Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:21926987). The APC/C complex catalyzes assembly of bra
Evidence Score:★☆☆☆☆ Gene-disease association found in Text Mining only★★☆☆☆ Found in Text Mining and Unknown/Other Associations★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations
ClinVar entries with uncertain/conflicting evidence, and associations from other databases
(OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
["Cell cycle","Oocyte meiosis","Ubiquitin mediated proteolysis","Progesterone-mediated oocyte maturation","Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids","Regulation of APC\/C activators between G1\/S and early anaphase","Senescence-Associated Secretory Phenotype (SASP)","CDK-mediated phosphorylation and removal of Cdc6","Autodegradation of Cdh1 by Cdh1:APC\/C","APC\/C:Cdc20 mediated degradation of Securin","APC\/C:Cdh1 mediated degradation of Cdc20 and other APC\/C:Cdh1 targeted proteins in late mitosis\/early G1"]
["Cell cycle","Oocyte meiosis","Ubiquitin mediated proteolysis","Progesterone-mediated oocyte maturation","Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids","Regulation of APC\/C activators between G1\/S and early anaphase","Senescence-Associated Secretory Phenotype (SASP)","CDK-mediated phosphorylation and removal of Cdc6","Autodegradation of Cdh1 by Cdh1:APC\/C","APC\/C:Cdc20 mediated degradation of Securin","APC\/C:Cdh1 mediated degradation of Cdc20 and other APC\/C:Cdh1 targeted proteins in late mitosis\/early G1"]
["Cell cycle","Oocyte meiosis","Ubiquitin mediated proteolysis","Progesterone-mediated oocyte maturation","Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids","Regulation of APC\/C activators between G1\/S and early anaphase","Senescence-Associated Secretory Phenotype (SASP)","CDK-mediated phosphorylation and removal of Cdc6","Autodegradation of Cdh1 by Cdh1:APC\/C","APC\/C:Cdc20 mediated degradation of Securin","APC\/C:Cdh1 mediated degradation of Cdc20 and other APC\/C:Cdh1 targeted proteins in late mitosis\/early G1"]
["Cell cycle","Oocyte meiosis","Ubiquitin mediated proteolysis","Progesterone-mediated oocyte maturation","Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids","Regulation of APC\/C activators between G1\/S and early anaphase","Senescence-Associated Secretory Phenotype (SASP)","CDK-mediated phosphorylation and removal of Cdc6","Autodegradation of Cdh1 by Cdh1:APC\/C","APC\/C:Cdc20 mediated degradation of Securin","APC\/C:Cdh1 mediated degradation of Cdc20 and other APC\/C:Cdh1 targeted proteins in late mitosis\/early G1"]
["Cell cycle","Oocyte meiosis","Ubiquitin mediated proteolysis","Progesterone-mediated oocyte maturation","Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids","Regulation of APC\/C activators between G1\/S and early anaphase","Senescence-Associated Secretory Phenotype (SASP)","CDK-mediated phosphorylation and removal of Cdc6","Autodegradation of Cdh1 by Cdh1:APC\/C","APC\/C:Cdc20 mediated degradation of Securin","APC\/C:Cdh1 mediated degradation of Cdc20 and other APC\/C:Cdh1 targeted proteins in late mitosis\/early G1"]
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Diseases Linked via Similar GenesDiseases curated for genes most similar to ANAPC15 (see Related Genes above), that are NOT already directly curated for ANAPC15 itself -- a lead worth checking, not a confirmed association.