Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	170961
Gene name	Ankyrin repeat domain 24
Gene symbol	ANKRD24
Synonyms (NCBI Gene)	-
Chromosome	19
Chromosome location	19p13.3

29 Show/Hide all (29)

miRTarBase ID	miRNA	Experiments	Reference
MIRT054118	hsa-miR-25-3p	Microarray	22995316
MIRT494855	hsa-miR-6895-5p	PAR-CLIP	23708386
MIRT494854	hsa-miR-7160-3p	PAR-CLIP	23708386
MIRT494853	hsa-miR-4512	PAR-CLIP	23708386
MIRT494852	hsa-miR-4786-3p	PAR-CLIP	23708386
MIRT494851	hsa-miR-4480	PAR-CLIP	23708386
MIRT494850	hsa-miR-1254	PAR-CLIP	23708386
MIRT494849	hsa-miR-3116	PAR-CLIP	23708386
MIRT494848	hsa-miR-5191	PAR-CLIP	23708386
MIRT494847	hsa-miR-2861	PAR-CLIP	23708386
MIRT494846	hsa-miR-1296-5p	PAR-CLIP	23708386
MIRT494845	hsa-miR-7843-3p	PAR-CLIP	23708386
MIRT494855	hsa-miR-6895-5p	PAR-CLIP	23708386
MIRT494854	hsa-miR-7160-3p	PAR-CLIP	23708386
MIRT494853	hsa-miR-4512	PAR-CLIP	23708386
MIRT494852	hsa-miR-4786-3p	PAR-CLIP	23708386
MIRT494851	hsa-miR-4480	PAR-CLIP	23708386
MIRT494850	hsa-miR-1254	PAR-CLIP	23708386
MIRT494849	hsa-miR-3116	PAR-CLIP	23708386
MIRT494848	hsa-miR-5191	PAR-CLIP	23708386
MIRT494847	hsa-miR-2861	PAR-CLIP	23708386
MIRT494846	hsa-miR-1296-5p	PAR-CLIP	23708386
MIRT494845	hsa-miR-7843-3p	PAR-CLIP	23708386
MIRT783249	hsa-miR-1197	CLIP-seq
MIRT783250	hsa-miR-4491	CLIP-seq
MIRT783251	hsa-miR-4657	CLIP-seq
MIRT783252	hsa-miR-4764-5p	CLIP-seq
MIRT783253	hsa-miR-4782-5p	CLIP-seq
MIRT783254	hsa-miR-765	CLIP-seq

12 Show/Hide all (12)

GO ID	Ontology	Definition	Evidence
GO:0003779	Function	Actin binding	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0007605	Process	Sensory perception of sound	IBA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0007605	Process	Sensory perception of sound	ISS
GO:0016020	Component	Membrane	IEA
GO:0032420	Component	Stereocilium	IEA
GO:0032420	Component	Stereocilium	ISS
GO:0042995	Component	Cell projection	IEA
GO:0060088	Process	Auditory receptor cell stereocilium organization	IEA
GO:0060088	Process	Auditory receptor cell stereocilium organization	ISS

MIM	HGNC	e!Ensembl
620234	29424	ENSG00000089847

Q8TF21

Protein name

Ankyrin repeat domain-containing protein 24

Protein function

Component of the stereocilia rootlet in hair cells of inner ear. Bridges the apical plasma membrane with the lower rootlet and maintains normal distribution of TRIOBP, thereby reinforcing stereocilia insertion points and organizing rootlets for

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00023	Ank	213 → 245	Ankyrin repeat	Repeat
PF12796	Ank_2	52 → 145	Ankyrin repeats (3 copies)	Repeat

Sequence

MKTLRARFKKTELRLSPTDLGSCPPCGPCPIPKPAARGRRQSQDWGKSDERLLQAVENND
APRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALH
LAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRS
GATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQP
GITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQG
APKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSL
HILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELP
DLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEAL
AEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNG
PTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETK
PTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAG
QAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEK
LQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGG
GGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQRE
EARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLA
ELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVC
SVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQL
ATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALA
TPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQR
LQAQGR

Sequence length

1146

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (13)
BREAST CARCINOMA	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANCER	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN ENDOMETRIOID CARCINOMA	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN SEROUS CARCINOMA	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS DISORDER	—	GenCC	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ANKRD24 (ankyrin repeat domain 24)

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