Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Pituitary dwarfism Pituitary short stature
33 genes
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1 of 33 corroborated by 2+ sources
FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(2), CHD7(1), WDR11(1), SEMA3E(1), SPRY4(1) +21 more
0.733 0.971 3.81e-91 3.48e-89 ✓ sig. Cluster 53 →
Pituitary dwarfism Sheehan syndrome
33 genes
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1 of 33 corroborated by 2+ sources
FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(2), CHD7(1), WDR11(1), SEMA3E(1), SPRY4(1) +21 more
0.733 0.971 3.81e-91 3.48e-89 ✓ sig. Cluster 53 →
Growth hormone deficiency Pituitary dwarfism
33 genes
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1 of 33 corroborated by 2+ sources
FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(2), CHD7(1), WDR11(1), SEMA3E(1), SPRY4(1) +21 more
0.733 0.971 3.81e-91 3.48e-89 ✓ sig. Cluster 53 →
Panhypopituitarism Pituitary dwarfism
35 genes
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2 of 35 corroborated by 2+ sources
FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(2), CHD7(1), WDR11(1), SEMA3E(1), SPRY4(1) +23 more
0.673 0.814 6.18e-91 5.62e-89 ✓ sig. Cluster 53 →
Hereditary hearing loss Isolated sensorineural deafness
44 genes
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44 of 44 corroborated by 2+ sources
ESRRB(2), EYA4(2), MYO15A(2), OTOF(2), PCDH15(2), TMC1(2), HGF(2), RDX(2), GSDME(2), GJB6(2), SLC26A4(2), COL11A2(2) +32 more
0.349 0.880 2.08e-90 1.89e-88 ✓ sig. Cluster 20 →
Keratinocyte carcinoma Skin cancer
46 genes
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TERT(1), TP53(1), BNC2(1), CUX1(1), FOXP1(1), HERC2(1), HLA-DQA1(1), HLA-DRB1(1), MYL10(1), RHOU(1), SMC2(1), TRPS1(1) +34 more
0.400 0.597 2.18e-90 1.96e-88 ✓ sig. Cluster 23 →
Congenital cartilage disorder Osteochondrodysplasias
30 genes
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16 of 30 corroborated by 2+ sources
HSPG2(2), SLC26A2(1), COL2A1(2), BMPR1B(1), COL11A1(2), DYM(1), FLNB(1), TRPS1(1), TRPV4(2), VEGFA(2), BCL2(2), FLNA(2) +18 more
0.882 1.000 3.54e-90 3.18e-88 ✓ sig. Cluster 133 →
Stevens-johnson syndrome Toxic epidermal necrolysis
37 genes
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3 of 37 corroborated by 2+ sources
LTBP3(1), HLA-C(2), IKZF1(3), SMC2(1), SPMIP7(1), UBE2K(1), UMAD1(1), ZBTB20(1), TAP2(1), POU5F1(1), ZNF423(1), HLA-B(3) +25 more
0.468 1.000 4.09e-90 3.66e-88 ✓ sig. —
Chronic obstructive pulmonary disease Obstructive airway disease
40 genes
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39 of 40 corroborated by 2+ sources
TP53(2), SERPINA1(2), CYP1A2(2), TRPV4(2), NOS3(2), HMOX1(2), ICAM1(2), TLR4(1), TNF(2), IL6(2), EPHX1(2), DSP(2) +28 more
0.388 0.952 3.20e-89 2.85e-87 ✓ sig. Cluster 22 →
Hypopituitarism Kallmann syndrome
34 genes
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21 of 34 corroborated by 2+ sources
FGF8(3), DUSP6(3), IL17RD(3), PROK2(4), TACR3(2), PROKR2(3), TCF12(2), GH1(1), CHD7(4), FGFR1(4), WDR11(3), SEMA3E(2) +22 more
0.667 0.895 3.71e-89 3.29e-87 ✓ sig. Cluster 53 →
Hypopituitarism Panhypopituitarism
35 genes
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1 of 35 corroborated by 2+ sources
FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(1), CHD7(1), FGFR1(1), WDR11(1), SEMA3E(1) +23 more
0.636 0.814 5.67e-89 5.01e-87 ✓ sig. Cluster 53 →
Diabetic angiopathies Diabetic peripheral angiopathy
28 genes
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16 of 28 corroborated by 2+ sources
ASS1(2), ADCY8(2), GCH1(1), HLA-DRB1(1), SERPINE1(1), SERPINF1(2), VEGFA(1), NOS3(2), AGER(2), CASP3(2), EPO(1), HMOX1(2) +16 more
0.966 1.000 1.76e-88 1.55e-86 ✓ sig. Cluster 76 →
Basal cell carcinoma Skin cancer
62 genes
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8 of 62 corroborated by 2+ sources
TERT(2), TP53(3), TPCN2(1), ATP8B4(1), BNC2(2), CUX1(1), EMSY(1), FADS2(1), FAM76B(1), FOXP1(1), HERC2(1), HLA-DQA1(1) +50 more
0.178 0.747 7.59e-88 6.64e-86 ✓ sig. Cluster 23 →
Cerebrovascular disorder Stroke
62 genes
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56 of 62 corroborated by 2+ sources
CASZ1(3), APOA1(2), SH2B3(3), FGA(3), ACE(2), HDAC9(3), ITGB3(2), MMP12(2), SMARCA4(1), SMOX(2), PLAU(2), F2(3) +50 more
0.179 0.738 1.23e-87 1.07e-85 ✓ sig. Cluster 6 →
Bipolar disorder Tourette syndrome
141 genes
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33 of 141 corroborated by 2+ sources
SOX5(2), RERE(1), ATP2A2(1), AKAP6(1), ANK3(3), BANK1(1), BRAF(1), C8orf90(1), CACNB2(2), CSMD1(2), CTNND1(1), DCC(1) +129 more
0.105 0.547 3.40e-87 2.95e-85 ✓ sig. —
Bipolar disorder Mood disorder
151 genes
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49 of 151 corroborated by 2+ sources
RERE(1), COMT(2), HDAC4(2), ATP2A2(2), CACNA1D(2), BLTP1(1), SERPINA1(2), ADCY8(2), ANK3(3), ARHGAP15(1), CACNA1E(1), DAO(1) +139 more
0.110 0.507 3.75e-87 3.24e-85 ✓ sig. Cluster 2 →
Kallmann syndrome Pituitary dwarfism
33 genes
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21 of 33 corroborated by 2+ sources
FGF8(3), DUSP6(3), IL17RD(3), PROK2(4), TACR3(2), PROKR2(3), TCF12(2), GH1(2), CHD7(4), WDR11(3), SEMA3E(2), SPRY4(3) +21 more
0.673 0.868 5.61e-87 4.83e-85 ✓ sig. Cluster 53 →
Basal cell carcinoma Skin neoplasms
74 genes
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12 of 74 corroborated by 2+ sources
TERT(2), TP53(3), TPCN2(1), ASIP(2), ATP8B4(1), BNC2(2), CUX1(1), EMSY(1), FADS2(1), FAM76B(1), FOXP1(1), GLI2(1) +62 more
0.185 0.510 2.18e-86 1.87e-84 ✓ sig. Cluster 23 →
Astrocytoma Central nervous system cancer
119 genes
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2 of 119 corroborated by 2+ sources
ADNP(1), HMCN1(1), TEAD1(1), AGBL1(1), ARHGEF28(1), C6orf118(1), CARD11(1), CTNNA3(1), DSCAM(1), EPHA4(1), FAM163A(1), G3BP1(2) +107 more
0.142 0.395 5.28e-85 4.51e-83 ✓ sig. Cluster 289 →
Autoimmune disease Systemic lupus erythematosus
101 genes
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26 of 101 corroborated by 2+ sources
SH2B3(3), ARHGAP31(1), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), C12orf42(1), DAG1(1), FUT2(1), HLA-DQB3(1), ICOS(1), IGF2(1) +89 more
0.134 0.500 9.89e-85 8.41e-83 ✓ sig. Cluster 39 →
Hypogonadotropic hypogonadism Panhypopituitarism
34 genes
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30 of 34 corroborated by 2+ sources
FGF8(5), DUSP6(5), IL17RD(4), PROK2(6), TACR3(6), PROKR2(7), TCF12(4), GH1(1), CHD7(5), FGFR1(5), WDR11(5), SEMA3E(4) +22 more
0.596 0.791 1.02e-84 8.63e-83 ✓ sig. Cluster 53 →
Celiac disease Systemic lupus erythematosus
99 genes
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22 of 99 corroborated by 2+ sources
SH2B3(3), ARHGAP31(1), BLTP1(1), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), BTNL2(1), CSK(3), DAG1(1), DDX6(1), ETS1(4) +87 more
0.132 0.513 1.80e-84 1.52e-82 ✓ sig. Cluster 39 →
Autoimmune thyroid disease Celiac disease
63 genes
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11 of 63 corroborated by 2+ sources
SH2B3(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), BTNL2(1), DAG1(1), ELMO1(1), FUT2(1), HLA-DQA1(4), HLA-DRA(2), HLA-DRB1(2), ICOS(2) +51 more
0.229 0.438 4.55e-84 3.82e-82 ✓ sig. Cluster 39 →
Keratinocyte carcinoma Non-melanoma skin carcinoma
51 genes
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ANKRD11(1), TP53(1), BNC2(1), CUX1(1), EPB41L1(1), FOXP1(1), GPX4(1), HERC2(1), HLA-DQA1(1), HLA-DRB1(1), MYL10(1), RHOU(1) +39 more
0.260 0.662 5.19e-84 4.34e-82 ✓ sig. Cluster 23 →
Neural tube defect Neural tube defects, x-linked
31 genes
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29 of 31 corroborated by 2+ sources
SKI(2), INS(2), GLI3(2), CYP1A2(2), MTHFD1L(1), PAX3(2), ZIC5(2), MTHFR(2), PYY(2), CSF2(2), NPY1R(2), IFNG(2) +19 more
0.633 1.000 5.55e-84 4.63e-82 ✓ sig. —

Showing 25 of 20825 pairs, sorted by significance (ascending). Click a column header to sort.