Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Arrhythmogenic right ventricular cardiomyopathy Cardiomyopathy
40 genes
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27 of 40 corroborated by 2+ sources
ABCC9(1), ACTN2(1), CTNNA3(7), DMD(2), DSG2(6), JUP(5), PKP2(7), PRKAG2(3), RBM20(1), TRPM4(1), DSP(4), MYH6(3) +28 more
0.156 0.769 6.25e-63 3.99e-61 ✓ sig. Cluster 3 →
Cataract Congenital cataract
40 genes
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38 of 40 corroborated by 2+ sources
LSS(6), BFSP2(5), CRYBB2(6), IARS2(1), MAF(4), PITX3(5), PGRMC1(2), VIM(4), CRYAA(6), EPHA2(6), PAX6(2), CRYBA4(5) +28 more
0.180 0.667 2.38e-62 1.51e-60 ✓ sig. Cluster 44 →
Insomnia Schizophrenia
395 genes
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122 of 395 corroborated by 2+ sources
SOX5(2), HMGA2(1), PAFAH1B1(2), DPYD(3), CUL9(1), WWOX(2), PRKG2(1), SPI1(1), CACNA1D(1), ALMS1(1), ADARB1(2), ADGRB3(1) +383 more
0.122 0.366 2.68e-62 1.70e-60 ✓ sig. Cluster 2 →
Developmental disability Neurodevelopmental disorder
82 genes
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47 of 82 corroborated by 2+ sources
CHD8(3), UBE3A(1), ANKRD11(2), RAI1(1), SHANK3(2), PTEN(2), ADNP(2), CTSF(1), ATRX(1), ARID1B(2), CELF4(2), DEAF1(4) +70 more
0.082 0.573 3.58e-62 2.27e-60 ✓ sig. Cluster 5 →
Major depressive disorder Obesity
359 genes
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116 of 359 corroborated by 2+ sources
SOX5(1), RERE(1), COMT(1), DMRT1(1), WWOX(1), PDE4D(2), ABT1(1), AGT(1), AKAP6(1), APOE(3), ARHGEF10L(1), AS3MT(1) +347 more
0.128 0.301 6.21e-62 3.92e-60 ✓ sig. Cluster 2 →
Bipolar disorder Depression
123 genes
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39 of 123 corroborated by 2+ sources
COMT(2), SEC24C(1), INS(2), APP(1), GFAP(1), ACE(1), ADRA1A(1), CNTNAP2(2), CTNND2(2), DAO(1), DISC1(1), DLG2(1) +111 more
0.089 0.441 6.31e-62 3.97e-60 ✓ sig. Cluster 2 →
Hypertrophy Left ventricular disease
30 genes
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30 of 30 corroborated by 2+ sources
ACTA1(2), ACE(2), AGT(2), CKM(2), HBEGF(2), PTPRF(2), REN(2), ADRB3(2), PPP3R1(2), CTNNB1(2), GDF15(2), AHR(2) +18 more
0.349 0.612 6.46e-62 4.05e-60 ✓ sig. Cluster 3 →
Asthma Crohn disease
184 genes
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58 of 184 corroborated by 2+ sources
GLI3(1), CEBPA(1), BLTP1(1), BTNL2(1), CCR7(3), CDHR3(3), CNTNAP2(1), CSMD1(1), EMSY(1), ERBB3(1), ETS1(1), FADS1(1) +172 more
0.117 0.267 9.50e-62 5.94e-60 ✓ sig. —
Hypothyroidism Systemic lupus erythematosus
109 genes
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21 of 109 corroborated by 2+ sources
RERE(1), SH2B3(3), TERT(3), IFIH1(3), AFF1(1), BTNL2(1), C12orf42(1), ETS1(4), FAM171A1(1), FKBPL(1), GABBR1(1), HLA-DQA1(3) +97 more
0.118 0.291 9.63e-62 6.00e-60 ✓ sig. Cluster 39 →
Eczema Respiratory system disease
73 genes
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2 of 73 corroborated by 2+ sources
RERE(1), CEBPA(1), RTEL1(1), CARD11(1), CCR7(1), EMSY(1), ETS1(1), FADS1(1), FADS2(1), HINT1(1), HLA-DQA1(1), HLA-DRB1(1) +61 more
0.137 0.303 4.23e-61 2.63e-59 ✓ sig. Cluster 245 →
Jeune thoracic dystrophy Short rib dysplasia-polydactyly syndrome
22 genes
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15 of 22 corroborated by 2+ sources
EVC2(1), IFT81(1), NEK1(3), IFT43(1), IFT80(2), CEP120(2), DYNC2H1(4), DYNC2I1(4), DYNC2I2(4), DYNC2LI1(2), DYNLT2B(2), IFT140(2) +10 more
0.611 0.917 4.57e-61 2.83e-59 ✓ sig. Cluster 17 →
Inflammatory bowel disease Multiple sclerosis
135 genes
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35 of 135 corroborated by 2+ sources
WWOX(1), GLI3(1), SH2B3(1), CEBPA(1), RBPJ(3), ABT1(1), ANKRD55(1), BTNL2(1), ELMO1(1), ETS1(1), FOXP1(1), FUT2(1) +123 more
0.119 0.234 5.64e-61 3.49e-59 ✓ sig. Cluster 75 →
Cannabis abuse Substance abuse
62 genes
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8 of 62 corroborated by 2+ sources
MCCC2(1), BNC1(1), BARHL2(1), CACNA1A(1), CADM2(1), CTTNBP2(1), ERC2(1), FOXP1(1), FOXP2(1), GABRA2(2), H4C8(1), IGSF11(1) +50 more
0.109 0.534 8.53e-61 5.26e-59 ✓ sig. Cluster 2 →
Cone dystrophy Retinitis pigmentosa
37 genes
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36 of 37 corroborated by 2+ sources
ABCA4(6), CNGA3(2), CNGB3(4), GNAT2(4), PDE6C(7), PDE6H(2), PRPH2(7), CACNA1F(2), ABHD12(2), MKKS(2), PCDH15(2), PDE6B(6) +25 more
0.103 0.974 1.64e-60 1.01e-58 ✓ sig. Cluster 7 →
Diabetes mellitus type 2 Major depressive disorder
678 genes
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180 of 678 corroborated by 2+ sources
SOX5(1), CYP17A1(1), HNF1B(6), KANSL1(1), BPTF(1), CASZ1(1), RERE(1), KIF15(1), COMT(2), SEC24C(2), HDAC4(2), ZFPM2(1) +666 more
0.155 0.346 7.59e-60 4.65e-58 ✓ sig. Cluster 2 →
Diabetes mellitus Heart failure
85 genes
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21 of 85 corroborated by 2+ sources
INS(2), CAT(2), ANKRD26(1), AKAP6(1), ALDH1A2(1), ANKRD31(1), APOB(1), APOC1(3), APOE(2), BAZ1B(1), BCL3(1), CRTC1(1) +73 more
0.125 0.287 1.76e-59 1.07e-57 ✓ sig. —
Non-melanoma skin carcinoma Skin neoplasms
48 genes
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4 of 48 corroborated by 2+ sources
TP53(2), ASIP(2), ATP8B4(1), BNC2(1), CUX1(1), FADS2(1), FOXP1(1), HERC2(1), HLA-DQA1(1), HLA-DQB3(1), HLA-DRB1(1), ICOS(1) +36 more
0.180 0.331 1.81e-59 1.10e-57 ✓ sig. Cluster 23 →
Macular dystrophy Retinitis pigmentosa
39 genes
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34 of 39 corroborated by 2+ sources
ABCA4(6), ATF6(2), CNGA3(2), CNGB3(2), BEST1(6), IMPG1(4), IMPG2(5), PRPH2(7), CACNA1F(2), COL18A1(1), CTNNA1(3), PDE6B(6) +27 more
0.108 0.886 1.86e-59 1.13e-57 ✓ sig. Cluster 7 →
Congenital heart disease Tetralogy of fallot
45 genes
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43 of 45 corroborated by 2+ sources
ANKRD11(2), TBX1(5), NR2F2(4), GATA4(6), NOTCH1(2), HAND1(4), MCTP2(2), NKX2-6(5), NRP1(3), RBFOX2(5), ROBO1(3), TBX5(2) +33 more
0.186 0.395 1.96e-59 1.19e-57 ✓ sig. Cluster 110 →
Anorexia nervosa Eating disorder
43 genes
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1 of 43 corroborated by 2+ sources
WWOX(1), AKAP6(2), ALDH4A1(1), ASB3(1), BLTP3A(1), CAMK1D(1), CSMD1(1), ERBB3(1), FOXP1(1), MGMT(1), NALF1(1), NCKIPSD(1) +31 more
0.153 0.597 2.41e-59 1.46e-57 ✓ sig. Cluster 67 →
Dilated cardiomyopathy Left ventricular noncompaction cardiomyopathy
35 genes
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28 of 35 corroborated by 2+ sources
PRDM16(4), ACTN2(7), CTNNA3(1), DMD(6), DSG2(7), EYA4(5), JUP(1), MYPN(7), PKP2(2), RBM20(8), DSP(7), MYH6(7) +23 more
0.126 0.921 4.35e-59 2.62e-57 ✓ sig. Cluster 3 →
Major depressive disorder Substance abuse
209 genes
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58 of 209 corroborated by 2+ sources
SOX5(1), BPTF(1), MCCC2(1), PER2(2), PER3(2), ADCY8(2), ADCYAP1R1(1), AKAP6(1), ALCAM(1), ANO4(1), ARHGAP15(1), AUTS2(1) +197 more
0.092 0.405 8.41e-59 5.05e-57 ✓ sig. Cluster 2 →
Diabetes mellitus type 2 Insomnia
438 genes
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25 of 438 corroborated by 2+ sources
SOX5(1), HMGA2(1), NF1(1), BPTF(1), DPYD(1), JMJD1C(1), RREB1(1), CACNA1D(2), BLTP1(1), ALMS1(1), ABCB9(1), ADAMTS18(1) +426 more
0.118 0.406 1.09e-58 6.55e-57 ✓ sig. Cluster 2 →
Melanoma Squamous cell carcinoma
123 genes
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38 of 123 corroborated by 2+ sources
ANKRD11(1), NF1(2), RREB1(1), MAP3K1(1), COL2A1(2), NOTCH2(2), PTEN(2), RTEL1(1), TERT(5), TP53(2), TPCN2(1), ASIP(2) +111 more
0.112 0.283 1.65e-58 9.87e-57 ✓ sig. —
Diabetic neuropathy Diabetic retinopathy
54 genes
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22 of 54 corroborated by 2+ sources
INS(2), ACE(2), AGT(2), CDKAL1(2), FSTL5(1), HLA-DRB1(2), HMG20A(1), JAZF1(1), MACF1(1), MACIR(1), NRXN3(1), NYAP2(1) +42 more
0.157 0.329 2.33e-58 1.39e-56 ✓ sig. Cluster 155 →

Showing 25 of 20825 pairs, sorted by significance (ascending). Click a column header to sort.