Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 291

6 diseases · 13 shared-gene connections
6 Diseases
990 Unique genes
0.202 Avg. similarity score
Central nervous system cancer Most-connected disease (5 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Central nervous system cancer 5 5 656
Glioblastoma 5 5 607
Glioma 5 3 758
Astrocytoma 4 4 301
thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies 4 3 1
systemic lupus erythematosus 18 3 2 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
RAP1B 5 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma and 1 more
AGBL1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
AKAP13 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
ARHGEF28 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
ASB1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
BLCAP 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
C6ORF118 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
CATSPERG 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
CCSER1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
CD70 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
CDH22 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
CLSTN2 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
CNTN5 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
COL23A1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
CRB2 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
CRYL1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
CTNNA3 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
DHX15 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
DLGAP1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
DPP10 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
DSCAM 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
DTNA 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
E2F6 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
ESR1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
FAM163A 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
FAT3 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
FBXO21 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
G3BP1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
GJB6 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
GPC6 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
GREB1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
HMCN1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
HTR1A 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
IFT43 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
IZUMO1R 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
KIAA0040 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
LCA5 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
LMF1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
LMO7 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
MAP1B 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
MAST4 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
MGAT4C 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
MLXIPL 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
PDZRN4 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
PLD4 4 / 6 Central nervous system cancer, Glioblastoma, Glioma, systemic lupus erythematosus 18
PLD5 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
PLK2 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
PPARGC1A 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
PPFIBP1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
PPP1R3A 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
PTPRK 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
RBFOX1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
RSPO3 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
SCOC 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
SERTAD2 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
SLC14A2 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
SMIM30 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
SNX9 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
STRBP 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
TBCD 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
TCERG1L 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
TEAD1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
TENM2 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
THSD7B 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
TNFSF14 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
TSPAN9 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
XCR1 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
ZBTB40 4 / 6 Astrocytoma, Central nervous system cancer, Glioblastoma, Glioma
AAMDC 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ABCA4 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ABCG5 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ACSM2A 3 / 6 Astrocytoma, Central nervous system cancer, Glioma
ACSM2B 3 / 6 Astrocytoma, Central nervous system cancer, Glioma
ACTB 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ADAMTS12 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ADAMTS14 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ADAMTS5 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ADNP 3 / 6 Astrocytoma, Central nervous system cancer, Glioma
AFG2A 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AFG3L2 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AKAP12 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AKAP7 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AKR1C2 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AKR1C3 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AKT3 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ALDH16A1 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ALDH1B1 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ALK 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AMY1C 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AMY2A 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AMY2B 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ANAPC16 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ANK3 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ANKRD18A 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ANO4 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
ANXA4 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AP3D1 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
AP5M1 3 / 6 Astrocytoma, Central nervous system cancer, Glioma
AP5Z1 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
APC 3 / 6 Central nervous system cancer, Glioblastoma, Glioma
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Breast cancer
BRAF, DLL3, ESR1, ESR2, FGFR1, HEY1, HEY2, KRAS, NCOA3, NOTCH1, NOTCH2, WNT7B
 KEGG 33 / 148 2.7× 9.75e-8 6.39e-6 ✓ sig.
Pathways in cancer
AR, BRAF, CTNNA2, CTNNA3, DLL3, ESR1, ESR2, FGFR1, HEY1, HEY2, HGF, HIF1A
 KEGG 79 / 533 1.8× 1.65e-7 1.01e-5 ✓ sig.
Endocrine resistance
BRAF, DLL3, ESR1, ESR2, KRAS, MMP9, NCOA3, NOTCH1, NOTCH2, AKT3, EGFR, IGF1
 KEGG 25 / 99 3.1× 2.86e-7 1.64e-5 ✓ sig.
Bladder cancer
BRAF, KRAS, MMP9, EGFR, TP53, CXCL8, EGF, MMP2, MYC, VEGFA, CDKN2A, ERBB2
 KEGG 14 / 41 4.1× 2.59e-6 1.10e-4 ✓ sig.
Central carbon metabolism in cancer
FGFR1, HIF1A, KRAS, MET, AKT3, EGFR, HK2, NTRK3, PDHA2, PIK3R1, TP53, MTOR
 KEGG 19 / 71 3.2× 2.98e-6 1.24e-4 ✓ sig.
Endometrial cancer
BRAF, CTNNA2, CTNNA3, KRAS, AKT3, APC, CTNNA1, EGFR, PIK3R1, TP53, EGF, MYC
 KEGG 17 / 59 3.5× 3.27e-6 1.33e-4 ✓ sig.
Proteoglycans in cancer
BRAF, COL1A2, ESR1, FGFR1, HGF, HIF1A, HPSE2, KRAS, MET, MMP9, PTPN11, WNT7B
 KEGG 37 / 204 2.2× 3.78e-6 1.51e-4 ✓ sig.
Melanoma
BRAF, FGFR1, HGF, KRAS, MET, PDGFD, AKT3, EGFR, IGF1, PIK3R1, TP53, CDK6
 KEGG 19 / 73 3.2× 4.67e-6 1.80e-4 ✓ sig.
EGFR tyrosine kinase inhibitor resistance
BRAF, HGF, KRAS, MET, NF1, NRG2, PDGFD, AKT3, EGFR, GAB1, IGF1, PIK3R1
 KEGG 20 / 80 3.0× 5.16e-6 1.95e-4 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
COL1A2, HGF, HIF1A, MMP3, MMP9, RHOU, FSCN1, PIK3R1, PIM1, PTGS2, RORA, SOCS5
 Reactome 24 / 108 2.7× 5.70e-6 2.11e-4 ✓ sig.
Non-small cell lung cancer
BRAF, FHIT, HGF, KRAS, MET, RARB, AKT3, ALK, EGFR, PIK3R1, TP53, CDK6
 KEGG 18 / 73 3.0× 1.86e-5 5.65e-4 ✓ sig.
Signaling by ERBB2 KD Mutants
KRAS, NRG2, EGFR, ERBB4, GAB1, PIK3R1, EGF, ERBB2, HRAS
 Reactome 9 / 25 4.4× 1.03e-4 2.31e-3 ✓ sig.
Prostate cancer
AR, BRAF, FGFR1, KRAS, MMP3, MMP9, PDGFD, AKT3, EGFR, ERG, IGF1, PIK3R1
 KEGG 20 / 98 2.5× 1.20e-4 2.60e-3 ✓ sig.
PI3K events in ERBB2 signaling
NRG2, EGFR, ERBB4, GAB1, PIK3R1, EGF, ERBB2
 Reactome 7 / 16 5.3× 1.49e-4 3.09e-3 ✓ sig.
Signaling by ERBB2 ECD mutants
KRAS, EGFR, GAB1, PIK3R1, EGF, ERBB2, HRAS
 Reactome 7 / 16 5.3× 1.49e-4 3.09e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
ADRA2A, FGFR1, HGF, NTRK2, NTS, PDGFD, PTPN11, AKR1C2, AKR1C3, EGFR, EPHA8, ERBB4
 GO:0051897 34 / 217 3.0× 1.28e-8 2.12e-6 ✓ sig.
axon guidance
CNTN1, CNTN5, CRPPA, DSCAM, EPHA4, EPHB1, ETV1, FEZ1, NOTCH1, NOTCH2, UNC5C, CDH4
 GO:0007411 31 / 192 3.0× 2.74e-8 4.08e-6 ✓ sig.
cell population proliferation
ALKBH3, CDK5RAP3, ESRRB, FGFR1, HPSE2, KRAS, MTA3, NF1, NOTCH1, NOTCH2, RAP1B, RARB
 GO:0008283 37 / 263 2.7× 5.54e-8 7.40e-6 ✓ sig.
cell migration
CDH22, CTNNA2, CTNNA3, DOCK1, DOCK2, EPHB1, FGFR1, FMNL2, GPC6, MMP9, NF1, PTPRK
 GO:0016477 39 / 303 2.4× 2.69e-7 2.77e-5 ✓ sig.
positive regulation of miRNA transcription
AR, HIF1A, NOTCH2, TEAD1, EGFR, SMARCA4, TERT, TP53, MYC, NOTCH3, WT1, FGF2
 GO:1902895 14 / 56 4.7× 9.01e-7 7.61e-5 ✓ sig.
positive regulation of endothelial cell chemotaxis
FGFR1, HSPB1, MET, PRKD1, SEMA5A, VEGFA, FGF2
 GO:2001028 7 / 13 10.2× 1.49e-6 1.14e-4 ✓ sig.
negative regulation of apoptotic process
BRAF, CEACAM5, HGF, HIF1A, HSPB1, MMP9, NOTCH2, PLK2, RARB, AAMDC, AKT3, ANXA4
 GO:0043066 54 / 524 1.9× 2.26e-6 1.59e-4 ✓ sig.
embryonic digestive tract development
PCSK5, PKDCC, RARB, STRA6, CXCL8, FOXF2, MYB, TNF
 GO:0048566 8 / 19 7.9× 2.70e-6 1.83e-4 ✓ sig.
regulation of cell population proliferation
BCL6B, BMP6, BRAF, HIF1A, MEAK7, NF1, NOTCH1, SAV1, TIAL1, ALK, BIRC6, CCND3
 GO:0042127 28 / 201 2.6× 2.74e-6 1.85e-4 ✓ sig.
intracellular glucose homeostasis
HIF1A, KLF15, PPARGC1A, CARTPT, HK2, NR1D1, PIK3R1, STXBP3, RAF1
 GO:0001678 9 / 27 6.3× 6.25e-6 3.58e-4 ✓ sig.
cell adhesion
CADM2, CCR3, CDH22, CEACAM5, CEACAM6, CLSTN2, CNTN1, CNTN5, CTNNA2, CTNNA3, DAB1, DSCAM
 GO:0007155 62 / 665 1.8× 1.07e-5 5.51e-4 ✓ sig.
Ras protein signal transduction
ADRA2A, G3BP1, KRAS, NF1, PLK2, RASGRF1, IGF1, KSR2, NTN1, RASGEF1B, RSU1, TP53
 GO:0007265 15 / 79 3.6× 1.45e-5 6.99e-4 ✓ sig.
pulmonary valve morphogenesis
HEY1, HEY2, NOTCH1, NOTCH2, ADAMTS5, STRA6, JAG1
 GO:0003184 7 / 18 7.3× 2.18e-5 9.60e-4 ✓ sig.
positive regulation of MAPK cascade
ADRA2A, AR, FGFR1, HGF, LRRK2, NTRK2, RASGRF1, CARTPT, DAB2IP, EDN1, EGFR, EPHA8
 GO:0043410 28 / 224 2.4× 2.19e-5 9.64e-4 ✓ sig.
intracellular signal transduction
AKAP11, ASB1, HSPB1, HUNK, ITK, LATS2, LRRK2, MAP4K5, MAST4, MYZAP, NOTCH2, NRG2
 GO:0035556 47 / 471 1.9× 2.34e-5 1.01e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Central nervous system cancer Glioma 0.833 643 < 1e-300 < 1e-300 ✓ sig.
Central nervous system cancer Glioblastoma 0.734 535 < 1e-300 < 1e-300 ✓ sig.
Glioblastoma Glioma 0.660 543 < 1e-300 < 1e-300 ✓ sig.
Astrocytoma Glioma 0.150 138 8.08e-101 9.62e-99 ✓ sig.
Astrocytoma Central nervous system cancer 0.142 119 5.28e-85 4.77e-83 ✓ sig.
Astrocytoma Glioblastoma 0.091 76 2.46e-40 1.10e-38 ✓ sig.
Astrocytoma thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies 0.003 1 1.95e-2 2.13e-2 ✓ sig.
Glioblastoma systemic lupus erythematosus 18 0.002 1 3.94e-2 4.13e-2 ✓ sig.
Glioblastoma thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies 0.002 1 3.94e-2 4.13e-2 ✓ sig.
Central nervous system cancer systemic lupus erythematosus 18 0.002 1 4.26e-2 4.44e-2 ✓ sig.
Central nervous system cancer thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies 0.002 1 4.26e-2 4.44e-2 ✓ sig.
Glioma systemic lupus erythematosus 18 0.001 1 4.92e-2 5.10e-2
Glioma thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies 0.001 1 4.92e-2 5.10e-2