Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	DDX6	Unknown	22810696 26071483 26764183 29937994 26416732 30239619 22895193	Open Targets	RNA degradation mRNA decay by 5' to 3' exoribonuclease
		DEK	Unknown	29967250 29937994 26416732 25344691 31336886 24755471	Open Targets	B-WICH complex positively regulates rRNA expression Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Transcriptional regulation of granulopoiesis
		DGCR8	Unknown	29937994 26416732 23856246 25957691 25344691 24755471 22895193	Open Targets	MicroRNA (miRNA) biogenesis
		DICER1	Unknown	22810696 29967250 30038269 26071483 29937994 26416732 29316426 25957691 26109429 25344691 29844865 24755471 22895193 28481359	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		DNAJB1	Unknown	26416732 29316426 25344691 28481359 29937994	Open Targets	Protein processing in endoplasmic reticulum Influenza A Regulation of HSF1-mediated heat shock response +4 more
		DNM2	Unknown	22810696 26416732 26336987 25957691 25344691 38725616 24755471 22895193	Open Targets	Phospholipase D signaling pathway Endocytosis Fc gamma R-mediated phagocytosis +13 more
		DNMT3A	Unknown	22810696 29967250 34680263 29937994 29316426 25589621 28145097 30475948 25344691 29844865 31336886 24755471 22895193 28481359	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		DROSHA	Unknown	22810696 29937994 26336987 25957691 25344691 24755471 22895193	Open Targets	Ribosome biogenesis in eukaryotes Proteoglycans in cancer MicroRNA (miRNA) biogenesis
		EBF1	Unknown	22810696 30038269 26071483 24699064 26764183 29937994 26416732 26336987 23856246 25957691 30239619 25344691 22895193	Open Targets	—
		ECT2L	Unknown	22810696 26071483 29937994 26416732 23856246 25957691 25344691 24755471 22895193	Open Targets	—
		EED	Unknown	22810696 29937994 26416732 26336987 25344691 24755471 28481359	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +4 more
		EGFR	Unknown	29665843 26416732 28120820 29316426 24755471 22810696 34680263 23856246 29844865 31400926 27929064 26071483 29937994 26336987 27756406 25957691 19789347 25344691 26968814 22895193 23680147 28978093 25617745 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EIF1AX	Unknown	30239619 26071483 28481359	Open Targets	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits +3 more
		EIF3E	Unknown	22895193 25344691 26071483	Open Targets	Hepatitis C L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation +4 more
		EIF4A2	Unknown	22810696 29937994 29316426 25957691 25344691 22895193 28481359	Open Targets	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA +4 more
		ELF3	Unknown	22810696 29937994 26416732 25957691 25344691 24755471 22895193	Open Targets	Pre-NOTCH Transcription and Translation
		ELF4	Unknown	24755471 25344691 25957691 29937994	Open Targets	—
		ELK4	Unknown	22810696 24755471 25344691 25957691 29937994	Open Targets	MAPK signaling pathway Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer
		ELL	Unknown	25957691 26109429 30239619 22895193 25344691	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +4 more
		ELN	Unknown	38725616 24755471 32375028 25344691 25957691	Open Targets	Cytoskeleton in muscle cells Protein digestion and absorption Degradation of the extracellular matrix +2 more
		EML4	Unknown	22810696 26071483 29937994 25957691 25344691 29844865 22895193	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		EPAS1	Unknown	22810696 26071483 29937994 23856246 25957691 26109429 25344691 24755471 22895193	Open Targets	HIF-1 signaling pathway Pathways in cancer Renal cell carcinoma +6 more
		EPHA3	Unknown	22810696 29967250 26071483 29937994 26416732 29316426 23856246 25957691 26109429 30239619 25344691 29844865 16959974 24755471 22895193 28481359	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPHA7	Unknown	22810696 26071483 26764183 29937994 26416732 29316426 25957691 30239619 16959974 25344691 29844865 24755471 22895193 28481359	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPS15	Unknown	22810696 26071483 29937994 25957691 25344691 24755471	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		ERBB2	Unknown	18186519 34680263 27004155 26071483 22810696 24755471 26764183 29937994 29665843 26416732 29316426 27756406 25957691 28145097 28978093 30239619 25344691 29844865 25617745 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	29665843 26416732 29316426 24755471 18186519 22810696 29967250 29844865 38725616 29420467 29937994 25957691 25344691 26764183 22895193 22014273 23680147 28978093 30239619 32375028 36142641 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERBB4	Unknown	16187281 29665843 27612425 26416732 29316426 24755471 18186519 30962964 22810696 29967250 23856246 27245685 28145097 26109429 29844865 25623536 26071483 29937994 26336987 27756406 25957691 25344691 26764183 22895193 27023146 30239619 28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERC1	Unknown	22810696 26071483 26764183 29937994 21203531 26336987 25957691 25344691 31336886 24755471 22895193	Open Targets	NF-kappa B signaling pathway
		ERCC3	Unknown	22810696 29967250 26764183 29937994 29316426 23856246 25344691 29844865 22895193 28481359	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC4	Unknown	26764183 29937994 26416732 29316426 25344691 29844865 22895193 28481359	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		ERCC5	Unknown	22810696 26764183 29937994 26336987 29316426 25957691 26109429 30239619 25344691 29844865 38725616 22895193 28481359	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		ERG	Unknown	22810696 26764183 29937994 21203531 26416732 29316426 26336987 25957691 17367471 25344691 29844865 24755471 22895193 28481359	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ESR1	Unknown	22810696 24943349 26071483 27302369 29937994 26416732 26336987 29316426 25957691 26109429 30239619 25344691 29844865 24755471 22895193 28481359	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		ETNK1	Unknown	26416732 22895193 25344691 29937994	Open Targets	Glycerophospholipid metabolism Metabolic pathways Synthesis of PE
		ETV1	Unknown	22810696 26071483 26416732 29316426 26109429 17367471 25344691 29844865 24755471 22895193 28481359	Open Targets	Transcriptional misregulation in cancer
		ETV4	Unknown	22810696 26071483 29937994 21203531 23856246 25957691 25344691 29844865 24755471	Open Targets	Transcriptional misregulation in cancer MAPK6/MAPK4 signaling
		ETV5	Unknown	22810696 29967250 24943349 29937994 26336987 23856246 25957691 30239619 25344691 22895193	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ETV6	Unknown	22810696 30038269 26416732 29316426 25957691 25344691 24755471 22895193 28481359	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EWSR1	Unknown	29937994 26416732 26336987 25957691 25344691 38725616 24755471 22895193	Open Targets	Transcriptional misregulation in cancer
		EXT2	Unknown	32375028 22895193 25344691 29844865 29937994	Open Targets	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis +2 more
		EZH2	Unknown	22810696 29967250 31400926 29937994 26416732 29316426 25957691 25344691 16959974 22895193 28481359	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		EZR	Unknown	24755471 26416732 22895193 25344691 25957691	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +6 more
		FADD	Unknown	26764183 25957691	Open Targets	Platinum drug resistance Apoptosis Apoptosis - multiple species +36 more
		FAM131B	Unknown	22810696 24755471 22895193 25344691 29937994	Open Targets	Signaling by BRAF and RAF fusions
		FAM135B	Unknown	22810696 26071483 29937994 26416732 26336987 23856246 25957691 30239619 25344691 31336886 24755471 22895193	Open Targets	—
		FAM47C	Unknown	22810696 30038269 29937994 26416732 25957691 32375028 25344691 38725616 22895193	Open Targets	—
		FANCA	Unknown	22810696 26071483 26764183 29937994 26416732 29316426 23856246 25957691 26109429 25344691 29844865 24755471 22895193 28481359	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCE	Unknown	26336987 25344691	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCF	Unknown	22810696 24755471 25957691 29937994	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway

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Colon adenocarcinoma

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