Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	BTK	Unknown	26071483 29937994 26416732 29316426 25957691 25344691 29844865 22895193 28481359	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Platelet activation +17 more
		BUB1B	Unknown	22810696 29967250 29937994 26336987 25957691 29844865 24755471 22895193	Open Targets	Cell cycle Human T-cell leukemia virus 1 infection Inactivation of APC/C via direct inhibition of the APC/C complex +9 more
		CACNA1D	Unknown	22810696 26071483 26764183 29937994 27612425 26416732 23856246 25957691 26109429 32375028 25344691 24755471 22895193	Open Targets	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +35 more
		CALR	Unknown	22895193 26071483 28481359	Open Targets	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CAMTA1	Unknown	22810696 26071483 26764183 29937994 26416732 26336987 25957691 25344691 24755471 22895193	Open Targets	—
		CANT1	Unknown	24755471 22895193 25344691 29937994	Open Targets	Purine metabolism Pyrimidine metabolism Metabolic pathways +2 more
		CARD11	Unknown	22810696 27023146 29967250 26071483 29665843 29937994 26416732 26336987 23856246 25957691 28120820 29316426 26109429 30239619 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CARS1	Unknown	22810696 29937994 25957691 26109429 25344691 31336886 24755471 22895193 38725616	Open Targets	Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation
		CASP3	Unknown	22810696 26071483 29937994 23856246 25957691 25344691	Open Targets	Platinum drug resistance MAPK signaling pathway p53 signaling pathway +53 more
		CASP8	Unknown	22810696 26650777 26071483 29937994 29316426 23856246 28978093 32375028 25344691 12949717 24755471 22895193 28481359	Open Targets	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CASP9	Unknown	22810696 26764183 23856246 25344691 29937994	Open Targets	Platinum drug resistance p53 signaling pathway PI3K-Akt signaling pathway +39 more
		CBFA2T3	Unknown	29937994 26416732 25344691 16959974 31336886 22895193 38725616	Open Targets	—
		CBFB	Unknown	25957691 28481359 29316426 25344691	Open Targets	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
		CBL	Unknown	22810696 29665843 26764183 29937994 25957691 25344691 29844865 22895193 28481359	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CBLB	Unknown	22810696 26071483 29937994 26416732 26336987 23856246 25957691 25344691 38725616 24755471 22895193	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CBLC	Unknown	26071483 23856246 25957691 25344691 24755471 22895193	Open Targets	Ubiquitin mediated proteolysis Endocytosis
		CCDC6	Unknown	22810696 29937994 26416732 25957691 25344691 22895193	Open Targets	Pathways in cancer Thyroid cancer
		CCNB1IP1	Unknown	25957691 25344691 29937994	Open Targets	—
		CCNC	Unknown	25957691	Open Targets	PPARA activates gene expression Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription +3 more
		CCND1	Unknown	26764183 26416732 25957691 25344691 22895193 28481359	Open Targets	Endocrine resistance FoxO signaling pathway Cell cycle +58 more
		CCND2	Unknown	24755471 30239619 25957691 28481359	Open Targets	FoxO signaling pathway Cell cycle p53 signaling pathway +18 more
		CCND3	Unknown	28481359 25344691 25957691	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more
		CCNE1	Unknown	26071483 26764183 28546418 25957691 25344691 22895193 28481359	Open Targets	Cell cycle Oocyte meiosis p53 signaling pathway +24 more
		CCR4	Unknown	22810696 25957691 26109429 25344691 24755471 22895193	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +4 more
		CCR7	Unknown	38725616 26416732 22895193 25344691	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +2 more
		CD209	Unknown	22810696 30038269 26071483 26416732 26336987 25957691 30239619 25344691 22895193	Open Targets	Virion - Human immunodeficiency virus Virion - Flavivirus and Alphavirus Virion - Ebolavirus, Lyssavirus and Morbillivirus +7 more
		CD274	Unknown	22895193 28481359 26336987	Open Targets	Cell adhesion molecules PD-L1 expression and PD-1 checkpoint pathway in cancer PD-1 signaling
		CD28	Unknown	22895193 25344691 29937994	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Intestinal immune network for IgA production +16 more
		CD79A	Unknown	29967250 26764183 29316426 25957691 25344691 24755471 22895193 28481359	Open Targets	B cell receptor signaling pathway Primary immunodeficiency CD22 mediated BCR regulation +1 more
		CD79B	Unknown	25957691 24755471 25344691 28481359	Open Targets	B cell receptor signaling pathway CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
		CDC73	Unknown	29967250 27612425 29937994 29316426 23856246 25957691 28465371 25344691 29844865 24755471 22895193 28481359	Open Targets	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state +3 more
		CDH1	Unknown	22810696 12096341 26764183 29937994 27756406 25957691 23856246 26109429 25344691 29844865 24755471 22895193 28481359	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDH10	Unknown	22810696 27612425 29937994 26416732 26336987 23856246 25957691 30239619 25344691 24755471 22895193	Open Targets	Adherens junctions interactions
		CDH11	Unknown	22810696 30038269 29967250 26071483 29937994 26416732 25957691 30239619 25344691 29844865 31336886 24755471 22895193	Open Targets	Adherens junctions interactions
		CDH17	Unknown	22810696 26071483 29937994 26336987 25957691 32375028 25344691 38725616 22895193	Open Targets	Gastric cancer Adherens junctions interactions
		CDK12	Unknown	22810696 29937994 26336987 23856246 28465371 25957691 29316426 26109429 30239619 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDK4	Unknown	29316426 28546418 25344691 29844865 24755471 22895193 28481359	Open Targets	Endocrine resistance Cell cycle p53 signaling pathway +40 more
		CDK6	Unknown	29316426 22895193 28481359	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +27 more
		CDKN1A	Unknown	22810696 26416732 23856246 25957691 30239619 25344691 28481359	Open Targets	Endocrine resistance Platinum drug resistance ErbB signaling pathway +56 more
		CDKN1B	Unknown	22810696 25344691 28481359 25957691	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	22810696 30038269 27023146 26071483 7972006 27612425 29316426 27756406 25957691 30239619 25344691 29844865 36142641 25617745 22895193 28481359	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CDKN2C	Unknown	29967250 25344691 28481359	Open Targets	Endocrine resistance Cell cycle Cushing syndrome +6 more
		CDX2	Unknown	24755471 25344691 25957691	Open Targets	Gastric cancer Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
		CEBPA	Unknown	34680263 26416732 28481359 29844865	Open Targets	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
		CEP43	Unknown	22810696 26071483 29937994 26336987 25957691 25344691 24755471	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		CEP89	Unknown	22810696 26071483 29937994 26416732 23856246 25957691 25344691 38725616 24755471 22895193	Open Targets	Anchoring of the basal body to the plasma membrane
		CHCHD7	Unknown	22895193	Open Targets	—
		CHD2	Unknown	22810696 26071483 29937994 25957691 32375028 25344691 38725616 24755471 22895193	Open Targets	—
		CHD4	Unknown	22810696 26764183 27612425 29937994 26416732 26336987 23856246 28465371 25957691 25344691 24755471 22895193	Open Targets	ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis +5 more
		CHIC2	Unknown	22810696 22895193 25957691	Open Targets	—

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Colon adenocarcinoma

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