Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 21

20 diseases · 51 shared-gene connections
20 Diseases
3,697 Unique genes
0.180 Avg. similarity score
Ovarian serous carcinoma Most-connected disease (11 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Ovarian serous carcinoma 11 11 270
Cancer 10 10 261
Estrogen-receptor negative breast cancer 9 9 296
Lung cancer 9 9 649
Ovarian cancer 9 9 466
Breast cancer 8 7 1,066
Colorectal cancer 8 7 976
Squamous cell carcinoma 7 6 789
Prostate cancer 6 6 962
Colorectal adenoma 5 5 139
Ovarian epithelial cancer 4 4 115
Androgenetic alopecia 3 3 408
Dental caries 2 2 231
Neoplasms 2 2 47
Uterine fibroid 2 2 306
hereditary mixed polyposis syndrome 2 2 1
C3hex olfactory ability 2 1 1
Essential pentosuria 1 1 1
myopathy with abnormal lipid metabolism 1 0 1
pili torti-developmental delay-neurological abnormalities syndrome 1 0 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
TERT 13 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 9 more
GREM1 12 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 8 more
RTEL1 12 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 8 more
EIF3H 11 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 7 more
HLA-B 11 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 7 more
HLA-DQA1 11 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 7 more
HLA-DRB5 11 / 20 Breast cancer, Cancer, Colorectal cancer, Dental caries and 7 more
MLLT10 11 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 7 more
NEK10 11 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 7 more
NSF 11 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 7 more
PIK3C2B 11 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 7 more
POU5F1B 11 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 7 more
SMAD7 11 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 7 more
TET2 11 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal adenoma and 7 more
THADA 11 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 7 more
TP53 11 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 7 more
ATXN2 10 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 6 more
BABAM1 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
BNC2 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
C11ORF65 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
CCDC170 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
CCDC91 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
CDCA7 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
CDYL2 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
EBF1 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
ESR1 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
HLA-DQB1 10 / 20 Breast cancer, Cancer, Colorectal cancer, Dental caries and 6 more
HLA-DRB1 10 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 6 more
HNF1B 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
IGF2BP2 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
IRF4 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
JAZF1 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
KANSL1 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
KIF20B 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
KLK15 10 / 20 Breast cancer, Cancer, Colorectal cancer, Dental caries and 6 more
KLK3 10 / 20 Breast cancer, Cancer, Colorectal cancer, Dental caries and 6 more
KRT5 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
LINC02210-CRHR1 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
MECOM 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
MRTFA 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
MYEOV 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
PARP1 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
PDLIM5 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
PIGU 10 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 6 more
POU2AF3 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
PREX1 10 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 6 more
PTHLH 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
RAD51B 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
RBMS1 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
RGS22 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
RREB1 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
SCG5 10 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 6 more
SLK 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
STMN3 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
STN1 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
TRIM46 10 / 20 Breast cancer, Cancer, Colorectal cancer, Dental caries and 6 more
TTC33 10 / 20 Breast cancer, Cancer, Colorectal adenoma, Colorectal cancer and 6 more
USHBP1 10 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 6 more
ZBTB38 10 / 20 Androgenetic alopecia, Breast cancer, Cancer, Colorectal cancer and 6 more
AGER 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
AHR 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
AIF1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
ANKRD11 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
ANKRD24 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
ANXA9 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
ARHGEF10L 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
ASIP 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
ATAD5 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
ATE1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
ATP8B1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
AZGP1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
BAD 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
BCL2L11 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
BIK 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
BPIFA3 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
BRCA2 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
BZW1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CALCRL 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CASP8 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CBFA2T2 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CCHCR1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CCND1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CCNE1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CDH15 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CDK5RAP1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CDKN2A 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CELF2 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CERS2 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CHD3 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CHMP4B 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CLK1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CMSS1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
CYBRD1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
DCAF4 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
DLGAP4 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
DNAJC1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
DPEP1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
DVL1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
EFHD1 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
EOMES 9 / 20 Breast cancer, Cancer, Colorectal cancer, Estrogen-receptor negative breast cancer and 5 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Endometrial cancer
AXIN1, CTNNB1, CDH1, TP53, AKT1, CCND1, CDKN1A, CTNNA1, CTNNA2, CTNNA3, EGFR, KRAS
 KEGG 36 / 59 2.0× 1.49e-6 6.88e-5 ✓ sig.
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
RAD51B, BARD1, BRCA1, BRCA2, EXO1, PALB2, RBBP8, RTEL1, ATM, BRIP1, BLM, RMI2
 Reactome 19 / 26 2.4× 1.09e-5 3.62e-4 ✓ sig.
Homologous recombination
BABAM2, RAD51B, BABAM1, BARD1, BRCA1, BRCA2, PALB2, RBBP8, ATM, RAD52, SEM1, BRIP1
 KEGG 26 / 41 2.1× 1.61e-5 4.98e-4 ✓ sig.
Homologous DNA Pairing and Strand Exchange
RAD51B, BARD1, BRCA1, BRCA2, EXO1, PALB2, RBBP8, ATM, BRIP1, BLM, RMI2, RAD51
 Reactome 18 / 25 2.3× 2.63e-5 7.47e-4 ✓ sig.
EGFR tyrosine kinase inhibitor resistance
BCL2, FGFR3, PDGFA, PRKCA, FGFR2, AKT1, BCL2L11, EGFR, GAB1, KRAS, P3R3URF-PIK3R3, PIK3CA
 KEGG 42 / 80 1.7× 4.06e-5 1.08e-3 ✓ sig.
Prostate cancer
AR, BCL2, CTNNB1, PDGFA, SRD5A2, TP53, FGFR2, AKT1, CCND1, CCNE1, CDKN1A, CREB5
 KEGG 49 / 98 1.6× 5.16e-5 1.31e-3 ✓ sig.
MET activates PTK2 signaling
COL24A1, LAMC3, LAMC1, COL1A1, COL1A2, COL5A2, LAMB2, HGF, ITGB1, MET, PTK2, LAMA5
 Reactome 20 / 30 2.2× 5.44e-5 1.37e-3 ✓ sig.
Bladder cancer
FGFR3, CDH1, TP53, CCND1, CDKN1A, EGFR, KRAS, CDKN2A, MMP9, CXCL8, HRAS, MAPK1
 KEGG 25 / 41 2.0× 6.10e-5 1.50e-3 ✓ sig.
p53-Dependent G1 DNA Damage Response
CCNE1, CDKN1A, CDKN1B, CCNA1, CCNA2, CCNE2, CDK2
 Reactome 7 / 7 3.2× 2.61e-4 4.81e-3 ✓ sig.
Melanoma
FGF5, PDGFA, CDH1, TP53, AKT1, CCND1, CDKN1A, EGFR, FGF10, KRAS, P3R3URF-PIK3R3, PIK3CA
 KEGG 37 / 73 1.6× 2.92e-4 5.25e-3 ✓ sig.
Non-small cell lung cancer
PRKCA, TP53, AKT1, CCND1, CDKN1A, EGFR, KIF5C, KRAS, P3R3URF-PIK3R3, PIK3CA, PIK3R1, BAD
 KEGG 37 / 73 1.6× 2.92e-4 5.25e-3 ✓ sig.
Colorectal cancer
AREG, AXIN1, BCL2, CTNNB1, SMAD3, TGFB1, TP53, AKT1, BCL2L11, CCND1, CDKN1A, EGFR
 KEGG 42 / 87 1.6× 4.53e-4 7.39e-3 ✓ sig.
RUNX3 regulates p14-ARF
CBFB, HDAC4, RUNX1, RUNX3, TGFB1, CCND1, KRAS, EP300
 Reactome 8 / 9 2.9× 5.25e-4 8.26e-3 ✓ sig.
Gastric cancer
AXIN1, BCL2, CTNNB1, FGF5, JUP, LRP6, SMAD3, TGFB1, WNT10A, WNT3, WNT6, WNT7B
 KEGG 65 / 150 1.4× 7.41e-4 1.08e-2 ✓ sig.
Pancreatic cancer
SMAD3, TGFB1, TP53, AKT1, BRCA2, CCND1, CDKN1A, EGFR, KRAS, MAPK10, P3R3URF-PIK3R3, PIK3CA
 KEGG 37 / 77 1.6× 1.08e-3 1.44e-2 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of transcription by RNA polymerase II
ALX4, AP3D1, AR, ATF1, ATXN1, AUTS2, BCL11A, BMP4, BMP7, CASZ1, CBFB, CDC5L
 GO:0045944 378 / 1,208 1.6× 5.62e-23 1.39e-19 ✓ sig.
positive regulation of DNA-templated transcription
AR, ATF7IP, BICRA, BMP4, BMP7, CASZ1, CITED4, CLOCK, CTNNB1, EPC1, FOXE1, FOXF2
 GO:0045893 239 / 778 1.6× 8.19e-14 4.57e-11 ✓ sig.
negative regulation of transcription by RNA polymerase II
AR, ATF7IP, ATXN1, BCL11A, BHLHE40, BMP4, CBFB, CBX5, CIC, CTNNB1, CUX1, DNMT3B
 GO:0000122 277 / 1,002 1.4× 4.25e-10 1.04e-7 ✓ sig.
negative regulation of DNA-templated transcription
ATF7IP, ATXN1, BHLHE40, BMP4, BMP7, CBX5, CDYL2, CIC, CLOCK, CTNNB1, EPC1, FOXF2
 GO:0045892 188 / 631 1.5× 6.57e-10 1.55e-7 ✓ sig.
stem cell proliferation
CDKN2C, CTNNB1, PBX1, RUNX2, TGFB1, WNT3, WNT7B, ZNRF3, TP53, BRCA2, CD34, FGF10
 GO:0072089 31 / 54 2.9× 1.18e-9 2.61e-7 ✓ sig.
odontogenesis of dentin-containing tooth
BMP4, BMP7, CTNNB1, EDA, EDAR, GLI2, HAND1, NFIC, RUNX2, TGFB1, WNT6, BCL2L11
 GO:0042475 30 / 56 2.7× 1.98e-8 3.08e-6 ✓ sig.
axon guidance
BMP7, CRPPA, ECE1, FYN, GLI2, LHX2, NOG, NRP2, OPHN1, WNT3, BOC, ALCAM
 GO:0007411 70 / 192 1.8× 4.99e-8 6.77e-6 ✓ sig.
positive regulation of miRNA transcription
AR, MYB, SMAD3, TEAD1, TGFB1, MRTFB, SMAD6, TERT, TP53, EGFR, KLF4, MRTFA
 GO:1902895 29 / 56 2.6× 9.13e-8 1.12e-5 ✓ sig.
DNA damage response
BABAM2, BCL2, CBX5, CDC5L, CLOCK, CRADD, DYRK2, ETAA1, HMGB1, MAPT, RAD51B, REV3L
 GO:0006974 166 / 577 1.5× 9.25e-8 1.13e-5 ✓ sig.
embryonic organ development
CTNNB1, PBX1, SYF2, TEAD1, UTP25, WNT7B, TP53, FGFR2, PALB2, PKD2, PTCH1, ZFPM2
 GO:0048568 24 / 42 2.9× 1.01e-7 1.21e-5 ✓ sig.
heart development
BMP4, BMP7, CTNNB1, ECE1, GLI2, HAND1, HDAC9, HOPX, KAT2B, NRP2, SH3PXD2B, TGFB1
 GO:0007507 90 / 273 1.7× 1.64e-7 1.83e-5 ✓ sig.
regulation of gene expression
AFF3, AR, BCL2, BMP4, CLOCK, CTNNB1, DNMT3B, GLI2, IRF1, ITCH, KAT2B, KLF15
 GO:0010468 122 / 402 1.5× 2.25e-7 2.39e-5 ✓ sig.
cell-cell adhesion
BCL2, BMP7, CDON, CTNNB1, JUP, LRP6, BOC, CDH1, COL19A1, BAIAP2, BAIAP2L1, CD34
 GO:0098609 75 / 218 1.7× 2.62e-7 2.72e-5 ✓ sig.
inner ear morphogenesis
FGFR2, CDH23, FGF10, TBX1, TBX3, FOXI1, KCNQ1, MAFB, NTN1, PAX8, FGFR1, ATOH1
 GO:0042472 31 / 65 2.4× 3.69e-7 3.62e-5 ✓ sig.
regulation of transcription by RNA polymerase II
ALX4, AR, ATF1, BBX, BCL11A, BHLHE40, BICRA, CBFB, CDC5L, CIC, CLOCK, CTNNB1
 GO:0006357 394 / 1,602 1.2× 4.71e-7 4.44e-5 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Cancer Ovarian serous carcinoma 0.583 196 < 1e-300 < 1e-300 ✓ sig.
Ovarian cancer Ovarian serous carcinoma 0.495 244 < 1e-300 < 1e-300 ✓ sig.
Lung cancer Squamous cell carcinoma 0.430 433 < 1e-300 < 1e-300 ✓ sig.
Breast cancer Estrogen-receptor negative breast cancer 0.261 282 3.16e-321 4.36e-318 ✓ sig.
Cancer Estrogen-receptor negative breast cancer 0.546 197 8.86e-315 1.15e-311 ✓ sig.
Estrogen-receptor negative breast cancer Ovarian serous carcinoma 0.528 196 6.32e-307 7.33e-304 ✓ sig.
Estrogen-receptor negative breast cancer Ovarian cancer 0.372 207 1.23e-261 1.09e-258 ✓ sig.
Cancer Ovarian cancer 0.374 198 1.63e-261 1.38e-258 ✓ sig.
Cancer Lung cancer 0.279 199 1.61e-228 9.36e-226 ✓ sig.
Lung cancer Ovarian serous carcinoma 0.276 199 3.04e-223 1.63e-220 ✓ sig.
Estrogen-receptor negative breast cancer Lung cancer 0.277 205 5.94e-221 3.05e-218 ✓ sig.
Estrogen-receptor negative breast cancer Squamous cell carcinoma 0.238 209 6.80e-208 3.00e-205 ✓ sig.
Cancer Squamous cell carcinoma 0.232 198 4.13e-207 1.72e-204 ✓ sig.
Cancer Prostate cancer 0.205 208 2.70e-206 1.10e-203 ✓ sig.
Ovarian serous carcinoma Squamous cell carcinoma 0.230 198 6.24e-202 2.46e-199 ✓ sig.
Breast cancer Ovarian cancer 0.214 270 2.28e-197 8.37e-195 ✓ sig.
Ovarian serous carcinoma Prostate cancer 0.199 205 3.61e-195 1.30e-192 ✓ sig.
Estrogen-receptor negative breast cancer Prostate cancer 0.202 212 8.71e-193 3.10e-190 ✓ sig.
Breast cancer Ovarian serous carcinoma 0.185 209 4.19e-192 1.44e-189 ✓ sig.
Cancer Colorectal cancer 0.194 201 4.57e-192 1.55e-189 ✓ sig.
Colorectal cancer Ovarian serous carcinoma 0.193 202 1.71e-188 5.37e-186 ✓ sig.
Colorectal cancer Estrogen-receptor negative breast cancer 0.195 208 1.09e-184 3.25e-182 ✓ sig.
Ovarian cancer Ovarian epithelial cancer 0.246 115 6.45e-182 1.85e-179 ✓ sig.
Lung cancer Ovarian cancer 0.241 217 4.86e-181 1.36e-178 ✓ sig.
Ovarian cancer Squamous cell carcinoma 0.219 226 2.16e-172 5.42e-170 ✓ sig.
Colorectal cancer Ovarian cancer 0.200 240 1.54e-167 3.70e-165 ✓ sig.
Ovarian cancer Prostate cancer 0.200 238 1.53e-166 3.64e-164 ✓ sig.
Breast cancer Prostate cancer 0.194 330 1.23e-153 2.52e-151 ✓ sig.
Breast cancer Lung cancer 0.189 273 1.88e-151 3.68e-149 ✓ sig.
Colorectal cancer Lung cancer 0.185 254 3.99e-141 7.20e-139 ✓ sig.
Colorectal adenoma Colorectal cancer 0.086 88 1.38e-70 1.05e-68 ✓ sig.
Colorectal adenoma Neoplasms 0.107 18 1.86e-25 4.92e-24 ✓ sig.
Breast cancer Uterine fibroid 0.048 63 2.76e-15 4.23e-14 ✓ sig.
Ovarian epithelial cancer Ovarian serous carcinoma 0.055 20 9.81e-15 1.46e-13 ✓ sig.
Dental caries Squamous cell carcinoma 0.043 42 5.45e-13 7.13e-12 ✓ sig.
Androgenetic alopecia Prostate cancer 0.051 66 7.22e-13 9.33e-12 ✓ sig.
Dental caries Lung cancer 0.044 37 2.13e-12 2.61e-11 ✓ sig.
Androgenetic alopecia Breast cancer 0.049 69 3.07e-12 3.72e-11 ✓ sig.
Androgenetic alopecia Colorectal cancer 0.048 64 1.23e-11 1.42e-10 ✓ sig.
Ovarian serous carcinoma Uterine fibroid 0.047 26 2.99e-11 3.31e-10 ✓ sig.
Cancer Colorectal adenoma 0.044 17 2.02e-10 2.08e-9 ✓ sig.
Colorectal adenoma Ovarian serous carcinoma 0.041 16 2.82e-9 2.57e-8 ✓ sig.
Estrogen-receptor negative breast cancer Ovarian epithelial cancer 0.038 15 5.42e-9 4.81e-8 ✓ sig.
Cancer Ovarian epithelial cancer 0.039 14 8.84e-9 7.52e-8 ✓ sig.
hereditary mixed polyposis syndrome Neoplasms 0.021 1 3.05e-3 4.02e-3 ✓ sig.
Colorectal adenoma hereditary mixed polyposis syndrome 0.007 1 9.03e-3 1.03e-2 ✓ sig.
Cancer Essential pentosuria 0.004 1 1.70e-2 1.86e-2 ✓ sig.
C3hex olfactory ability Lung cancer 0.002 1 4.21e-2 4.40e-2 ✓ sig.
myopathy with abnormal lipid metabolism Squamous cell carcinoma 0.001 1 5.12e-2 5.31e-2
Colorectal cancer pili torti-developmental delay-neurological abnormalities syndrome 0.001 1 6.34e-2 6.48e-2
Breast cancer C3hex olfactory ability 0.001 1 6.92e-2 7.07e-2