Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	TRIP11	Unknown	22810696 29967250 26071483 29937994 26336987 25957691 26109429 32375028 25344691 29844865 38725616 24755471 22895193	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	22810696 29967250 30038269 26071483 26764183 29937994 26416732 26336987 28546418 25957691 26109429 30239619 25344691 29844865 31336886 24755471 22895193 38725616	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC1	Unknown	29967250 27023146 29937994 26416732 29316426 22014273 25957691 23856246 30239619 25344691 29844865 31336886 22895193 28481359 38725616	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	22810696 29937994 26416732 29316426 23856246 25957691 26109429 30239619 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	22810696 26071483 29937994 26416732 29316426 25589621 25957691 25344691 29844865 22895193 28481359	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		U2AF1	Unknown	22810696 29937994 26416732 26336987 29316426 25957691 25344691 38725616 22895193 28481359	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		UBR5	Unknown	22810696 29967250 30038269 26071483 26764183 29937994 26416732 26336987 23856246 25957691 32375028 25344691 29844865 31336886 24755471 22895193 38725616 17932254	Open Targets	Ubiquitin mediated proteolysis
		USP44	Unknown	25957691 23856246 25344691 22810696 29937994	Open Targets	Ub-specific processing proteases
		USP6	Unknown	22810696 24699064 29937994 26336987 23856246 25957691 25344691 22895193	Open Targets	—
		USP8	Unknown	22810696 24699064 27612425 26416732 26336987 25957691 26109429 30239619 25344691 22895193	Open Targets	Mitophagy - animal Endocytosis Cushing syndrome +4 more
		USP9X	Unknown	22810696 29937994 26416732 25957691 25344691 29844865 38725616 22895193	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		VAV1	Unknown	22810696 26071483 29937994 26416732 25957691 25344691 24755471 22895193	Open Targets	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +30 more
		VHL	Unknown	34680263 26764183 29937994 27756406 25957691 25344691 25617745 22895193 28481359	Open Targets	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more
		VTI1A	Unknown	25957691 22895193 26071483 25344691 29937994	Open Targets	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		WDCP	Unknown	22810696 23856246 25344691 29937994	Open Targets	—
		WIF1	Unknown	22810696 26071483 29937994 25957691 24755471 22895193	Open Targets	Wnt signaling pathway
		WNK2	Unknown	22810696 26071483 26764183 29937994 26416732 25957691 26109429 32375028 25344691 38725616 24755471 22895193	Open Targets	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		WRN	Unknown	22810696 29967250 26071483 26764183 29937994 26416732 26336987 23856246 25957691 32375028 16959974 25344691 29844865 24755471 22895193	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more
		WT1	Unknown	22810696 26071483 29937994 26416732 29316426 25344691 29844865 22895193 28481359	Open Targets	Transcriptional misregulation in cancer
		WWTR1	Unknown	26071483 29937994 25957691 25344691 24755471 22895193	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo +5 more
		XPA	Unknown	22810696 22895193 29937994	Open Targets	Platinum drug resistance Nucleotide excision repair Formation of Incision Complex in GG-NER +3 more
		XPC	Unknown	29967250 29937994 25957691 30239619 25344691 22895193	Open Targets	Nucleotide excision repair SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER +1 more
		XPO1	Unknown	22810696 29937994 29316426 23856246 25957691 25344691 29844865 22895193 28481359	Open Targets	Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 +15 more
		YAP1	Unknown	22810696 26071483 29937994 25957691 30239619 25344691 38725616 22895193 28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 +5 more
		YWHAE	Unknown	22810696 26336987 25344691 38725616	Open Targets	Cell cycle Oocyte meiosis PI3K-Akt signaling pathway +22 more
		ZBTB16	Unknown	22810696 26764183 26416732 25957691 25344691 22895193	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia +2 more
		ZCCHC8	Unknown	25957691 24755471 25344691 38725616 29937994	Open Targets	—
		ZEB1	Unknown	22810696 26071483 29937994 26416732 23856246 25957691 26109429 25344691 24755471 22895193	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer +1 more
		ZFHX3	Unknown	22810696 29937994 22895193 26336987 23856246 28546418 29316426 25957691 26416732 32375028 25344691 38725616 24755471 26764183 28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZMYM2	Unknown	22810696 29937994 26416732 25957691 25344691 38725616 22895193	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
		ZMYM3	Unknown	22810696 30038269 29937994 23856246 25957691 25344691 22895193	Open Targets	—
		ZNF331	Unknown	22810696 29937994 26416732 25957691 30239619 25344691 24755471 22895193	Open Targets	Generic Transcription Pathway
		ZNF384	Unknown	24755471 22895193 25957691 29844865	Open Targets	—
		ZNF429	Unknown	22810696 26071483 25957691 25344691 24755471 22895193	Open Targets	Generic Transcription Pathway
		ZNF479	Unknown	22810696 27612425 26336987 25957691 25344691 22895193	Open Targets	Generic Transcription Pathway
		ZNF521	Unknown	22810696 29967250 26071483 29937994 26416732 23856246 25957691 28546418 26109429 25344691 29844865 22895193 17932254	Open Targets	—
		ZNRF3	Unknown	26764183 29937994 25957691 25344691 38725616 24755471 22895193	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination
		ZRSR2	Unknown	29967250 26071483 26416732 29316426 25957691 25344691 24755471 22895193 28481359	Open Targets	mRNA Splicing - Minor Pathway

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Colon adenocarcinoma

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