TNFSF12-TNFSF13 (TNFSF12-TNFSF13 readthrough)

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Gene miRNA Other IDs Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 407977
• Gene name: TNFSF12-TNFSF13 readthrough
• Gene symbol: TNFSF12-TNFSF13
• Synonyms (NCBI Gene): TWE-PRIL
• Chromosome: 17
• Chromosome location: 17p13.1
• Summary: This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane a

miRNA Show/Hide all (79)

miRTarBase ID	miRNA	Experiments	Reference
MIRT2132683	hsa-miR-1254	CLIP-seq
MIRT2132684	hsa-miR-3116	CLIP-seq
MIRT2132685	hsa-miR-4749-3p	CLIP-seq
MIRT2132686	hsa-miR-661	CLIP-seq
MIRT2353720	hsa-miR-383	CLIP-seq
MIRT2132685	hsa-miR-4749-3p	CLIP-seq
MIRT2353721	hsa-miR-4772-5p	CLIP-seq
MIRT2396126	hsa-miR-1247	CLIP-seq
MIRT2132685	hsa-miR-4749-3p	CLIP-seq
MIRT2396127	hsa-miR-566	CLIP-seq
MIRT2462081	hsa-miR-185	CLIP-seq
MIRT2462082	hsa-miR-4306	CLIP-seq
MIRT2462083	hsa-miR-4534	CLIP-seq
MIRT2462084	hsa-miR-4644	CLIP-seq
MIRT2462085	hsa-miR-615-5p	CLIP-seq
MIRT2647834	hsa-miR-1302	CLIP-seq
MIRT2462081	hsa-miR-185	CLIP-seq
MIRT2647835	hsa-miR-3122	CLIP-seq
MIRT2647836	hsa-miR-3151	CLIP-seq
MIRT2647837	hsa-miR-3189-3p	CLIP-seq
MIRT2647838	hsa-miR-342-5p	CLIP-seq
MIRT2647839	hsa-miR-3649	CLIP-seq
MIRT2647840	hsa-miR-3913-5p	CLIP-seq
MIRT2647841	hsa-miR-4265	CLIP-seq
MIRT2647842	hsa-miR-4296	CLIP-seq
MIRT2647843	hsa-miR-4298	CLIP-seq
MIRT2462082	hsa-miR-4306	CLIP-seq
MIRT2647844	hsa-miR-4322	CLIP-seq
MIRT2647845	hsa-miR-4447	CLIP-seq
MIRT2647846	hsa-miR-4472	CLIP-seq
MIRT2462083	hsa-miR-4534	CLIP-seq
MIRT2462084	hsa-miR-4644	CLIP-seq
MIRT2647847	hsa-miR-4651	CLIP-seq
MIRT2647848	hsa-miR-4664-5p	CLIP-seq
MIRT2647849	hsa-miR-4671-5p	CLIP-seq
MIRT2647850	hsa-miR-491-5p	CLIP-seq
MIRT2647851	hsa-miR-578	CLIP-seq
MIRT2647852	hsa-miR-581	CLIP-seq
MIRT2647853	hsa-miR-608	CLIP-seq
MIRT2462085	hsa-miR-615-5p	CLIP-seq
MIRT2693706	hsa-miR-124	CLIP-seq
MIRT2647834	hsa-miR-1302	CLIP-seq
MIRT2693707	hsa-miR-1827	CLIP-seq
MIRT2462081	hsa-miR-185	CLIP-seq
MIRT2693708	hsa-miR-2467-3p	CLIP-seq
MIRT2647835	hsa-miR-3122	CLIP-seq
MIRT2693709	hsa-miR-3136-5p	CLIP-seq
MIRT2647836	hsa-miR-3151	CLIP-seq
MIRT2647837	hsa-miR-3189-3p	CLIP-seq
MIRT2647838	hsa-miR-342-5p	CLIP-seq
MIRT2693710	hsa-miR-3616-3p	CLIP-seq
MIRT2693711	hsa-miR-3622b-5p	CLIP-seq
MIRT2647839	hsa-miR-3649	CLIP-seq
MIRT2693712	hsa-miR-3688-5p	CLIP-seq
MIRT2647840	hsa-miR-3913-5p	CLIP-seq
MIRT2693713	hsa-miR-4254	CLIP-seq
MIRT2647841	hsa-miR-4265	CLIP-seq
MIRT2647842	hsa-miR-4296	CLIP-seq
MIRT2647843	hsa-miR-4298	CLIP-seq
MIRT2462082	hsa-miR-4306	CLIP-seq
MIRT2647844	hsa-miR-4322	CLIP-seq
MIRT2693714	hsa-miR-4439	CLIP-seq
MIRT2647845	hsa-miR-4447	CLIP-seq
MIRT2647846	hsa-miR-4472	CLIP-seq
MIRT2462083	hsa-miR-4534	CLIP-seq
MIRT2462084	hsa-miR-4644	CLIP-seq
MIRT2647847	hsa-miR-4651	CLIP-seq
MIRT2647848	hsa-miR-4664-5p	CLIP-seq
MIRT2647849	hsa-miR-4671-5p	CLIP-seq
MIRT2693715	hsa-miR-4709-3p	CLIP-seq
MIRT2647850	hsa-miR-491-5p	CLIP-seq
MIRT2693716	hsa-miR-506	CLIP-seq
MIRT2647851	hsa-miR-578	CLIP-seq
MIRT2647852	hsa-miR-581	CLIP-seq
MIRT2647853	hsa-miR-608	CLIP-seq
MIRT2462085	hsa-miR-615-5p	CLIP-seq
MIRT2693717	hsa-miR-619	CLIP-seq
MIRT2693718	hsa-miR-644	CLIP-seq
MIRT2693719	hsa-miR-943	CLIP-seq

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Interactions View interactions

Pathways

Reactome Pathway

TNFR2 non-canonical NF-kB pathway

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (13)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	35379992	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	30061737, 35872910, 39024449, 39537608	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FLUTTER	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOEMBOLIC STROKE	—	GWAS catalog	35872910	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	37069358	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMMON VARIABLE IMMUNODEFICIENCY	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	37947095	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IGA GLOMERULONEPHRITIS	—	GWAS catalog	22197929, 25305756, 37337107, 39343836	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYELOPROLIFERATIVE DISORDER	—	GWAS catalog	37684235	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	40205036	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	40205036	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN SEROUS CARCINOMA	—	GWAS catalog	41266372	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	30194396	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (66)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acne	Acne	BEFREE	31135089		★☆☆☆☆ Found in Text Mining only
Acne Vulgaris	Acne	BEFREE	31135089		★☆☆☆☆ Found in Text Mining only
Adult type dermatomyositis	Dermatomyositis	BEFREE	28351660		★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	15056843, 24479820, 28390291		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	15056843, 24479820, 28390291		★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	BEFREE	29971943		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Atrial Fibrillation	Atrial Fibrillation	GWASCAT_DG	30061737		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autoimmune Diseases	Autoimmune Diseases	BEFREE	28351660		★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet Syndrome	BEFREE	31161935		★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	28800513		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	22767506, 23073510		★☆☆☆☆ Found in Text Mining only
Bullous pemphigoid	Bullous Pemphigoid	BEFREE	28351660		★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	28216373		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	29971943		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	29548604, 30241442		★☆☆☆☆ Found in Text Mining only
Carotid Atherosclerosis	Carotid Atherosclerosis	BEFREE	28828963		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	18793781		★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	28390291		★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	29981796		★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	21483105		★☆☆☆☆ Found in Text Mining only
Dermatitis	Dermatitis	BEFREE	28530223		★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	28530223		★☆☆☆☆ Found in Text Mining only
Dermatomyositis	Dermatomyositis	BEFREE	28351660		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	16503147		★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	28530223		★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	20189297		★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	28216373		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	12651623		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	12651623		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	12651623		★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	29981796		★☆☆☆☆ Found in Text Mining only
IGA Glomerulonephritis	Glomerulonephritis	GWASCAT_DG	22197929		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IGA Glomerulonephritis	Glomerulonephritis	GWASDB_DG	22197929		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Inflammatory dermatosis	Dermatitis	BEFREE	28530223		★☆☆☆☆ Found in Text Mining only
Invasive Ductal Breast Carcinoma	Invasive Duct and Lobular Carcinoma	BEFREE	23073510		★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	18793781, 20557950		★☆☆☆☆ Found in Text Mining only
Kidney Failure, Acute	Kidney Failure	BEFREE	20651166, 28684863, 29588419, 31593741		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus	Lupus Erythematosus	BEFREE	26403095, 28351660		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Discoid	Lupus Erythematosus	BEFREE	26403095		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	17307753, 26403095		★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus Nephritis	BEFREE	22727560, 25814248, 27595519, 29668584		★☆☆☆☆ Found in Text Mining only
Lupus Vulgaris	Lupus Vulgaris	BEFREE	26403095		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	19846118		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22767506, 23073510		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	20189297		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	24970477		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25239934, 30414907		★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	30241442		★☆☆☆☆ Found in Text Mining only
Miscarriage	Miscarriage	BEFREE	28462593		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	30786899		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11067885, 12496418, 23974006, 24130833, 25239934, 26446946, 28455246		★☆☆☆☆ Found in Text Mining only
Nongranulomatous uveitis	Nongranulomatous uveitis	BEFREE	31161935		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	16503147		★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	BEFREE	30377055		★☆☆☆☆ Found in Text Mining only
Plexiform leiomyoma	Plexiform leiomyoma	GWASCAT_DG	30194396		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	30241442		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	24970477		★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	28530223		★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	21483105		★☆☆☆☆ Found in Text Mining only
Renal fibrosis	Renal fibrosis	BEFREE	25343824		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	17307753		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of skin	Skin carcinoma	BEFREE	30414907		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	25239934		★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	BEFREE	19846118		★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	GWASCAT_DG	30194396		★☆☆☆☆ Found in Text Mining only
Vasculitis of the skin	Vasculitis	BEFREE	23457623		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

TNFSF12 4 shared diseasesAtrial flutter, Cardioembolic stroke, Common variable immunodeficiency, Iga nephropathy 2 shared pathwaysTNFR2 non-canonical NF-kB pathway, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 4 shared evidence sourcesGWAS catalog (Atrial flutter), GWAS catalog (Cardioembolic stroke), Disgenet (Common variable immunodeficiency), GWAS catalog (Iga nephropathy) Related via 4 shared diseases including Atrial flutter, Cardioembolic stroke — evidence mostly GWAS catalog. TNFSF13 4 shared diseasesCommon variable immunodeficiency, Iga nephropathy, Myeloproliferative disorder, Ovarian serous carcinoma 4 shared evidence sourcesDisgenet (Common variable immunodeficiency), GWAS catalog (Iga nephropathy), GWAS catalog (Myeloproliferative disorder), GWAS catalog (Ovarian serous carcinoma) Related via 4 shared diseases including Common variable immunodeficiency, Iga nephropathy — evidence mostly GWAS catalog. SCMH1 2 shared diseasesAtrial flutter, Cardioembolic stroke 2 shared evidence sourcesGWAS catalog (Atrial flutter), GWAS catalog (Cardioembolic stroke) Related via 2 shared diseases including Atrial flutter, Cardioembolic stroke — evidence mostly GWAS catalog. FAM13B 2 shared diseasesAtrial flutter, Cardioembolic stroke 2 shared evidence sourcesGWAS catalog (Atrial flutter), GWAS catalog (Cardioembolic stroke) Related via 2 shared diseases including Atrial flutter, Cardioembolic stroke — evidence mostly GWAS catalog. PPFIA4 2 shared diseasesAtrial flutter, Cardioembolic stroke 2 shared evidence sourcesGWAS catalog (Atrial flutter), GWAS catalog (Cardioembolic stroke) Related via 2 shared diseases including Atrial flutter, Cardioembolic stroke — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
TNFSF12	4	["Atrial flutter","Cardioembolic stroke","Common variable immunodeficiency","Iga nephropathy"]	2	["TNFR2 non-canonical NF-kB pathway","TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"]	4	["GWAS catalog (Atrial flutter)","GWAS catalog (Cardioembolic stroke)","Disgenet (Common variable immunodeficiency)","GWAS catalog (Iga nephropathy)"]
TNFSF13	4	["Common variable immunodeficiency","Iga nephropathy","Myeloproliferative disorder","Ovarian serous carcinoma"]	0	[]	4	["Disgenet (Common variable immunodeficiency)","GWAS catalog (Iga nephropathy)","GWAS catalog (Myeloproliferative disorder)","GWAS catalog (Ovarian serous carcinoma)"]
SCMH1	2	["Atrial flutter","Cardioembolic stroke"]	0	[]	2	["GWAS catalog (Atrial flutter)","GWAS catalog (Cardioembolic stroke)"]
FAM13B	2	["Atrial flutter","Cardioembolic stroke"]	0	[]	2	["GWAS catalog (Atrial flutter)","GWAS catalog (Cardioembolic stroke)"]
PPFIA4	2	["Atrial flutter","Cardioembolic stroke"]	0	[]	2	["GWAS catalog (Atrial flutter)","GWAS catalog (Cardioembolic stroke)"]

Diseases Linked via Similar Genes

Cardiac arrhythmia Linked via 2 of 5 related genesFAM13B, PPFIA4 Brain injuries Linked via 1 of 5 related genesTNFSF12 Female infertility Linked via 1 of 5 related genesTNFSF12 Testicular disease Linked via 1 of 5 related genesTNFSF12 Agammaglobulinemia Linked via 1 of 5 related genesTNFSF13

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Cardiac arrhythmia	2	["FAM13B","PPFIA4"]
Brain injuries	1	["TNFSF12"]
Female infertility	1	["TNFSF12"]
Testicular disease	1	["TNFSF12"]
Agammaglobulinemia	1	["TNFSF13"]