Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Atrial fibrillation Cardioembolic stroke
54 genes
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35 of 54 corroborated by 2+ sources
PRRX1(3), ESR2(3), GORAB(1), KCNN2(3), KCNN3(3), NCOR2(1), RBM20(3), TBX5(3), TNFSF12-TNFSF13(1), TRIM36(1), VRTN(1), IGF1R(3) +42 more
0.059 0.535 6.90e-41 2.94e-39 ✓ sig. —
Leber hereditary optic neuropathy Melas syndrome
15 genes
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13 of 15 corroborated by 2+ sources
IL1A(2), IL1B(2), ND1(2), ND2(2), SOD2(2), ATP6(2), ND6(2), COX3(2), ATP8(1), COX1(2), ND5(2), COX2(2) +3 more
0.469 0.833 6.19e-41 2.64e-39 ✓ sig. Cluster 32 →
Jeune syndrome Short-rib thoracic dysplasia
17 genes
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17 of 17 corroborated by 2+ sources
NEK1(4), IFT80(6), CEP120(5), DYNC2H1(6), DYNC2I1(6), DYNC2I2(6), DYNC2LI1(5), DYNLT2B(4), IFT140(3), IFT172(5), IFT52(5), INTU(3) +5 more
0.347 0.739 5.94e-41 2.55e-39 ✓ sig. Cluster 22 →
Congenital contractural arachnodactyly Marfan syndrome
18 genes
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6 of 18 corroborated by 2+ sources
FBN1(7), LTBP3(1), FBN2(7), SLC2A10(1), TGFB2(2), THSD4(1), BGN(1), SMAD3(1), COL3A1(2), TGFBR1(3), TGFBR2(3), LOX(1) +6 more
0.327 0.621 5.65e-41 2.43e-39 ✓ sig. Cluster 12 →
Developmental coordination disorder Motor skills disorder
12 genes
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12 of 12 corroborated by 2+ sources
PTEN(2), DISC1(2), RPTOR(2), SQSTM1(2), SOD1(2), FGFR2(2), CNR1(2), SHANK1(2), CAMKMT(2), NDUFS4(2), OGG1(2), AKAP5(2)
0.857 1.000 3.52e-41 1.51e-39 ✓ sig. —
Colobomatous microphthalmia Microphthalmia
15 genes
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15 of 15 corroborated by 2+ sources
TENM3(5), SHH(6), SOX2(4), STRA6(4), SIX6(4), OTX2(4), PORCN(3), RAX(4), VSX2(7), RBP4(6), MAB21L2(6), ALDH1A3(4) +3 more
0.385 1.000 3.14e-41 1.35e-39 ✓ sig. Cluster 56 →
Congestive ophthalmopathy Graves ophthalmopathy
13 genes
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3 of 13 corroborated by 2+ sources
SCD(2), ICAM1(1), IL10(1), IL2(1), TNF(1), PTGS2(2), IL3(1), CTLA4(1), IL23R(1), PTPN22(1), IL1RN(1), TSHR(2) +1 more
0.684 1.000 1.96e-41 8.46e-40 ✓ sig. Cluster 147 →
Graves ophthalmopathy Myopathic ophthalmopathy
13 genes
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3 of 13 corroborated by 2+ sources
SCD(2), ICAM1(1), IL10(1), IL2(1), TNF(1), PTGS2(2), IL3(1), CTLA4(1), IL23R(1), PTPN22(1), IL1RN(1), TSHR(2) +1 more
0.684 1.000 1.96e-41 8.46e-40 ✓ sig. Cluster 147 →
Congenital contractural arachnodactyly Thoracic aortic aneurysm and aortic dissection
18 genes
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18 of 18 corroborated by 2+ sources
SKI(2), FBN1(6), FBN2(8), PLOD1(2), SLC2A10(2), TGFB2(5), THSD4(3), BGN(5), SMAD3(6), COL3A1(2), EFEMP2(3), TGFBR1(6) +6 more
0.340 0.621 1.88e-41 8.15e-40 ✓ sig. Cluster 12 →
Cone-rod dystrophy Leber congenital amaurosis
25 genes
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16 of 25 corroborated by 2+ sources
ABCA4(7), CNGB3(1), PRPH2(4), AIPL1(6), ALMS1(1), PDE6B(1), RIMS1(3), USH2A(1), CRB1(6), CRX(8), GUCY2D(7), PROM1(6) +13 more
0.205 0.347 1.51e-41 6.55e-40 ✓ sig. Cluster 7 →
Distal spinal muscular atrophy Hereditary motor and sensory neuropathies
20 genes
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2 of 20 corroborated by 2+ sources
AARS1(1), SETX(1), TRPV4(3), DCTN1(1), DYNC1H1(1), NEFL(1), LITAF(1), SH3TC2(1), BSCL2(1), HSPB1(1), PLEKHG5(1), GARS1(1) +8 more
0.256 0.645 1.46e-41 6.37e-40 ✓ sig. Cluster 15 →
Atrial fibrillation Coronary artery disease
184 genes
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54 of 184 corroborated by 2+ sources
SOX5(3), CASZ1(3), JMJD1C(1), ZFPM2(1), ANKRD26(1), ACE(2), AGT(2), ALDH1A2(1), ANKRD31(1), APOB(3), APOC1(1), BAZ1B(1) +172 more
0.101 0.213 1.26e-41 5.49e-40 ✓ sig. Cluster 78 →
Idiopathic steroid-resistant nephrotic syndrome Nephrotic syndrome
23 genes
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21 of 23 corroborated by 2+ sources
WT1(5), NUP107(4), ACTN4(2), ARHGAP24(2), MYO1E(2), NUP160(5), NUP85(4), PAX2(2), PTPRO(4), TRPC6(2), PLCE1(6), MAGI2(4) +11 more
0.134 0.821 1.09e-41 4.76e-40 ✓ sig. Cluster 30 →
Connective tissue disease Desbuquois syndrome
51 genes
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51 of 51 corroborated by 2+ sources
HSPG2(2), HDAC4(2), SOX9(2), TRIP11(2), SLC26A2(2), COL2A1(2), FGFR3(2), FBN1(2), NOTCH1(3), ALPL(2), PEX7(2), COL11A1(2) +39 more
0.080 0.436 4.08e-42 1.79e-40 ✓ sig. —
Holoprosencephaly Microform holoprosencephaly
15 genes
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15 of 15 corroborated by 2+ sources
FGF8(3), CDON(6), GLI2(6), SHH(5), PTCH1(7), SIX3(6), FGFR1(3), GAS1(5), ZIC2(6), DLL1(3), DISP1(4), CRIPTO(4) +3 more
0.484 0.938 2.52e-42 1.11e-40 ✓ sig. Cluster 96 →
Breast neoplasms Lung neoplasms
68 genes
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3 of 68 corroborated by 2+ sources
WT1(1), DPYD(1), NOTCH2(1), PTEN(1), CHEK2(2), TERT(1), TP53(1), JAG1(1), EGFR(1), ERBB3(1), RARB(1), SPP1(1) +56 more
0.097 0.268 1.96e-42 8.62e-41 ✓ sig. Cluster 5 →
Congestive heart failure Kidney failure
46 genes
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20 of 46 corroborated by 2+ sources
INS(1), CAT(2), TP53(1), GATM(2), ACE(2), AGT(1), APOE(1), EPHX2(1), PRKAG2(2), SERPINE1(2), VEGFA(1), NOS3(1) +34 more
0.119 0.257 1.79e-42 7.89e-41 ✓ sig. —
Cutaneous squamous cell carcinoma Skin neoplasms
25 genes
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2 of 25 corroborated by 2+ sources
BNC2(1), FOXP1(1), HLA-DQA1(1), ICOS(1), TRPS1(1), WEE1(1), ZNF143(1), OCA2(1), RALY(1), IRF4(1), KRT5(1), AHR(1) +13 more
0.157 0.658 1.24e-42 5.48e-41 ✓ sig. Cluster 29 →
Cardiomyopathy Long qt syndrome
38 genes
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18 of 38 corroborated by 2+ sources
CTNNA3(1), DSG2(1), JUP(1), KCNE2(7), PKP2(1), RBM20(1), TRPM4(1), POMC(2), DSP(1), CACNA1C(6), MYH6(3), TMPO(1) +26 more
0.123 0.373 1.23e-42 5.46e-41 ✓ sig. —
Immune system disease Myasthenia gravis
20 genes
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5 of 20 corroborated by 2+ sources
FAM76B(1), HLA-DQA1(2), HLA-DRB1(2), TNIP1(1), TRPM1(1), ATXN2(1), POMC(2), TBX18(1), CEP43(1), CTLA4(1), HLA-B(2), PTPN22(2) +8 more
0.308 0.526 8.03e-43 3.56e-41 ✓ sig. Cluster 1 →
Hydranencephaly Lissencephaly
18 genes
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1 of 18 corroborated by 2+ sources
CASK(1), ARL3(1), NDE1(6), TMEM216(1), TMEM237(1), SEPSECS(1), KIAA0586(1), KIAA0753(1), CHMP1A(1), IFT74(1), TUBB3(1), AMPD2(1) +6 more
0.327 0.818 3.58e-43 1.59e-41 ✓ sig. Cluster 110 →
Age-related macular degeneration Macular degeneration
26 genes
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16 of 26 corroborated by 2+ sources
ABCA4(2), HMCN1(3), CFI(4), APOE(3), VEGFA(2), C2(3), C3(3), PON1(1), GSTM1(1), RAD51B(1), CFB(3), CRP(1) +14 more
0.208 0.388 3.10e-43 1.38e-41 ✓ sig. Cluster 187 →
Peripheral vascular disease Vascular disease
20 genes
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CSTPP1(1), HDAC9(1), NFAT5(1), TCF7L2(1), ATXN2(1), CHRNA3(1), TWIST1(1), ABO(1), SLC19A2(1), CELSR2(1), LPA(1), PSRC1(1) +8 more
0.303 0.606 3.09e-43 1.38e-41 ✓ sig. Cluster 307 →
Diabetes mellitus Stroke
61 genes
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9 of 61 corroborated by 2+ sources
ANKRD26(1), ALDH1A2(1), ANKRD31(1), APOB(1), APOC1(1), BAZ1B(1), BCL3(1), CDKAL1(2), FADS1(1), FADS2(1), LIPC(1), MAML3(1) +49 more
0.109 0.206 2.88e-43 1.29e-41 ✓ sig. —
Melanoma Ovarian serous carcinoma
66 genes
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18 of 66 corroborated by 2+ sources
ANKRD11(1), RREB1(1), MAP3K1(1), ACD(2), RTEL1(1), TERT(5), TP53(2), ASIP(2), BNC2(1), CDH15(1), EPB41L1(1), FOXP1(1) +54 more
0.103 0.244 2.49e-43 1.12e-41 ✓ sig. —

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.