Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	CHST11	Unknown	38725616 30038269 26416732 22895193 25344691	Open Targets	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Chondroitin sulfate biosynthesis
		CIC	Unknown	22810696 27023146 29937994 29316426 25957691 26109429 32375028 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	Spinocerebellar ataxia
		CIITA	Unknown	22810696 26071483 29937994 25957691 30239619 32375028 25344691 38725616 24755471 22895193	Open Targets	Antigen processing and presentation Toxoplasmosis Tuberculosis +3 more
		CLIP1	Unknown	22810696 26071483 26764183 29937994 26416732 25957691 30239619 25344691 24755471 22895193	Open Targets	mTOR signaling pathway Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		CLP1	Unknown	22810696 29937994 26109429 25344691 38725616 24755471 22895193	Open Targets	mRNA surveillance pathway tRNA processing in the nucleus mRNA Splicing - Major Pathway +3 more
		CLTC	Unknown	22810696 26071483 29937994 26336987 23856246 25957691 25344691 24755471 22895193	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +18 more
		CLTCL1	Unknown	22810696 26071483 29937994 26416732 26336987 25957691 25344691 24755471	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +8 more
		CNBD1	Unknown	22810696 30038269 26071483 29937994 26416732 25957691 25344691 22895193	Open Targets	—
		CNBP	Unknown	24755471 29937994	Open Targets	—
		CNOT3	Unknown	26071483 26336987 25957691 30239619 25344691 38725616 24755471 22895193	Open Targets	RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
		CNTNAP2	Unknown	22810696 26071483 29937994 26416732 22895193 23856246 25957691 25344691 24755471 26764183	Open Targets	Cell adhesion molecules
		CNTRL	Unknown	22810696 26071483 29937994 26416732 25957691 26109429 25344691 38725616 24755471 22895193	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		COL1A1	Unknown	22810696 26071483 26764183 29937994 26416732 26336987 23856246 25957691 30239619 32375028 25344691 29844865 24755471 22895193	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +26 more
		COL2A1	Unknown	22810696 29937994 26416732 23856246 25957691 30239619 25344691 31336886 24755471 22895193	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +14 more
		COL3A1	Unknown	22810696 29967250 26071483 29937994 26416732 26336987 25957691 32375028 16959974 25344691 24755471 22895193	Open Targets	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
		COX6C	Unknown	24755471 26416732 25957691	Open Targets	Oxidative phosphorylation Metabolic pathways Cardiac muscle contraction +12 more
		CPEB3	Unknown	22810696 22895193 25344691 25957691 26336987	Open Targets	Oocyte meiosis Progesterone-mediated oocyte maturation
		CREB1	Unknown	22810696 29967250 26071483 29937994 26416732 26336987 25957691 30239619 25344691	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis +53 more
		CREB3L1	Unknown	22810696 29937994 30239619 32375028 25344691 24755471 22895193	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +32 more
		CREB3L2	Unknown	22810696 21203531 22895193 25344691 26071483	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +32 more
		CREBBP	Unknown	22810696 29967250 26071483 29937994 26416732 29316426 23856246 25957691 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CRLF2	Unknown	38725616 26109429 28481359	Open Targets	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Interleukin-7 signaling
		CRNKL1	Unknown	26416732 26336987 23856246 25344691 22895193 17932254	Open Targets	Spliceosome mRNA Splicing - Major Pathway
		CRTC1	Unknown	22810696 26071483 29937994 25957691 25344691 29844865 38725616 24755471 22895193	Open Targets	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CRTC3	Unknown	29937994	Open Targets	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CSF1R	Unknown	22810696 24755471 26071483 29665843 29937994 26416732 27756406 25957691 25344691 29844865 25617745 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CSF3R	Unknown	22810696 29937994 26336987 29316426 25957691 30239619 25344691 38725616 24755471 22895193 28481359	Open Targets	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		CSMD3	Unknown	30038269 21203531 26416732 24755471 22810696 29967250 23856246 26109429 16959974 29844865 31336886 38725616 26071483 27302369 29937994 26336987 25957691 25344691 26764183 22895193 30239619 32375028	Open Targets	—
		CTCF	Unknown	22810696 29937994 29316426 23856246 32375028 25344691 22895193 28481359	Open Targets	—
		CTNNA1	Unknown	22810696 29967250 26071483 10023666 29937994 26416732 25957691 30239619 25344691 29844865 24755471 22895193 17932254	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +9 more
		CTNNA2	Unknown	22810696 30038269 26071483 27612425 29937994 26336987 25957691 26109429 30239619 25344691 38725616 24755471 22895193	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		CTNNB1	Unknown	26650777 9377556 12096341 16021566 27612425 21203531 26416732 29316426 16356174 25589621 24755471 21726664 30962964 22810696 34680263 19378335 29069792 23983431 15573917 12110635 29844865 10197610 38725616 20544848 27566247 10362137 21901162 26071483 29937994 19679059 11746989 25957691 23430953 26336987 27756406 25344691 22895193 12912937 17101323 23009572 12408524 28978093 30239619 28548127 23471846 25617745 28481359 31226844	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		CTNND1	Unknown	22810696 26071483 29937994 26336987 25957691 26109429 30239619 25344691 24755471 22895193	Open Targets	Rap1 signaling pathway Adherens junction Leukocyte transendothelial migration +3 more
		CTNND2	Unknown	22810696 26071483 26764183 29937994 26416732 23856246 25957691 26109429 30239619 25344691 16959974 24755471 22895193	Open Targets	Wnt signaling pathway
		CUL3	Unknown	29967250 22810696 26071483 29937994 26336987 23856246 25957691 30239619 25344691 38725616 22895193 28481359	Open Targets	Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL +4 more
		CUX1	Unknown	22810696 26416732 26336987 25957691 26109429 30239619 25344691 38725616 24755471 22895193	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		CXCR4	Unknown	22810696 26416732 28481359 29937994	Open Targets	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Calcium signaling pathway +15 more
		CYLD	Unknown	22810696 27023146 20854080 26071483 21420166 29937994 26416732 23856246 25957691 26109429 25344691 29844865 22895193	Open Targets	NF-kappa B signaling pathway Necroptosis Osteoclast differentiation +9 more
		CYP2C8	Unknown	22810696 27023146 26071483 29937994 25344691 24755471 22895193	Open Targets	Arachidonic acid metabolism Linoleic acid metabolism Retinol metabolism +10 more
		CYSLTR2	Unknown	22810696 26416732 25957691 26109429 24755471 22895193	Open Targets	Calcium signaling pathway Neuroactive ligand-receptor interaction Glucagon signaling in metabolic regulation +6 more
		DAXX	Unknown	26416732 29316426 25957691 25344691 22895193 28481359	Open Targets	MAPK signaling pathway Apoptosis Parkinson disease +6 more
		DCAF12L2	Unknown	22810696 26071483 29937994 26416732 26336987 25957691 25344691 24755471 22895193	Open Targets	—
		DCC	Unknown	22810696 26071483 29937994 26416732 26336987 23856246 25957691 16959974 29844865 25344691 38725616 24755471 22895193	Open Targets	Axon guidance Pathways in cancer Colorectal cancer +3 more
		DCTN1	Unknown	26071483 29937994 26416732 26336987 25957691 32375028 25344691 24755471 22895193	Open Targets	Motor proteins Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis +15 more
		DDB2	Unknown	22810696 25957691	Open Targets	Nucleotide excision repair p53 signaling pathway Ubiquitin mediated proteolysis +23 more
		DDIT3	Unknown	25957691 22895193 16959974	Open Targets	MAPK signaling pathway Protein processing in endoplasmic reticulum Apoptosis +9 more
		DDR2	Unknown	22810696 34680263 29665843 27612425 29937994 27105424 26336987 22014273 29316426 25344691 29844865 24755471 27155048 22895193 28481359	Open Targets	Non-integrin membrane-ECM interactions
		DDX10	Unknown	26071483 29937994 26416732 25957691 25344691 31336886 24755471 22895193 38725616	Open Targets	—
		DDX3X	Unknown	22810696 29937994 26416732 25957691 25344691 24755471 22895193	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		DDX5	Unknown	22810696 26071483 29937994 26336987 25957691 25344691 24755471 22895193	Open Targets	Spliceosome Transcriptional misregulation in cancer Proteoglycans in cancer +3 more

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Colon adenocarcinoma

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