Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	ARHGEF10L	Unknown	22810696 24943349 29937994 26416732 25957691 16959974 25344691 24755471 22895193	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF12	Unknown	22810696 26071483 29937994 25957691 26109429 30239619 25344691 24755471 22895193	Open Targets	Vascular smooth muscle contraction Axon guidance Platelet activation +12 more
		ARID1A	Unknown	22009941 22810696 26650777 26071483 34680263 25617745 29665843 29937994 24382590 26416732 29316426 23856246 25957691 26109429 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	29967250 30038269 22810696 26071483 26764183 29937994 24382590 26416732 29316426 26336987 25957691 26109429 25344691 38725616 24755471 31336886 22895193 28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	22810696 24943349 29665843 29937994 24382590 26416732 26336987 29316426 25957691 23856246 25344691 29844865 24755471 22895193 28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ARNT	Unknown	22810696 26071483 26764183 29937994 26416732 25957691 25344691 29844865 38725616 22895193	Open Targets	HIF-1 signaling pathway Efferocytosis Cushing syndrome +10 more
		ASPM	Unknown	22810696 26071483 26764183 29937994 26416732 26336987 23856246 25957691 28546418 26109429 25344691 38725616 24755471 22895193	Open Targets	—
		ASPSCR1	Unknown	32375028 22895193 25344691 25957691 29937994	Open Targets	Transcriptional misregulation in cancer
		ASXL1	Unknown	22810696 26071483 29937994 26416732 26336987 27245685 25957691 29316426 21209843 30475948 30239619 25344691 29844865 31336886 24755471 22895193 28481359	Open Targets	Polycomb repressive complex UCH proteinases
		ASXL2	Unknown	29937994 29316426 26336987 25957691 25344691 24755471 22895193 28481359	Open Targets	Polycomb repressive complex UCH proteinases
		ATF1	Unknown	22895193 25957691 29844865	Open Targets	Aldosterone synthesis and secretion Transcriptional misregulation in cancer CREB phosphorylation +1 more
		ATIC	Unknown	22810696 29937994 26416732 23856246 25957691 25344691 24755471 22895193	Open Targets	Purine metabolism One carbon pool by folate Metabolic pathways +2 more
		ATM	Unknown	26650777 27612425 26416732 25589621 24755471 30962964 29967250 22810696 34680263 23856246 30475948 26109429 29844865 31400926 26071483 29937994 27756406 25957691 25344691 22895193 27023146 28978093 30239619 28481359 31226844	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP1A1	Unknown	22810696 26764183 29937994 25957691 25344691 24755471 22895193	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction +18 more
		ATP2B3	Unknown	22810696 26764183 29937994 26416732 23856246 25957691 26109429 25344691 24755471 22895193	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +9 more
		ATR	Unknown	22810696 26071483 29937994 22895193 29316426 28465371 25957691 26109429 25344691 29844865 38725616 18186519 28481359	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		ATRX	Unknown	22810696 27023146 29967250 29937994 26416732 29316426 23856246 25957691 25589621 26109429 25344691 29844865 24755471 27566247 22895193 28481359	Open Targets	Cell cycle
		AXIN1	Unknown	26764183 29937994 10862053 29316426 11746989 25957691 23856246 32375028 25344691 38725616 22895193 28481359	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN2	Unknown	22810696 26071483 29937994 26416732 29316426 25957691 28978093 30239619 21541676 26109429 25344691 36142641 24755471 22895193 28481359 38725616	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		B2M	Unknown	22810696 29937994 26416732 29316426 23856246 25957691 26109429 17086209 25344691 22895193 28481359	Open Targets	Antigen processing and presentation Human cytomegalovirus infection Human T-cell leukemia virus 1 infection +14 more
		BAP1	Unknown	22810696 22958294 26071483 25957691 26109429 29844865 22895193 28481359	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BARD1	Unknown	22810696 29967250 29937994 26109429 25344691 24755471 22895193 28481359	Open Targets	Homologous recombination HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +11 more
		BAX	Unknown	22810696 20979647 29937994 11508658 19503063 16380996 25344691 10607839 38725616 24755471 22895193	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +52 more
		BAZ1A	Unknown	22810696 29937994 26336987 32375028 25344691 24755471 22895193	Open Targets	ATP-dependent chromatin remodeling
		BCL10	Unknown	29967250 22810696 29937994 29316426 25957691 25344691 28481359	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		BCL11A	Unknown	22810696 29967250 26764183 29937994 26336987 25957691 30239619 25344691 29844865 31336886 24755471 22895193	Open Targets	—
		BCL11B	Unknown	29967250 26764183 29937994 26336987 25957691 16959974 25344691 24755471 22895193	Open Targets	Transcriptional misregulation in cancer
		BCL2	Unknown	24943349 29316426 32375028 25344691 29844865 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
		BCL2L12	Unknown	38725616 26416732 25344691	Open Targets	—
		BCL3	Unknown	24755471 22895193 25344691 25957691 29844865	Open Targets	C-type lectin receptor signaling pathway TNF signaling pathway
		BCL6	Unknown	22810696 25957691 32375028 25344691 29844865 24755471 22895193 28481359	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCL7A	Unknown	22895193 26764183 29937994	Open Targets	ATP-dependent chromatin remodeling
		BCL9	Unknown	22810696 29967250 26071483 26764183 29937994 26416732 26336987 25957691 25344691 29844865 38725616 24755471 22895193	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCL9L	Unknown	22810696 30038269 26071483 27612425 26416732 26336987 23856246 25957691 26109429 30239619 25344691 38725616 24755471 31336886 22895193	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCLAF1	Unknown	22810696 26764183 29937994 26416732 26336987 23856246 26109429 32375028 25344691 22895193	Open Targets	—
		BCOR	Unknown	22810696 29967250 29937994 26416732 26336987 29316426 25957691 23856246 27245685 32375028 25344691 38725616 24755471 22895193 28481359	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	22810696 29967250 26071483 26764183 29937994 26416732 26336987 23856246 25957691 30239619 25344691 38725616 24755471 22895193	Open Targets	Polycomb repressive complex
		BCR	Unknown	22810696 27023146 26071483 26416732 25957691 25344691 29844865 38725616 22895193	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BIRC3	Unknown	22810696 30038269 29937994 25344691 29844865 28481359	Open Targets	Platinum drug resistance NF-kappa B signaling pathway Ubiquitin mediated proteolysis +23 more
		BIRC6	Unknown	22810696 30038269 26071483 29937994 26416732 25957691 25344691 38725616 24755471 22895193	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BLM	Unknown	22810696 29967250 29937994 26416732 29316426 32375028 25344691 38725616 24755471 28481359	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		BMP5	Unknown	22810696 29937994 26416732 26336987 23856246 25957691 25344691 22895193	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway
		BMPR1A	Unknown	22810696 26071483 27612425 29937994 21203531 29316426 26336987 25957691 25344691 29844865 22895193 28481359	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +4 more
		BRAF	Unknown	30036146 26650777 21289333 21704278 23534748 31227518 19378335 22586484 23660947 29998005 16959974 22376079 20501503 17096326 22114137 26018827 18992635 23104212 16699497 19679059 27756406 25673644 15294323 21423154 16404419 21520036 22392911 22879926 26968814 14668801 22895193 18832519 20979647 19581844 31450901 15674332 15702478 18938072 21390154 14688025 24759670 23125007 24755471 24367680 24764675 21726664 24737664 21103049 21315413 20679909 28936923 21931273 24498230 25708741 26071483 18757341 27302369 26336987 22147942 22712570 19959686 18759827 21659424 22752373 24990411 18339680 23680147 28978093 32375028 22427190 25617745 27239120 21646616 30038269 20651341 12068308 28243320 26416732 28120820 29316426 20496269 18186519 20635392 23856246 25194673 37369457 20444249 22684223 21901162 21161938 29937994 19637313 28951457 25344691 15729718 24743703 25686118 22586653 24841357 30239619 20305537 23569465 18422752 24755613 22558339 32669268 21203531 25589621 23446022 23355298 18922929 22810696 29967250 34680263 23983431 15790700 29844865 18519771 23425390 31400926 21285991 19404844 16143123 24964857 24928083 25957691 23095620 23792567 20664940 19001320 18208804 19026650 22740969 21791485 25050586 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	22810696 34680263 29937994 26416732 26336987 29316426 25957691 25344691 22895193 28481359	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRD3	Unknown	22810696 26071483 26764183 29937994 23856246 25957691 32375028 25344691 29844865 22895193	Open Targets	—
		BRD4	Unknown	22810696 29937994 26416732 29316426 23856246 25957691 26109429 32375028 25344691 24755471 22895193 28481359	Open Targets	—
		BRIP1	Unknown	22810696 29967250 26071483 29937994 26416732 25589621 25957691 25344691 29844865 24755471 22895193 28481359	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +8 more
		BTG1	Unknown	24755471 26071483	Open Targets	RNA degradation FOXO-mediated transcription of cell cycle genes
		BTG2	Unknown	24755471 25344691 25957691	Open Targets	RNA degradation TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

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Colon adenocarcinoma

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