MGAT4C (MGAT4 family member C)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 25834
• Gene name: MGAT4 family member C
• Gene symbol: MGAT4C
• Synonyms (NCBI Gene): GNTIVH, HGNT-IV-H
• Chromosome: 12
• Chromosome location: 12q21.31-q21.32

miRNA Show/Hide all (167)

miRTarBase ID	miRNA	Experiments	Reference
MIRT607502	hsa-miR-8485	HITS-CLIP	22927820
MIRT608757	hsa-miR-3614-3p	HITS-CLIP	22927820
MIRT608756	hsa-miR-377-3p	HITS-CLIP	22927820
MIRT671090	hsa-miR-1287-3p	HITS-CLIP	22927820
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT608757	hsa-miR-3614-3p	HITS-CLIP	23313552
MIRT608756	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT671090	hsa-miR-1287-3p	HITS-CLIP	23313552
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT607502	hsa-miR-8485	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607502	hsa-miR-8485	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607502	hsa-miR-8485	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607502	hsa-miR-8485	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607502	hsa-miR-8485	HITS-CLIP	23824327
MIRT608757	hsa-miR-3614-3p	HITS-CLIP	23824327
MIRT608756	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT671090	hsa-miR-1287-3p	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607502	hsa-miR-8485	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607502	hsa-miR-8485	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607502	hsa-miR-8485	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607502	hsa-miR-8485	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607502	hsa-miR-8485	HITS-CLIP	23824327
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607502	hsa-miR-8485	HITS-CLIP	24906430
MIRT608757	hsa-miR-3614-3p	HITS-CLIP	24906430
MIRT608756	hsa-miR-377-3p	HITS-CLIP	24906430
MIRT607502	hsa-miR-8485	HITS-CLIP	24906430
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	24906430
MIRT607502	hsa-miR-8485	HITS-CLIP	24906430
MIRT607501	hsa-miR-4797-5p	HITS-CLIP	24906430
MIRT514085	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT514084	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT514083	hsa-miR-496	PAR-CLIP	20371350
MIRT514082	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT549533	hsa-miR-4731-3p	PAR-CLIP	21572407
MIRT549532	hsa-miR-4801	PAR-CLIP	21572407
MIRT541528	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT549531	hsa-miR-4719	PAR-CLIP	21572407
MIRT541527	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT541522	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT541521	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT541520	hsa-miR-3924	PAR-CLIP	21572407
MIRT541528	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT541527	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT541522	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT541521	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT541520	hsa-miR-3924	PAR-CLIP	21572407
MIRT541532	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT541531	hsa-miR-300	PAR-CLIP	21572407
MIRT541530	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT541529	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT541528	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT541527	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT541526	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT541525	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT541524	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT541523	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT541522	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT541521	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT541520	hsa-miR-3924	PAR-CLIP	21572407
MIRT514085	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT514084	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT514083	hsa-miR-496	PAR-CLIP	23446348
MIRT514082	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT449056	hsa-miR-5584-5p	PAR-CLIP	22100165
MIRT449057	hsa-miR-607	PAR-CLIP	22100165
MIRT449055	hsa-miR-1305	PAR-CLIP	22100165
MIRT449054	hsa-miR-335-3p	PAR-CLIP	22100165
MIRT671090	hsa-miR-1287-3p	HITS-CLIP	27418678
MIRT608757	hsa-miR-3614-3p	HITS-CLIP	27418678
MIRT608757	hsa-miR-3614-3p	HITS-CLIP	27418678
MIRT608757	hsa-miR-3614-3p	HITS-CLIP	27418678
MIRT608756	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608756	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608756	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	27418678
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	27418678
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	27418678
MIRT576619	hsa-miR-8485	HITS-CLIP	27418678
MIRT576619	hsa-miR-8485	HITS-CLIP	27418678
MIRT576619	hsa-miR-8485	HITS-CLIP	27418678
MIRT576619	hsa-miR-8485	HITS-CLIP	27418678
MIRT576619	hsa-miR-8485	HITS-CLIP	22927820
MIRT608757	hsa-miR-3614-3p	HITS-CLIP	22927820
MIRT608756	hsa-miR-377-3p	HITS-CLIP	22927820
MIRT671090	hsa-miR-1287-3p	HITS-CLIP	22927820
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT608757	hsa-miR-3614-3p	HITS-CLIP	23313552
MIRT608756	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT671090	hsa-miR-1287-3p	HITS-CLIP	23313552
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT576619	hsa-miR-8485	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576619	hsa-miR-8485	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576619	hsa-miR-8485	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576619	hsa-miR-8485	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576619	hsa-miR-8485	HITS-CLIP	23824327
MIRT608757	hsa-miR-3614-3p	HITS-CLIP	23824327
MIRT608756	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT671090	hsa-miR-1287-3p	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576619	hsa-miR-8485	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576619	hsa-miR-8485	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576619	hsa-miR-8485	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576619	hsa-miR-8485	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT576619	hsa-miR-8485	HITS-CLIP	23824327
MIRT576618	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT514085	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT514084	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT514083	hsa-miR-496	PAR-CLIP	20371350
MIRT514082	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT549533	hsa-miR-4731-3p	PAR-CLIP	21572407
MIRT549532	hsa-miR-4801	PAR-CLIP	21572407
MIRT541528	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT549531	hsa-miR-4719	PAR-CLIP	21572407
MIRT541527	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT541522	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT541521	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT541520	hsa-miR-3924	PAR-CLIP	21572407
MIRT541528	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT541527	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT541522	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT541521	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT541520	hsa-miR-3924	PAR-CLIP	21572407
MIRT541532	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT541531	hsa-miR-300	PAR-CLIP	21572407
MIRT541530	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT541529	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT541528	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT541527	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT541526	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT541525	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT541524	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT541523	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT541522	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT541521	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT541520	hsa-miR-3924	PAR-CLIP	21572407
MIRT514085	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT514084	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT514083	hsa-miR-496	PAR-CLIP	23446348
MIRT514082	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT449056	hsa-miR-5584-5p	PAR-CLIP	22100165
MIRT449057	hsa-miR-607	PAR-CLIP	22100165
MIRT449055	hsa-miR-1305	PAR-CLIP	22100165
MIRT449054	hsa-miR-335-3p	PAR-CLIP	22100165

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006487	Process	Protein N-linked glycosylation	IBA
GO:0008375	Function	Acetylglucosaminyltransferase activity	IBA
GO:0008375	Function	Acetylglucosaminyltransferase activity	IEA
GO:0008454	Function	Alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	IEA
GO:0008454	Function	Alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0019082	Process	Viral protein processing	TAS
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 607385
• HGNC: 30871
• e!Ensembl: ENSG00000182050

Protein

• UniProt ID: Q9UBM8
• Protein name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-acetylglucosaminyltransferase IV homolog) (hGnT-IV-H) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GlcNAc-T IVc) (GnT-IVc) (N-acet
• Protein function: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04666	Glyco_transf_54	52 → 330		Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, adrenal gland, testis, liver, brain and fetal brain. Not expressed in pancreas. {ECO:0000269|PubMed:10570912}.
• Sequence:

  MFKFHQMKHIFEILDKMRCLRKRSTVSFLGVLVIFLLFMNLYIEDSYVLEGDKQLIRETS
  THQLNSERYVHTFKDLSNFSGAINVTYRYLAATPLQRKRYLTIGLSSVKRKKGNYLLETI
  KSIFEQSSYEELKEISVVVHLADFNSSWRDAMVQDITQKFAHHIIAGRLMVIHAPEEYYP
  ILDGLKRNYNDPEDRVKFRSKQNVDYAFLLNFCANTSDYYVMLEDDVRCSKNFLTAIKKV
  IASLEGTYWVTLEFSKLGYIGKLYHSHDLPRLAHFLLMFYQEMPCDWLLTHFRGLLAQKN
  VIRFKPSLFQHMGYYSSYKGTENKLKDDDFEEESFDIPDNPPASLYTNMNVFENYEASKA
  YSSVDEYFWGKPPSTGDVFVIVFENPIIIKKIKVNTGTEDRQNDILHHGALDVGENVMPS
  KQRRQCSTYLRLGEFKNGNFEMSGVNQKIPFDIHCMRIYVTKTQKEWLIIRSISIWTS

• Sequence length: 478

Pathways

KEGG Pathway	Reactome Pathway
N-Glycan biosynthesis	N-Glycan antennae elongation
Various types of N-glycan biosynthesis
Metabolic pathways

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (11)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ASTROCYTOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATHEROSCLEROSIS	—	GWAS catalog	40465716	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	34446935	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BELL'S PALSY	—	GWAS catalog	33602968	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONOTRUNCAL HEART MALFORMATIONS	—	GWAS catalog	34356046	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	29317602	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL VESSEL STROKE	—	GWAS catalog	34031191	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	34446935	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Chronic kidney disease stage 5	Kidney Disease	BEFREE	31092297		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	31092297		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35456975	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35456975	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Kidney Failure, Chronic	Kidney Failure	BEFREE	31092297		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	22496589		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	22496589		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	22496589	Stimulate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

MGAT4B 3 shared pathwaysN-Glycan biosynthesis, Various types of N-glycan biosynthesis, N-Glycan antennae elongation Related via 3 shared pathways including N-Glycan biosynthesis, Various types of N-glycan biosynthesis. SFTA2 2 shared diseasesBell's palsy, Conotruncal cardiac defect 2 shared evidence sourcesGWAS catalog (Bell's palsy), GWAS catalog (Conotruncal cardiac defect) Related via 2 shared diseases including Bell's palsy, Conotruncal cardiac defect — evidence mostly GWAS catalog. MGAT4D 2 shared pathwaysN-Glycan biosynthesis, Various types of N-glycan biosynthesis Related via 2 shared pathways including N-Glycan biosynthesis, Various types of N-glycan biosynthesis. MGAT5 2 shared pathwaysN-Glycan biosynthesis, N-Glycan antennae elongation Related via 2 shared pathways including N-Glycan biosynthesis, N-Glycan antennae elongation. MGAT4A 3 shared pathwaysN-Glycan biosynthesis, Various types of N-glycan biosynthesis, N-Glycan antennae elongation Related via 3 shared pathways including N-Glycan biosynthesis, Various types of N-glycan biosynthesis.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
MGAT4B	0	[]	3	["N-Glycan biosynthesis","Various types of N-glycan biosynthesis","N-Glycan antennae elongation"]	0	[]
SFTA2	2	["Bell's palsy","Conotruncal cardiac defect"]	0	[]	2	["GWAS catalog (Bell's palsy)","GWAS catalog (Conotruncal cardiac defect)"]
MGAT4D	0	[]	2	["N-Glycan biosynthesis","Various types of N-glycan biosynthesis"]	0	[]
MGAT5	0	[]	2	["N-Glycan biosynthesis","N-Glycan antennae elongation"]	0	[]
MGAT4A	0	[]	3	["N-Glycan biosynthesis","Various types of N-glycan biosynthesis","N-Glycan antennae elongation"]	0	[]

Diseases Linked via Similar Genes

Asthma Linked via 2 of 5 related genesSFTA2, MGAT5 Bipolar disorder Linked via 2 of 5 related genesSFTA2, MGAT4A Schizophrenia Linked via 2 of 5 related genesSFTA2, MGAT5 Systemic lupus erythematosus Linked via 2 of 5 related genesSFTA2, MGAT5 Autism Linked via 1 of 5 related genesSFTA2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Asthma	2	["SFTA2","MGAT5"]
Bipolar disorder	2	["SFTA2","MGAT4A"]
Schizophrenia	2	["SFTA2","MGAT5"]
Systemic lupus erythematosus	2	["SFTA2","MGAT5"]
Autism	1	["SFTA2"]