250 34680263 9018074 10025877 19731079 21516079 1773797 28214514 11231481 23983431 27245685 28145097 22537608 28188185 26109429 25695693 29844865 10956407 25623536 27566247 15017656 31400926 24964857 25957691 10754986 23792572 7731696 7797596 21128077 26764183 20176655 28551381 25248721 9345343 22583358 9419979 27023146 19026650 22740969 23765179 22014273 28546418 9018769 15449173 24304820 21029218 21189386 25050586 11289147 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		MSH2	Causal	22810696 26071483 31400926 29937994 27612425 29316426 25957691 28465371 25194673 10793088 28978093 12386821 9445183 25344691 29844865 36142641 22895193 8952554 28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Causal	27612425 26416732 29316426 24755471 22810696 29967250 23856246 25194673 26109429 29844865 38725616 11508658 31400926 26071483 29937994 26336987 25957691 20565851 32664968 19503063 25344691 22895193 27023146 20979647 30387329 28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		NF1	Causal	12522551 27612425 26416732 29316426 24755471 22810696 23856246 16959974 29844865 31336886 38725616 31400926 26071483 29937994 26336987 25957691 28465371 25344691 22895193 30239619 1568247 28481359 31226844	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		PIK3CA	Causal	18602395 32944848 26650777 24943349 30038269 27612425 18628094 32669268 26416732 28120820 29316426 25589621 15520168 23125007 24755471 21726664 22810696 29967250 19731079 19378335 22586484 21103049 34680263 20664172 19223544 27245685 28936923 26109429 27154293 28939743 25695693 29844865 25623536 38725616 27566247 31400926 17363507 20951698 16376301 26071483 27302369 20571907 29937994 23542178 26336987 27756406 25957691 18022911 22357840 22392911 25344691 26968814 24676216 22895193 22553375 26764183 28551381 27023146 22740969 38023256 22014273 29072370 22586653 23680147 24841357 28978093 30239619 25617745 22753589 28481359 17932254	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Causal	22810696 29967250 30038269 26071483 31400926 29937994 26416732 29316426 23856246 25957691 28465371 23680147 11606375 25344691 29844865 24755471 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PMS2	Causal	22810696 29937994 26416732 26336987 29316426 25957691 30387329 26109429 28978093 32664968 25344691 29844865 22895193 28481359	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		PPP2R1A	Causal	29967250 27023146 26764183 29937994 25957691 26109429 30239619 25344691 29844865 22895193 28481359	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PTEN	Causal	26650777 32669268 26416732 28120820 25589621 27087592 15026806 24755471 27155048 22810696 34680263 21103049 23856246 28936923 26109429 10607839 29844865 38725616 27566247 31400926 29937994 26336987 27756406 25957691 25344691 22895193 28978093 25617745 28481359 17932254	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		RB1	Causal	22810696 34680263 26071483 25617745 29937994 29316426 23856246 25957691 27245685 27756406 25344691 24755471 22895193 28481359	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		SBDS	Causal	25957691 29844865	Open Targets	Ribosome biogenesis in eukaryotes
		SMARCB1	Causal	22810696 27023146 26764183 29937994 26416732 29316426 27756406 25957691 25344691 38725616 24755471 22895193 28481359	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		TP53	Causal	32944848 26650777 30036146 29665843 10328221 8697967 11275993 31227518 29069792 10999735 27154293 16959974 19794270 31336886 8635153 37391803 27756406 9052405 22895193 9453486 24470207 29438965 9470817 16827139 15674332 15702478 36142641 9030251 31226844 7860623 9036877 8267380 14688025 9807634 24755471 9450908 21726664 12457032 21103049 12093899 10697269 38725616 29420467 8033106 26071483 27302369 23542178 26336987 32664968 38023256 10328215 28978093 32375028 8039618 25617745 18602395 30038269 28243320 26416732 28120820 29316426 27087592 22178590 30962964 11406538 23856246 30475948 8554149 28939743 9537240 10095452 11384100 11390535 21901162 29937994 9036876 23430953 25344691 29842994 7651727 14534749 24841357 30239619 16760300 24699064 11992552 27612425 32669268 21203531 30631260 25589621 11241240 25574089 22810696 29967250 34680263 1945416 11231481 15492791 27245685 28145097 26109429 15057748 8690195 25695693 29844865 25623536 27566247 31400926 10760817 25957691 9413950 26764183 28551381 27023146 8317886 23400451 22014273 28546418 17118779 11317955 12663519 16110022 28481359	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		WAS	Causal	25957691 22895193 25344691 29844865	Open Targets	Chemokine signaling pathway Adherens junction Tight junction +7 more
		A1CF	Unknown	30239619 22895193 28546418 29937994	Open Targets	mRNA Editing: C to U Conversion Formation of the Editosome
		ABI1	Unknown	22810696 26071483 29937994 26336987 25957691 31336886 24755471 22895193	Open Targets	Pathogenic Escherichia coli infection Salmonella infection Regulation of actin dynamics for phagocytic cup formation +3 more
		ABL1	Unknown	22810696 26071483 25617745 26764183 29937994 29316426 27756406 30239619 32375028 25344691 36142641 24755471 22895193 28481359	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		ABL2	Unknown	22810696 29967250 26071483 29937994 26416732 26336987 25957691 30239619 25344691 29844865 24755471 22895193	Open Targets	ErbB signaling pathway Ras signaling pathway Chemical carcinogenesis - reactive oxygen species +2 more
		ACKR3	Unknown	22810696 26071483 29937994 26416732 25957691 25344691 16959974 31336886 24755471 22895193	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine receptors bind chemokines +1 more
		ACSL3	Unknown	22810696 27612425 29937994 25957691 25344691 24755471 22895193	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +8 more
		ACSL6	Unknown	26071483 24699064 29937994 26416732 25957691 30239619 25344691 38725616 24755471 22895193	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +7 more
		ACVR1	Unknown	29316426 25957691 30239619 25344691 24755471 28481359	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +2 more
		ACVR1B	Unknown	22810696 29967250 29937994 26336987 28978093 26109429 25344691 22895193	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +1 more
		ACVR2A	Unknown	22810696 26071483 20011542 29937994 26764183 21203531 26416732 26336987 23856246 25957691 14988818 28978093 19503063 32375028 25344691 29844865 31336886 24755471 22895193 38725616	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +3 more
		AFDN	Unknown	22810696 26071483 29937994 26416732 26336987 23856246 25957691 30239619 32375028 25344691 38725616 24755471 22895193	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		AFF1	Unknown	22810696 30038269 26071483 29937994 25957691 25344691 29844865 24755471 22895193	Open Targets	Transcriptional misregulation in cancer
		AFF3	Unknown	22810696 29967250 26071483 26764183 29937994 26416732 23856246 25957691 25344691 29844865 24755471 22895193	Open Targets	—
		AFF4	Unknown	22810696 26764183 29937994 26416732 23856246 25957691 25344691 38725616 22895193	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +1 more
		AKAP9	Unknown	22810696 29967250 26071483 26764183 29937994 26416732 26336987 23856246 25957691 26109429 30239619 25344691 16959974 29844865 38725616 24755471 31336886 22895193	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		AKT1	Unknown	22810696 34680263 18504432 26416732 26336987 27756406 25957691 29316426 25344691 26968814 29844865 31400926 28481359 21726664	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		AKT2	Unknown	22810696 26336987 29316426 25957691 30239619 25344691 29844865 24755471 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +122 more
		AKT3	Unknown	22810696 26071483 25589621 25957691 23856246 25344691 38725616 24755471 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +119 more
		ALDH2	Unknown	22810696 26071483 29937994 23856246 25344691 38725616 22895193	Open Targets	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ALK	Unknown	29665843 26416732 29316426 25589621 24755471 22810696 29967250 23856246 27245685 28145097 29844865 19383809 27566247 26071483 29937994 27756406 25957691 25344691 26764183 22895193 27023146 32375028 28481359 17932254	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AMER1	Unknown	26650777 26416732 28120820 29316426 24755471 22810696 29967250 23856246 28145097 29844865 31336886 26071483 27302369 29937994 26336987 25957691 25344691 26764183 22895193 28551381 28978093 30239619 25617745 28481359	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		ANK1	Unknown	22810696 26071483 26764183 29937994 26416732 25957691 26109429 30239619 25344691 24755471 22895193	Open Targets	Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions +1 more
		APOBEC3B	Unknown	22810696 22895193 25344691 26336987 29937994	Open Targets	Viral life cycle - HIV-1 Human immunodeficiency virus 1 infection mRNA Editing: C to U Conversion +1 more
		AR	Unknown	22810696 27023146 26071483 29937994 26416732 29316426 23856246 25957691 30239619 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARAF	Unknown	22810696 26071483 29937994 29316426 25957691 38725616 22895193 28481359 17932254	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +41 more
		ARHGAP26	Unknown	25957691 24755471 22895193 25344691 29937994	Open Targets	Rho GTPase cycle
		ARHGAP35	Unknown	22810696 29937994 26416732 25957691 25344691 24755471 22895193	Open Targets	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ARHGAP5	Unknown	22810696 29937994 25957691 25344691 38725616 22895193	Open Targets	Focal adhesion Leukocyte transendothelial migration Rho GTPase cycle
		ARHGEF10	Unknown	22810696 26071483 29937994 25957691 25344691 22895193 17932254	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

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Colon adenocarcinoma

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