LINC02210-CRHR1 (LINC02210-CRHR1 readthrough)

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Gene Other IDs Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 104909134
• Gene name: LINC02210-CRHR1 readthrough
• Gene symbol: LINC02210-CRHR1
• Synonyms (NCBI Gene): CRHR1-IT1-CRHR1, MGC57346-CRHR1
• Chromosome: 17
• Chromosome location: 17q21.31
• Summary: This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Interactions View interactions

Pathways

Reactome Pathway

Class B/2 (Secretin family receptors)

G alpha (s) signalling events

ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (34)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	25778476, 34743297, 35589863	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	28272467	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	30804558, 38250258	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	36819030, 37636041	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANCER	—	GWAS catalog	32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORTICOBASAL DEGENERATION DISORDER	—	GWAS catalog	26077951	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	39046104	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	38102678	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	39966646	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	29942085, 37426090	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	36939796	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDER	—	GWAS catalog	29942085	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SYSTEM ATROPHY	—	GWAS catalog	27629089	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROLITHIASIS	—	GWAS catalog	40216741	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	27067015, 29255261, 29942085, 30643256	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	37386247	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	40205036	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	40205036	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	32887889, 36819030, 37636041	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN ENDOMETRIOID CARCINOMA	—	GWAS catalog	32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN SEROUS CARCINOMA	—	GWAS catalog	32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	19915575, 21292315, 27182965, 31660654, 31701892, 38155330, 39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PEPTIC ULCER DISEASE	—	GWAS catalog	38102678	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	GWAS catalog	38637617	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	31374203, 33169155, 35396580	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN DISEASE	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	32887889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	36762574	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (66)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
ACTH-Secreting Pituitary Adenoma	Pituitary adenoma	BEFREE	9745449		★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	BEFREE	12843181, 9745449		★☆☆☆☆ Found in Text Mining only
Alopecia, Male Pattern	Alopecia, Male Pattern	GWASDB_DG	22693459		★☆☆☆☆ Found in Text Mining only
Amyloidosis	Amyloidosis	BEFREE	25697705		★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	15192151, 15310462, 15365580, 29477954, 30248435, 30499109, 30979915		★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	GWASCAT_DG	29942085		★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	15192151, 15310462, 15365580, 16806114, 20383137, 29477954, 30248435, 30499109, 30979915		★☆☆☆☆ Found in Text Mining only
Bulimia	Bulimia	BEFREE	28833350		★☆☆☆☆ Found in Text Mining only
Carcinoma of Endocrine Gland	Endocrine Gland cancer	BEFREE	29315139		★☆☆☆☆ Found in Text Mining only
Cholestasis of pregnancy	Cholestasis of pregnancy	BEFREE	23478074		★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	25015995, 29115460		★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	27754786		★☆☆☆☆ Found in Text Mining only
Corticobasal degeneration	Corticobasal Degeneration	GWASCAT_DG	26077951		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	21360527		★☆☆☆☆ Found in Text Mining only
Dejerine-Sottas Disease (disorder)	Charcot-Marie-Tooth disease	BEFREE	29115460		★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	15365580, 16122764, 17585962, 20383137, 22748421, 22957021, 24166410, 24931706, 24933348, 25802844, 28183242, 28461011, 29080675, 30499109, 31737064		★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	22000570		★☆☆☆☆ Found in Text Mining only
Eating Disorders	Eating Disorders	BEFREE	11526468, 28833350		★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	22000570		★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	BEFREE	21289256, 30427841		★☆☆☆☆ Found in Text Mining only
Ependymoma	Ependymoma	BEFREE	12843181		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	29805572		★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	27754786		★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	30354709		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	28750017, 31199033		★☆☆☆☆ Found in Text Mining only
Infantile Spasm	Infantile Spasms	BEFREE	23123321		★☆☆☆☆ Found in Text Mining only
insulinoma	Insulinoma	BEFREE	21106875		★☆☆☆☆ Found in Text Mining only
Intestinal Diseases	Intestinal Diseases	BEFREE	28240194		★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable Bowel Syndrome	BEFREE	22957021, 27497153, 28240194		★☆☆☆☆ Found in Text Mining only
Kidney Failure, Chronic	Kidney Failure	BEFREE	28823817, 29776484, 31330967		★☆☆☆☆ Found in Text Mining only
Linear atrophy	Atrophy	BEFREE	27497153		★☆☆☆☆ Found in Text Mining only
Lung Diseases, Interstitial	Lung Diseases	GWASDB_DG	23583980		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	16122764, 22194899, 23529111, 26271720, 27544317		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder	Mental Depression	GWASCAT_DG	29942085		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12843181, 25015995, 25960164		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	20630588, 23821771		★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	BEFREE	12843181		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	15365580, 16122764, 17585962, 20383137, 22748421, 22957021, 24166410, 24931706, 24933348, 25802844, 28183242, 28461011, 29080675, 30499109, 31737064		★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	20010888, 31344440		★☆☆☆☆ Found in Text Mining only
Mixed anxiety and depressive disorder	Mixed Anxiety And Depressive Disorder	BEFREE	11526468, 28823817, 30124114		★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood Disorder	BEFREE	16611089, 17363685, 30499109		★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood Disorder	GWASCAT_DG	29942085		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12843181, 16837614, 23821771, 9745449		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	25960164		★☆☆☆☆ Found in Text Mining only
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	24933348		★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	23821771		★☆☆☆☆ Found in Text Mining only
Panic Disorder	Panic Disorder	BEFREE	18452185		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	GWASCAT_DG	19915575, 21292315, 27182965		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	GWASDB_DG	19915575, 21044948, 21292315, 21738487, 22438815, 22451204, 24842889		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Post-Traumatic Stress Disorder	Stress Disorder	BEFREE	24077033, 27550842, 28663121, 28793974, 30124114, 30807663, 31291236		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Primary biliary cirrhosis	Biliary Cirrhosis	GWASDB_DG	22961000		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	29315139		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	BEFREE	22350180		★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	24933348		★☆☆☆☆ Found in Text Mining only
Recurrent major depressive episodes	Mental Depression	BEFREE	22194899		★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	11247813, 9166723		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	11352772, 21360527		★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	12843181		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	31374203		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Shy-Drager Syndrome	Shy-Drager Syndrome	GWASCAT_DG	27629089		★☆☆☆☆ Found in Text Mining only
Skin lesion	Skin Lesion	BEFREE	28951706		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	22948128, 23539366, 29115460		★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	BEFREE	16122764, 27544317		★☆☆☆☆ Found in Text Mining only
Vitiligo	Vitiligo	BEFREE	27663146		★☆☆☆☆ Found in Text Mining only
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Vitiligo-associated SYSTEMIC LUPUS ERYTHEMATOSUS	BEFREE	27663146		★☆☆☆☆ Found in Text Mining only
West Syndrome	West Syndrome	BEFREE	23123321		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

NSF 5 shared diseasesCancer, Estrogen-receptor negative breast cancer, Hypertrophic cardiomyopathy, Ovarian serous carcinoma, Peptic ulcer disease 5 shared evidence sourcesGWAS catalog (Cancer), GWAS catalog (Estrogen-receptor negative breast cancer), GWAS catalog (Hypertrophic cardiomyopathy), GWAS catalog (Ovarian serous carcinoma), GWAS catalog (Peptic ulcer disease) Related via 5 shared diseases including Cancer, Estrogen-receptor negative breast cancer — evidence mostly GWAS catalog. CALCRL 3 shared diseasesCancer, Estrogen-receptor negative breast cancer, Ovarian serous carcinoma 2 shared pathwaysG alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production 3 shared evidence sourcesGWAS catalog (Cancer), GWAS catalog (Estrogen-receptor negative breast cancer), GWAS catalog (Ovarian serous carcinoma) Related via 3 shared diseases including Cancer, Estrogen-receptor negative breast cancer — evidence mostly GWAS catalog. PTHLH 4 shared diseasesCancer, Estrogen-receptor negative breast cancer, Gastroesophageal reflux disease, Ovarian serous carcinoma 3 shared pathwaysG alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production, Class B/2 (Secretin family receptors) 4 shared evidence sourcesGWAS catalog (Cancer), GWAS catalog (Estrogen-receptor negative breast cancer), GWAS catalog (Gastroesophageal reflux disease), GWAS catalog (Ovarian serous carcinoma) Related via 4 shared diseases including Cancer, Estrogen-receptor negative breast cancer — evidence mostly GWAS catalog. PTH2R 1 shared diseaseMood disorder 3 shared pathwaysG alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production, Class B/2 (Secretin family receptors) 1 shared evidence sourceGWAS catalog (Mood disorder) Related via 3 shared pathways including G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production — evidence mostly GWAS catalog. PTH2 3 shared pathwaysG alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production, Class B/2 (Secretin family receptors) Related via 3 shared pathways including G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
NSF	5	["Cancer","Estrogen-receptor negative breast cancer","Hypertrophic cardiomyopathy","Ovarian serous carcinoma","Peptic ulcer disease"]	0	[]	5	["GWAS catalog (Cancer)","GWAS catalog (Estrogen-receptor negative breast cancer)","GWAS catalog (Hypertrophic cardiomyopathy)","GWAS catalog (Ovarian serous carcinoma)","GWAS catalog (Peptic ulcer disease)"]
CALCRL	3	["Cancer","Estrogen-receptor negative breast cancer","Ovarian serous carcinoma"]	2	["G alpha (s) signalling events","ADORA2B mediated anti-inflammatory cytokines production"]	3	["GWAS catalog (Cancer)","GWAS catalog (Estrogen-receptor negative breast cancer)","GWAS catalog (Ovarian serous carcinoma)"]
PTHLH	4	["Cancer","Estrogen-receptor negative breast cancer","Gastroesophageal reflux disease","Ovarian serous carcinoma"]	3	["G alpha (s) signalling events","ADORA2B mediated anti-inflammatory cytokines production","Class B\/2 (Secretin family receptors)"]	4	["GWAS catalog (Cancer)","GWAS catalog (Estrogen-receptor negative breast cancer)","GWAS catalog (Gastroesophageal reflux disease)","GWAS catalog (Ovarian serous carcinoma)"]
PTH2R	1	["Mood disorder"]	3	["G alpha (s) signalling events","ADORA2B mediated anti-inflammatory cytokines production","Class B\/2 (Secretin family receptors)"]	1	["GWAS catalog (Mood disorder)"]
PTH2	0	[]	3	["G alpha (s) signalling events","ADORA2B mediated anti-inflammatory cytokines production","Class B\/2 (Secretin family receptors)"]	0	[]

Diseases Linked via Similar Genes

Coronary artery disease Linked via 2 of 5 related genesNSF, CALCRL Diabetes mellitus type 2 Linked via 2 of 5 related genesCALCRL, PTHLH Developmental and epileptic encephalopathy Linked via 1 of 5 related genesNSF Hypertension Linked via 1 of 5 related genesNSF Ovarian epithelial cancer Linked via 1 of 5 related genesNSF

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Coronary artery disease	2	["NSF","CALCRL"]
Diabetes mellitus type 2	2	["CALCRL","PTHLH"]
Developmental and epileptic encephalopathy	1	["NSF"]
Hypertension	1	["NSF"]
Ovarian epithelial cancer	1	["NSF"]