Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 89

12 diseases · 15 shared-gene connections
12 Diseases
534 Unique genes
0.072 Avg. similarity score
Lymphoid leukemia Most-connected disease (5 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Lymphoid leukemia 5 5 28
Hodgkin lymphoma 4 4 111
Lymphocytic leukemia 4 4 115
Leukemia 3 3 43
Multiple myeloma 3 3 143
Myeloid leukemia 3 3 150
Lymphocytic b-cell leukemia 2 2 34
Promyelocytic leukemia 2 2 50
Dentici novelli neurodevelopmental syndrome 1 1 1
SYNCRIP-related neurodevelopmental disorder 1 1 1
hypotaurinemic retinal degeneration and cardiomyopathy 1 1 1
immunodeficiency, common variable, 14 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
IRF4 6 / 12 Hodgkin lymphoma, Leukemia, Lymphocytic b-cell leukemia, Lymphocytic leukemia and 2 more
SP140 6 / 12 Hodgkin lymphoma, Leukemia, Lymphocytic b-cell leukemia, Lymphocytic leukemia and 2 more
ACOXL 5 / 12 Hodgkin lymphoma, Lymphocytic b-cell leukemia, Lymphocytic leukemia, Lymphoid leukemia and 1 more
BCL2 5 / 12 Hodgkin lymphoma, Lymphocytic b-cell leukemia, Lymphocytic leukemia, Multiple myeloma and 1 more
BMF 5 / 12 Hodgkin lymphoma, Lymphocytic b-cell leukemia, Lymphocytic leukemia, Lymphoid leukemia and 1 more
GRAMD1B 5 / 12 Hodgkin lymphoma, Leukemia, Lymphocytic leukemia, Lymphoid leukemia and 1 more
ACTRT3 4 / 12 Leukemia, Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
EXOC2 4 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
HLA-DQB1 4 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
IRF8 4 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
LPP 4 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma, Myeloid leukemia
MYNN 4 / 12 Leukemia, Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
QPCT 4 / 12 Hodgkin lymphoma, Lymphocytic b-cell leukemia, Lymphocytic leukemia, Multiple myeloma
AQP9 3 / 12 Leukemia, Myeloid leukemia, Promyelocytic leukemia
BAK1 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
BCL2L11 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
CIB3 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
DNMT3A 3 / 12 Leukemia, Myeloid leukemia, Promyelocytic leukemia
DTNB 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
ELL2 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
EOMES 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
FABP3 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
FAS 3 / 12 Lymphocytic leukemia, Lymphoid leukemia, Myeloid leukemia
HLA-DQA1 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
HLA-DRB1 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
MNS1 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
NCAPH2 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
NCK1 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
PHLPP1 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
PTPN11 3 / 12 Leukemia, Myeloid leukemia, Promyelocytic leukemia
SERINC2 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
TERT 3 / 12 Lymphocytic leukemia, Lymphoid leukemia, Myeloid leukemia
TNFSF8 3 / 12 Lymphocytic b-cell leukemia, Multiple myeloma, Myeloid leukemia
ULK4 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
WT1 3 / 12 Leukemia, Myeloid leukemia, Promyelocytic leukemia
ZNF280D 3 / 12 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
C11ORF21 2 / 12 Lymphocytic b-cell leukemia, Lymphocytic leukemia
CCND1 2 / 12 Leukemia, Multiple myeloma
CCSER1 2 / 12 Hodgkin lymphoma, Multiple myeloma
CD44 2 / 12 Myeloid leukemia, Promyelocytic leukemia
CD86 2 / 12 Hodgkin lymphoma, Multiple myeloma
CEBPA 2 / 12 Myeloid leukemia, Promyelocytic leukemia
CFLAR 2 / 12 Leukemia, Lymphocytic leukemia
CHEK2 2 / 12 Leukemia, Myeloid leukemia
CSF2 2 / 12 Multiple myeloma, Myeloid leukemia
CSF3 2 / 12 Multiple myeloma, Myeloid leukemia
DAPK1 2 / 12 Multiple myeloma, Myeloid leukemia
DMRTA1 2 / 12 Lymphocytic leukemia, Lymphoid leukemia
EPHX1 2 / 12 Multiple myeloma, Myeloid leukemia
ERG 2 / 12 Leukemia, Myeloid leukemia
FARP2 2 / 12 Lymphocytic b-cell leukemia, Lymphocytic leukemia
FLT3 2 / 12 Myeloid leukemia, Promyelocytic leukemia
GIPC2 2 / 12 Hodgkin lymphoma, Multiple myeloma
GRIP1 2 / 12 Lymphoid leukemia, Multiple myeloma
HBS1L 2 / 12 Hodgkin lymphoma, Multiple myeloma
HGF 2 / 12 Multiple myeloma, Myeloid leukemia
HSPB1 2 / 12 Multiple myeloma, Myeloid leukemia
IDH1 2 / 12 Myeloid leukemia, Promyelocytic leukemia
IDH2 2 / 12 Myeloid leukemia, Promyelocytic leukemia
IL6 2 / 12 Lymphocytic b-cell leukemia, Multiple myeloma
IRF2BP2 2 / 12 immunodeficiency, common variable, 14, Promyelocytic leukemia
JAK2 2 / 12 Leukemia, Myeloid leukemia
KIT 2 / 12 Myeloid leukemia, Promyelocytic leukemia
KMT2A 2 / 12 Leukemia, Myeloid leukemia
KMT2E 2 / 12 Leukemia, Myeloid leukemia
LEF1 2 / 12 Lymphocytic b-cell leukemia, Lymphocytic leukemia
LPAR1 2 / 12 Hodgkin lymphoma, Myeloid leukemia
LRRC34 2 / 12 Lymphocytic leukemia, Multiple myeloma
MECOM 2 / 12 Multiple myeloma, Myeloid leukemia
MEGF11 2 / 12 Hodgkin lymphoma, Lymphoid leukemia
NPM1 2 / 12 Myeloid leukemia, Promyelocytic leukemia
NQO1 2 / 12 Multiple myeloma, Myeloid leukemia
NRAS 2 / 12 Myeloid leukemia, Promyelocytic leukemia
PALD1 2 / 12 Lymphocytic leukemia, Lymphoid leukemia
PRAME 2 / 12 Leukemia, Multiple myeloma
PRKD2 2 / 12 Lymphocytic b-cell leukemia, Lymphocytic leukemia
PTPRK 2 / 12 Hodgkin lymphoma, Lymphocytic leukemia
SLC6A6 2 / 12 hypotaurinemic retinal degeneration and cardiomyopathy, Myeloid leukemia
SP140L 2 / 12 Lymphoid leukemia, Multiple myeloma
SPARC 2 / 12 Multiple myeloma, Myeloid leukemia
SYNCRIP 2 / 12 Leukemia, SYNCRIP-related neurodevelopmental disorder
THEMIS 2 / 12 Hodgkin lymphoma, Lymphocytic leukemia
TNFSF10 2 / 12 Leukemia, Myeloid leukemia
TP53 2 / 12 Lymphocytic b-cell leukemia, Lymphoid leukemia
TSBP1 2 / 12 Hodgkin lymphoma, Lymphocytic leukemia
ZBTB7A 2 / 12 Lymphocytic leukemia, Myeloid leukemia
ZNF526 2 / 12 Dentici novelli neurodevelopmental syndrome, Hodgkin lymphoma
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Pathways in cancer
CEBPA, RUNX1, TERT, CSF3R, BAK1, BCL2, BCL2L11, CAMK2D, CASP8, ETS1, FAS, LEF1
 KEGG 86 / 533 3.6× 1.58e-26 3.49e-23 ✓ sig.
Acute myeloid leukemia
CEBPA, RUNX1, LEF1, MAP2K2, RPS6KB1, MAPK3, BAD, CCND1, FLT3, KIT, KRAS, SPI1
 KEGG 26 / 68 8.6× 2.96e-18 1.81e-15 ✓ sig.
Transcriptional misregulation in cancer
CEBPA, ETV6, RUNX1, BAK1, FLI1, CD86, RUNX2, TCF3, BIRC2, BIRC3, ERG, KMT2A
 KEGG 38 / 198 4.3× 1.24e-14 3.82e-12 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
BCL2, IRF4, OPRM1, RHOU, GATA3, IL13, CCND1, JAK2, IL6, PTGS2, TP53, VEGFA
 Reactome 28 / 108 5.8× 1.51e-14 4.54e-12 ✓ sig.
EGFR tyrosine kinase inhibitor resistance
BCL2, BCL2L11, MAP2K2, RPS6KB1, MAPK3, PDGFD, BAD, JAK2, PTEN, KRAS, IL6, PLCG2
 KEGG 23 / 80 6.5× 3.21e-13 7.51e-11 ✓ sig.
Apoptosis
BAK1, BCL2, BCL2L11, CASP10, CASP8, CFLAR, FAS, MAP2K2, ITPR2, MAPK3, BAD, BIRC2
 KEGG 28 / 137 4.6× 8.47e-12 1.54e-9 ✓ sig.
Platinum drug resistance
BAK1, BCL2, CASP8, FAS, MAPK3, BAD, BIRC2, BIRC3, GSTM1, GSTO1, TOP2A, ATM
 KEGG 20 / 75 6.0× 5.25e-11 8.03e-9 ✓ sig.
Chronic myeloid leukemia
RUNX1, BAK1, MAP2K2, SMAD3, ABL1, BCR, MAPK3, BAD, CCND1, PTPN11, KRAS, TP53
 KEGG 20 / 77 5.8× 8.86e-11 1.29e-8 ✓ sig.
Human T-cell leukemia virus 1 infection
CHEK2, TERT, BUB1B, ETS1, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, MAP2K2, SMAD3, HLA-DRA, MAPK3
 KEGG 33 / 224 3.3× 1.14e-9 1.26e-7 ✓ sig.
Hepatocellular carcinoma
TERT, BAK1, LEF1, MAP2K2, RPS6KB1, SMAD3, LRP5, MAPK3, BAD, CCND1, GSTM1, GSTO1
 KEGG 28 / 170 3.7× 1.66e-9 1.74e-7 ✓ sig.
PI3K-Akt signaling pathway
CSF3R, BCL2, BCL2L11, MAP2K2, PHLPP1, RPS6KB1, LPAR1, MAPK3, PDGFD, BAD, CCND1, DDIT4
 KEGG 43 / 361 2.7× 3.16e-9 3.14e-7 ✓ sig.
Colorectal cancer
BAK1, BCL2, BCL2L11, LEF1, MAP2K2, RPS6KB1, SMAD3, MAPK3, BAD, CCND1, KRAS, PMAIP1
 KEGG 19 / 87 4.9× 6.21e-9 5.77e-7 ✓ sig.
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
BCL2, BCL2L11, BMF, BAD, PMAIP1, STAT3, BCL2L1
 Reactome 7 / 9 17.5× 1.10e-8 9.49e-7 ✓ sig.
Hematopoietic cell lineage
CSF3R, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRA, FLT3, KIT, CD5, IL6, ITGA4, TFRC
 KEGG 20 / 100 4.5× 1.24e-8 1.05e-6 ✓ sig.
Bladder cancer
MAP2K2, MAPK3, RPS6KA5, CCND1, KRAS, TP53, VEGFA, DAPK1, MYC, NRAS, DAPK2, CDKN2A
 KEGG 13 / 41 7.1× 1.29e-8 1.08e-6 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of transcription by RNA polymerase II
CBFB, CEBPA, ETV6, GATA2, RUNX1, APP, ASCL2, CSRNP1, DRD2, EOMES, ETS1, FLI1
 GO:0045944 99 / 1,208 2.9× 6.10e-22 1.28e-18 ✓ sig.
apoptotic process
CHEK2, APP, BAK1, BCL2, BCL2L11, BMF, BUB1B, CASP10, CASP8, CFLAR, CLPTM1L, CSRNP1
 GO:0006915 71 / 747 3.3× 3.10e-19 4.48e-16 ✓ sig.
positive regulation of gene expression
CEBPA, GATA2, ACTA2, APP, ETS1, KPNA7, LEF1, MAP2K2, SMAD3, GATA3, IL13, PTPN22
 GO:0010628 52 / 504 3.6× 9.33e-16 7.29e-13 ✓ sig.
positive regulation of DNA-templated transcription
CEBPA, CHEK2, GATA2, RUNX1, CXXC1, EOMES, ETS1, FLI1, HLA-DRB1, IRF4, IRF8, LEF1
 GO:0045893 66 / 778 3.0× 1.90e-15 1.42e-12 ✓ sig.
negative regulation of apoptotic process
TERT, BCL2, CFLAR, FAS, LEF1, RPS6KB1, SMAD3, AHI1, BAD, BIRC2, BIRC3, IL2
 GO:0043066 51 / 524 3.4× 1.89e-14 1.17e-11 ✓ sig.
negative regulation of transcription by RNA polymerase II
CBFB, CEBPA, ETV6, GATA2, RUNX1, APP, ASCL2, EOMES, IRF8, JARID2, LEF1, NCK1
 GO:0000122 69 / 1,002 2.4× 9.62e-12 3.55e-9 ✓ sig.
macrophage differentiation
CEBPA, CASP8, CFLAR, HLA-DRB1, GATA3, NPM1, SPI1, VEGFA, CSF1R, CSF2, CEBPE, IFNG
 GO:0030225 13 / 37 12.3× 1.39e-11 4.96e-9 ✓ sig.
cell population proliferation
CEBPA, BCL2, DRD2, JARID2, SMAD3, GATA3, RUNX2, BAP1, CCND1, SPHK1, KIT, KRAS
 GO:0008283 31 / 263 4.1× 2.47e-11 8.18e-9 ✓ sig.
response to ethanol
BAK1, CASP8, DRD2, GATA3, IL13, BIRC2, CCND1, DNMT3A, IL2, POLB, TNFRSF11A, CDO1
 GO:0045471 20 / 110 6.4× 3.74e-11 1.18e-8 ✓ sig.
positive regulation of apoptotic process
APP, BAK1, BCL2, BCL2L11, BMF, CASP8, FAS, IRF8, SPDEF, ABL1, EPHA7, LPAR1
 GO:0043065 34 / 326 3.6× 7.89e-11 2.30e-8 ✓ sig.
response to gamma radiation
CHEK2, BAK1, BCL2, GATA3, POLB, TP53, PML, BRCA2, LIG4, PARP1, SOD2
 GO:0010332 11 / 27 14.3× 8.07e-11 2.35e-8 ✓ sig.
regulation of gene expression
APP, BCL2, EOMES, JARID2, ABL1, MAPK3, MYOD1, RUNX2, AR, BAP1, DNMT3A, KMT2A
 GO:0010468 38 / 402 3.3× 1.10e-10 3.13e-8 ✓ sig.
intrinsic apoptotic signaling pathway in response to DNA damage
CHEK2, BAK1, BCL2, BCL2L11, ABL1, BAD, ATM, POLB, MYC, PML, BCL2L1, BRCA2
 GO:0008630 14 / 54 9.1× 2.32e-10 6.10e-8 ✓ sig.
regulation of apoptotic process
BAK1, BCL2, BCL2L11, CASP10, CASP8, CFLAR, ETS1, FAS, PHLPP1, ZBTB7A, LRP5, BAD
 GO:0042981 29 / 254 4.0× 2.36e-10 6.20e-8 ✓ sig.
positive regulation of miRNA transcription
GATA2, TERT, ETS1, SMAD3, GATA3, AR, WT1, IL6, TP53, SPI1, MYC, STAT3
 GO:1902895 14 / 56 8.7× 3.94e-10 9.69e-8 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Hodgkin lymphoma Lymphocytic leukemia 0.152 30 1.88e-39 8.18e-38 ✓ sig.
Hodgkin lymphoma Multiple myeloma 0.138 31 5.27e-38 2.21e-36 ✓ sig.
Lymphocytic leukemia Multiple myeloma 0.131 30 9.00e-36 3.54e-34 ✓ sig.
Lymphocytic leukemia Lymphoid leukemia 0.108 14 2.73e-23 6.42e-22 ✓ sig.
Lymphoid leukemia Multiple myeloma 0.075 12 6.90e-18 1.25e-16 ✓ sig.
Lymphocytic b-cell leukemia Lymphocytic leukemia 0.071 10 4.09e-14 5.77e-13 ✓ sig.
Myeloid leukemia Promyelocytic leukemia 0.063 12 4.13e-14 5.82e-13 ✓ sig.
Hodgkin lymphoma Lymphoid leukemia 0.069 9 2.33e-13 3.14e-12 ✓ sig.
Leukemia Myeloid leukemia 0.054 10 8.28e-12 9.68e-11 ✓ sig.
Lymphocytic b-cell leukemia Lymphoid leukemia 0.086 5 3.66e-9 3.30e-8 ✓ sig.
Leukemia Lymphoid leukemia 0.075 5 1.25e-8 1.05e-7 ✓ sig.
Leukemia SYNCRIP-related neurodevelopmental disorder 0.023 1 2.79e-3 3.74e-3 ✓ sig.
immunodeficiency, common variable, 14 Promyelocytic leukemia 0.020 1 3.25e-3 4.24e-3 ✓ sig.
Dentici novelli neurodevelopmental syndrome Hodgkin lymphoma 0.009 1 7.21e-3 8.52e-3 ✓ sig.
hypotaurinemic retinal degeneration and cardiomyopathy Myeloid leukemia 0.007 1 9.74e-3 1.11e-2 ✓ sig.