Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 137

9 diseases · 14 shared-gene connections
9 Diseases
717 Unique genes
0.052 Avg. similarity score
Colonic neoplasms Most-connected disease (5 links)
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Disease Searched: Colonic neoplasms Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Colonic neoplasms 5 5 203
Ovarian neoplasms 5 5 131
Renal cell carcinoma 5 5 139
Colorectal neoplasms 4 4 291
Pancreatic neoplasms 4 4 117
extraoral halitosis due to methanethiol oxidase deficiency 2 2 1
Acantholytic blistering of oral and laryngeal mucosa 1 1 1
hereditary sclerosing poikiloderma with tendon and pulmonary involvement 1 1 1
neurodevelopmental disorder with hypotonia, neuropathy, and deafness 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
SOD2 5 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms and 1 more
TNFSF10 5 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms and 1 more
TP53 5 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms and 1 more
ALOX12B 4 / 9 Colonic neoplasms, Ovarian neoplasms, Pancreatic neoplasms, Renal cell carcinoma
ALOX5 4 / 9 Colonic neoplasms, Ovarian neoplasms, Pancreatic neoplasms, Renal cell carcinoma
BAP1 4 / 9 Colonic neoplasms, Ovarian neoplasms, Pancreatic neoplasms, Renal cell carcinoma
BIRC5 4 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Renal cell carcinoma
CTNNB1 4 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
EGFR 4 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
KRAS 4 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
MLH1 4 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
MYC 4 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
PTGS2 4 / 9 Colonic neoplasms, Colorectal neoplasms, Pancreatic neoplasms, Renal cell carcinoma
TYMS 4 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
CCND2 3 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms
CDH1 3 / 9 Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
CXCL8 3 / 9 Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
DPYD 3 / 9 Colonic neoplasms, Colorectal neoplasms, Pancreatic neoplasms
EPCAM 3 / 9 Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
ERBB2 3 / 9 Colonic neoplasms, Ovarian neoplasms, Renal cell carcinoma
HNF1B 3 / 9 Colonic neoplasms, Pancreatic neoplasms, Renal cell carcinoma
IFNA2 3 / 9 Colorectal neoplasms, Pancreatic neoplasms, Renal cell carcinoma
KDR 3 / 9 Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
MECOM 3 / 9 Colonic neoplasms, Ovarian neoplasms, Pancreatic neoplasms
MKI67 3 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms
MSH2 3 / 9 Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
MTOR 3 / 9 Colonic neoplasms, Ovarian neoplasms, Renal cell carcinoma
PIK3CA 3 / 9 Colorectal neoplasms, Ovarian neoplasms, Renal cell carcinoma
PPARG 3 / 9 Colonic neoplasms, Colorectal neoplasms, Pancreatic neoplasms
PTEN 3 / 9 Ovarian neoplasms, Pancreatic neoplasms, Renal cell carcinoma
SELENBP1 3 / 9 Colorectal neoplasms, extraoral halitosis due to methanethiol oxidase deficiency, Ovarian neoplasms
SLC2A1 3 / 9 Colonic neoplasms, Ovarian neoplasms, Renal cell carcinoma
SPARC 3 / 9 Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms
STAT3 3 / 9 Colonic neoplasms, Ovarian neoplasms, Pancreatic neoplasms
TET2 3 / 9 Colonic neoplasms, Colorectal neoplasms, Renal cell carcinoma
TNF 3 / 9 Colonic neoplasms, Colorectal neoplasms, Pancreatic neoplasms
TP63 3 / 9 Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms
TYMP 3 / 9 Colonic neoplasms, Colorectal neoplasms, Pancreatic neoplasms
ACHE 2 / 9 Colorectal neoplasms, Renal cell carcinoma
AKT1 2 / 9 Colorectal neoplasms, Ovarian neoplasms
APC 2 / 9 Colonic neoplasms, Colorectal neoplasms
ATP7B 2 / 9 Colorectal neoplasms, Ovarian neoplasms
AXIN2 2 / 9 Colonic neoplasms, Colorectal neoplasms
BAX 2 / 9 Colonic neoplasms, Colorectal neoplasms
BCL2 2 / 9 Colonic neoplasms, Colorectal neoplasms
BRCA1 2 / 9 Ovarian neoplasms, Pancreatic neoplasms
BRCA2 2 / 9 Ovarian neoplasms, Pancreatic neoplasms
BSG 2 / 9 Pancreatic neoplasms, Renal cell carcinoma
CCL20 2 / 9 Colonic neoplasms, Pancreatic neoplasms
CCND1 2 / 9 Colonic neoplasms, Colorectal neoplasms
CCNH 2 / 9 Colonic neoplasms, Ovarian neoplasms
CCR5 2 / 9 Colonic neoplasms, Colorectal neoplasms
CD44 2 / 9 Colorectal neoplasms, Pancreatic neoplasms
CDKN2A 2 / 9 Colorectal neoplasms, Pancreatic neoplasms
CRYAB 2 / 9 Colonic neoplasms, Renal cell carcinoma
CYP1B1 2 / 9 Colorectal neoplasms, Ovarian neoplasms
DLC1 2 / 9 Colorectal neoplasms, Ovarian neoplasms
DNMT1 2 / 9 Colonic neoplasms, Renal cell carcinoma
DSG3 2 / 9 Acantholytic blistering of oral and laryngeal mucosa, Colonic neoplasms
DYRK1A 2 / 9 Colonic neoplasms, Pancreatic neoplasms
EFEMP1 2 / 9 Colorectal neoplasms, Pancreatic neoplasms
FAM111B 2 / 9 hereditary sclerosing poikiloderma with tendon and pulmonary involvement, Renal cell carcinoma
FLCN 2 / 9 Colorectal neoplasms, Renal cell carcinoma
FOLR1 2 / 9 Colonic neoplasms, Ovarian neoplasms
GADD45A 2 / 9 Ovarian neoplasms, Pancreatic neoplasms
GRIK2 2 / 9 Colonic neoplasms, Ovarian neoplasms
GSTM1 2 / 9 Colorectal neoplasms, Renal cell carcinoma
HOXD1 2 / 9 Colorectal neoplasms, Ovarian neoplasms
HOXD9 2 / 9 Colorectal neoplasms, Ovarian neoplasms
HSPB1 2 / 9 Colonic neoplasms, Renal cell carcinoma
IFNA1 2 / 9 Colorectal neoplasms, Pancreatic neoplasms
IGF2 2 / 9 Colonic neoplasms, Colorectal neoplasms
IL6 2 / 9 Ovarian neoplasms, Renal cell carcinoma
IL6ST 2 / 9 Colorectal neoplasms, Ovarian neoplasms
INPP4B 2 / 9 Pancreatic neoplasms, Renal cell carcinoma
KLF5 2 / 9 Colorectal neoplasms, Pancreatic neoplasms
LGR5 2 / 9 Colonic neoplasms, Colorectal neoplasms
MACIR 2 / 9 Colonic neoplasms, Ovarian neoplasms
MET 2 / 9 Ovarian neoplasms, Renal cell carcinoma
MMP2 2 / 9 Colorectal neoplasms, Pancreatic neoplasms
MMP9 2 / 9 Colonic neoplasms, Pancreatic neoplasms
MSH6 2 / 9 Colorectal neoplasms, Pancreatic neoplasms
MSLN 2 / 9 Ovarian neoplasms, Pancreatic neoplasms
MTHFR 2 / 9 Colonic neoplasms, Colorectal neoplasms
NME2 2 / 9 Colorectal neoplasms, Ovarian neoplasms
ODC1 2 / 9 Colonic neoplasms, Colorectal neoplasms
PMS2 2 / 9 Colorectal neoplasms, Pancreatic neoplasms
PRKN 2 / 9 Colonic neoplasms, Ovarian neoplasms
PROM1 2 / 9 Colonic neoplasms, Colorectal neoplasms
RELA 2 / 9 Colonic neoplasms, Renal cell carcinoma
RHPN2 2 / 9 Colonic neoplasms, Colorectal neoplasms
SERPINB5 2 / 9 Colonic neoplasms, Colorectal neoplasms
SFRP2 2 / 9 Colorectal neoplasms, Renal cell carcinoma
SLC19A1 2 / 9 Colonic neoplasms, Colorectal neoplasms
SLCO1B3 2 / 9 Colonic neoplasms, Colorectal neoplasms
SMAD4 2 / 9 Colorectal neoplasms, Pancreatic neoplasms
SMAD7 2 / 9 Colonic neoplasms, Colorectal neoplasms
SPTBN4 2 / 9 neurodevelopmental disorder with hypotonia, neuropathy, and deafness, Renal cell carcinoma
SRC 2 / 9 Colonic neoplasms, Colorectal neoplasms
TCF7L2 2 / 9 Colonic neoplasms, Colorectal neoplasms
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Pathways in cancer
ALK, APAF1, BIRC5, BIRC7, DAPK1, ELOC, EPAS1, ERBB2, GSTM1, GSTP1, GSTT1, IFNA2
 KEGG 119 / 533 3.7× 1.85e-38 1.08e-34 ✓ sig.
ABC transporters
ABCC12, ABCA1, ABCA10, ABCA12, ABCA13, ABCA3, ABCA4, ABCA5, ABCA6, ABCA8, ABCA9, ABCB1
 KEGG 30 / 45 11.2× 1.56e-26 2.94e-23 ✓ sig.
Colorectal cancer
BIRC5, MTOR, PIK3CA, TP53, APC, AXIN2, BAK1, BAX, BCL2, CCND1, CDKN1A, CTNNB1
 KEGG 36 / 87 6.9× 7.42e-22 7.10e-19 ✓ sig.
Hepatocellular carcinoma
GSTM1, GSTP1, GSTT1, KEAP1, MET, MTOR, PBRM1, PIK3CA, PTEN, TP53, APC, AXIN2
 KEGG 49 / 170 4.8× 3.44e-21 2.96e-18 ✓ sig.
Bladder cancer
DAPK1, ERBB2, TP53, VEGFA, CCND1, CDKN1A, EGFR, KRAS, MMP9, MYC, SRC, TYMP
 KEGG 24 / 41 9.8× 1.67e-19 1.15e-16 ✓ sig.
Gastric cancer
ERBB2, MET, MTOR, PIK3CA, TP53, APC, AXIN2, BAK1, BAX, BCL2, CCND1, CDKN1A
 KEGG 41 / 150 4.6× 5.25e-17 2.34e-14 ✓ sig.
Platinum drug resistance
APAF1, BIRC5, ERBB2, GSTM1, GSTP1, GSTT1, PIK3CA, TP53, ATP7A, BAK1, BAX, BCL2
 KEGG 29 / 75 6.5× 6.84e-17 2.96e-14 ✓ sig.
Pancreatic cancer
ERBB2, MTOR, PIK3CA, RELA, TP53, VEGFA, BAK1, BAX, CCND1, CDKN1A, EGFR, KRAS
 KEGG 29 / 77 6.3× 1.58e-16 6.36e-14 ✓ sig.
Chronic myeloid leukemia
PIK3CA, RELA, TP53, BAK1, BAX, CCND1, CDKN1A, KRAS, MECOM, MYC, NFKB1, TGFBR2
 KEGG 29 / 77 6.3× 1.58e-16 6.36e-14 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications
IL6, PIK3CA, RELA, VEGFA, BAX, BCL2, CCND1, ICAM1, IL1B, JUN, KRAS, NFKB1
 KEGG 33 / 101 5.5× 1.81e-16 7.17e-14 ✓ sig.
HIF-1 signaling pathway
ELOC, EPAS1, ERBB2, FLT1, IL6, IL6R, LDHB, MTOR, PDHB, PGK1, PIK3CA, RELA
 KEGG 34 / 110 5.2× 4.27e-16 1.56e-13 ✓ sig.
Endometrial cancer
ERBB2, PIK3CA, PTEN, TP53, APC, AXIN2, BAK1, BAX, CCND1, CDKN1A, CTNNB1, EGFR
 KEGG 25 / 59 7.1× 7.32e-16 2.56e-13 ✓ sig.
Hepatitis B
APAF1, BIRC5, IFNA2, IL6, PIK3CA, RELA, TP53, BAX, BCL2, CDKN1A, JUN, KRAS
 KEGG 41 / 163 4.2× 1.28e-15 4.29e-13 ✓ sig.
Human cytomegalovirus infection
AKAP13, IFNA2, IL6, IL6R, MTOR, PIK3CA, PTGS2, RELA, TP53, TSC1, VEGFA, GNG7
 KEGG 49 / 226 3.6× 1.30e-15 4.33e-13 ✓ sig.
Thyroid cancer
TP53, BAK1, BAX, CCND1, CDKN1A, CTNNB1, KRAS, LEF1, MYC, PPARG, TCF7L2, TPM3
 KEGG 20 / 37 9.1× 1.55e-15 5.12e-13 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
negative regulation of cell population proliferation
BAP1, BCHE, BTG3, FLCN, IL6, NDRG1, NF2, PBRM1, PTEN, RNF139, SFRP2, SOD2
 GO:0008285 72 / 444 4.2× 1.04e-25 3.93e-22 ✓ sig.
response to xenobiotic stimulus
ADIPOQ, ALAD, BCHE, CAT, EEF2, GPX1, RELA, SFRP2, SOD2, TP53, DNMT3A, BAK1
 GO:0009410 51 / 248 5.4× 3.03e-23 7.86e-20 ✓ sig.
apoptotic process
APAF1, BIRC5, BIRC7, CASP2, CRADD, DAPK1, GPX1, HNF1B, IFNA2, PAK1, PIDD1, PRAME
 GO:0006915 91 / 747 3.2× 4.98e-23 1.25e-19 ✓ sig.
positive regulation of DNA-templated transcription
HNF1A, HNF1B, IL6, MITF, RELA, TFE3, TP53, VHL, BICRA, DYRK1A, BRD4, CDX2
 GO:0045893 91 / 778 3.0× 8.64e-22 1.79e-18 ✓ sig.
response to hypoxia
ADIPOQ, ALAD, APAF1, CAT, CRYAB, EPAS1, KCNMA1, PAK1, RYR1, SLC2A1, SOD2, VHL
 GO:0001666 40 / 176 5.9× 3.83e-20 6.31e-17 ✓ sig.
negative regulation of apoptotic process
ANXA4, BIRC5, BIRC7, CASP2, CAT, CRYAB, DAPK1, ERBB2, FMN2, GSTP1, HNF1B, HSPA9
 GO:0043066 70 / 524 3.5× 4.52e-20 7.41e-17 ✓ sig.
positive regulation of apoptotic process
APAF1, CASP2, CRADD, CTSD, DAPK1, FLCN, HSPA9, IL6, KCNMA1, PIDD1, SFRP2, TGM2
 GO:0043065 54 / 326 4.3× 6.11e-20 9.66e-17 ✓ sig.
positive regulation of cell population proliferation
BIRC5, FLT1, IL6, IL6R, MTOR, PAK1, PRAME, PTEN, RELA, SFRP2, FLT4, VEGFA
 GO:0008284 69 / 532 3.4× 4.35e-19 5.97e-16 ✓ sig.
positive regulation of gene expression
ALOX12B, CNN2, ERBB2, HNF1B, IL13, IL6, MITF, RELA, TP53, ZNF804A, DNMT1, VEGFA
 GO:0010628 65 / 504 3.4× 6.61e-18 7.54e-15 ✓ sig.
positive regulation of transcription by RNA polymerase II
EPAS1, HNF1A, HNF1B, IL13, IL6, MET, MITF, MLLT10, MSGN1, OGG1, POMC, PTEN
 GO:0045944 109 / 1,208 2.4× 2.80e-17 2.88e-14 ✓ sig.
regulation of cell population proliferation
ALK, BIRC7, ERBB2, FLT1, MITF, NF2, PTGS2, SFRP2, TP53, DNMT1, CTNNB1, CXCL10
 GO:0042127 37 / 201 4.8× 1.50e-15 1.13e-12 ✓ sig.
MAPK cascade
AKAP13, LRRK2, NF2, PAK1, ITPKB, MAP3K20, CCL3, CCR5, CTNNB1, EGFR, KRAS, MAP2K6
 GO:0000165 31 / 147 5.5× 6.19e-15 4.16e-12 ✓ sig.
positive regulation of vascular endothelial growth factor production
BSG, IL6, PTGS2, RELA, FLT4, IL1B, NOX1, STAT3, ARNT, CYP1B1, GATA4, IL6ST
 GO:0010575 16 / 32 13.0× 6.34e-15 4.25e-12 ✓ sig.
regulation of cell cycle
BAP1, BIRC7, NF2, PRCC, PTEN, TP53, TSC1, BAK1, BAX, BCL2, CCND1, CCND2
 GO:0051726 40 / 262 4.0× 7.34e-14 4.14e-11 ✓ sig.
regulation of apoptotic process
ALK, APAF1, BIRC7, CARD11, CASP2, CRADD, CTSB, DAPK1, NF2, SFRP2, TGM2, TP53
 GO:0042981 39 / 254 4.0× 1.25e-13 6.70e-11 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Ovarian neoplasms Pancreatic neoplasms 0.117 26 4.26e-30 1.31e-28 ✓ sig.
Colonic neoplasms Colorectal neoplasms 0.088 40 2.07e-29 6.14e-28 ✓ sig.
Colorectal neoplasms Pancreatic neoplasms 0.085 32 1.62e-28 4.69e-27 ✓ sig.
Colonic neoplasms Ovarian neoplasms 0.091 28 2.99e-26 7.76e-25 ✓ sig.
Colorectal neoplasms Ovarian neoplasms 0.079 31 1.54e-25 3.85e-24 ✓ sig.
Colonic neoplasms Pancreatic neoplasms 0.081 24 3.65e-22 7.63e-21 ✓ sig.
Colonic neoplasms Renal cell carcinoma 0.055 18 3.11e-13 3.93e-12 ✓ sig.
Ovarian neoplasms Renal cell carcinoma 0.054 14 1.22e-11 1.34e-10 ✓ sig.
Pancreatic neoplasms Renal cell carcinoma 0.053 13 4.16e-11 4.29e-10 ✓ sig.
extraoral halitosis due to methanethiol oxidase deficiency Ovarian neoplasms 0.008 1 8.51e-3 9.84e-3 ✓ sig.
hereditary sclerosing poikiloderma with tendon and pulmonary involvement Renal cell carcinoma 0.007 1 9.03e-3 1.03e-2 ✓ sig.
neurodevelopmental disorder with hypotonia, neuropathy, and deafness Renal cell carcinoma 0.007 1 9.03e-3 1.03e-2 ✓ sig.
Acantholytic blistering of oral and laryngeal mucosa Colonic neoplasms 0.005 1 1.32e-2 1.47e-2 ✓ sig.
Colorectal neoplasms extraoral halitosis due to methanethiol oxidase deficiency 0.003 1 1.89e-2 2.06e-2 ✓ sig.