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Gene Gene information from NCBI Gene database.
Entrez ID 2788
Gene name G protein subunit gamma 7
Gene symbol GNG7
Synonyms (NCBI Gene)
HG3B
Chromosome 19
Chromosome location 19p13.3
miRNA miRNA information provided by mirtarbase database.
220 Show/Hide all (220)
miRTarBase ID miRNA Experiments Reference
MIRT049296 hsa-miR-92a-3p CLASH 23622248
MIRT734968 hsa-miR-183-3p Luciferase reporter assayWestern blottingImmunohistochemistry (IHC) 33139493
MIRT735086 hsa-miR-876-5p Luciferase reporter assayWestern blottingqRT-PCR 34221006
MIRT755527 hsa-miR-146a-3p qRT-PCRRNA-seqELISA 34728702
MIRT1024550 hsa-miR-1224-5p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0001662 Process Behavioral fear response IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005834 Component Heterotrimeric G-protein complex IBA
GO:0005834 Component Heterotrimeric G-protein complex IEA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604430 4410 ENSG00000176533
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60262
Protein name Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Protein function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G prote
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00631 G-gamma 3 → 68 GGL domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer. {ECO:0000269|PubMed:18219292}.
Sequence
Sequence length 68
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Ras signaling pathway Activation of G protein gated Potassium channels
Chemokine signaling pathway Glucagon signaling in metabolic regulation
Hormone signaling G-protein activation
PI3K-Akt signaling pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Apelin signaling pathway ADP signalling through P2Y purinoceptor 12
Circadian entrainment G beta:gamma signalling through PI3Kgamma
Retrograde endocannabinoid signaling Prostacyclin signalling through prostacyclin receptor
Glutamatergic synapse Adrenaline,noradrenaline inhibits insulin secretion
Cholinergic synapse Ca2+ pathway
Serotonergic synapse G alpha (q) signalling events
GABAergic synapse G alpha (12/13) signalling events
Dopaminergic synapse G beta:gamma signalling through PLC beta
Olfactory transduction G alpha (s) signalling events
Relaxin signaling pathway ADP signalling through P2Y purinoceptor 1
Morphine addiction G alpha (i) signalling events
Alcoholism G alpha (z) signalling events
Human cytomegalovirus infection Glucagon-type ligand receptors
Kaposi sarcoma-associated herpesvirus infection Thromboxane signalling through TP receptor
Human immunodeficiency virus 1 infection Vasopressin regulates renal water homeostasis via Aquaporins
Pathways in cancer Thrombin signalling through proteinase activated receptors (PARs)
  Presynaptic function of Kainate receptors
  Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
  G beta:gamma signalling through BTK
  G beta:gamma signalling through CDC42
  Extra-nuclear estrogen signaling
  ADORA2B mediated anti-inflammatory cytokines production
  Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (8)
Phenotype Name Clinical Significance Source Reference Evidence Score
ALZHEIMER DISEASE — GWAS catalog 39998322
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLONIC NEOPLASM — GWAS catalog 36077729
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL NEOPLASMS — CTD 18219292
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GALLBLADDER DISEASE — GWAS catalog 39024449
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION — GWAS catalog 38104120
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (29)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 32525932 Associate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Carcinoma Renal Cell Renal cell carcinoma Pubtator 30945310, 37704946 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 36938730 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Chronic kidney disease stage 5 Kidney Disease BEFREE 31092297
★★★★★
★☆☆☆☆
Found in Text Mining only
Cognition Disorders Cognition disorder Pubtator 32525932 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 35545337 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 30945310
★★★★★
★☆☆☆☆
Found in Text Mining only
Esophageal Neoplasms Esophagus Neoplasm CTD_human_DG 18219292
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gastrointestinal Neoplasms Gastrointestinal neoplasm Pubtator 18219292 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Head and Neck Carcinoma Head And Neck Carcinoma BEFREE 22183866
★★★★★
★☆☆☆☆
Found in Text Mining only