Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Diabetes mellitus type 1 Hypothyroidism
107 genes
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25 of 107 corroborated by 2+ sources
RERE(1), SH2B3(3), IFIH1(1), BTNL2(1), CAMK4(1), ERBB3(1), ETS1(2), FADS1(1), FADS2(1), FAM76B(1), GLIS3(3), HLA-C(1) +95 more
0.144 0.286 1.44e-74 1.09e-72 ✓ sig. Cluster 39 →
Atrial fibrillation Heart failure
150 genes
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49 of 150 corroborated by 2+ sources
YWHAE(1), CASZ1(3), ZFPM2(1), ATP2A2(3), ANKRD26(1), BRWD1(1), CACNA1D(1), ACE(2), AGT(3), AKAP6(3), ALDH1A2(1), ANKRD31(1) +138 more
0.127 0.319 2.29e-74 1.72e-72 ✓ sig. Cluster 6 →
Ischemic heart disease Myocardial infarction
84 genes
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59 of 84 corroborated by 2+ sources
PRDM16(2), APOA1(1), SH2B3(3), TP53(1), ABCG8(2), ACE(2), APOB(2), APOE(3), ICA1L(2), JCAD(2), KALRN(2), KCNE2(2) +72 more
0.126 0.494 2.96e-74 2.22e-72 ✓ sig. Cluster 6 →
Attention deficit hyperactivity disorder Insomnia
258 genes
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12 of 258 corroborated by 2+ sources
SOX5(1), HMGA2(1), BPTF(1), JMJD1C(1), CACNA1D(1), ALMS1(1), ABCB9(1), ADARB1(1), AFF3(1), AKAP6(1), ARHGAP15(1), AS3MT(3) +246 more
0.134 0.239 5.86e-74 4.38e-72 ✓ sig. Cluster 2 →
Celiac disease Juvenile idiopathic arthritis
69 genes
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13 of 69 corroborated by 2+ sources
RUNX1(1), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), HLA-DQA1(4), HLA-DRA(1), HLA-DRB1(3), IGF2(1), LRRK2(1) +57 more
0.176 0.358 9.42e-74 7.01e-72 ✓ sig. —
Autoimmune disease Common variable immunodeficiency
48 genes
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4 of 48 corroborated by 2+ sources
ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), ICOS(4), IGF2(1), IKZF1(4), LRRK2(1), TENM3(1), TTC33(1), IL10(1) +36 more
0.209 0.640 1.57e-73 1.17e-71 ✓ sig. Cluster 39 →
complex neurodevelopmental disorder Intellectual developmental disorder
79 genes
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79 of 79 corroborated by 2+ sources
CHD8(4), HNRNPU(2), CACNA1D(2), CHD2(2), CNTNAP2(2), CUL3(2), EPB41L1(4), GRIA1(6), GRIK2(6), GRIN2B(5), KCNQ2(2), KMT5B(5) +67 more
0.093 0.669 7.71e-73 5.70e-71 ✓ sig. Cluster 5 →
Non-melanoma skin carcinoma Skin cancer
47 genes
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TP53(1), ATP8B4(1), BNC2(1), CUX1(1), FADS2(1), FOXP1(1), HERC2(1), HLA-DQA1(1), HLA-DQB3(1), HLA-DRB1(1), ICOS(1), MYL10(1) +35 more
0.228 0.566 2.22e-72 1.63e-70 ✓ sig. Cluster 23 →
Celiac disease Common variable immunodeficiency
47 genes
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5 of 47 corroborated by 2+ sources
ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), ICOS(4), IGF2(1), LRRK2(1), TENM3(1), TTC33(1), IL10(1), CRB1(1) +35 more
0.212 0.627 2.34e-72 1.72e-70 ✓ sig. Cluster 39 →
Limb girdle muscular dystrophy Muscular dystrophy
30 genes
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28 of 30 corroborated by 2+ sources
DAG1(2), GMPPB(3), PLEC(2), SGCA(5), HMGCR(4), CRPPA(3), TRAPPC11(6), ANO5(4), TNPO3(3), SGCD(6), LMNA(1), TTN(3) +18 more
0.500 0.789 3.59e-72 2.63e-70 ✓ sig. Cluster 243 →
Coronary artery disease Stroke
139 genes
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51 of 139 corroborated by 2+ sources
SOX5(1), CASZ1(2), PRDM16(3), APOA1(2), SH2B3(3), ANKRD26(1), ACE(2), ALDH1A2(1), ANKRD31(1), APOB(3), APOC1(1), BAZ1B(1) +127 more
0.105 0.430 3.71e-72 2.70e-70 ✓ sig. Cluster 6 →
Metabolic syndrome Schizophrenia
466 genes
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162 of 466 corroborated by 2+ sources
SOX5(2), DPYD(3), HSPG2(2), RERE(1), COMT(3), ZFPM2(1), PDE4D(2), ATP2A2(2), BMPR1B(1), SH2B3(2), DOCK6(1), RBPJ(1) +454 more
0.138 0.358 1.27e-70 9.18e-69 ✓ sig. Cluster 2 →
Multiple sclerosis Systemic lupus erythematosus
142 genes
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45 of 142 corroborated by 2+ sources
RREB1(1), SH2B3(3), TERT(3), AFF1(1), ANKRD55(1), BTNL2(1), DOCK10(1), ETS1(4), FUT2(1), HLA-DQA1(3), HLA-DQB3(1), HLA-DRA(3) +130 more
0.130 0.247 1.27e-70 9.18e-69 ✓ sig. —
Colorectal adenoma Colorectal cancer
88 genes
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1 of 88 corroborated by 2+ sources
BMP2(1), RTEL1(1), TERT(1), FAM193A(1), FMN1(1), HLA-DQA1(1), HLA-DRB1(1), MAP2K5(1), NALF1(1), NXN(1), PLCL1(1), PREX1(1) +76 more
0.086 0.633 1.38e-70 9.95e-69 ✓ sig. Cluster 16 →
Autoimmune thyroid disease Juvenile idiopathic arthritis
61 genes
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11 of 61 corroborated by 2+ sources
RERE(2), ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), HLA-DQA1(2), HLA-DRA(2), HLA-DRB1(2), IGF2(1), LRRK2(1), RHOH(1) +49 more
0.174 0.424 1.80e-70 1.29e-68 ✓ sig. —
Hearing loss Hereditary hearing loss
46 genes
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46 of 46 corroborated by 2+ sources
ESRRB(3), EYA4(3), MYO15A(3), OTOF(3), PCDH15(4), TMC1(2), HGF(2), RDX(3), GSDME(3), DIAPH1(2), MYO1A(2), GJB6(4) +34 more
0.117 0.920 3.59e-70 2.57e-68 ✓ sig. Cluster 20 →
Ciliary dyskinesia Congenital nasopharyngeal atresia
30 genes
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28 of 30 corroborated by 2+ sources
DNAI2(6), HYDIN(7), NME8(8), DNAH5(7), DNAAF2(7), RSPH3(6), CCDC39(7), CCDC40(6), DNAAF1(6), DNAH11(7), DNAI1(5), ODAD1(7) +18 more
0.330 1.000 4.37e-70 3.11e-68 ✓ sig. Cluster 9 →
Liver cirrhosis Nonalcoholic fatty liver disease
78 genes
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37 of 78 corroborated by 2+ sources
CAT(2), PTEN(2), CDH2(1), SERPINA1(3), ACE(2), APOC1(1), APOE(1), COMMD1(3), CYP1A2(2), FARP1(1), HLA-DQA1(2), HLA-DRB1(2) +66 more
0.155 0.295 9.78e-70 6.95e-68 ✓ sig. Cluster 285 →
Ankylosing spondylitis Common variable immunodeficiency
51 genes
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7 of 51 corroborated by 2+ sources
ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), IGF2(1), IKZF1(4), LRRK2(1), TENM3(1), TTC33(1), IL10(1), CRB1(1) +39 more
0.151 0.680 1.29e-69 9.14e-68 ✓ sig. —
Lissencephaly Macrogyria
27 genes
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6 of 27 corroborated by 2+ sources
PAFAH1B1(5), CTNNA2(2), DYNC1H1(1), CASK(1), ARL3(1), NDE1(5), TMEM216(1), TMEM237(1), SEPSECS(1), KIAA0586(1), KIAA0753(1), CHMP1A(1) +15 more
0.509 0.931 4.23e-69 2.99e-67 ✓ sig. Cluster 109 →
Developmental and epileptic encephalopathy genetic developmental and epileptic encephalopathy
36 genes
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36 of 36 corroborated by 2+ sources
WWOX(6), ABAT(3), CACNA1E(6), CUX2(6), PACS2(6), SIK1(6), SYNJ1(6), SZT2(7), GLUL(6), RYR3(3), ITPA(6), GABRB3(6) +24 more
0.163 1.000 1.90e-68 1.34e-66 ✓ sig. —
Combined oxidative phosphorylation deficiency Mitochondrial disease
46 genes
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45 of 46 corroborated by 2+ sources
MICOS13(5), MRPS22(5), AARS2(7), MRPL39(4), MTRFR(7), NARS2(6), ATP5F1A(5), TRIT1(5), MRPS23(4), SLC25A26(6), EARS2(4), FARS2(7) +34 more
0.174 0.676 3.61e-68 2.53e-66 ✓ sig. Cluster 50 →
Diabetic eye disease Diabetic retinopathy
38 genes
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4 of 38 corroborated by 2+ sources
APOE(2), CDKAL1(2), HMG20A(1), JAZF1(1), KLHL42(1), MACF1(1), MACIR(1), NRXN3(1), NYAP2(1), TCF7L2(1), TRPS1(1), PPARG(1) +26 more
0.217 0.792 6.59e-68 4.60e-66 ✓ sig. Cluster 155 →
Asthma Psoriasis
197 genes
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54 of 197 corroborated by 2+ sources
RERE(1), COLEC10(1), CAT(2), RUNX1(1), BLTP1(1), APOE(3), BTNL2(1), CSMD1(3), CTNND2(1), EMSY(1), ERBB3(1), ETS1(1) +185 more
0.123 0.269 3.43e-67 2.39e-65 ✓ sig. —
Marfan syndrome Thoracic aortic aneurysm and aortic dissection
28 genes
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27 of 28 corroborated by 2+ sources
FBN1(8), NOTCH1(2), JAG1(2), COL5A1(2), FBN2(4), PRKG1(5), SLC2A10(2), TGFB2(5), THSD4(3), FLNA(3), BGN(5), SMAD3(6) +16 more
0.491 0.683 4.65e-67 3.22e-65 ✓ sig. Cluster 43 →

Showing 25 of 20825 pairs, sorted by significance (ascending). Click a column header to sort.