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Gene Gene information from NCBI Gene database.
Entrez ID 119504
Gene name Anaphase promoting complex subunit 16
Gene symbol ANAPC16
Synonyms (NCBI Gene)
APC16C10orf104CENP-27MSAGbA570G20.3
Chromosome 10
Chromosome location 10q22.1
miRNA miRNA information provided by mirtarbase database.
745 Show/Hide all (745)
miRTarBase ID miRNA Experiments Reference
MIRT003887 hsa-miR-15a-5p Microarray 18362358
MIRT004381 hsa-miR-16-5p Microarray 18362358
MIRT020492 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT705719 hsa-miR-6771-3p HITS-CLIP 23313552
MIRT705718 hsa-miR-300 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28 Show/Hide all (28)
GO ID Ontology Definition Evidence Reference
GO:0000775 Component Chromosome, centromeric region IEA
GO:0000776 Component Kinetochore IBA
GO:0000776 Component Kinetochore IDA 20813266
GO:0000776 Component Kinetochore IEA
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613427 26976 ENSG00000166295
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96DE5
Protein name Anaphase-promoting complex subunit 16 (APC16) (Cyclosome subunit 16)
Protein function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:20360068). The APC/C complex acts by mediating ubiquit
PDB 4RG6 , 4RG9 , 4UI9 , 5A31 , 5G04 , 5G05 , 5KHR , 5KHU , 5L9T , 5L9U , 5LCW , 6Q6G , 6Q6H , 6TLJ , 6TM5 , 6TNT , 8PKP , 8TAR , 8TAU , 9GAW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17256 ANAPC16 27 → 106 Anaphase-promoting complex, subunit 16 Family
Sequence
Sequence length 110
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Cell cycle Inactivation of APC/C via direct inhibition of the APC/C complex
Oocyte meiosis APC/C:Cdc20 mediated degradation of Cyclin B
Ubiquitin mediated proteolysis Autodegradation of Cdh1 by Cdh1:APC/C
Progesterone-mediated oocyte maturation APC/C:Cdc20 mediated degradation of Securin
Human T-cell leukemia virus 1 infection APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
  Regulation of APC/C activators between G1/S and early anaphase
  APC/C:Cdc20 mediated degradation of mitotic proteins
  Phosphorylation of the APC/C
  APC-Cdc20 mediated degradation of Nek2A
  Separation of Sister Chromatids
  Senescence-Associated Secretory Phenotype (SASP)
  CDK-mediated phosphorylation and removal of Cdc6
  Transcriptional Regulation by VENTX
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
CENTRAL NERVOUS SYSTEM CANCER — GWAS catalog 36810956
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME — GWAS catalog 36810956
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA — GWAS catalog 36810956
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Renal Cell Carcinoma Renal Carcinoma GWASCAT_DG 28598434
★★★★★
★☆☆☆☆
Found in Text Mining only